Plant composite powder, preparation method and application thereof

Abstract

The present application relates to the technical field of health food, in particular to a plant composite powder and a preparation method and application thereof. The plant composite powder comprises the following components in parts by weight: 1-20 parts of small green oranges, 1-30 parts of Chinese yam, 3-30 parts of perilla leaves, 10-50 parts of lilies, 1-10 parts of fried small red beans, 0.1-1 parts of white kidney beans, 1-30 parts of snow pears, 0.1-5 parts of white horse beans, and 0.05-1 parts of mogroside. The present application combines lilies and small green oranges with the effect of soothing nerves and helping sleep with perilla leaves with the effect of promoting lung and dredging collaterals, and adds Chinese yam and white horse beans for invigorating spleen and replenishing qi, fried small red beans and white kidney beans for removing dampness and swelling, snow pears for nourishing yin and moistening dryness, and mogroside for adjusting flavors, to form a synergistic formula based on the theory of heart-spleen-lung coordination, so as to achieve the dual effects of improving sleep and relieving allergic rhinitis.

Description

Technical Field

[0001] This invention relates to the field of health food technology, and in particular to a plant compound powder, its preparation method, and its application. Background Technology

[0002] Sleep disorders and allergic rhinitis are two common clinical health problems, and there is a close physiological link between them. Poor sleep quality can lead to immune dysfunction, potentially exacerbating allergic inflammatory responses; conversely, the discomfort symptoms of allergic rhinitis, such as nasal congestion, runny nose, and itchy nose, can interfere with falling asleep and maintaining sleep, creating a vicious cycle of "rhinitis worsening insomnia, and insomnia worsening allergies." Therefore, simultaneously improving sleep quality and alleviating rhinitis symptoms is crucial for breaking this cycle and improving patients' quality of life.

[0003] Currently, commercially available products addressing the aforementioned issues have the following limitations: First, their functions are singular. Sleep aids (such as jujube seed extract and melatonin supplements) primarily act on the central nervous system, focusing on improving difficulty falling asleep and maintaining sleep; while products relieving rhinitis (such as antihistamines and nasal corticosteroid sprays) mainly target local nasal inflammation. Both types of products are typically designed for a single symptom, failing to consider the pathophysiological relationship between the two symptoms and thus failing to achieve holistic treatment. Second, they lack convenience or have side effects. While chemical drugs are fast-acting, they may be accompanied by adverse reactions such as drowsiness, dry mouth, drug tolerance, or drug dependence, raising concerns about their long-term safety. Traditional Chinese medicine decoctions, while emphasizing holistic treatment, are cumbersome to prepare, inconvenient to carry, and have poor patient compliance, making long-term use difficult. Third, their formulations lack refined compatibility. Although some existing dietary therapy products use ingredients that are both food and medicine, they often contain only one type of ingredient or are simply piled up together. They lack systematic theoretical guidance on the compatibility of ingredients to address the pathological mechanisms of the interaction between insomnia and rhinitis, resulting in limited functional effects.

[0004] Therefore, developing a compound product based on the theory of food and medicine sharing the same origin, which can simultaneously and gently regulate sleep and rhinitis symptoms, and is easy to carry and consume daily, has significant value and promising prospects. Summary of the Invention

[0005] The purpose of this invention is to address the problems existing in the prior art by providing a plant-based compound powder, its preparation method, and its application. This involves scientifically combining lily and small green tangerines, which have calming and sleep-aiding effects, with perilla leaves, which have lung-clearing and orifice-opening effects. It is further supplemented with yam and white hyacinth bean, which invigorate the spleen and replenish qi; stir-fried red adzuki bean and white kidney bean, which promote diuresis and reduce swelling; snow pear, which nourishes yin and moistens dryness; and monk fruit glycosides, which harmonize the flavors. This forms a synergistic formula based on the theory of "harmonizing the heart, spleen, and lungs," thereby achieving the dual effects of simultaneously improving sleep and relieving allergic rhinitis.

[0006] To achieve the above objectives, the present invention provides a plant compound powder comprising the following components in parts by weight: 1-20 parts of small green tangerine, 1-30 parts of yam, 3-30 parts of perilla leaf, 10-50 parts of lily, 1-10 parts of roasted red adzuki bean, 0.1-1 part of white kidney bean, 1-30 parts of snow pear, 0.1-5 parts of white hyacinth bean, and 0.05-1 part of monk fruit glycoside.

[0007] In one optional embodiment, the weight parts of each component are as follows: 5-15 parts of small green tangerine, 5-20 parts of yam, 10-25 parts of perilla leaf, 20-40 parts of lily bulb, 3-8 parts of roasted red adzuki bean, 0.2-0.8 parts of white kidney bean, 5-20 parts of snow pear, 1-3 parts of white hyacinth bean, and 0.1-0.5 parts of monk fruit glycoside.

[0008] This invention also provides a method for preparing the aforementioned plant compound powder, comprising the following steps: The components are mixed and sterilized to obtain the plant composite powder.

[0009] In an optional embodiment, before mixing the components, a pretreatment step is included for each component; the pretreatment specifically includes: washing and slicing the small green tangerines, snow pears, yams, perilla leaves, and lilies, and then drying them at a temperature controlled at ≤60℃; after drying, pulverizing them separately and passing them through an 80-100 mesh sieve to obtain small green tangerine powder, snow pear powder, yam powder, perilla leaf powder, and lily powder; and pulverizing the roasted red beans, white kidney beans, and white hyacinth beans separately and passing them through a 60-80 mesh sieve to obtain roasted red bean powder, white kidney bean powder, and white hyacinth bean powder.

[0010] In an optional embodiment, the mixing is carried out in a three-dimensional motion mixer or a V-type mixer; the relative humidity of the mixing is ≤45%; and mixing is stopped when the coefficient of variation (CV) of the mixing uniformity is ≤5%.

[0011] In one optional embodiment, the sterilization process is either irradiation sterilization or steam sterilization; the irradiation sterilization dose is ≤6kGy; the steam sterilization temperature is 100-110℃ and the time is 3-7s.

[0012] In one optional implementation, after sterilization, the product is automatically packaged and sealed according to predetermined specifications in a clean environment to obtain the finished plant composite powder.

[0013] The present invention also provides the application of the plant compound powder described herein or the plant compound powder prepared according to the preparation method of the plant compound powder described herein in the preparation of foods, health products or medicines for improving sleep.

[0014] The present invention also provides the application of the plant compound powder described above, or the plant compound powder prepared according to the preparation method of the plant compound powder described above, in the preparation of food, health products or medicines for relieving allergic rhinitis.

[0015] The present invention also provides the application of the plant compound powder described herein or the plant compound powder prepared according to the preparation method of the plant compound powder described herein in the preparation of foods, health products or medicines that simultaneously improve sleep and relieve allergic rhinitis.

[0016] The beneficial effects of this invention are as follows: (1) Based on the traditional Chinese medicine theory of "harmonizing the heart, spleen, and lungs," this invention scientifically combines lily and small green tangerine, which have calming and sleep-aiding effects, with perilla leaves, which have lung-clearing and orifice-opening effects. It is further supplemented with yam and white hyacinth bean, which strengthen the spleen and replenish qi; stir-fried red adzuki bean and white kidney bean, which promote diuresis and reduce swelling; snow pear, which nourishes yin and moistens dryness; and monk fruit glycosides, which harmonize the flavors, forming a novel formula with multi-target synergistic effects. Experimental Example 3 shows that the plant compound powder of this invention can simultaneously improve sleep quality and alleviate allergic rhinitis symptoms, achieving a dual-regulation effect of "sleep-rhinitis," effectively breaking the vicious cycle of insomnia and rhinitis mutually influencing each other. At the same time, the plant compound powder of this invention has good safety, no toxic side effects, and is suitable for long-term consumption as a daily health food or functional food.

[0017] (2) The preparation method of the present invention adopts a low-temperature drying process, which preserves the heat-sensitive active ingredients in the raw materials to the maximum extent; by controlling the fineness of the pulverization and the uniformity of the mixing, the quality stability between batches of the product is ensured; irradiation sterilization or low-temperature steam instantaneous sterilization is used to effectively kill microorganisms while minimizing the impact on the powder properties and nutritional components. The preparation process is simple and feasible, suitable for industrial production, and the resulting plant compound powder has a fresh taste, good solubility, and is easy to carry, which significantly improves patients' compliance with the medication.

[0018] In summary, this invention provides a plant-based compound powder that can simultaneously improve sleep and relieve allergic rhinitis. Through precise formulation and scientific preparation, it achieves synergistic effects on multiple targets, and has good safety and stable and controllable quality, thus possessing significant clinical application value and broad market prospects. Attached Figure Description

[0019] Figure 1 This is a schematic diagram of the evaluation results of sleep quality and rhinitis symptoms in this invention. Detailed Implementation

[0020] The following embodiments are provided to better understand the present invention and are not limited to the preferred embodiments described. They do not constitute a limitation on the content and scope of protection of the present invention. Any product that is the same as or similar to the present invention, derived by any person under the guidance of the present invention or by combining the features of the present invention with other prior art, falls within the protection scope of the present invention.

[0021] For experiments not specifically described in the examples, the procedures or conditions should be followed according to the conventional experimental procedures described in the literature in this field. Unless otherwise specified, all raw materials used are commercially available ordinary food ingredients that meet the relevant national food standards. Reagents or instruments whose manufacturers are not specified are all commercially available conventional reagent products.

[0022] In the following embodiments and comparative examples of the present invention, the stir-fried red beans are prepared by stir-frying red beans over a low heat until the skin is slightly cracked and emits a charred aroma.

[0023] Example 1 This embodiment provides a plant-based compound powder, comprising the following components in parts by weight: 10 portions of small green tangerines, 15 portions of yam, 15 portions of perilla leaves, 30 portions of lily bulbs, 5 portions of stir-fried red beans, 0.5 portions of white kidney beans, 15 portions of snow pears, 2 portions of white hyacinth beans, and 0.3 portions of monk fruit glycosides.

[0024] This invention also provides a method for preparing the above-mentioned plant compound powder, comprising the following steps: Pretreatment: Wash the small green tangerines, snow pears, yams, perilla leaves, and lilies separately with clean water to remove surface impurities. Cut each component into thin slices and place them in a drying device for low-temperature drying at 55℃ until the moisture content is below 8%. Grind each dried component separately using a grinder and pass them through an 80-mesh sieve to obtain small green tangerine powder, snow pear powder, yam powder, perilla leaf powder, and lily powder, for later use. Grind the roasted red beans, white kidney beans, and white lentils separately using a grinder and pass them through an 80-mesh sieve to obtain roasted red bean powder, white kidney bean powder, and white lentil powder, for later use.

[0025] Mixing: Add all the above powdered raw materials (small green tangerine powder, snow pear powder, yam powder, perilla leaf powder, lily powder, roasted red bean powder, white kidney bean powder, white hyacinth bean powder) and monk fruit glycosides into a three-dimensional motion mixer, control the relative humidity of the mixing environment to 40%, carry out closed mixing, and take samples to test the mixing uniformity coefficient of variation (CV) to 3.8%, and stop mixing.

[0026] Sterilization and Packaging: The uniformly mixed composite powder is sterilized by cobalt-60 irradiation at a dose of 5 kGy. After sterilization, the powder is automatically packaged into aluminum foil composite film bags in 5-gram portions in a cleanroom and sealed to obtain the finished plant composite powder.

[0027] Example 2 This embodiment provides a plant-based compound powder, comprising the following components in parts by weight: 8 portions of small green tangerines, 20 portions of yam, 20 portions of perilla leaves, 35 portions of lily bulbs, 6 portions of stir-fried red beans, 0.3 portions of white kidney beans, 12 portions of snow pears, 1.5 portions of white hyacinth beans, and 0.2 portions of monk fruit glycosides.

[0028] This invention also provides a method for preparing the above-mentioned plant compound powder, comprising the following steps: Pretreatment: Same as in Example 1.

[0029] Mixing: Add all the above powdered raw materials (small green tangerine powder, snow pear powder, yam powder, perilla leaf powder, lily powder, roasted red bean powder, white kidney bean powder, white hyacinth bean powder) and monk fruit glycosides into a V-type mixer, control the relative humidity of the mixing environment to 40%, carry out sealed mixing, and take samples to test the coefficient of variation (CV) of the mixing uniformity. If it is 4.1%, stop mixing.

[0030] Sterilization and Packaging: The uniformly mixed compound powder is steam-sterilized at 105℃ for 5 seconds. After sterilization, it is rapidly cooled and automatically packaged into aluminum foil composite film bags in 3-gram portions in a clean room, then sealed to obtain the finished plant compound powder.

[0031] Example 3 This embodiment provides a plant-based compound powder, comprising the following components in parts by weight: 12 portions of small green tangerines, 10 portions of yam, 12 portions of perilla leaves, 25 portions of lily bulbs, 4 portions of stir-fried red beans, 0.7 portions of white kidney beans, 18 portions of snow pears, 2.5 portions of white hyacinth beans, and 0.4 portions of monk fruit glycosides.

[0032] This invention also provides a method for preparing the above-mentioned plant compound powder, comprising the following steps: Pretreatment: Same as in Example 1.

[0033] Mixing: Same as in Example 1.

[0034] Sterilization and Packaging: The uniformly mixed composite powder is sterilized by cobalt-60 irradiation at a dose of 4 kGy. After sterilization, the powder is automatically packaged into aluminum foil composite film bags in 10-gram portions in a cleanroom and sealed to obtain the finished plant composite powder.

[0035] Comparative Example 1 This comparative example provides a plant compound powder that is basically the same as that in Example 1, except that perilla leaves and lily bulbs were not added.

[0036] Comparative Example 2 This comparative example provides a plant compound powder that is basically the same as Example 1, except that the weight parts of some components have been adjusted, specifically 25 parts of small green tangerine, 35 parts of yam, 5 parts of lily, and 2 parts of monk fruit glycosides.

[0037] Experimental Example 1 The efficacy of the plant compound powder of this invention in improving sleep was evaluated by observing its effect on the sleep time induced by sodium pentobarbital in mice.

[0038] Test samples: plant composite powders prepared in Examples 1-2 and Comparative Examples 1-2.

[0039] Experimental animals: SPF-grade KM mice, male, weighing 18-22g, used for experiments after 3 days of acclimatization feeding.

[0040] Grouping and Administration: Mice were randomly divided into 5 groups of 12 mice each: blank control group, Example 1 group, Example 2 group, Comparative Example 1 group, and Comparative Example 2 group. Example 1 group, Example 2 group, Comparative Example 1 group, and Comparative Example 2 group were administered the corresponding test sample (prepared as a suspension of the required concentration using physiological saline) by gavage at a dose of 2.0 g / kg body weight. The blank control group was administered an equal volume of physiological saline by gavage. The gavage volume for all mice was 20 mL / kg body weight. All animals were administered the sample once daily for 30 consecutive days.

[0041] Direct sleep experiment: After the last administration, observe whether the animals in each group exhibit direct sleep (i.e., the righting reflex of mice disappears for more than 1 minute within 60 minutes after administration). Record the number of animals exhibiting direct sleep in each group.

[0042] Experiment to prolong the sleep time of sodium pentobarbital: 30 minutes after the last administration, each group of animals was intraperitoneally injected with a suprathreshold dose of sodium pentobarbital (45 mg / kg body weight). The disappearance of the righting reflex in mice was used as the indicator of falling asleep, and the recovery of the righting reflex was used as the indicator of awakening. The duration of sleep of the mice (the time from the disappearance of the righting reflex to the recovery of the righting reflex) was recorded.

[0043] The experimental results are as follows: Direct sleep experiment: During the experiment, no mice in any group showed direct sleep, indicating that the plant compound powder of the present invention does not have a direct hypnotic effect and is a mild conditioning agent.

[0044] Experiment on prolonging sodium pentobarbital sleep time: The results of sleep time are shown in Table 1.

[0045] Table 1 Sleep duration results

[0046] The results showed that, compared with the blank control group, the sleep duration of mice in both Example 1 and Example 2 groups was significantly prolonged, indicating that the plant compound powder of the present invention has the effect of improving sleep. Compared with Example 1 group, the sleep duration of Comparative Example 1 group (lacking perilla leaves and lily) and Comparative Example 2 group (component dosages exceeding the range) was significantly shortened, indicating that the specific component compatibility and dosage range of the present invention play a key role in achieving its sleep-improving efficacy.

[0047] Experiment Example 2 The effects of the plant compound powder of this invention on allergic rhinitis symptoms were observed using an ovalbumin (OVA)-induced allergic rhinitis mouse model.

[0048] Test sample: Same as in Experiment 1.

[0049] Experimental animals: SPF-grade BALB / c mice, female, weighing 18-20g, used for experiments after acclimatization feeding for 1 week.

[0050] Model establishment and grouping: Mice were randomly divided into 6 groups of 10 mice each: normal control group, model control group, Example 1 group, Example 2 group, Comparative Example 1 group, and Comparative Example 2 group. Except for the normal control group, all other groups used OVA to establish an allergic rhinitis model. Specific methods: On days 1, 7, and 14, each mouse was intraperitoneally injected with 0.2 mL of PBS suspension containing 20 μg OVA and 2 mg aluminum hydroxide adjuvant for basal sensitization. Starting from day 21, each mouse was challenged by intranasal instillation of 10 μL of PBS solution containing 2 mg / mL OVA (5 μL per nasal cavity) once daily for 7 consecutive days. The normal control group received the same amount of PBS instilled in the same manner. All groups began gavage administration on day 21 (the day of the first challenge) for 14 consecutive days. The dosage was the same as in Example 1 (2.0 g / kg body weight). The normal control group and model control group were administered an equal volume of physiological saline by gavage.

[0051] Behavioral observation: Within 10 minutes after the last provocation, the number of times the mice scratched their noses and sneezed was observed and recorded.

[0052] Serum OVA-sIgE level determination: 24 hours after the last challenge, blood was collected from the orbital cavity, serum was separated, and the absorbance (OD value) was measured at a wavelength of 450 nm according to the ELISA kit instructions to reflect the relative level of OVA-specific IgE (OVA-sIgE) in the serum.

[0053] Eosinophil (EOS) infiltration count in the nasal mucosa: Mice were sacrificed after blood collection, and nasal mucosal tissue was harvested, fixed, embedded, and sectioned routinely. Hematoxylin-eosin (HE) staining was performed, and the number of eosinophils in five fields of view in each section was counted under an optical microscope (400×), and the average value was taken. The results of rhinitis relief are shown in Table 2.

[0054] Table 2 Results of Rhinitis Relief

[0055] The results showed that, compared with the model control group, the number of times mice scratched their noses, sneezed, had serum OVA-sIgE levels, and EOS infiltration counts in the nasal mucosa were significantly reduced in both Example 1 and Example 2 groups, indicating that the plant compound powder of the present invention can effectively relieve the symptoms of allergic rhinitis. Compared with Example 1 group, all indicators in Comparative Example 1 and Comparative Example 2 groups were significantly worse, further confirming the synergistic effect of specific components in the formulation of the present invention and the necessity of precise dosage range.

[0056] Experimental Example 3 Human trials were conducted to comprehensively evaluate the efficacy and safety of the plant-based compound powder of this invention on subjects suffering from both sleep disorders and allergic rhinitis.

[0057] Inclusion criteria for trial participants: (1) Meeting the diagnostic criteria for allergic rhinitis in the Chinese Guidelines for the Diagnosis and Treatment of Allergic Rhinitis (2022) and having symptoms lasting for ≥1 year; (2) Meeting the diagnostic criteria for chronic insomnia in the Chinese Guidelines for the Diagnosis and Treatment of Adult Insomnia, with a Pittsburgh Sleep Quality Index (PSQI) score >7; (3) Age 18-60 years, gender not limited; (4) Voluntary participation and signing of informed consent form. Exclusion criteria: (1) Pregnant or lactating women; (2) Those who have taken antihistamines, glucocorticoids, sedative-hypnotics, or other drugs that may affect the trial results within the past month; (3) Those with severe heart, liver, kidney, endocrine system diseases, or mental illnesses; (4) Those with allergic constitutions or allergies to the ingredients of this trial product.

[0058] Grouping and Dosage: A randomized, double-blind, placebo-controlled design was used. 120 eligible subjects were randomly assigned to two groups of 60 each: an experimental group and a control group. The experimental group received the plant-based compound powder prepared in Example 1, while the control group received a placebo (composed of edible dextrin, food coloring, and a small amount of mogrosides to ensure a similar taste to the experimental group) with identical appearance, packaging, and taste. The dosage for both groups was one sachet (5g / sachet) twice daily, dissolved in warm water, for four consecutive weeks.

[0059] Sleep quality assessment: The Pittsburgh Sleep Quality Index (PSQI) was used to score all subjects before and after the trial to assess subjective sleep quality, sleep onset time, sleep duration, sleep efficiency, sleep disorders, use of hypnotics, and daytime dysfunction.

[0060] Rhinitis symptom evaluation: Before and after the trial, the total rhinitis symptom score (TNSS) of the subjects was recorded, including 4 items: nasal congestion, runny nose, nasal itching, and sneezing. Each item was scored from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, 3 = severe), with a total score of 0 to 12.

[0061] Safety evaluation: Blood routine, urine routine, liver and kidney function of subjects were tested before and after the trial, and the occurrence time, manifestation, severity and treatment of all adverse events during the trial were recorded in detail.

[0062] A total of 120 subjects were enrolled in the trial, with 112 valid subjects ultimately completing the trial, resulting in 8 dropouts (dropout rate 6.7%). Two subjects dropped out in the experimental group (1 due to business travel interruption, 1 lost to follow-up), and 6 subjects dropped out in the control group (3 withdrew due to perceived ineffectiveness, 2 due to time conflicts, 1 lost to follow-up). The final number of valid subjects included in the statistical analysis was 58 in the experimental group and 54 in the control group. The baseline data of the two groups were comparable in terms of age, gender, and disease duration, with no statistically significant differences.

[0063] The average values ​​were taken to obtain the evaluation results of sleep quality and rhinitis symptoms, as shown in Table 3. Simultaneously, a schematic diagram of the evaluation results of sleep quality and rhinitis symptoms was drawn, as shown below. Figure 1 As shown in the figure. Furthermore, safety evaluation results showed that during the trial, two subjects in the experimental group experienced mild abdominal distension at the beginning of medication. No special treatment was given, and the symptoms subsided spontaneously after continued medication, without affecting the trial progress. No adverse events were reported in the control group. Blood routine tests, urine routine tests, and liver and kidney function indicators of both groups were within the normal range before and after the trial.

[0064] Table 3. Evaluation results of sleep quality and rhinitis symptoms

[0065] The results show that the plant compound powder of the present invention can significantly improve the sleep quality of patients with sleep disorders and effectively relieve their allergic rhinitis symptoms, achieving the dual effect of "sleep-rhinitis" regulation. It is safe, has no toxic side effects, and is suitable for long-term consumption.

[0066] Therefore, this invention scientifically combines lily and small green tangerine, which have the effect of calming the nerves and aiding sleep, with perilla leaves, which have the effect of clearing the lungs and opening the orifices. It also adds yam and white hyacinth bean, which invigorate the spleen and replenish qi, stir-fried red adzuki bean and white kidney bean, which promote diuresis and reduce swelling, snow pear, which nourishes yin and moistens dryness, and monk fruit glycoside, which harmonizes the flavors. This forms a synergistic formula based on the theory of "harmonizing the heart, spleen and lungs", thereby achieving the dual effects of improving sleep and relieving allergic rhinitis.

[0067] Finally, it should be noted that the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the scope of protection of this invention.

Claims

1. A plant-based composite powder, characterized in that, The ingredients include the following components in parts by weight: 1-20 parts small green tangerines, 1-30 parts yam, 3-30 parts perilla leaves, 10-50 parts lily bulbs, 1-10 parts roasted red beans, 0.1-1 part white kidney beans, 1-30 parts snow pears, 0.1-5 parts white hyacinth beans, and 0.05-1 part monk fruit glycosides.

2. The plant-based composite powder according to claim 1, characterized in that, The weight proportions of each component are as follows: 5-15 parts of small green tangerine, 5-20 parts of yam, 10-25 parts of perilla leaf, 20-40 parts of lily bulb, 3-8 parts of stir-fried red adzuki bean, 0.2-0.8 parts of white kidney bean, 5-20 parts of snow pear, 1-3 parts of white hyacinth bean, and 0.1-0.5 parts of monk fruit glycoside.

3. The method for preparing the plant composite powder according to claim 1 or 2, characterized in that, Includes the following steps: The components are mixed and sterilized to obtain the plant composite powder.

4. The method for preparing the plant composite powder according to claim 3, characterized in that, The relative humidity of the mixture is ≤45%; mixing is stopped when the coefficient of variation of the uniformity of the mixture is ≤5%.

5. The method for preparing the plant composite powder according to claim 3, characterized in that, The sterilization process is carried out by irradiation sterilization or steam sterilization.

6. The method for preparing the plant composite powder according to claim 5, characterized in that, The dose for irradiation sterilization is ≤6 kGy.

7. The method for preparing the plant composite powder according to claim 5, characterized in that, The steam sterilization temperature is 100-110℃, and the time is 3-7 seconds.

8. The use of the plant compound powder according to claim 1 or 2, or the plant compound powder prepared by the method according to any one of claims 3-7, in the preparation of food, health products or medicines for improving sleep.

9. The use of the plant compound powder according to claim 1 or 2, or the plant compound powder prepared by the method according to any one of claims 3-7, in the preparation of food, health products or medicines for relieving allergic rhinitis.

10. The use of the plant compound powder according to claim 1 or 2, or the plant compound powder prepared by the method according to any one of claims 3-7, in the preparation of food, health products or medicines that simultaneously improve sleep and relieve allergic rhinitis.

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