An enteral nutritional supplement for hyperlipidemia, its preparation method and application

Abstract

The present application belongs to the technical field of enteral nutrition preparation, and particularly relates to an enteral nutrition supplement for hyperlipidemia, a preparation method and application thereof. The enteral nutrition supplement comprises the following raw materials: medium-chain triglyceride, camellia chrysanthemum culture and cherry blossom polyphenol, and further comprises protein 15-25 parts, carbohydrate 40-50 parts, compound vitamin 0.01-0.05 parts and mineral 1-5 parts. The prepared enteral nutrition supplement is composed of a fat system completely formed by medium-chain fatty acid ester, and the blood fat is improved by synergistic effect of the camellia chrysanthemum culture and the cherry blossom polyphenol, so as to solve the application problem of traditional long-chain fat nutrition support under specific pathological conditions such as fatty liver, chylous fistula and chronic pancreatitis.

Description

Technical Field

[0001] This invention belongs to the field of enteral nutrition preparation technology, specifically relating to an enteral nutrition supplement for hyperlipidemia, its preparation method, and its application. Background Technology

[0002] Hyperlipidemia, a common cardiovascular metabolic disease, is characterized by abnormally elevated blood lipid levels, including cholesterol and triglycerides exceeding normal ranges. This condition not only directly increases the risk of atherosclerosis but is also closely associated with major diseases such as coronary heart disease and stroke. Traditional treatment strategies mainly rely on dietary intervention, exercise therapy, and lipid-lowering drugs, but these suffer from poor patient compliance and unstable long-term effects. Especially for hyperlipidemia patients with malnutrition or impaired digestive function, conventional nutritional support methods are often insufficient to meet their metabolic needs, necessitating the development of targeted enteral nutrition intervention programs.

[0003] Enteral nutrition, a treatment method that provides metabolic energy and nutritional matrix through the gastrointestinal tract via oral or tube feeding, has demonstrated unique advantages in chronic disease management. Its core mechanism lies in directly supplementing essential nutrients, improving the body's negative energy balance, and simultaneously maintaining the integrity of the intestinal mucosa and immune function. Studies have shown that enteral nutrition can exert its lipid-lowering effect through multiple pathways: on the one hand, formulas rich in ω-3 polyunsaturated fatty acids can regulate the activity of lipid metabolism enzymes and inhibit inflammatory responses; on the other hand, dietary fiber components can promote cholesterol excretion and reduce the absorption of exogenous lipids.

[0004] Chinese invention patent application CN105077253A discloses a complete nutritional formula food for elderly patients with hyperlipidemia and its preparation method. The raw materials include: deep-sea fish collagen peptide powder, maltodextrin, resistant starch, whey protein powder, fructooligosaccharides, MCT powder, resistant dextrin, EPA, Ganoderma lucidum polysaccharide, apigenin or celery seed extract, sea buckthorn flavonoids or sea buckthorn extract, sucralose, amino acids, vitamins, and inorganic salts. The complete nutritional formula food contains EPA, apigenin, and sea buckthorn flavonoids. This complete nutritional formula makes up for the deficiencies of existing complete nutritional formula foods for elderly patients with hyperlipidemia. The nutrient ratio is balanced, which can effectively prevent and reduce blood lipids, thereby reducing a series of syndromes caused by hyperlipidemia.

[0005] Another Chinese invention patent application, CN103402532A, discloses an enteral nutrition agent that maintains excellent emulsification even when mixed with gastric and intestinal juices, and is unlikely to cause diarrhea even when digestive and absorptive functions are reduced, despite containing lipids. Specifically, egg yolk lysophospholipids, medium-chain triglycerides, and fatty acids are added to the aforementioned lipid-containing enteral nutrition agent. The ratio of medium-chain triglycerides to lipids is 20-65% by mass. When mixed with artificial gastric juice at a 1:1 ratio, the average particle size (by volume) is less than 10 μm, and when mixed with artificial intestinal juice at a 1:1 ratio, the average particle size (by volume) is less than 5 μm.

[0006] However, existing enteral nutrition products still have significant limitations in the application of hyperlipidemia. Either their lipid-regulating effects are uncertain, or they contain too many components, failing to maximize the effects and interactions between the components. Some products have excessively high fat content or contain long-chain fatty acids, which may exacerbate lipid metabolism disorders; others lack antioxidants and other components, failing to synergistically improve the lipid profile and intestinal microenvironment. Summary of the Invention

[0007] To overcome the above technical problems, the present invention provides an enteral nutrition supplement for hyperlipidemia, its preparation method and application.

[0008] To achieve the above objectives, the technical solution provided by this invention is as follows: On one hand, the present invention provides an enteral nutrition supplement for hyperlipidemia, comprising the following ingredients: medium-chain triglycerides, Camellia chrysantha culture and cherry blossom polyphenols.

[0009] Medium-chain fatty acid esters (MCTs) are a class of ester compounds formed by the esterification reaction of medium-chain fatty acids with carbon chains of C6-C12 and alcohols (especially glycerol). MCTs are the most representative example. Their molecular structure consists of the dehydration condensation of one molecule of glycerol and three molecules of medium-chain fatty acid. Common industrial products are caprylic / capric triglycerides, often in a 1:1 or 2:1 ratio, exhibiting both low melting point and high stability. These substances have a density between 0.94-0.96 g / mL and a viscosity of only 24-32 mPa·s, significantly lower than long-chain fatty acid esters. They also possess excellent water solubility and oxidative stability, with iodine values ​​typically below 1.0 and peroxide values ​​not exceeding 10 mmol / kg, making them resistant to rancidity and polymerization.

[0010] In the food industry, medium-chain fatty acid esters are widely used in ketogenic diet formulations, functional low-calorie fat substitutes, chocolate coating anti-frost, ice crystal inhibition in ice cream, flavor solvents, and dairy product emulsification stabilization systems. In the pharmaceutical and nutritional fields, due to their metabolic characteristics of not requiring bile emulsification, entering the liver directly via the portal vein, and providing rapid β-oxidation energy (completed within 15–20 minutes), they are used in postoperative parenteral nutrition, support for fat malabsorption syndrome, adjunctive intervention for metabolic diseases, and foods for special medical purposes (FSMP). Moreover, they do not accumulate as body fat, making them suitable for people trying to lose weight. They are efficient, safe, and multifunctional nutritional and industrial raw materials.

[0011] Camellia petelotii culture is a novel food ingredient produced using plant tissue culture technology. It is made from the leaves of Camellia petelotii through processes such as sterilization, callus induction, culture, collection, drying, and pulverization. Its main components include dietary fiber, protein, various minerals, and 16 amino acids. It is rich in bioactive substances such as tea polyphenols (≥6.0 g / 100g) and total flavonoids (≥4.0 g / 100g), providing a variety of high-quality proteins and minerals for the enteral nutrition supplement of this invention. Furthermore, Camellia petelotii culture is rich in tea polyphenols and total flavonoids, exhibiting strong free radical scavenging capabilities. Cherry blossom polyphenols, mainly composed of quercetin, kaempferol, and their glycoside derivatives, possess anti-inflammatory, antioxidant, and vascular protective effects. This invention has found that both have a synergistic effect in scavenging reactive oxygen free radicals and inhibiting lipid peroxidation, thus promoting improved lipid metabolism.

[0012] Cherry blossom polyphenols are a novel food ingredient made from the petals of the Japanese late-blooming cherry (Prunus cerasifera), a plant belonging to the genus Prunus in the Rosaceae family. The process involves modern plant extraction techniques, including ethanol extraction, filtration, concentration, drying, and pulverization. The core active substance of this ingredient is total polyphenolic compounds, with a content of no less than 12 g / 100 g. These mainly include polyphenolic molecules such as 5-O-caffeoyl glucose, quercetin-3-O-glucoside, catechins, flavonol glycosides, and ellagic acid. Modern research shows that they possess antioxidant and anti-glycation effects. Among these, quercetin, catechins, and ellagic acid can regulate blood lipids, lowering TC, TG, and LDL, and raising HDL. The mechanisms include inhibiting cholesterol absorption. Some studies have also reported potential effects in lowering blood sugar.

[0013] In some specific embodiments of the present invention, the ingredients include the following by weight: 5-15 parts of medium-chain triglycerides, 0.5-2 parts of Camellia chrysantha culture, and 0.1-0.5 parts of cherry blossom polyphenols.

[0014] In some specific embodiments of the present invention, the medium-chain triglycerides can be commercially available or prepared in-house.

[0015] Palm kernel oil and coconut oil contain high levels of medium-chain triglycerides.

[0016] In some specific embodiments of the present invention, the raw materials further include 15-25 parts of protein, 40-50 parts of carbohydrates, 0.01-0.05 parts of complex vitamins, and 1-5 parts of minerals.

[0017] In some specific embodiments of the present invention, the protein source is selected from one or two of whey protein powder and casein, by weight. In some specific embodiments of the present invention, the source of the carbohydrate is selected from one or two of banana powder, fructooligosaccharides, and oat flour; In some specific embodiments of the present invention, the compound vitamin is selected from one or more of vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K1, pantothenic acid, biotin, niacin, and folic acid.

[0018] Preferably, the mineral is selected from sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine, selenium, chromium, and molybdenum.

[0019] In some specific embodiments of the present invention, the source of the protein includes whey protein powder and casein in a mass ratio of 1:1-2.

[0020] Preferably, the carbohydrate source includes banana powder, fructooligosaccharides, and oat flour in a mass ratio of 1:2-5:0.5-2.

[0021] Preferably, the compound vitamins include 0.1-0.5 parts of vitamin A, 0.1-0.5 parts of vitamin B1, 0.1-0.5 parts of vitamin B2, 0.1-0.5 parts of vitamin B6, and vitamin B... 12 0.001-0.005 parts, vitamin C 1-5 parts, vitamin D3 0.001-0.005 parts, niacin 1-5 parts and folic acid 0.05-0.1 parts.

[0022] Preferably, the minerals are selected from sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine, selenium, chromium and molybdenum in a mass ratio of 400-500:600-800:0.2-0.6:100-120:5-10:1-5:0.5-1:300-500:100-300:0.03-0.07:300-400:0.01-0.04:0.01-0.02:0.01-0.04.

[0023] Secondly, the present invention provides a method for preparing an enteral nutrition supplement, comprising the following steps: (1) Mix the Camellia chrysantha culture and cherry blossom polyphenols evenly; (2) Add multivitamins and minerals and mix well; (3) Add medium-chain triglycerides, protein, and carbohydrates and mix well to obtain the final product.

[0024] In some specific embodiments of the present invention, the raw materials of the compound vitamin are mixed evenly in advance in step (2).

[0025] Thirdly, the present invention provides the application of the above-mentioned enteral nutrition supplement in the preparation of products that help regulate blood lipids.

[0026] Compared with the prior art, the technical advantages of the present invention are as follows: (1) This invention relates to a special medical purpose complete nutritional formula food (enteral nutrition supplement) designed specifically for patients with hyperlipidemia, fatty liver, chylous leakage, and chronic pancreatitis, and its preparation method. The core innovation of this product lies in its fat system, which is composed entirely of medium-chain fatty acids. By synergistically improving blood lipids with Camellia chrysantha culture and cherry blossom polyphenols, it aims to solve the application problems of traditional long-chain fatty acid nutritional support under specific pathological conditions such as fatty liver, chylous leakage, and chronic pancreatitis.

[0027] (2) This invention abandons traditional vegetable oils (long-chain fatty acids) and uses 100% medium-chain fatty acids (MCT) as the sole fat source. Medium-chain fatty acids have a small molecular weight and high water solubility, and can be directly absorbed into the liver via the portal vein system to provide rapid energy without relying on bile salts and pancreatic enzymes, bypassing the intestinal lymphatic system. This characteristic fundamentally avoids the generation of chylomicrons and lymphatic vessel burden caused by the digestion and absorption of long-chain fats, and is a targeted nutritional intervention against the pathological mechanism of chylous leakage.

[0028] (3) While achieving a fat revolution, this product is scientifically formulated with high-quality protein, balanced carbohydrates, essential vitamins, minerals and dietary fiber. In addition, it ensures that patients receive comprehensive and balanced nutritional support during use, meets the body's metabolic and repair needs, and maintains a positive nitrogen balance.

[0029] (4) Precise metabolic friendliness: Medium-chain fatty acids are rapidly oxidized and do not easily accumulate in the body, which can effectively reduce serum triglyceride levels. Combined with the components of this invention, it provides a solution for patients with hyperlipidemia that combines nutritional therapy and metabolic regulation. Detailed Implementation

[0030] The present invention will be described below through specific embodiments to make the technical solution of the present invention easier to understand and master, but the present invention is not limited thereto. Unless otherwise specified, the experimental methods described in the following embodiments are conventional methods; unless otherwise specified, the reagents and materials are all commercially available.

[0031] The supplier of the medium-chain triglycerides is Shanghai Baisifu Food Development Co., Ltd., the product name is caprylic / capric triglyceride, the brand is KLKOLEO, and the model is odo food grade.

[0032] The supplier of the Camellia chrysantha culture is Dalian Puruikang Biotechnology Co., Ltd., with total flavonoids ≥4% and tea polyphenols ≥6%.

[0033] The cherry blossom polyphenol supplier is Ningxia Xiangcao Biotechnology Co., Ltd., and it is a 10% food-grade powder.

[0034] The supplier of alpha-linolenic acid is Shanxi Qingye Biotechnology Co., Ltd., product number QYSW-210-502; The supplier of linoleic acid is Shandong Tianfu Biotechnology Co., Ltd., product number 635-8.

[0035] Example 1 This embodiment provides an enteral nutrition supplement, which, by weight, contains the following ingredients: 15 parts protein, 42 parts carbohydrates, 0.01 parts complex vitamins, 10 parts medium-chain triglycerides, 1 part Camellia chrysantha culture, 0.2 parts cherry blossom polyphenols, and 2 parts minerals.

[0036] The protein is whey protein powder and casein in a 1:1 mass ratio, and the carbohydrate is banana powder, fructooligosaccharides and oat flour in a 1:2:0.5 mass ratio.

[0037] The complex vitamins comprise vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K1, pantothenic acid, biotin, niacin, and folic acid in a mass ratio of 0.3:0.1:0.1:1:0.001:20:0.003:60:0.03:1:0.01:3:0.1.

[0038] The minerals are selected from sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine, selenium, chromium and molybdenum in a mass ratio of 400:600:0.2:100:5:1:0.5:300:100:0.03:300:0.01:0.01.

[0039] The preparation method steps are as follows: (1) Place all raw materials evenly in a stainless steel tray, dry at 60°C for 2 hours, crush, pass through an 80-mesh sieve, and weigh them according to their weight parts. (2) Mix the golden camellia culture and cherry blossom polyphenols evenly; (3) Place the protein, carbohydrates, and medium-chain triglycerides in a three-dimensional mixer and mix them evenly; (4) Add the sieved vitamins and minerals to the mixer in a gradient manner and mix them. (5) Mix the well-mixed system from steps (2) to (4) again until it is well mixed.

[0040] Example 2 This embodiment provides an enteral nutrition supplement, which, by weight, comprises the following ingredients: 24 parts protein, 48 parts carbohydrates, 0.05 parts complex vitamins, 15 parts medium-chain triglycerides, 2 parts Camellia chrysantha culture, 0.5 parts cherry blossom polyphenols, and 5 parts minerals.

[0041] The protein is whey protein powder and casein in a mass ratio of 1:2, and the carbohydrate is banana powder, fructooligosaccharides and oat flour in a mass ratio of 1:5:2.

[0042] The complex vitamins comprise vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K1, pantothenic acid, biotin, niacin, and folic acid in a mass ratio of 0.5:0.5:1:5:0.003:50:0.008:80:0.05:5:0.02:8:0.3.

[0043] The minerals are selected from sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine, selenium, chromium and molybdenum in a mass ratio of 500:800:0.6:120:10:5:1:500:300:0.07:400:0.04:0.02:0.04.

[0044] The preparation method steps are as follows: (1) Place all raw materials evenly in a stainless steel tray, dry at 60°C for 2 hours, crush, pass through an 80-mesh sieve, and weigh them according to their weight parts. (2) Mix the golden camellia culture and cherry blossom polyphenols evenly; (3) Place the protein, carbohydrates, and medium-chain triglycerides in a three-dimensional mixer and mix them evenly; (4) Add the sieved vitamins and minerals to the mixer in a gradient manner and mix them. (5) Mix the well-mixed system from steps (2) to (4) again until it is well mixed.

[0045] Example 3 This embodiment provides an enteral nutrition supplement, which, by weight, includes the following ingredients: 21 parts protein, 45 parts carbohydrates, 0.02 parts complex vitamins, 5 parts medium-chain triglycerides, 1 part Camellia chrysantha culture, 0.3 parts cherry blossom polyphenols, and 3 parts minerals.

[0046] The protein sources include whey protein powder and casein in a mass ratio of 1:2, and the carbohydrate sources include banana powder, fructooligosaccharides, and oat flour in a mass ratio of 1:3:1.

[0047] The compound vitamins consist of vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K1, pantothenic acid, biotin, niacin, and folic acid in a mass ratio of 0.4:0.2:0.5:3:0.002:30:0.005:70:0.04:3:0.01:5:0.2.

[0048] The minerals are selected from sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine, selenium, chromium and molybdenum in a mass ratio of 450:700:0.5:110:6:3:0.8:400:200:0.05:350:0.03:0.01:0.02.

[0049] The preparation method steps are as follows: (1) Place all raw materials evenly in a stainless steel tray, dry at 60°C for 2 hours, crush, pass through an 80-mesh sieve, and weigh them according to their weight parts. (2) Mix the golden camellia culture and cherry blossom polyphenols evenly; (3) Place the protein, carbohydrates, and medium-chain triglycerides in a three-dimensional mixer and mix them evenly; (4) Add the sieved vitamins and minerals to the mixer in a gradient manner and mix them. (5) Mix the well-mixed system from steps (2) to (4) again until it is well mixed.

[0050] Comparative Example 1 The only difference between this comparative example and Example 1 is that the Camellia chrysantha culture is replaced with cherry blossom polyphenols.

[0051] Comparative Example 2 The only difference between this comparative example and Example 1 is that cherry blossom polyphenols are replaced with Camellia chrysantha culture.

[0052] Comparative Example 3 The only difference between this comparative example and Example 1 is that 10 parts of medium-chain triglycerides were replaced with 2 parts of medium-chain triglycerides, 4 parts of linoleic acid, and 4 parts of α-linolenic acid.

[0053] Comparative Example 4 The only difference between this comparative example and Example 1 is the ratio of raw materials. Specifically, the raw materials, by weight, are as follows: 10 parts protein, 35 parts carbohydrates, 0.01 parts complex vitamins, 22 parts medium-chain triglycerides, 0.2 parts Camellia chrysantha culture, 1 part cherry blossom polyphenols, and 2 parts minerals.

[0054] Comparative Example 5 The only difference between this comparative example and Example 1 is the specific raw materials for the protein and carbohydrates. Specifically, the protein is a 1:1 mass ratio of soy protein isolate and whey protein, and the carbohydrates are a 1:1 mass ratio of crystalline fructose and maltodextrin.

[0055] Experiment 1: Pharmacodynamic Experiment of Lipid-Lowering Agents Eighty-eight healthy male SD rats, weighing 200±20g, were selected. After one week of normal acclimatization, eight rats were fed a normal diet as the control group, while the remaining rats were fed a high-fat diet (a mixture of 60% basal diet, 10% lard, 20% sucrose, 5% cholesterol, and 5% sodium cholate). All rats had free access to water. After four weeks of feeding, their body weight was measured to establish a hyperlipidemia model in rats.

[0056] The hyperlipidemic model rats were then randomly divided into 10 groups: model group, positive group, Examples 1-3, and Comparative Examples 1-5, with 8 rats in each group. Examples 1-3 and Comparative Examples 1-5 were administered the corresponding enteral nutrition supplements at a dosage of 2 g product / kg. The enteral nutrition supplements were dissolved and dispersed in water to prepare a 0.4 g / mL solution. The model group and normal group were given the same dose of physiological saline. The positive group was administered simvastatin suspension at 1.5 mg / kg by gavage. After 4 weeks of gavage, the rats were fasted but allowed free access to water for 12 hours. Serum levels of total triglycerides, total cholesterol, low-density lipoprotein, and high-density lipoprotein were measured. All experimental data were statistically analyzed using SPSS 13.0 software, and t-tests were used for comparisons between groups. The results are shown in Table 1.

[0057] Table 1. Effects of each group on regulating lipid metabolism

[0058] Note: Compared with the blank group, *P<0.05, **P<0.01; compared with the model group, #P<0.05, ##P<0.01; compared with Example 1 group, △P<0.05, △△P<0.01.

[0059] Table 1 shows that, after screening of raw materials and proportions, the enteral nutrition supplement provided by this invention can reduce total cholesterol, low-density lipoprotein and triglycerides in rats to a certain extent. Although it is not superior to the positive group, as a nutritional supplement, it can help regulate blood lipids, and the nutritional supplement has a relatively significant effect on improving high-density lipoprotein.

[0060] Furthermore, the present invention has the following advantages: A revolutionary fat source: Abandoning traditional vegetable oils (long-chain fatty acids), this invention uses 100% medium-chain fatty acids (MCT) as the sole fat source. Medium-chain fatty acids have a small molecular weight and high water solubility, allowing for direct absorption into the liver via the portal vein system for rapid energy supply, bypassing the intestinal lymphatic system, without relying on bile salts and pancreatic enzymes. This characteristic fundamentally avoids the formation of chylomicrons and lymphatic vessel burden caused by the digestion and absorption of long-chain fats, representing a targeted nutritional intervention against the pathological mechanism of chylous leakage.

[0061] Comprehensive nutritional support: While achieving a fat revolution, this invention scientifically combines high-quality protein, balanced carbohydrates, essential vitamins, and minerals to ensure that patients receive comprehensive and balanced nutritional support during use, meeting the body's metabolic and repair needs and maintaining a positive nitrogen balance.

[0062] Precise metabolic friendliness: Medium-chain fatty acids are rapidly oxidized and do not easily accumulate in the body, effectively reducing serum triglyceride levels. This provides a solution that combines nutritional therapy and metabolic regulation for patients with hyperlipidemia, fatty liver, chylous leakage, and chronic pancreatitis, aiming to solve the application challenges of traditional long-chain fatty acid nutritional support under specific pathological conditions.

[0063] The above detailed description is a specific description of one of the feasible embodiments of the present invention. This embodiment is not intended to limit the patent scope of the present invention. All equivalent implementations or modifications that do not depart from the present invention should be included within the scope of the technical solution of the present invention.

Claims

1. An enteral nutrition supplement for hyperlipidemia, characterized in that, It includes the following ingredients: medium-chain triglycerides, Camellia chrysanthemi culture, and cherry blossom polyphenols.

2. The enteral nutrition supplement according to claim 1, characterized in that, By weight, it includes the following ingredients: 5-15 parts medium-chain triglycerides, 0.5-2 parts Camellia chrysantha culture, and 0.1-0.5 parts cherry blossom polyphenols.

3. The enteral nutrition supplement according to claim 2, characterized in that, The raw materials also include 15-25 parts protein, 40-50 parts carbohydrates, 0.01-0.05 parts compound vitamins, and 1-5 parts minerals.

4. The enteral nutrition supplement according to claim 3, characterized in that, The protein source is selected from one or both of whey protein powder and casein, based on parts by weight. And / or, the source of the carbohydrate is selected from one or two of banana powder, fructooligosaccharides, and oat flour; And / or, the multivitamin is selected from vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin B1, vitamin B2, vitamin B2, vitamin B3, vitamin B4, vitamin B5, vitamin B6, vitamin B1, vitamin B2 ... 12 One or more of the following: Vitamin C, Vitamin D, Vitamin E, Vitamin K1, Pantothenic Acid, Biotin, Niacin, and Folic Acid; And / or, the mineral is selected from sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine, selenium, chromium and molybdenum.

5. The enteral nutrition supplement according to claim 3, characterized in that, The protein sources include whey protein powder and casein in a mass ratio of 1:1-2.

6. The enteral nutrition supplement according to claim 3, characterized in that, The carbohydrate sources include banana powder, fructooligosaccharides, and oat flour in a mass ratio of 1:2-5:0.5-2.

7. The enteral nutrition supplement according to claim 3, characterized in that, The compound vitamins comprise vitamin A, vitamin B1, vitamin B2, vitamin B6, and vitamin B1 in a mass ratio of 0.3-0.5:0.1-0.5:0.1-1:1-5:0.001-0.003:20-50:0.003-0.008:60-80:0.03-0.05:1-5:0.01-0.02:3-8:0.1-0.

3. 12 Vitamins C, D, E, K1, pantothenic acid, biotin, niacin, and folic acid.

8. The enteral nutrition supplement according to claim 3, characterized in that, The minerals are selected from sodium, potassium, copper, magnesium, iron, zinc, manganese, calcium, phosphorus, iodine, chlorine, selenium, chromium and molybdenum in a mass ratio of 400-500:600-800:0.2-0.6:100-120:5-10:1-5:0.5-1:300-500:100-300:0.03-0.07:300-400:0.01-0.04:0.01-0.02:0.01-0.

04.

9. A method for preparing the enteral nutrition supplement according to any one of claims 5-8, characterized in that, Includes the following steps: (1) Mix the Camellia chrysantha culture and cherry blossom polyphenols evenly; (2) Add multivitamins and minerals and mix well; (3) Add medium-chain triglycerides, protein, and carbohydrates and mix well to obtain the final product.

10. The use of the enteral nutrition supplement according to any one of claims 1-8 in the preparation of products that assist in regulating blood lipids.

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