Traditional Chinese medicine composition with whitening, anti-inflammatory and acne-removing effects, extraction method and application thereof

Abstract

The present application provides a traditional Chinese medicine composition with whitening, anti-inflammatory and acne-removing effects, and an extraction method and application thereof, aiming at solving the technical problems of single effect, poor safety and antagonistic components of existing acne-removing and whitening products. The traditional Chinese medicine composition comprises basic raw materials, and the basic raw materials comprise pearl powder, saffron, cinnamomum subavenium leaf, green tea, bergamot, almond, camellia flower and sweet cinnamon. The extraction method of the traditional Chinese medicine composition comprises a water vapor distillation method and a solvent extraction method, and can obtain pure distillate, essential oil or thick extract, respectively. The present application also relates to cosmetics of the traditional Chinese medicine composition or extract thereof and a preparation method thereof, and the use of the traditional Chinese medicine composition or extract thereof in preparing cosmetics with whitening, anti-inflammatory and acne-removing effects. The traditional Chinese medicine composition in the present application realizes multi-target synergistic effect through scientific compounding, has significant whitening, anti-inflammatory and acne-removing comprehensive effects, is high in safety, mild and non-irritating, and is suitable for long-term use.

Description

Technical Field

[0001] This invention relates to the fields of cosmetics and pharmaceutical technology, and in particular to a traditional Chinese medicine composition with whitening, anti-inflammatory and acne-removing effects, its extraction method and application. Background Technology

[0002] Acne is a series of inflammatory reactions triggered by the skin's inability to properly excrete sebum. It is a chronic inflammatory skin condition occurring in the hair follicle and sebaceous gland tissue, primarily affecting areas with high sebum secretion such as the face, chest, and back. The causes of acne are complex, usually resulting from the combined effects of multiple factors. The main triggers include abnormal androgen regulation of sebaceous glands, abnormal keratinization of the sebaceous gland ducts, excessive proliferation of Propionibacterium acnes, and inflammatory immune responses.

[0003] Acne not only affects a patient's appearance but also leads to decreased self-confidence, reduced quality of life, and even mental health issues such as depression. In their efforts to prevent acne and alleviate symptoms, some patients become impatient and resort to unsafe or improper acne treatments. These products may contain exfoliating agents, corticosteroids, and other ingredients that, with prolonged use, can damage the integrity of the stratum corneum, inhibit lipid synthesis, and ultimately impair the skin barrier.

[0004] Acne treatment products on the market can be categorized by the source of their active ingredients into those containing pure herbal extracts and those containing chemically synthesized ingredients. The source, type, and content of the active ingredients in acne treatment cosmetics not only determine the effectiveness of acne treatment but also, to some extent, affect the health of consumers. Currently, some acne treatment products, in pursuit of significant results, often add antibiotics, hormones, or chemicals that have a strong irritant effect on the skin. Examples include pharmaceutical antibiotics such as lincomycin, chloramphenicol, chlortetracycline hydrochloride, tetracycline hydrochloride, doxycycline hydrochloride, minocycline hydrochloride, oxytetracycline dihydrate, and metronidazole; pharmaceutical corticosteroids such as dexamethasone sodium phosphate; and substances like salicylic acid and adapalene. Long-term use of such products can damage the skin barrier function, inhibit the synthesis of lipids in the stratum corneum, leading to skin sensitivity, dryness, redness, and even steroid-dependent dermatitis, seriously endangering the health of consumers.

[0005] The depth of skin color depends primarily on the content and distribution of melanin; therefore, the core of skin whitening lies in regulating melanin production and distribution. Existing skin whitening regulatory mechanisms targeting melanin production and distribution mainly include: inhibiting melanin formation, inhibiting melanin granule transfer, promoting the shedding of skin containing more melanin, blocking signal transduction pathways in the melanin production process, and reducing exogenous factors that cause melanin formation.

[0006] However, existing chemical whitening agents and acne treatments, besides having issues such as irritation or limited effectiveness, often focus on single-effect products (e.g., simple whitening or simple anti-inflammation), and their ingredient combinations lack synergistic design, making it difficult to achieve multi-target effects. Some formulas suffer from irrational ingredient ratios, leading to antagonistic interactions between active ingredients and affecting overall efficacy. Therefore, there is an urgent need to develop a product with significant anti-acne, whitening, and anti-inflammatory effects, while also being safe, stable, and easily absorbed. Summary of the Invention

[0007] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine composition with whitening, anti-inflammatory, and acne-removing effects, centered on natural plant ingredients, along with its extraction method and application. This addresses the problems of single efficacy, poor safety, and antagonistic components in existing acne-removing and whitening products. By screening natural ingredients such as pearl powder, saffron (or crassirhizoma crocus), and camphor leaves, this invention utilizes the synergistic effects of multiple components and targets to achieve comprehensive whitening, anti-inflammatory, and acne-removing effects. This overcomes the shortcomings of existing natural medicine technologies, such as focusing on single efficacy and unreasonable formula proportions. Its safety is significantly superior to chemically synthesized products, and it is gentle and non-irritating during use, making it suitable for long-term use.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] A traditional Chinese medicine composition with whitening, anti-inflammatory and acne-removing effects includes basic raw materials, which include: pearl powder, saffron, camphor leaves, green tea, Buddha's hand, almond, camellia, and nard.

[0010] This invention, through scientific screening and formulation, organically combines eight traditional Chinese medicinal herbs—pearl powder, saffron, camphor leaf, green tea, bergamot, almond, camellia, and nard—to form a synergistic effect. All raw materials in this composition are natural medicinal plant ingredients that have undergone long-term clinical or human use verification, ensuring high biocompatibility. This formulation is unprecedented in existing technologies, marking the first time that camphor leaf, a unique plant in the Lauraceae family, has been applied to cosmetics. Synergistic effects are achieved through compositional and proportional optimization with core ingredients such as pearl powder and saffron. Compared to traditional whitening formulas that primarily focus on inhibiting a single tyrosinase pathway, this invention innovatively integrates multiple pathways—whitening, anti-inflammatory, and sebum secretion regulation—achieving a multi-target synergistic effect through a series of unique combinations. This results in a formula that is less prone to drug resistance, gentle and non-irritating, suitable for sensitive skin, and offers both skincare and therapeutic benefits.

[0011] Optionally, the basic raw materials include the following ingredients in parts by weight: 50-150 parts pearl powder, 10-50 parts saffron, 50-150 parts camphor leaves, 50-150 parts green tea, 50-150 parts Buddha's hand, 50-150 parts almonds, 20-100 parts camellia flowers, and 10-50 parts spikenard.

[0012] Optionally, the basic raw materials include the following ingredients in parts by weight: 100 parts pearl powder, 20 parts saffron, 100 parts camphor leaves, 100 parts green tea, 100 parts Buddha's hand, 100 parts almonds, 50 parts camellia flowers, and 20 parts spikenard.

[0013] Optionally, the traditional Chinese medicine composition also includes auxiliary ingredients, which are selected from one or more of the following: Oroxylum indicum, Abelmoschus mandshurica, Witch hazel, Glycyrrhiza uralensis, Portulaca oleracea, and Gentiana scabra. Further optimization of composition and proportion enhances synergistic effects: A combination of Pterocarya stenoptera leaf, green tea, and Oroxylum indicum forms a comprehensive anti-oxidation and anti-glycation combination to prevent dullness and sagging skin; saffron, Abelmoschus mandshurica, Portulaca oleracea, Gentiana scabra, and Glycyrrhiza uralensis forms a soothing and repairing barrier combination to achieve immediate soothing and root-cause anti-inflammatory effects; pearl powder, Glycyrrhiza uralensis, Oroxylum indicum, and Citrus medica form a multi-target whitening and brightening combination to synergistically whiten and fade spots from multiple angles; Nardostachys jatamansi, Witch hazel, Almond, and Camellia japonica form a deep anti-aging and repairing combination, with both collagen-promoting and strong moisturizing effects; and Abelmoschus mandshurica, Camellia japonica, and Almond form an oil-water-replenishing moisturizing combination to mimic a healthy sebum film for long-lasting hydration. These synergistic combinations break away from the single-effect design approach, achieving comprehensive multi-target conditioning.

[0014] Optionally, the dosage range of auxiliary raw materials can be: 30-100 parts of Oroxylum indicum, 30-100 parts of Abelmoschus manihot, 30-100 parts of witch hazel, 30-100 parts of licorice, 30-100 parts of purslane, and 30-100 parts of gentian.

[0015] Optionally, the dosage range of auxiliary raw materials can be: 40-60 parts of Oroxylum indicum, 40-60 parts of Abelmoschus manihot, 40-60 parts of witch hazel, 40-60 parts of licorice, 40-60 parts of purslane, and 40-60 parts of gentian.

[0016] Optionally, the auxiliary raw materials are selected from one or more of the following medicinal materials: 50 parts of Oroxylum indicum, 50 parts of Abelmoschus mandshurica, 50 parts of witch hazel, 50 parts of licorice, 50 parts of purslane, and 50 parts of gentian.

[0017] An extraction method for the above-mentioned traditional Chinese medicine composition, wherein the method is steam distillation or solvent extraction.

[0018] Optionally, the steam distillation method includes the following steps:

[0019] Step S11: Take the raw materials, crush and mix them;

[0020] Step S12: Add purified water or a mixture of purified water and sodium chloride, and heat at 80-100℃ for extraction;

[0021] Step S13: Collect hydrosols or essential oils that are 2-5 times the total weight of the base ingredients.

[0022] Optionally, the solvent extraction method includes the following steps:

[0023] Step S21: Take the raw materials, crush and mix them;

[0024] Step S22: Extract by reflux at 60℃-80℃ 2-3 times with 50%-70% (v / v) ethanol-water mixed solvent for 1-2 hours each time;

[0025] Step S23: Combine the extracts and concentrate under reduced pressure to obtain a thick extract.

[0026] The above extraction process combines low-temperature short-time distillation or supercritical extraction with traditional distillation, resulting in higher activity retention and processing efficiency.

[0027] A cosmetic product comprising the aforementioned traditional Chinese medicine composition or an extract prepared by the aforementioned method.

[0028] Optionally, the dosage forms of the cosmetics include lotions, essential oils, sprays, creams, emulsions, or masks. The prepared cosmetic dosage forms are comprehensive, including lotions, creams, and masks, and can be adapted to different skin types. In particular, the lotions provide a refreshing and comfortable user experience without being sticky, and their efficacy has been verified by human experience and clinical trials, demonstrating outstanding and reliable results.

[0029] A method for preparing the above-mentioned cosmetic involves mixing the above-mentioned traditional Chinese medicine composition or the extract prepared by the above method with excipients acceptable in the cosmetic field to form a corresponding dosage form.

[0030] A method for preparing a traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition solution includes the following steps:

[0031] Step X11: Weigh the components of phase A according to the following weight percentages: glycerin 2.0%, sodium hyaluronate 0.2%, hydroxyethyl urea 0.5%, triethanolamine 0.1%, propylene glycol 2.0%, and 90% of the hydrosol of the traditional Chinese medicine composition prepared by the above method. Mix them evenly and place them in an aqueous phase tank for heating.

[0032] Step X12: Weigh the components of phase B according to the following weight percentages: 0.1% carbomer and 2.6% purified water, and mix thoroughly.

[0033] Step X13: When phase A in step X11 is heated to 85°C, phase B in step X12 is added to phase A. After thorough mixing, the mixture is pumped into an emulsification tank and the cooling water circulation is turned on to cool it down.

[0034] Step X14: Weigh the components of phase C according to the following weight percentages: aloe vera extract 1.5%, phenoxyethanol 0.5%, hexanediol 0.5%, and mix thoroughly.

[0035] Step X15: When the emulsification tank cools down to 40°C, add phase C from step X14, stir evenly, and then discharge to obtain the solution.

[0036] A method for preparing a traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition emulsion includes the following steps:

[0037] Step X21: Weigh the components of phase A according to the following weight percentages: 5.0% cetearyl alcohol ethylhexanoate, 5.0% glycerol, 5.0% PEG-20 methyl glucose sesquistearate, 2.5% behenol, 2.0% methyl glucose sesquistearate, 2.0% glyceryl stearate, and 1.5% phenoxyethanol. Add them to the oil phase heating tank, heat to 80°C, and sterilize by maintaining the temperature. Set aside for later use.

[0038] Step X22: Weigh the components of phase B according to the following weight percentages: 1,3-butanediol 5.0%, tocopheryl acetate 1.0%, purified water 60.0%, add them to the aqueous phase heating tank, heat to 80°C, keep warm for sterilization, and set aside for later use;

[0039] Step X23: Pump phase B from step X22 into the emulsification tank, keep the temperature of the emulsification tank at 80°C, start homogenization and stirring, slowly add phase A from step X21 into phase B, homogenize after complete addition, continue stirring after homogenization, turn on cooling water to cool down, and reduce stirring speed.

[0040] Step X24: Weigh the components of phase C according to the following weight percentages: 1.0% ascorbate glucoside and 10.0% of the extract of traditional Chinese medicine composition prepared by the above method, and mix them evenly;

[0041] Step X25: After the emulsification tank cools to 40°C, add phase C from step X24, stir evenly, and then discharge to obtain the emulsion. The relative density of the thick extract at 60°C is 1.1-1.2 g / mL.

[0042] A method for preparing a cream containing a traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition includes the following steps:

[0043] Step X31: Weigh the components of phase A according to the following weight percentages: 5.0% cetearyl alcohol ethylhexanoate, 5.0% olive oil, 5.0% PEG-20 methyl glucoside sesquistearate, 2.0% behenol, 2.0% methyl glucoside sesquistearate, 2.0% glyceryl stearate, and 1.5% phenoxyethanol. Add them to the oil phase heating tank, heat to 80°C, and sterilize by maintaining the temperature. Set aside for later use.

[0044] Step X32: Weigh the components of phase B according to the following weight percentages: 1,3-butanediol 5.0%, tocopheryl acetate 1.0%, lecithin 0.5%, purified water 60.0%, add them to the aqueous phase heating tank, heat to 80°C, keep warm and sterilize, and set aside for later use;

[0045] Step X33: Pump phase B from step X32 into the emulsification tank, keep the temperature of the emulsification tank at 80°C, start homogenization and stirring, slowly add phase A from step X31 into phase B, homogenize after complete addition, continue stirring after homogenization, turn on cooling water, and reduce the speed to 12 rpm.

[0046] Step X34: Weigh the components of phase C according to the following weight percentages: 1.0% ascorbate glucoside and 10.0% of the extract of traditional Chinese medicine composition prepared by the above method, and mix them evenly;

[0047] Step X35: Cool the emulsification tank to 40°C, add phase C from step X34 into the emulsification tank, stir continuously for 30 minutes, and then discharge the material to produce a traditional Chinese medicine acne-removing, anti-inflammatory, and whitening cream.

[0048] The use of the above-mentioned traditional Chinese medicine composition or the extract prepared by the above method in the preparation of cosmetics with whitening, anti-inflammatory and acne-removing effects.

[0049] The roles and mechanisms of the above-mentioned raw materials in this invention are as follows:

[0050] Pearl powder: whitening and brightening, oil control and astringent, promotes repair, and gives skin a radiant glow. Pearl powder is derived from marine or freshwater mollusks, such as the pearl oyster (Pinctada martensii), and is made by grinding the nacre secreted by them. Its rich content of natural calcium carbonate provides absorption capacity, cleanses pores, gently exfoliates, and controls oil; various amino acids (such as alanine and glycine) participate in skin metabolism, promote collagen synthesis, and help skin repair; abundant trace elements (such as zinc, selenium, copper, and manganese) act as cofactors for antioxidant enzymes (such as SOD), scavenging free radicals; and natural luster factors form an extremely fine reflective layer on the skin surface, providing an immediate brightening and radiance effect.

[0051] Saffron (Crocus sativus L.): Possesses excellent antioxidant, anti-inflammatory, soothing, skin-brightening, and microcirculation-improving effects. Saffron is a plant belonging to the genus Crocus in the Iridaceae family. Crocin, crocin glycosides, and crocin aldehyde are its main active ingredients. Crocin is a water-soluble carotenoid glycoside, the primary source of saffron's color, and also its main antioxidant and anti-inflammatory components. Crocin glycosides and crocin aldehyde respectively contribute to saffron's bitterness and aroma. Studies have shown that saffron extract can significantly reduce the levels of pro-inflammatory cytokines induced by stimulants such as lipopolysaccharide (LPS), including tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Crocin, thanks to its numerous unsaturated double bonds, possesses strong antioxidant capabilities, helping to neutralize reactive oxygen species (ROS) at inflamed sites and reduce oxidative stress damage to tissues, which is an important complement to its anti-inflammatory effects. Crocin and crocin are extremely powerful natural antioxidants, with antioxidant capacity far exceeding that of vitamin C. They can effectively combat free radicals and delay photoaging. The flavonoids they contain can assist in antioxidation and have anti-inflammatory properties. The volatile oils they contain can promote skin penetration and have a unique fragrance that has a soothing effect on emotions.

[0052] Litsea leaf (also known as leopard skin camphor leaf): The leaves of plants belonging to the genus Litsea in the family Lauraceae, contain flavonoids such as isoquercitrin and catechins, as well as various phenolic compounds such as chlorogenic acid. In cosmetics, it offers highly effective antioxidant, anti-glycation, antibacterial, anti-inflammatory, and elastin protection. Its total flavonoid content far exceeds that of ordinary tea leaves, powerfully scavenging free radicals and specifically protecting elastin from glycation damage, thus maintaining skin elasticity. The polyphenols it contains also synergistically enhance its antioxidant properties.

[0053] Green tea offers broad-spectrum antioxidant, anti-inflammatory, anti-seborrheic (oil-controlling), and environmental pollution-protective benefits. Its main active ingredient, catechins, especially epigallocatechin gallate, is a core antioxidant and anti-inflammatory component that effectively combats UV damage and inhibits acne-causing bacteria activity. Its rich polyphenol content has astringent properties, controlling oil secretion. Caffeine promotes microcirculation, helping to improve puffiness and dark circles.

[0054] Buddha's Hand: Generally refers to the fruit of a plant in the genus Citrus of the Rutaceae family. It has antibacterial, anti-inflammatory, sebum-regulating, and natural aromatic properties. Its active ingredients mainly include bergamot lactone, bergamot polyphenols, and bergamot flavonoids, which are the material basis for its anti-inflammatory and antioxidant activities. Bergamot lactone inhibits melanin production by regulating key upstream signaling pathways affecting melanocyte proliferation, differentiation, and melanin synthesis—MAPK (mitogen-activated protein kinase) and AKT (protein kinase B). Bergamot polyphenol extract has strong anti-inflammatory activity, reducing the release of inflammatory factors such as TNF-α and IL-6 by inhibiting the NF-κB signaling pathway. Meanwhile, bergamot volatile oil also contains substances such as limonene, which brings a refreshing citrus aroma, has a psychologically soothing effect, and also possesses certain antibacterial and anti-inflammatory effects.

[0055] Almonds: This usually refers to sweet almonds, not bitter almonds containing amygdalin. They are rich in sweet almond oil (a natural emollient) and mandelic acid (a gentle exfoliating ingredient). Unsaturated fatty acids (such as oleic acid and linoleic acid) can mimic the skin's lipid barrier structure, repairing it and providing long-lasting hydration; Vitamin E is a skin-friendly antioxidant that nourishes the skin; and the phytosterols they contain have anti-inflammatory and soothing effects, enhancing the skin's moisturizing ability. This deeply moisturizes, softens, and improves roughness.

[0056] Camellia: A general term referring to the flowers of plants in the genus *Camellia*, its main active ingredient is camellia flower polyphenols (CFP). Camellia flower polyphenols primarily exert their anti-inflammatory effects by dually inhibiting the NF-κB and MAPK signaling pathways. Its high oleic acid content has excellent compatibility with human sebum, strong permeability, and can form a protective film on the skin surface to lock in moisture. The camellia saponins it contains have cleansing, emulsifying, and anti-inflammatory effects. Vitamin E and polyphenols provide antioxidant protection. Therefore, it has long-lasting moisturizing, nourishing and softening, antioxidant, and skin-brightening effects.

[0057] Nardostachys jatamansi: Ancient texts and prescriptions record its whitening, beautifying, moisturizing, and skin-preventing and treating dry and itchy skin. Modern research confirms its anti-aging, skin-repairing, skin-stabilizing, and antibacterial effects. In cosmetics, it is mainly used in products with soothing, antibacterial, and antioxidant effects. Its main components include volatile oils, nardostachysone, and geraniol isovalerate. These components endow nardostachys jatamansi with antibacterial and anti-inflammatory properties, balance oil production, soothe sensitive skin, provide antioxidant effects, and offer neuroprotection. Sesquiterpenoids such as nardostachysone can effectively promote fibroblast proliferation and collagen production, and protect collagen and elastin by inhibiting the activity of matrix metalloproteinases (MMPs), thus reducing wrinkles; the volatile oil components give it a unique aroma and have calming and antibacterial effects.

[0058] The role of auxiliary ingredients:

[0059] Wood Orchid: Also known as Thousand Sheet Paper, it mainly contains orchidine, baicalin, and flavonoids, which can effectively inhibit tyrosinase activity and reduce melanin production; it also has strong antioxidant and anti-UV properties. Its phenylpropanoids can assist in antioxidant and anti-inflammatory effects, thus exerting antioxidant, whitening, anti-inflammatory, and photoprotective effects.

[0060] Yellow okra: Its polysaccharide molecules, which are natural polysaccharides (known as plant-based hyaluronic acid), can hold a large amount of water, and its moisturizing performance is even better than that of hyaluronic acid, making it an excellent natural moisturizer. At the same time, it also has natural calming and soothing properties, which can relieve skin discomfort such as redness and itching caused by dryness and external stimuli, and repair damaged skin barriers. It is very suitable for sensitive skin and skin care after medical aesthetic treatments (such as laser treatments and chemical peels).

[0061] Witch hazel: Originating in North America, witch hazel has excellent astringent properties, soothing skin discomfort, firming and moisturizing the skin, leaving it soft and supple. It also enhances keratinocyte turnover, maintaining skin elasticity and helping to tighten pores, as well as combat aging and wrinkles. The distilled floral water can be used for skincare; it's a powerful antioxidant and astringent, very effective in improving acne.

[0062] Licorice: It can whiten and lighten dark spots, has anti-inflammatory and soothing properties, is anti-allergenic, and enhances sun protection. Key active ingredients include glycyrrhizin, derived from licorice root, a recognized "whitening gold" that powerfully inhibits tyrosinase activity and possesses anti-inflammatory and antioxidant effects. Dipotassium glycyrrhizate is a classic anti-inflammatory and soothing ingredient that can quickly relieve skin irritation and redness; glycyrrhizin flavonoids can assist in whitening and antioxidant effects.

[0063] Purslane: Its extracts can soothe and reduce allergies, fight bacteria and inflammation, and deeply moisturize. Key active ingredients, such as alkaloids (e.g., purslane amides A and B), are core soothing components that inhibit the release of inflammatory mediators like histamine, quickly relieving itching and stinging. Polysaccharides form a breathable moisturizing film on the skin surface, preventing moisture loss. The Omega-3 fatty acids it contains also have anti-inflammatory properties.

[0064] Gentian extract: Soothes sensitivity, strengthens the skin barrier, reduces inflammation, and promotes blood circulation. Its main active ingredients, such as gentiopicrin and other secoiridoid glycosides, are the core anti-inflammatory components, inhibiting inflammatory pathways like NF-κB and reducing skin inflammation. Abundant flavonoids also contribute to its antioxidant and soothing effects.

[0065] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0066] 1. This invention is the first to apply the leaves of the Lauraceae plant *Cinnamomum camphora* to whitening and acne-removing cosmetics, using them in combination with pearl powder, saffron, and other ingredients. No similar reports have been found domestically or internationally. Based on traditional Chinese medicine theory and modern pharmacological research, this composition forms multiple synergistic effects: *Cinnamomum camphora* leaves, combined with green tea and *Oroxylum indicum*, constitute a comprehensive anti-oxidation and anti-glycation combination, forming a three-dimensional defense against photoaging, glycation, and environmental stress, comprehensively preventing dullness and sagging skin; saffron, combined with *Hippophae rhamnoides*, purslane, gentian, and licorice, constitute a soothing and repairing barrier combination, achieving multiple effects such as immediate soothing, root-cause anti-inflammation, and prevention of pigmentation, beneficial for sensitive skin care and strengthening the skin barrier; pearl powder, combined with licorice, *Oroxylum indicum*, and bergamot, constitutes... This multi-target whitening and brightening combination works synergistically across multiple stages, including inhibiting melanin production and accelerating pigment metabolism, to achieve a more comprehensive and gentle whitening and spot-fading effect. Nardostachys jatamansi, combined with witch hazel, almond, and camellia, forms a deep anti-aging and repair combination, offering dual benefits of promoting collagen production and strengthening skin hydration, working together to improve wrinkles and sagging, and restore skin elasticity. Hibiscus mutabilis, combined with camellia and almond, forms a moisturizing combination that simultaneously replenishes both moisture and oil, mimicking the structure of a healthy sebum film for long-lasting hydration. These synergistic combinations break away from the traditional single-effect design approach, achieving comprehensive conditioning through multiple targets and pathways.

[0067] 2. Tyrosinase activity inhibition experiments verified that the extract of the composition of this invention has a significant inhibitory effect on tyrosinase, indicating its clear whitening effect. Clinical trial observation results showed that after 42 days of using the cosmetics prepared by this invention, the effectiveness rate for treating pigmentation and dullness reached over 90%, with significant whitening and brightening effects. Clinical tests on acne treatment efficacy showed that the solution prepared by this invention had an average effective rate of over 90% and an average significant efficacy rate of over 80% for various types of acne, significantly higher than the control group, confirming its clear anti-inflammatory and acne-reducing effects.

[0068] 3. All raw materials used in this invention are natural medicinal plant ingredients or edible pearl powder, and have been verified through long-term clinical or folk use, demonstrating high biocompatibility. Compared with commercially available acne treatment products that contain antibiotics, hormones, or strong chemical exfoliants, this invention's product is gentler, will not damage the skin barrier function with long-term use, and will not cause skin sensitivity, dryness, redness, or other problems. It is suitable for daily care for people with sensitive skin, offering both skincare and therapeutic benefits.

[0069] 4. This invention provides two extraction processes: steam distillation and solvent extraction. By rationally controlling process parameters such as extraction temperature, time, and solvent concentration, the active ingredients in the raw materials can be effectively preserved, improving extraction efficiency. In particular, the hydrosol extraction process using steam distillation yields a refreshing, non-sticky product with an excellent user experience. This invention can be prepared into various dosage forms such as lotions, essential oils, sprays, emulsions, creams, and masks to meet the needs of different skin types and usage scenarios, and has good market application prospects. Attached Figure Description

[0070] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0071] Figure 1 The graph shows the results of the tyrosinase activity inhibition rate determination in Example 5 of this invention. Detailed Implementation

[0072] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0073] Example 1

[0074] Preparation of extracts from traditional Chinese medicine compositions (steam distillation method).

[0075] Weigh the raw materials according to the following parts by weight: 100 parts pearl powder, 20 parts saffron, 100 parts camphor leaves, 100 parts green tea, 100 parts Buddha's hand, 100 parts almonds, 50 parts camellia flowers, and 20 parts spikenard.

[0076] After the above-mentioned basic raw materials are crushed and mixed, they are extracted using steam distillation.

[0077] The steam distillation method specifically includes the following steps:

[0078] Step S11: Take the pulverized and mixed basic raw materials;

[0079] Step S12: Add purified water and an appropriate amount of sodium chloride, heat and extract at 80-100℃;

[0080] Step S13: Collect the distillate, the amount of which is 2-5 times the total weight of the basic raw materials, to obtain the hydrosol of the traditional Chinese medicine composition.

[0081] Example 2

[0082] Preparation of extracts from traditional Chinese medicine compositions (including steam distillation of auxiliary materials).

[0083] Weigh the following ingredients by weight: 100 parts pearl powder, 20 parts saffron, 100 parts camphor leaves, 100 parts green tea, 100 parts Buddha's hand, 100 parts almonds, 50 parts camellia, 20 parts nard, 50 parts butterfly pea, 50 parts yellow hollyhock, 50 parts witch hazel, 50 parts licorice, 50 parts purslane, and 50 parts gentian.

[0084] After the above-mentioned basic and auxiliary raw materials are pulverized and mixed, they are extracted using steam distillation. The steam distillation method is basically the same as the extraction method described in Example 1, that is: after the above-mentioned raw materials are pulverized and mixed, steam distillation is carried out at 80℃-100℃, the distillate is collected, and the collected hydrosol is 2-5 times the weight of the medicinal materials. After being mixed evenly, the hydrosol of the traditional Chinese medicine composition is obtained.

[0085] Example 3

[0086] Extracts of traditional Chinese medicine compositions (solvent reflux extraction method).

[0087] Weigh the raw materials according to the following parts by weight: 100 parts pearl powder, 20 parts saffron, 100 parts camphor leaves, 100 parts green tea, 100 parts Buddha's hand, 100 parts almonds, 50 parts camellia flowers, and 20 parts spikenard.

[0088] After the above-mentioned basic raw materials are crushed and mixed, they are extracted by reflux extraction using 4-6 times the amount of ethanol-water mixed solvent.

[0089] The solvent reflux extraction method specifically includes the following steps:

[0090] Step S21: Take the pulverized and mixed basic raw materials;

[0091] Step S22: Reflux extraction is performed using an ethanol-water mixed solvent with a volume fraction of 60% ethanol at a temperature of 60℃-80℃, with each extraction lasting 2 hours, for a total of 3 extractions.

[0092] Step S23: Filter and combine the extracts from multiple extractions, and concentrate under reduced pressure to a relative density of 1.1-1.2 g / mL at 60°C to obtain the thick extract of the traditional Chinese medicine composition.

[0093] In other embodiments, the traditional Chinese medicine composition may also be extracted using other methods, such as supercritical fluid extraction, as long as the natural drug extraction method is applicable.

[0094] Example 4

[0095] Preparation of extracts from traditional Chinese medicine compositions (solvent reflux extraction method including auxiliary raw materials).

[0096] Weigh the following ingredients by weight: 100 parts pearl powder, 20 parts saffron, 100 parts camphor leaves, 100 parts green tea, 100 parts Buddha's hand, 100 parts almonds, 50 parts camellia, 20 parts nard, 50 parts butterfly pea, 50 parts yellow hollyhock, 50 parts witch hazel, 50 parts licorice, 50 parts purslane, and 50 parts gentian.

[0097] After pulverizing and mixing the above-mentioned basic and auxiliary raw materials, extraction was performed using a solvent reflux extraction method. The solvent reflux extraction method is basically the same as the extraction method described in Example 3, namely: after pulverizing and mixing the raw materials, reflux extraction was performed using a 4-6 times volume of ethanol-water mixed solvent, with an ethanol volume fraction of 60%, a temperature of 60℃-80℃, and an extraction time of 2 hours per extraction, for a total of 3 extractions. The extracts were filtered, combined, and concentrated under reduced pressure to a relative density of 1.1-1.2 g / mL (60℃) to obtain a thick extract.

[0098] Example 5

[0099] Tyrosinase activity inhibition rate determination

[0100] To verify the whitening effect of the traditional Chinese medicine composition of the present invention, the tyrosinase activity inhibition rate of the thick extract of the traditional Chinese medicine composition prepared in Examples 3 and 4 was determined.

[0101] (1) Preparation of phosphate buffer (pH=6.8): Prepare 0.1 mol / L solutions of disodium hydrogen phosphate and sodium dihydrogen phosphate respectively. Take 231.5 mL of disodium hydrogen phosphate solution, add 268.5 mL of sodium dihydrogen phosphate solution, dilute with water to 750 mL, and shake well to obtain the solution.

[0102] (2) Preparation of tyrosinase solution: Take tyrosinase with an activity unit of 188 IU / mg and prepare a solution of 0.8 mg / mL with phosphate buffer (pH=6.8).

[0103] (3) Preparation of L-DOPA solution: L-DOPA is prepared into a 0.005% solution using phosphate buffer (pH=6.8).

[0104] (4) The thick extracts of traditional Chinese medicine compositions prepared in Examples 3 and 4 were dissolved in dimethyl sulfoxide to prepare solutions with a concentration of 1 mg / mL. Then, 10 μg / mL sample dilutions were prepared in phosphate buffer (pH=6.8) and stored in a refrigerator at 4 degrees Celsius for later use.

[0105] (5) Measurement method:

[0106] Before the assay, accurately prepare the following test samples using a micropipette:

[0107] C1 test sample: Add 50 μL of tyrosinase solution to 100 μL of phosphate buffer solution (pH=6.8);

[0108] C2 test sample: 150 μL phosphate buffer solution (pH=6.8);

[0109] T1 test sample: Add 50 μL of tyrosinase solution to 100 μL of sample dilution;

[0110] T2 test sample: 50 μL phosphate buffer solution (pH=6.8) added to 100 μL sample diluent;

[0111] The sample was added to each well of a 96-well plate and reacted at 25°C for 10 min. Then, 50 μL of L-DOPA solution was added, and the reaction was continued at 25°C for 1 h. Immediately after the reaction, the absorbance (AC1, AC2, AT1, AT2) of C1, C2, T1 of the nine samples, and T2 of the nine samples was measured at 490 nm. Kojic acid was used as a positive control. The inhibitory effect on tyrosinase was assessed, and the inhibition rate was expressed as the tyrosinase inhibition rate. The tyrosinase inhibition rate was calculated using the following formula:

[0112] Inhibition rate = [1-(AT1-AT2) / (AC1-AC2)]×100%.

[0113] (6) Measurement results: The test results are shown in Figure 1 As shown, the experimental results indicate that the extracts of the traditional Chinese medicine compositions prepared in Examples 3 and 4 both exhibit significant inhibitory effects on tyrosinase. Subsequent studies also showed that the hydrosols of the traditional Chinese medicine compositions prepared according to Examples 1 and 2 also exhibited significant inhibitory effects on tyrosinase.

[0114] Example 6

[0115] Preparation method of traditional Chinese medicine acne-removing, anti-inflammatory and whitening composition solution

[0116] The formulation of the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition solution is shown in Table 1.

[0117] Table 1 shows the formulation of the solution of traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition.

[0118]

[0119] Based on the components of each phase in Table 1, the preparation steps of the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition solution are as follows:

[0120] Step X11: Accurately weigh each component in phase A and place it in an aqueous phase tank for heating;

[0121] Step X12: Accurately weigh all components in phase B and mix thoroughly.

[0122] Step X13: When phase A in step X11 is heated to 85°C, phase B in step X12 is added to phase A. After maintaining this temperature for 20 minutes, the mixture is pumped into an emulsification tank, and the cooling water circulation is turned on to cool it down.

[0123] Step X14: Accurately weigh all components in phase C and mix thoroughly.

[0124] Step X15: When the emulsification tank cools down to 40°C, add phase C from step X14, stir for 20 minutes, and then discharge to prepare a traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition solution.

[0125] Example 7

[0126] Preparation method of traditional Chinese medicine acne-removing, anti-inflammatory and whitening composition solution

[0127] In this embodiment, the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition solution contains auxiliary raw materials. Its preparation method is basically the same as that of Example 6, except that the traditional Chinese medicine composition hydrosol described in phase A is replaced with the traditional Chinese medicine composition hydrosol prepared in Example 2, thus obtaining the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition solution. The specific formula is shown in Table 2.

[0128] Table 2 shows the formulation of a solution containing traditional Chinese medicine for acne treatment, anti-inflammatory, and skin whitening (including auxiliary ingredients).

[0129]

[0130] According to the components of each phase in Table 2, first accurately weigh each item in phase A, put it into the aqueous phase tank and heat it. When the temperature reaches 85°C, add the well-mixed phase B, keep it for 20 minutes, and then pump it into the emulsification tank. Turn on the cooling water circulation to cool down. Then cool down to 40°C and add the accurately weighed phase C. Stir for 20 minutes and then discharge the material to prepare the traditional Chinese medicine acne-removing, anti-inflammatory and whitening composition solution.

[0131] Example 8

[0132] Preparation method of traditional Chinese medicine acne-removing, anti-inflammatory and whitening composition emulsion

[0133] The formulation of the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening emulsion is shown in Table 3.

[0134] Table 3 shows the emulsion formulation of traditional Chinese medicine acne-removing, anti-inflammatory, and whitening compositions.

[0135]

[0136] Based on the components of each phase in Table 3, the preparation steps of the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition emulsion are as follows:

[0137] Step X21: Accurately weigh all the components in phase A, add them to the oil phase heating tank, heat to 80°C, keep warm for 20 minutes to sterilize, and set aside for later use;

[0138] Step X22: Accurately weigh all items in phase B, add them to the aqueous phase heating tank, heat to 80°C, keep warm for 20 minutes to sterilize, and set aside for later use;

[0139] Step X23: Pump phase B from step X22 into the emulsification tank, keep the temperature of the emulsification tank at 80°C, start homogenization and stirring, and set the stirring speed to 20 rpm. Slowly add phase A from step X21 into phase B. After complete addition, homogenize for 300 seconds. After homogenization, continue stirring for 15 minutes, turn on the cooling water to cool down, and reduce the stirring speed to 12 rpm.

[0140] Step X24: Accurately weigh all components in phase C and mix thoroughly.

[0141] Step X25: Cool the emulsification tank to 40°C, add phase C from step X24 into the emulsification tank, stir continuously for 30 minutes, and then discharge the material to produce a traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition emulsion.

[0142] Example 9

[0143] Preparation method of traditional Chinese medicine acne-removing, anti-inflammatory and whitening composition emulsion

[0144] In this embodiment, the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition emulsion contains auxiliary raw materials, and its preparation method is basically the same as that of Example 8. The difference is that the traditional Chinese medicine composition extract described in phase A is replaced with the traditional Chinese medicine composition extract prepared in Example 4, thus obtaining the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition emulsion.

[0145] Example 10

[0146] Preparation method of a cream containing traditional Chinese medicine for acne treatment, anti-inflammatory and whitening.

[0147] The formula for the herbal acne-removing, anti-inflammatory, and whitening cream is shown in Table 4.

[0148] Table 4 shows the formula for a cream containing traditional Chinese medicine acne-removing, anti-inflammatory, and whitening ingredients.

[0149]

[0150] Based on the components of each phase in Table 4, the preparation steps of the traditional Chinese medicine acne-removing, anti-inflammatory, and whitening composition cream are as follows:

[0151] Step X31: Accurately weigh all the components in phase A, add them to the oil phase heating tank, heat to 80°C, keep warm for 20 minutes to sterilize, and set aside for later use;

[0152] Step X32: Accurately weigh all items in phase B, add them to the aqueous phase heating tank, heat to 80°C, keep warm for 20 minutes to sterilize, and set aside for later use;

[0153] Step X33: Pump phase B from step X32 into the emulsification tank, keep the temperature of the emulsification tank at 80°C, start homogenization and stirring, and stir at a speed of 20 rpm. Slowly add phase A from step X31 into phase B. After complete addition, homogenize for 300 seconds. After homogenization, continue stirring for 15 minutes, turn on the cooling water, and reduce the speed to 12 rpm.

[0154] Step X34: Accurately weigh all components in phase C and mix thoroughly.

[0155] Step X35: Cool the emulsification tank to 40°C, add phase C from step X34 into the emulsification tank, stir continuously for 30 minutes, and then discharge the material to produce a traditional Chinese medicine acne-removing, anti-inflammatory, and whitening cream.

[0156] Example 11

[0157] Clinical trial observation

[0158] The traditional Chinese medicine acne-removing, anti-inflammatory, and whitening compositions prepared in Examples 6, 7, 8, and 10 were subjected to clinical trials and observations.

[0159] Subjects: Individuals aged 25-45 years with facial pigmentation and dullness, including 60 women (randomly divided into three groups) and 60 men (randomly divided into three groups).

[0160] Instructions for use: After cleansing your face in the morning and evening, take an appropriate amount of the product prepared in Examples 6, 7, 8, and 10 and apply or spray it evenly to your face, allowing your skin to fully absorb it; 28 days is one course of treatment.

[0161] Therapeutic criteria:

[0162] (1) Significant effect: The yellowish pigmentation fades by more than 90%;

[0163] (2) Effective: The yellowish pigmentation fades by more than 50%;

[0164] (3) Ineffective: The pigmentation is dark yellow and does not fade.

[0165] The trial results showed that after 42 days of use, the effectiveness rate of Example 6 was 93.5%, that of Example 7 was 95%, that of Example 8 was 94.5%, and that of Example 10 was 95.5%.

[0166] Example 12

[0167] Acne treatment effect test

[0168] The acne-removing and whitening lotions prepared in Examples 6 and 7 were used as test samples A and B, respectively, and were subjected to clinical trials along with the control solution. The control solution was prepared by replacing an equal amount of the hydrosol in the formulation with purified water, following the preparation method of Examples 6 or 7.

[0169] Participants: 300 acne patients aged 15-30 with acne, papules, pustules, cysts, blackheads, etc., approximately 60 in each group. They were divided into 3 groups of about 20 people each, with the male-female ratio in each group as even as possible.

[0170] The method of use is as follows: First, cleanse your face with water, then take an appropriate amount of this product and spray it evenly onto the affected area. Use it once in the morning and once in the evening for at least 3 consecutive weeks.

[0171] Evaluation indicators: The effectiveness and efficacy are evaluated based on the following criteria, including inflammation improvement, skin radiance, and acne removal rate (the percentage of acne spots treated out of the total number of acne spots treated).

[0172] Judgment criteria:

[0173] (1) Basic cure: Skin is shiny, inflammation has basically disappeared, and acne removal rate is >90%;

[0174] (2) Significant effect: Skin is more shiny, inflammation is significantly improved, and acne removal rate is >60%;

[0175] (3) Improvement: Skin is slightly shiny, some inflammation has improved, and the acne removal rate is >30%;

[0176] (4) Ineffective: Improvement of dull skin and inflammation, acne removal rate <30%.

[0177] Calculation formula:

[0178] Effectiveness rate = (Number of cases basically cured + Number of cases showing significant improvement + Number of cases showing improvement) / Total number of cases × 100%

[0179] Significant efficacy rate = (Number of cases basically cured + Number of cases showing significant improvement) / Total number of cases × 100%

[0180] The experimental results are shown in Table 5.

[0181] Table 5 shows the results of the acne treatment efficacy test.

[0182]

[0183] The results showed that the average effective rate of the present invention for acne reached over 90%, and the average significant efficacy rate reached over 80%, both significantly higher than the control group. The experimental results proved that the traditional Chinese medicine composition prepared by the present invention has a clear acne-removing effect and has a significant effect on various types of acne.

[0184] Furthermore, subsequent studies have shown that Examples 8-10 also have significant acne-removing effects and are effective for various types of acne-prone skin.

[0185] The compositions of the present invention can also be used to prepare corresponding sprays, gels, films, ointments and suspensions.

[0186] In the foregoing, only certain exemplary embodiments have been briefly described. As those skilled in the art will recognize, the described embodiments can be modified in various ways without departing from the spirit or scope of the invention. Therefore, the drawings and description are considered to be exemplary in nature and not restrictive.

Claims

1. A traditional Chinese medicine composition with whitening, anti-inflammatory, and acne-removing effects, characterized in that, The product includes basic ingredients, which include: pearl powder, saffron, camphor leaves, green tea, Buddha's hand, almonds, camellia flowers, and spikenard.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The basic raw materials include the following raw materials in parts by weight: Pearl powder 50-150 parts, saffron 10-50 parts, camphor leaves (leopard skin) 50-150 parts, green tea 50-150 parts, Buddha's hand 50-150 parts, almonds 50-150 parts, camellia flowers 20-100 parts, and nard 10-50 parts. or, 100 parts pearl powder, 20 parts saffron, 100 parts camphor leaves, 100 parts green tea, 100 parts Buddha's hand, 100 parts almonds, 50 parts camellia flowers, and 20 parts spikenard.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, The traditional Chinese medicine composition also includes auxiliary materials, which are selected from one or more of the following: Oroxylum indicum, Abelmoschus manihot, Witch hazel, Glycyrrhiza uralensis, Portulaca oleracea, and Gentiana scabra, in parts by weight of 30-100.

4. The traditional Chinese medicine composition according to claim 3, characterized in that, The auxiliary raw materials are selected from one or more of the following raw materials in parts by weight: 40-60 parts of Oroxylum indicum, 40-60 parts of Abelmoschus manihot, 40-60 parts of Witch hazel, 40-60 parts of Glycyrrhiza uralensis, 40-60 parts of Portulaca oleracea, and 40-60 parts of Gentiana scabra; or, 50 parts of wood butterfly, 50 parts of yellow hollyhock, 50 parts of witch hazel, 50 parts of licorice, 50 parts of purslane, and 50 parts of gentian.

5. A method for extracting the traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, The method is either steam distillation or solvent extraction.

6. The method according to claim 5, characterized in that, The steam distillation method includes the following steps: Step S11: Take the raw materials, crush and mix them; Step S12: Add purified water or a mixture of purified water and sodium chloride, and heat at 80-100℃ for extraction; Step S13: Collect hydrosols or essential oils that are 2-5 times the total weight of the base ingredients.

7. The method according to claim 5, characterized in that, The solvent extraction method includes the following steps: Step S21: Take the raw materials, crush and mix them; Step S22: Extract by reflux at 60℃-80℃ for 2-3 times with a 50%-70% ethanol-water mixed solvent, each time for 1-2 hours; Step S23: Combine the extracts and concentrate under reduced pressure to obtain a thick extract.

8. A cosmetic product, characterized in that, Includes the traditional Chinese medicine composition according to any one of claims 1-4 or the extract prepared by the method according to any one of claims 5-7.

9. A method for preparing the cosmetic according to claim 8, characterized in that, The traditional Chinese medicine composition according to any one of claims 1-4 or the extract prepared by the method according to any one of claims 5-7 is mixed with excipients acceptable in the cosmetic field to prepare the corresponding dosage form.

10. The use of the traditional Chinese medicine composition according to any one of claims 1-4 or the extract prepared by the method according to any one of claims 5-7 in the preparation of cosmetics with whitening, anti-inflammatory and acne-removing effects.

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