Use of Guiling tablet in the preparation of a drug for treating stress urinary incontinence or bladder cough

Abstract

The application belongs to the technical field of Chinese patent medicines, and provides a use of Guiling tablets in the preparation of a medicine for treating stress urinary incontinence or bladder cough. On the basis of the known efficacy of Guiling tablets, a commercially available Chinese patent medicine, for treating kidney deficiency causing asthma and lung deficiency causing chronic cough, the application uses the kidney tonifying and qi consolidating effect of Guiling tablets to treat stress urinary incontinence or bladder cough, and very significant effects are observed on the incontinence of urine caused by excessive cough and asthma due to kidney deficiency in the middle-aged and the elderly, especially in middle-aged and elderly women.

Description

Technical Field

[0001] This application belongs to the field of traditional Chinese medicine technology. Specifically, this application provides the use of Guiling tablets in the preparation of a drug for treating stress urinary incontinence or bladder cough. Background Technology

[0002] Guiling tablets are a traditional Chinese medicine product that has been marketed by Jilin Lihua Pharmaceutical Co., Ltd. for many years. Its ingredients include ephedra, poppy shell, roasted bitter almond, schisandra, walnut kernel, and cardamom, among others. Its functions and indications are to astringe lung qi, relieve cough and asthma. It is used for asthma due to kidney deficiency and chronic cough due to lung deficiency. Currently, there are no reports on its efficacy in treating urinary incontinence. Summary of the Invention

[0003] Based on clinical observations and market feedback, Guiling tablets have a very significant effect on urinary incontinence caused by excessive coughing and wheezing due to kidney deficiency in middle-aged and elderly people, especially middle-aged and elderly women.

[0004] The components of Guiling tablets include: Ephedra: Warming and dispersing, it primarily enters the lung meridian. It can open up blockages in the skin and pores to allow lung qi to flow freely; internally, it descends rebellious qi to restore the lung's normal function of descending and dispersing. Therefore, it is good at relieving asthma and is an essential medicine for treating cough and chest tightness caused by lung qi stagnation. It is often used in conjunction with other cough-relieving and asthma-relieving medicines such as bitter almond. Poppy shell: Primarily enters the lung meridian and has a strong effect of astringing lung qi and stopping cough. It is suitable for chronic cough due to lung deficiency. Bitter almond: It has a bitter and descending nature and is good at descending and dispersing rebellious lung qi. It also disperses congested lung qi. It is mainly descending, but also disperses, making it an essential medicine for treating cough and asthma. Schisandra: It can astringe lung qi and nourish kidney yin, making it an essential medicine for treating chronic cough and asthma due to deficiency. Entering the kidney meridian, it can tonify the kidney, astringe essence, and stop seminal emission. It is a commonly used medicine for treating frequent urination and enuresis due to kidney deficiency and weak seminal control. Walnut kernel: It is good at tonifying the lung and kidney and relieving cough and asthma. It treats asthma due to deficiency of the lung and kidney and failure of the kidney to receive qi. In addition to its lung-astringing and cough-relieving effects, it also has a therapeutic effect on kidney qi deficiency. Cardamom: It dispels dampness and promotes qi circulation; its pungent and dispersing properties enter the lungs to expel dampness. The combined effects of these herbs work synergistically to astringe lung qi, relieve cough and asthma, and are suitable for symptoms such as asthma due to kidney deficiency and chronic cough due to lung deficiency.

[0005] When "bladder cough" is diagnosed as a "kidney qi deficiency" syndrome, the cause is often old age, weakness, prolonged illness, and general debility, leading to kidney qi deficiency, impaired qi transformation, and bladder dysfunction. Clinical symptoms include involuntary urination after coughing, sneezing, crying, laughing, or lifting heavy objects. This product, while relieving cough, also tonifies the kidneys and strengthens qi, which is consistent with the etiology of bladder cough (Western medical condition: stress urinary incontinence). Therefore, from a formulation analysis perspective, this product is feasible for treating urinary incontinence caused by excessive coughing and wheezing due to kidney deficiency.

[0006] Based on the above, on the one hand, this application provides the use of Guiling tablets in the preparation of a medicine for treating stress urinary incontinence or bladder cough.

[0007] Furthermore, the stress urinary incontinence or bladder cough mentioned refers to stress urinary incontinence or bladder cough in middle-aged and elderly individuals.

[0008] Furthermore, the stress urinary incontinence or bladder cough refers to stress urinary incontinence or bladder cough in middle-aged and elderly women.

[0009] Furthermore, the stress urinary incontinence or bladder cough refers to stress urinary incontinence or bladder cough in postmenopausal women.

[0010] Furthermore, the drug reduces the frequency of coughing and urinary incontinence.

[0011] Furthermore, the raw materials of Guiling tablets include 300-500 parts by weight of ephedra, 200-400 parts by weight of poppy shell, 100-300 parts by weight of roasted bitter almond, 100-300 parts by weight of schisandra, 100-300 parts by weight of walnut kernel, and 20-30 parts by weight of cardamom.

[0012] Furthermore, the raw materials of the Guiling tablets include 400 parts by weight of ephedra, 300 parts by weight of poppy shell, 200 parts by weight of roasted bitter almond, 200 parts by weight of schisandra, 200 parts by weight of walnut kernel, and 25 parts by weight of cardamom.

[0013] Furthermore, the raw materials for the Guiling tablets also include excipients.

[0014] Furthermore, the excipients include starch and absorbents.

[0015] Furthermore, the preparation method of the Guiling tablets includes: (1) Extract the volatile oil from cardamom to obtain cardamom volatile oil and cardamom residue; (2) Boil the cardamom residue with ephedra, poppy shell and walnut kernel twice with water; combine the decoctions and filter; concentrate the filtrate, add 0.5-3 times 70-90% ethanol, mix well, let stand, filter; recover the ethanol from the filtrate and concentrate to obtain a thick extract. (3) Stir-fry bitter almonds and press to remove oil; extract twice with schisandra chinensis by reflux with 80% ethanol; combine the extracts and filter; recover ethanol from the filtrate until there is no alcohol taste, and concentrate to obtain a thick extract; (4) Combine the thick extract obtained in steps (2) and (3), dry under reduced pressure, pulverize into fine powder, add appropriate amounts of binder and filler, mix, granulate, dry, take cardamom volatile oil, add absorbent, mix well, add to dry granules, mix well, and compress into tablets.

[0016] Furthermore, the preparation method of the Guiling tablets includes: (1) Extract the volatile oil from cardamom to obtain cardamom volatile oil and cardamom residue; (2) Boil the cardamom residue with ephedra, poppy shells, and walnut kernels twice, the first time for 4 hours and the second time for 2.5 hours; combine the decoctions and filter; concentrate the filtrate and add 1 Mix with 2 times 80% ethanol, let stand, and filter; recover the ethanol from the filtrate and concentrate to obtain a thick extract; (3) Stir-fry bitter almonds and press to remove oil; extract twice with schisandra chinensis by reflux with 80% ethanol, the first time for 2 hours and the second time for 1 hour; combine the extracts and filter; recover ethanol from the filtrate until there is no alcohol taste, and concentrate to obtain a thick extract; (4) Combine the thick extract obtained in steps (2) and (3), dry under reduced pressure, pulverize into fine powder, add starch, mix, granulate, dry below 60°C, take cardamom volatile oil, add absorbent, mix well, add to dry granules, mix well, and compress into tablets.

[0017] The terms "stress urinary incontinence" and "bladder cough" used in this application are different descriptions of the same disease in modern medicine, Western medicine, traditional Chinese medicine, and folk medicine. The core symptom of both is urinary incontinence that occurs when abdominal pressure increases. The triggers include coughing, sneezing, laughing, and exercise, and it is especially common in postpartum, middle-aged and elderly / postmenopausal individuals with pelvic floor muscle relaxation and urethral sphincter dysfunction. Traditional Chinese medicine believes that its pathogenesis is mostly related to the dysfunction of the lungs, spleen, and kidneys, especially due to insufficient kidney qi, sinking of middle qi, and lack of ability to consolidate and retain qi.

[0018] Excipients include, but are not limited to, binders, fillers, absorbents, disintegrants, antioxidants, preservatives, coating agents, flavor masking agents, and taste-correcting agents. Binders / fillers may include, but are not limited to, starches, dextrins, lactose, mannitol, cellulose, povidones, lactose, and sorbitol. Absorbents may include, but are not limited to, calcium carbonate, dicalcium phosphate, starch, dextrin, lactose, cellulose, and mannitol. These components are not the active pharmaceutical ingredients; pharmaceutical professionals may routinely select and adjust them based on factors such as dosage form and equipment.

[0019] Tablets of various specifications and coatings are all within the scope of protection of this application, and those skilled in the art can use the above-mentioned excipients to conventionally design and prepare these tablets. Detailed Implementation

[0020] Example 1: Statistical Analysis of Therapeutic Effects Detailed identity and contact information for the following cases have been collected (not shown for privacy reasons). The medication used was Guiling tablets from Jilin Lihua Pharmaceutical Co., Ltd.; dosage and administration: oral administration, 4 tablets each time, twice a day.

[0021] Table 1. Statistical analysis of the efficacy of Guiling tablets in treating stress urinary incontinence or bladder cough.

Claims

1. Use of Guiling tablets in the preparation of drugs for treating stress urinary incontinence or bladder cough.

2. The use according to claim 1, wherein the stress urinary incontinence or bladder cough is stress urinary incontinence or bladder cough in middle-aged and elderly people.

3. The use according to claim 2, wherein the stress urinary incontinence or bladder cough is stress urinary incontinence or bladder cough in middle-aged and elderly women.

4. The use according to claim 1, wherein the stress urinary incontinence or bladder cough is postmenopausal stress urinary incontinence or bladder cough.

5. The use according to any one of claims 1-4, wherein the drug reduces the frequency of coughing and urinary incontinence.

6. The use according to any one of claims 1-5, wherein the raw materials of the Guiling tablets include 300-500 parts by weight of ephedra, 200-400 parts by weight of poppy shell, 100-300 parts by weight of roasted bitter almond, 100-300 parts by weight of schisandra, 100-300 parts by weight of walnut kernel, and 20-30 parts by weight of cardamom.

7. According to the use described in claim 6, the raw materials of the Guiling tablets include 400 parts by weight of ephedra, 300 parts by weight of poppy shell, 200 parts by weight of roasted bitter almond, 200 parts by weight of schisandra, 200 parts by weight of walnut kernel, and 25 parts by weight of cardamom.

8. In accordance with the use described in claim 6 or 7, the raw materials of the Guiling tablets further include starch and an absorbent.

9. The method for preparing the Guiling tablets according to any one of claims 6-8 comprises: (1) Extract the volatile oil from cardamom to obtain cardamom volatile oil and cardamom residue; (2) Boil the cardamom residue with ephedra, poppy shell and walnut kernel twice with water; combine the decoctions and filter; concentrate the filtrate, add 0.5-3 times 70-90% ethanol, mix well, let stand, filter; recover the ethanol from the filtrate and concentrate to obtain a thick extract. (3) Stir-fry bitter almonds and press to remove oil; extract twice with schisandra chinensis by reflux with 80% ethanol; combine the extracts and filter; recover ethanol from the filtrate until there is no alcohol taste, and concentrate to obtain a thick extract; (3) Combine the thick extract obtained in steps (2) and (3), dry under reduced pressure, pulverize into fine powder, add appropriate amounts of binder and filler, mix, granulate, dry, take cardamom volatile oil, add absorbent, mix well, add to dry granules, mix well, and compress into tablets.

10. The method for preparing the Guiling tablets according to claim 9 comprises: (1) Extract the volatile oil from cardamom to obtain cardamom volatile oil and cardamom residue; (2) Boil the cardamom residue with ephedra, poppy shells, and walnut kernels twice, the first time for 4 hours and the second time for 2.5 hours; combine the decoctions and filter; concentrate the filtrate and add 1 Mix with 2 times 80% ethanol, let stand, and filter; recover the ethanol from the filtrate and concentrate to obtain a thick extract; (3) Stir-fry bitter almonds and press to remove oil; extract twice with schisandra chinensis by reflux with 80% ethanol, the first time for 2 hours and the second time for 1 hour; combine the extracts and filter; recover ethanol from the filtrate until there is no alcohol taste, and concentrate to obtain a thick extract; (4) Combine the thick extract obtained in steps (2) and (3), dry under reduced pressure, pulverize into fine powder, add starch, mix, granulate, dry below 60°C, take cardamom volatile oil, add absorbent, mix well, add to dry granules, mix well, and compress into tablets.

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