Dihydroimidazopyrimidopyrimidinones and uses thereof
By designing 8,9-dihydroimidozolo[1,2-a]pyrimido[5,4-e]pyrimidine-5(6H)-ketone compounds with low hERG channel inhibitory activity as Wee1 kinase inhibitors, the off-target side effects of existing drugs in cancer treatment have been solved, achieving more efficient and safer cancer treatment.
CN122161828APending Publication Date: 2026-06-05IMPACT THERAPEUTICS (SHANGHAI) INC +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- IMPACT THERAPEUTICS (SHANGHAI) INC
- Filing Date
- 2024-11-01
- Publication Date
- 2026-06-05
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Figure CN122161828A_ABST
Abstract
Provided are compounds of Formula I, or stereoisomers, tautomers, N-oxides, hydrates, solvates, isotopically labeled compounds, or pharmaceutically acceptable salts thereof, or mixtures thereof. Compounds of Formula I are inhibitors of Wee1 kinase. Thus, these compounds are useful in the treatment of diseases caused by abnormal Weel activity. (I).
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