Lysosome-targeting three-dimensional network nanogel, preparation method and application thereof

CN122163528APending Publication Date: 2026-06-09INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INSTITUTE OF BASIC MEDICAL SCIENCES CHINESE ACADEMY OF MEDICAL SCIENCES
Filing Date
2024-12-06
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

In existing technologies, lysosomal drugs (LDs) are difficult to deliver precisely to tumor cell lysosomes and achieve homeostasis in vivo, resulting in non-specific organelle localization and side effects at high concentrations, especially in the treatment of AML where there is a lack of effective differentiation therapy strategies.

Method used

A lysosome-targeted three-dimensional network nanogel is used to form nanoparticles by combining cisplatin and other drug molecules with hyaluronic acid. By utilizing the tumor targeting and phagocytic activity of hyaluronic acid, lysosome localization and sustained release of LDs drugs can be achieved, and the localization of drugs in lysosomes can be regulated.

Benefits of technology

This study achieved precise delivery of LDs to tumor cells, reduced side effects, improved the differentiation therapy effect of AML cells, prolonged the survival of leukemia mice, and reduced drug toxicity.

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Abstract

The present application provides a kind of lysosome targeting three-dimensional network nanogel, its preparation method and application.The three-dimensional network nanogel of the present application includes: lysosome targeting drug and hyaluronic acid.The present application prepares lysosome targeting drug into hyaluronic acid nanogel, and utilizes nanogel to target drug delivery to lysosome in tumor cell.According to the difference of lysosome targeting drug used, can be in vivo intervention to lysosome homeostasis of tumor cell, realize leukemia differentiation therapy and other purposes.
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