An mRNA vaccine and a preparation method and application thereof

By designing mRNA vaccines containing signal peptides and localization signals, the immune response of host cells is activated, overcoming the limitations of existing tumor treatments and the low efficiency of vaccine delivery, and achieving effective treatment for tumors and fibrosis.

CN122167590APending Publication Date: 2026-06-09SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD +2
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN RHEGEN BIOTECHNOLOGY CO LTD
Filing Date
2024-12-06
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing cancer treatments such as surgery, radiotherapy, chemotherapy, and immunotherapy have limitations. DNA vaccines and viral vector vaccines have low delivery efficiency, resulting in insufficient immune responses and making it difficult to effectively treat solid tumors and diseases such as fibrosis.

Method used

Design a fusion protein comprising a signal peptide, an antigen, and a localization signal sequence, encoded as an mRNA molecule, and delivered via lipid nanoparticles to activate the immune response of host cells.

Benefits of technology

It achieves specific killing of tumor cells and fibroblasts, reduces tumor volume, prolongs survival, and improves the effectiveness of the immune response.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122167590A_ABST
    Figure CN122167590A_ABST
Patent Text Reader

Abstract

This invention provides an mRNA vaccine, its preparation method, and its application. Specifically, this invention provides a fusion protein, which, from its N-terminus to its C-terminus, sequentially includes a signal peptide sequence, a (linker peptide + antigen + linker peptide) Γ— N sequence, and a localization signal sequence; wherein N β‰₯ 1; the antigen is a disease-related antigen and / or a specific antigen. This invention also provides an mRNA molecule comprising a sequence encoding the above-mentioned fusion protein. The mRNA molecule of this invention can be used to prepare drugs for the prevention and treatment of solid tumors and fibrosis, and can activate antigen-specific T cells to kill tumor cells or fibroblasts, thereby reducing tumor size or eliminating fibrosis and prolonging survival.
Need to check novelty before this filing date? Find Prior Art