A bioactive glass-based cranial defect repair composite material and a method of making the same

By using a composite material of collagen, bioactive glass, natural polysaccharides, hydroxyapatite, and a modifier, the problem of insufficient mechanical strength and antibacterial properties of bioactive glass in skull defect repair was solved, and a skull defect repair material with high mechanical strength and antibacterial properties was prepared.

CN122182863BActive Publication Date: 2026-07-24HUBEI SHUANGXING PHARMA CO LTD
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Patent Information

Application Number
CN202610671543.9
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2026-05-15
Publication Date
2026-07-24
Estimated Expiration
2046-05-15

AI Technical Summary

Technical Problem

Existing bioactive glass materials suffer from high brittleness, low mechanical strength, and insufficient toughness in the repair of skull defects, making it difficult to withstand complex mechanical loads. Furthermore, traditional composite materials have insufficient antibacterial properties.

Method used

A skull defect repair material with bending resistance and antibacterial properties was prepared by using a composite material of collagen, bioactive glass, natural polysaccharides, hydroxyapatite, modifiers, and antibacterial agents through high-pressure homogenization, freeze-drying, and irradiation sterilization.

Benefits of technology

This study achieved high mechanical strength and antibacterial properties in bioactive glass-based skull defect repair materials, which can effectively resist complex mechanical loads and reduce the risk of postoperative infection.

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Abstract

The application discloses a bioactive glass-based skull defect repairing composite material and a preparation method thereof, and relates to the technical field of skull defect repairing materials.The bioactive glass-based skull defect repairing composite material comprises the following raw materials in parts by weight: collagen 10-12 parts, bioactive glass 40-50 parts, natural polysaccharide 5-8 parts, hydroxyapatite 20-30 parts, modified reinforcing agent 6-8 parts, antibacterial agent 1-2 parts and deionized water 100-150 parts.The bioactive glass-based skull defect repairing composite material prepared by the application has good bending resistance and antibacterial performance.
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