An aryl isoxazoline ester compound and isomers or pharmaceutically acceptable salts thereof, and use thereof
By designing aryl isoxazoline ester compounds to enhance their lipophilicity and hydrophobic interaction with insect targets, the problems of insecticide resistance and non-target biotoxicity were solved, achieving highly efficient and low-toxicity insecticidal effects, suitable for large-scale application.
CN122187757APending Publication Date: 2026-06-12SHENZHEN UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN UNIV
- Filing Date
- 2026-03-10
- Publication Date
- 2026-06-12
AI Technical Summary
Technical Problem
Existing pesticides have led to increased pesticide resistance in pests due to long-term use, and they are highly toxic to non-target organisms, affecting agricultural production and the ecological environment.
Method used
Develop aryl isoxazoline esters and their isomers or pharmaceutically acceptable salts, and enhance insecticidal activity and reduce toxicity to non-target organisms by optimizing structural design to improve lipophilicity and hydrophobic interaction with insect targets.
Benefits of technology
This compound exhibits highly effective insecticidal activity, low toxicity, safety for non-target organisms such as bees, suitability for large-scale application, low likelihood of developing resistance, and environmental friendliness.
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Figure CN122187757A_ABST
Abstract
The application provides aryl isoxazoline ester compounds and isomers or pharmaceutically acceptable salts thereof, and applications thereof, the structure of the aryl isoxazoline ester compounds is shown in formula (I): (I); wherein, R1, R2, R3 are independently selected from hydrogen atom, halogen atom and the like; R4 is selected from C1-C5 alkyl substituted or unsubstituted by a first substituent, C2-C6 alkenyl substituted or unsubstituted by a first substituent and the like; R5 is selected from hydrogen atom, C1-C8 alkyl substituted or unsubstituted by a second substituent, C2-C8 alkenyl substituted or unsubstituted by a second substituent and the like; L1 is -(C=O)O-. The aryl isoxazoline ester compounds have good lipophilicity, are more easily absorbed by pests, and have stronger hydrophobic interaction with insect target receptors, and thus have excellent insecticidal activity. In addition, the aryl isoxazoline ester compounds have high safety to non-target organisms, and are suitable for large-scale application.
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