A digital microfluidic system and method for in-situ low background raman detection

By depositing gold or aluminum films in local areas of digital microfluidic chips and combining them with confocal micro Raman spectroscopy, the problems of insufficient detection and background noise in particulate matter and cell analysis in existing technologies have been solved, achieving low-cost, high signal-to-noise ratio Raman detection with recyclable samples.

CN122193191APending Publication Date: 2026-06-12FUDAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIVERSITY
Filing Date
2026-03-31
Publication Date
2026-06-12

AI Technical Summary

⚠Technical Problem

Existing technologies for particulate matter and cell analysis suffer from problems such as insufficient detection, high cost, complex sample preparation, and significant impact from background noise, especially in Raman spectroscopy.

⚗Method used

By combining confocal micro Raman spectroscopy with digital microfluidics, and depositing gold or aluminum films in local areas of the digital microfluidic chip, combined with high-vacuum resistance evaporation coating technology, in-situ low-background Raman detection can be achieved. This method is simple to prepare, low in cost, and has a high signal-to-noise ratio.

🎯Benefits of technology

It achieves high signal-to-noise ratio Raman detection, reduces background noise, improves imaging contrast, allows for sample recovery, broadens application areas, and costs only 1/4 of traditional systems.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention discloses a digital microfluidic system and method for in-situ low-background Raman detection. The system includes: a digital microfluidic platform and a chip; the digital microfluidic platform forwards microfluidic control signals to the chip, which controls the movement of a droplet containing the sample; a localized area of ​​the chip cover plate is coated with a gold or aluminum film; a confocal Raman spectrometer for acquiring microscopic images and Raman spectral data of the sample; and a Raman data processing module for processing the acquired microscopic images and Raman spectral data. During operation, after the chip controls the droplet to move to the gold or aluminum film-coated localized area of ​​the chip cover plate, the chip is removed and inverted and mounted on the confocal Raman spectrometer for acquiring microscopic images and Raman spectral data. This invention enables microscopic image acquisition and in-situ low-background, high signal-to-noise ratio Raman spectroscopy detection at a relatively low cost, and can be applied to the characterization and identification of biological samples such as microorganisms and cells, as well as particulate matter.
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