High-loading chitosan drug-loaded microspheres and preparation method thereof
By introducing alkyl ketone-N,N-dimethylbenzylammonium chloride as a crosslinking agent into chitosan microspheres, chemical bonds and electrostatic interactions are formed, solving the problem of poor loading effect of chitosan microspheres and achieving high loading capacity of rosemary extract and clove essential oil.
CN122208533APending Publication Date: 2026-06-16烟台圣华生物科技有限公司
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 烟台圣华生物科技有限公司
- Filing Date
- 2026-04-03
- Publication Date
- 2026-06-16
AI Technical Summary
Technical Problem
Existing chitosan microspheres have low loading capacity and drug loading rate for drugs and essential oils, which affects the therapeutic effect of the microspheres.
Method used
Alkyl ketone-N,N-dimethylbenzylammonium chloride was used as a crosslinking agent to chemically condense with carboxymethyl chitosan to form stable chemical bonds and introduce benzene rings and quaternary ammonium salt groups. The loading capacity of chitosan microspheres was improved through π-π interactions and electrostatic interactions.
Benefits of technology
It significantly improved the loading capacity and drug loading rate of chitosan microspheres for rosemary extract and clove essential oil, forming a more stable cross-linked structure.
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Abstract
The application relates to the technical field of medical treatment, and discloses high-load chitosan drug-loaded microspheres and a preparation method thereof. The target drug, a surfactant and stirring are added into a solvent to prepare an oil phase; carboxymethyl chitosan is added into distilled water to prepare a water phase by stirring; the water phase is added dropwise into the oil phase to perform emulsification by stirring; alkyl ketone-N,N-dimethyl benzyl ammonium chloride is added to perform crosslinking reaction, and the high-load chitosan drug-loaded microspheres are obtained. The benzene ring and the quaternary ammonium salt group are introduced into the chitosan, the benzene ring can form pi-pi interaction with rosemary acid, eugenol and other substances containing benzene rings in rosemary extract and eugenol and other substances containing benzene rings in clove essential oil, meanwhile, the quaternary ammonium salt cation can form electrostatic interaction with rosemary acid, clove acid and other substances containing carboxyl groups in rosemary extract and clove essential oil, so that the drug loading capacity of the chitosan microspheres for rosemary extract and clove essential oil is further improved.
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