An acupuncture-bci closed-loop neuromodulation system and method based on emotional index feedback

Abstract

This invention discloses an acupuncture-BCI closed-loop neural modulation system and method based on emotion index feedback. The system includes: an EEG acquisition module, worn on the head of the subject to acquire EEG signals; an EEG processing module, used to process the EEG signals to obtain a first amplitude, a second amplitude, and a third amplitude; an emotion index generation module, used to process the first, second, and third amplitudes to obtain a current emotion index; an intensity calculation module, used to process the current emotion index and a preset initial stimulus intensity set to obtain a single acupoint intensity set and a composite effect value; an intensity adjustment module, used to process the single acupoint intensity set and the composite effect value to obtain a adjustment intensity set; and a multi-channel acupuncture module, used to output N stimulation currents based on the adjustment intensity set or the initial stimulus intensity set. This invention can improve the accuracy and stability of modulation, achieving a balance between modulation efficiency and safety tolerance.

Description

Technical Field

[0001] This invention belongs to the field of neuromodulation technology, specifically a closed-loop neuromodulation system and method based on emotion index feedback using acupuncture-BCI. Background Technology

[0002] Mood disorders (such as anxiety, tension, and depression) have become common health problems in modern society, affecting not only mental health but also potentially triggering chain reactions such as sleep disorders and somatic discomfort, severely reducing quality of life. Currently, mood regulation interventions are mainly divided into three categories: drug therapy, psychological intervention, and physical neuromodulation. Drug therapy carries risks of side effects and dependence, psychological intervention is limited by professional resources and intervention periods, while physical intervention techniques, represented by acupuncture, have received widespread attention in the field of mood regulation due to their safety and support from traditional Chinese medicine theory. Traditional acupuncture and existing electroacupuncture techniques in mood regulation rely heavily on the physician's clinical experience, lacking objective and dynamic regulatory evidence. The main problems are: (1) High subjectivity and poor stability of effects: The selection of acupoints, stimulation intensity (such as the force of twisting and the time of needle retention) and stimulation mode of traditional acupuncture rely entirely on the physician's experience and judgment. Differences in operation among different physicians may lead to significant differences in intervention effects. For example, when stimulating the "Baihui" acupoint for anxiety, an inexperienced physician may fail to trigger the neuromodulation effect due to insufficient stimulation intensity, or cause scalp tingling and discomfort due to excessive stimulation intensity, making it difficult to achieve standardized intervention.

[0003] (2) Open-ended adjustment, no real-time feedback mechanism: Most existing electroacupuncture devices are in "fixed parameter output" mode. Once the stimulation intensity is set (e.g., 0.3), the device is automatically adjusted. 0.5 Furthermore, the intervention process cannot be dynamically adjusted according to the subject's emotional changes. For example, if the subject's emotions have calmed down from anxiety to stability, but the electroacupuncture device maintains the initial high-intensity stimulation, it may lead to over-excitation of acupoints, causing dizziness and local muscle tension. Conversely, if the emotions are not relieved but the stimulation is not increased, the intervention efficiency will be low.

[0004] Meanwhile, brain-computer interface (BCI) technology, with its ability to accurately acquire and analyze electroencephalogram (EEG) signals, provides a technological foundation for the objective quantification of emotional states. Combining BCI with acupuncture represents an important development direction for addressing the issues of "high subjectivity and delayed feedback" in emotion regulation. Currently, although a few studies have attempted to combine acupuncture with BCI, the following limitations exist: First, there is a lack of closed-loop regulation: In the existing combination program, BCI is only used for pre-treatment emotional state assessment (such as determining whether the subject meets the indications for acupuncture intervention) or post-treatment effect verification. It does not participate in real-time regulation during the treatment process. Once the acupuncture intensity is set, emotional changes are no longer monitored through BCI during the treatment process. In essence, it is still an open regulation, which cannot solve the problem of "feedback lag".

[0005] Second, the synergistic effect of multiple acupoints is overlooked: Emotional regulation often requires the simultaneous stimulation of multiple related acupoints (such as the combination of "Baihui-Neiguan-Taichong," which corresponds to the effects of "calming the mind and relieving palpitations" and "soothing the liver and relieving depression," respectively). However, in existing multi-acupoint acupuncture regulation, safety is judged only by simply superimposing the intensity of single acupoints, without considering the synergistic or antagonistic effects between acupoints. For example, when "Baihui" and "Neiguan" are stimulated simultaneously, their superimposed effect may be much greater than the sum of the effects of stimulating a single acupoint. If the intensity is still set independently according to the safety threshold of a single acupoint, it is easy to cause the total stimulation to exceed the tolerance of the person being regulated, causing discomfort. Furthermore, "Baihui" and "Shenmen" have a weak antagonistic (effect cancellation) effect. Simply superimposing them may cancel out part of the regulatory effect, resulting in a waste of resources.

[0006] Therefore, there is an urgent need for an acupuncture-BCI closed-loop neuromodulation system that can overcome the above problems. Summary of the Invention

[0007] The technical problem to be solved by this invention is to provide an acupuncture-BCI closed-loop neural regulation system and method based on emotion index feedback, which can improve the accuracy and stability of regulation and achieve a balance between regulation efficiency and safety tolerance.

[0008] To address the aforementioned technical problems, the first aspect of this invention discloses an acupuncture-BCI closed-loop neuromodulation system based on emotion index feedback. The system includes an EEG acquisition module, an EEG processing module, an emotion index generation module, an intensity calculation module, an intensity adjustment module, and a multi-channel acupuncture module. The EEG acquisition module is connected to the EEG processing module and is worn on the head of the subject to acquire EEG signals. The EEG processing module is connected to the emotion index generation module and is used to process the EEG signal to obtain a first amplitude, a second amplitude, and a third amplitude. The emotion index generation module is data-connected to the intensity calculation module and is used to process the first amplitude, the second amplitude, and the third amplitude to obtain the current emotion index. The intensity calculation module is connected to the intensity adjustment module and is used to process the current emotion index and the preset initial stimulus intensity set to obtain the single acupoint intensity set and the composite effect value. The initial stimulation intensity set includes N initial stimulation intensity values; the single acupoint intensity set includes N single acupoint intensity values; N is an integer greater than 1. The intensity adjustment module is data-connected to the multi-channel acupuncture module and is used to process the single acupoint intensity set and the composite effect value to obtain an adjusted intensity set; the adjusted intensity set includes N adjusted intensity values; The multi-channel acupuncture module is used to output N stimulation currents based on the set of adjustable intensity or the set of initial stimulation intensity.

[0009] As an optional implementation, in a first aspect of the present invention, processing the first amplitude, the second amplitude, and the third amplitude to obtain the current sentiment index includes: A1. Based on a preset set of thresholds, the first amplitude, the second amplitude, and the third amplitude are subjected to amplitude limiting processing to obtain a set of limited amplitudes; The threshold set includes a first threshold. TA Second threshold TB Third threshold TC Fourth threshold TD Fifth threshold TE and the sixth threshold TF The set of restricted amplitude values ​​includes a first restricted amplitude value. ta Second limited amplitude tb and the third limited amplitude tc ; A2. Using an index generation model, process the threshold set and the restricted amplitude set to obtain the current sentiment index; The expression for the exponential generation model is: .

[0010] In the formula, EIC The current sentiment index; and These are the preset first and second coefficients, respectively. .

[0011] As an optional implementation, in the first aspect of the present invention, the expression for limiting the amplitude of the first amplitude, the second amplitude, and the third amplitude is: .

[0012] In the formula, tx , ty and tz These are the first amplitude, the second amplitude, and the third amplitude, respectively.

[0013] As an optional implementation, in the first aspect of the present invention, the intensity calculation module includes a single acupoint intensity calculation unit, a synergistic effect calculation unit, and a composite effect calculation unit; The single acupoint intensity calculation unit is connected to the emotion index generation module, the intensity adjustment module, the synergistic effect calculation unit, and the synthetic effect calculation unit. It is used to process the current emotion index, the initial stimulus intensity set, the preset target emotion index, and the individual sensitivity using the single acupoint intensity calculation model to obtain the single acupoint intensity set. The synergistic effect calculation unit is data-connected to the synthetic effect calculation unit and is used to process the single acupoint intensity set using the synergistic effect calculation model to obtain the synergistic effect value. The synthetic effect calculation unit is connected to the intensity adjustment module and is used to process the single acupoint intensity set and the synergistic effect value using the synthetic effect calculation model to obtain the synthetic effect value.

[0014] As an optional implementation, in the first aspect of the present invention, the expression of the single acupoint intensity calculation model is: .

[0015] In the formula, The first of the single acupoint intensity set i The intensity value of each acupoint; The first of the initial stimulus intensity set i The initial stimulus intensity value; K The individual sensitivity; EIC and EIT These are the current sentiment index and the target sentiment index, respectively. ,and i It is an integer.

[0016] As an optional implementation, in the first aspect of the present invention, the expression of the synergistic effect calculation model is: .

[0017] In the formula, LX The synergistic effect value; and The first of the single acupoint intensity set ia and ib The intensity value of each acupoint; For the preset synergy coefficient matrix CC The ia Line number ib The element values ​​of the column; CC It is an N x N symmetric matrix.

[0018] As an optional implementation, in the first aspect of the present invention, the expression of the composite effect calculation model is: .

[0019] In the formula, LT The value of the synthetic effect; The first of the single acupoint intensity set ic The intensity value of each acupoint; LX The synergistic effect value; For a pre-defined set of independent coefficients DC The ic Each independent coefficient; the set of independent coefficients DC This includes N independent coefficients.

[0020] As an optional implementation, in the first aspect of the present invention, processing the set of single acupoint intensity and the composite effect value to obtain a set of modulated intensity includes: The first judgment result is obtained by determining whether the combined effect value is greater than a preset safety effect threshold. When the first judgment result is yes, the intensity adjustment model is used to adjust the single acupoint intensity set, the synthetic effect value and the safety effect threshold to obtain the adjusted intensity set. When the first judgment result is negative, the N adjustment intensity values ​​are respectively set as the N single-acupoint intensity values.

[0021] As an optional implementation, in the first aspect of the present invention, the expression of the intensity adjustment model is: .

[0022] In the formula, The first of the set of adjustment intensities k The aforementioned adjustment intensity value; The first of the single acupoint intensity set k The intensity value of each acupoint; LT and These are the synthetic effect value and the safety effect threshold, respectively. ,and k It is an integer.

[0023] A second aspect of this invention discloses an acupuncture-BCI closed-loop neural modulation method based on emotion index feedback, the method comprising: S1. Wear the EEG acquisition module on the head of the subject; attach the N electrode pads of the multi-channel acupuncture module to the N acupoints to be stimulated on the subject, and set the N stimulation currents of the multi-channel acupuncture module to the N initial stimulation intensity values ​​of the initial stimulation intensity set. S2. Use the EEG acquisition module to acquire EEG signals; S3. Using the EEG processing module, the EEG signal is processed to obtain a first amplitude, a second amplitude, and a third amplitude. S4. Using the emotion index generation module, process the first amplitude, the second amplitude, and the third amplitude to obtain the current emotion index; S5. Using the intensity calculation module, the current emotion index is processed to obtain the set of single acupoint intensity and the composite effect value; S6. Using the intensity adjustment module, the set of intensity of the single acupoint and the composite effect value are processed to obtain the set of adjustable intensity. S7. Set the N stimulation currents of the multi-channel acupuncture module to N adjustment intensity values ​​of the adjustment intensity set respectively; S8. Repeat S2~S7 until the current sentiment index is not lower than the target sentiment index.

[0024] Compared with the prior art, the embodiments of the present invention have the following beneficial effects: (1) By repeatedly executing the closed-loop process of “signal acquisition-emotion judgment-intensity adjustment”, the acupuncture intensity can be dynamically adapted to the changes in emotion in real time, overcoming the problem of “feedback lag” and improving the accuracy of regulation.

[0025] (2) By using the current emotional index, objective physiological indicators can replace subjective judgment, making emotional state quantifiable and traceable, thereby providing a unified basis for regulation, eliminating the influence of "experience differences" on the effect, and greatly improving the stability and repeatability of the regulation effect.

[0026] (3) Utilize the synergistic effect between acupoints to uniformly regulate the stimulation intensity of multiple acupoints, avoid blindly regulating a single acupoint which may lead to failure to achieve the intended effect or over-tolerance of total stimulation, and achieve a balance between regulation efficiency and safety tolerance. Attached Figure Description

[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0028] Figure 1This is a schematic diagram of the structure of an acupuncture-BCI closed-loop neural regulation system based on emotion index feedback disclosed in an embodiment of the present invention.

[0029] Figure 2 This is a schematic diagram of the strength calculation module of an acupuncture-BCI closed-loop neural regulation system based on emotion index feedback disclosed in an embodiment of the present invention.

[0030] Figure 3 This is a flowchart illustrating an acupuncture-BCI closed-loop neural modulation method based on emotion index feedback disclosed in an embodiment of the present invention. Detailed Implementation

[0031] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0032] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0033] In the description of this invention, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0034] Example 1 Please see Figure 1 and 2 . Figure 1 This is a schematic diagram of the structure of an acupuncture-BCI closed-loop neural regulation system based on emotion index feedback disclosed in an embodiment of the present invention. Figure 2 This is a schematic diagram of the intensity calculation module of an acupuncture-BCI closed-loop neural modulation system based on emotion index feedback, as disclosed in an embodiment of the present invention. Figure 1 The described acupuncture-BCI closed-loop neuromodulation system based on emotion index feedback is applied in the field of neuromodulation, such as neuromodulation of emotional disorders like anxiety, tension, and depression. This invention does not limit its application to specific cases. Figure 1 As shown, the system includes an EEG acquisition module, an EEG processing module, an emotion index generation module, an intensity calculation module, an intensity adjustment module, and a multi-channel acupuncture module.

[0035] The EEG acquisition module is connected to the EEG processing module and is worn on the head of the subject to acquire EEG signals.

[0036] It should be noted that the above-mentioned EEG acquisition unit can be OpenBCI Cyton, and this embodiment of the invention does not limit it.

[0037] It should be noted that the aforementioned EEG acquisition module acquires data within a predetermined window time each time, obtaining an EEG signal with a duration equal to the window time. To balance feedback speed and modulation accuracy, the aforementioned window time can be set to 5 seconds.

[0038] The EEG processing module is connected to the emotion index generation module and is used to process the EEG signal to obtain a first amplitude, a second amplitude, and a third amplitude.

[0039] It should be noted that the units for the first, second, and third amplitude values ​​mentioned above are... .

[0040] The emotion index generation module is connected to the intensity calculation module and is used to process the first amplitude, the second amplitude, and the third amplitude to obtain the current emotion index.

[0041] The intensity calculation module is connected to the intensity adjustment module and is used to process the current emotion index and the preset initial stimulus intensity set to obtain the single acupoint intensity set and the composite effect value.

[0042] The initial stimulus intensity set includes N initial stimulus intensity values.

[0043] It should be noted that the N initial stimulation intensity values ​​correspond to the N acupoints to be stimulated. Furthermore, each initial stimulation intensity value is set to be less than the safe stimulation current threshold (the maximum intensity without discomfort, in units of...) for the corresponding acupoint. Taking three acupoints covering three different locations—scalp, wrist, and foot—as examples: (1) Baihui acupoint, located on the top of the head, has thin scalp skin, is close to the skull, has relatively even nerve distribution, and no large blood vessels. The corresponding safe stimulation current threshold is 0.8. Exceeding this value can easily cause scalp tingling; therefore, the corresponding initial stimulation intensity value can be set to 0.8. ×37.5%=0.3 This balances the basic sedative effect with scalp tolerance, leaving room for subsequent enhancement. (2) The Neiguan acupoint, located on the wrist, has thin skin and is close to the median nerve, making it highly sensitive. The corresponding safe stimulation current threshold is 0.7. Exceeding this value can easily cause radiating numbness and pain in the wrist; therefore, the corresponding initial stimulation intensity value can be set to 0.7. ×28.6%=0.2 This can trigger the basic response of "relieving tension" and avoid stimulating the median nerve, which can cause discomfort. (3) The Taichong acupoint is located on the foot. It is located between the metatarsal bones on the dorsum of the foot. The skin and muscle layers are relatively thick, and the nerve sensitivity is low. The corresponding safe stimulation current threshold is 1.0. Exceeding this value can easily cause excessive soreness and swelling in the feet. Therefore, the corresponding initial stimulation intensity value can be set to 1.0. ×40%=0.4 This allows the stimulation to penetrate the skin and superficial muscles, reaching the deep layers of acupoints to produce the basic effect of "soothing the liver and relieving depression," and the level is far below 1.0. The discomfort threshold.

[0044] The set of single acupoint intensity includes N single acupoint intensity values; N is an integer greater than 1.

[0045] The intensity adjustment module is connected to the multi-channel acupuncture module for processing the single acupoint intensity set and the composite effect value to obtain an adjusted intensity set; the adjusted intensity set includes N adjusted intensity values.

[0046] The multi-channel acupuncture module is used to output N stimulation currents based on the set of adjustable intensity or the set of initial stimulation intensity.

[0047] It should be noted that the above-mentioned multi-channel acupuncture module is an electroacupuncture device with N independent outputs, which can control the stimulation current of each of the N channels. Before use, the corresponding electrode pads of the N channels need to be attached to the corresponding acupoints of the person being regulated.

[0048] In an optional embodiment, the above-described processing of the EEG signal to obtain a first amplitude, a second amplitude, and a third amplitude includes: The first, second, and third filters are initialized as Goertzel filters with center frequencies of 10 Hz, 21.5 Hz, and 5.5 Hz, respectively.

[0049] The EEG signal was processed using the first filter, the second filter, and the third filter, respectively, to obtain... wave signal, wave signal and wave signal.

[0050] Set the first, second, and third amplitude values ​​to... wave signal, wave signal and The average amplitude of the wave signal within the window time.

[0051] In another optional embodiment, the processing of the first amplitude, the second amplitude, and the third amplitude to obtain the current sentiment index includes: A1. Based on a preset set of thresholds, the first amplitude, the second amplitude, and the third amplitude are subjected to amplitude limiting processing to obtain a set of limited amplitudes.

[0052] The threshold set includes a first threshold. TA Second threshold TB Third threshold TC Fourth threshold TD Fifth threshold TE and the sixth threshold TF The set of restricted amplitude values ​​includes a first restricted amplitude value. ta Second limited amplitude tb and the third limited amplitude tc .

[0053] It should be noted that the aforementioned first threshold TA Second threshold TB , representing the minimum and maximum thresholds of the first amplitude, respectively; the aforementioned third threshold TC and the fourth threshold TD , representing the minimum and maximum thresholds of the second amplitude, respectively; the aforementioned fifth threshold TE and the sixth threshold TF , where represent the minimum and maximum threshold values ​​for the third amplitude, respectively.

[0054] Preferably, TA , TB , TC , TD , TE and TF , respectively , , , , and .

[0055] A2. Using an index generation model, process the threshold set and the restricted amplitude set to obtain the current sentiment index.

[0056] The expression for the exponential generation model is: .

[0057] In the formula, EIC The current sentiment index; and These are the preset first and second coefficients, respectively. .

[0058] Preferably, the above and They are 0.6 and 0.4 respectively.

[0059] It should be noted that the above tabn For normalized ta and tb The ratio, tcn For normalized ,pass and right tabn and tcn Performing a weighted sum ensures that the result is... EIC Between 0 and 100.

[0060] It should be noted that when a person is anxious, Wave rise (corresponding to) tb (rise) Wave reduction (corresponding to) ta (reduced), at the same time Wave rise (corresponding to) tc (Elevation), leading to EIC Lower; when a person is relaxed, Wave rise (corresponding to) ta (rise) Wave reduction (corresponding to) tb (reduced), at the same time Wave reduction (corresponding to) tc (reduction), leading to EIC The current emotional index indicates an increase in the level of emotion. This demonstrates that the emotional state changes of the person being regulated can be quantified without relying on subjective descriptions, providing a precise "emotional judgment basis" for subsequent closed-loop acupuncture regulation.

[0061] In yet another optional embodiment, the expression for limiting the first amplitude, the second amplitude, and the third amplitude is: .

[0062] In the formula, tx , ty and tz These are the first amplitude, the second amplitude, and the third amplitude, respectively.

[0063] In another optional embodiment, the intensity calculation module includes a single acupoint intensity calculation unit, a synergistic effect calculation unit, and a combined effect calculation unit.

[0064] The single acupoint intensity calculation unit is connected to the emotion index generation module, the intensity adjustment module, the synergistic effect calculation unit, and the synthetic effect calculation unit. It is used to process the current emotion index, the initial stimulus intensity set, the preset target emotion index, and the individual sensitivity using the single acupoint intensity calculation model to obtain the single acupoint intensity set.

[0065] Optionally, the target sentiment index can be set to a value range of [60, 80].

[0066] Preferably, the target sentiment index is 70.

[0067] Optionally, the range of the above individual sensitivity is [0.01, 0.06].

[0068] The synergistic effect calculation unit is data-connected to the synthetic effect calculation unit and is used to process the single acupoint intensity set using the synergistic effect calculation model to obtain the synergistic effect value.

[0069] The synthetic effect calculation unit is connected to the intensity adjustment module and is used to process the single acupoint intensity set and the synergistic effect value using the synthetic effect calculation model to obtain the synthetic effect value.

[0070] In yet another alternative embodiment, such as Figure 2 As shown, the intensity calculation module includes a single acupoint intensity calculation unit, a synergistic effect calculation unit, and a combined effect calculation unit.

[0071] The single acupoint intensity calculation unit is connected to the emotion index generation module, the intensity adjustment module, the synergistic effect calculation unit, and the synthetic effect calculation unit. It is used to process the current emotion index, the initial stimulus intensity set, the preset target emotion index, and the individual sensitivity using the single acupoint intensity calculation model to obtain the single acupoint intensity set. The initial stimulus intensity set includes N initial stimulus intensity values.

[0072] The synergistic effect calculation unit is data-connected to the synthetic effect calculation unit and is used to process the single acupoint intensity set using the synergistic effect calculation model to obtain the synergistic effect value.

[0073] The synthetic effect calculation unit is connected to the intensity adjustment module and is used to process the single acupoint intensity set and the synergistic effect value using the synthetic effect calculation model to obtain the synthetic effect value.

[0074] In yet another optional embodiment, the expression for the single acupoint intensity calculation model is: .

[0075] In the formula, The first of the single acupoint intensity set i The intensity value of each acupoint; The first of the initial stimulus intensity set i The initial stimulus intensity value; K The individual sensitivity; EIC and EIT These are the current sentiment index and the target sentiment index, respectively. ,and i It is an integer.

[0076] It should be noted that when EIC < EIT When this occurs, it indicates that the subject is still emotionally anxious or depressed relative to the target state, and the regulation needs to be strengthened based on the initial stimulus intensity; when EIC = EIT When the initial stimulus intensity is maintained, it indicates that the subject's emotional state is within acceptable limits; when... EIC > EIT When this occurs, it indicates that the subject is relatively excited compared to the target state, and the intensity of the stimulus needs to be reduced to regulate it.

[0077] It should be noted that the aforementioned individual sensitivity is used to adjust the amplification factor of the emotional quantification bias. Its value is set according to the individual subject. When the subject is insensitive to the stimulus, a larger value, such as 0.05, is set to enhance the stimulus; conversely, when the subject is sensitive to the stimulus, a smaller value, such as 0.02, is set to weaken the stimulus. Therefore, by introducing individual sensitivity, subjects with different physiological characteristics can receive an appropriate stimulus intensity, improving the effectiveness of personalized intervention.

[0078] It can be seen that the single acupoint intensity calculation model can quantify the bias in emotion ( EIT and EIC The difference between the two is transformed into "precise acupuncture stimulation intensity", while taking into account the characteristics of different subjects and the safety of stimulation, avoiding blind stimulation with fixed intensity, and realizing dynamic adjustment of stimulation intensity according to emotional changes.

[0079] In yet another optional embodiment, the expression for the synergistic effect calculation model is: .

[0080] In the formula, LX The synergistic effect value; and The first of the single acupoint intensity set ia and ib The intensity value of each acupoint; For the preset synergy coefficient matrix CC The ia Line number ib The element values ​​of the column; CC It is an N x N symmetric matrix.

[0081] It should be noted that when stimulating two or more acupoints simultaneously, even if the intensity of each acupoint is less than its own safe stimulation current threshold, the total stimulation may still exceed the subject's tolerance (e.g., causing tingling or dizziness). A synergy matrix can reflect the proportion of the "additional contribution" of synergistic stimulation between any two acupoints to the overall effect.

[0082] Optionally, the values ​​of each element in the above synergy coefficient matrix range from [-0.2, 0.4], with units of... The effects of each element in different ranges are as follows: (1) Strong synergy (value greater than 0.3 and less than or equal to 0.4), the combined effect of the two acupoints is much greater than the sum of the single acupoints, significantly enhancing the regulatory force; (2) Weak synergy (value greater than 0.1 and less than or equal to 0.3), the combined effect of the two acupoints is slightly greater than the sum of the single acupoints, slightly enhancing the regulatory force; (3) No obvious interaction (value greater than -0.05 and less than or equal to 0.1), the combined effect of the two acupoints is approximately equal to the sum of the single acupoints, with no enhancement or cancellation; (4) Weak antagonism (value greater than or equal to -0.2 and less than or equal to -0.05), the combined effect of the two acupoints is slightly less than the sum of the single acupoints, slightly canceling the regulatory force.

[0083] Taking the four acupoints "Baihui, Neiguan, Taichong and Shenmen" as examples, the elements in the corresponding synergy coefficient matrix can be shown in Table 1. The diagonal elements are 0, which means that they do not have a synergistic effect.

[0084]

[0085] In yet another optional embodiment, the expression for the composite effect calculation model is: .

[0086] In the formula, LT The value of the synthetic effect; The first of the single acupoint intensity set ic The intensity value of each acupoint; LXThe synergistic effect value; For a pre-defined set of independent coefficients DC The ic Each independent coefficient; the set of independent coefficients DC This includes N independent coefficients.

[0087] It should be noted that the above N independent coefficients are used to quantify the independent contribution of the N acupoints to emotion regulation, and the stronger the regulation ability of the acupoint, the higher the value of the corresponding independent coefficient.

[0088] Optionally, the range of the above independent coefficients is [0.5, 0.9], and the unit is... .

[0089] Taking the four acupoints "Baihui, Neiguan, Taichong, and Shenmen" as examples: (1) Baihui is located in a scalp with evenly distributed nerves and no large blood vessels. Its TCM function is "calming the mind and soothing the nerves, calming the liver and suppressing yang". It has the strongest effect on regulating anxiety and tension. The corresponding independent coefficient can be set to 0.9; (2) Neiguan is located superficially on the wrist, close to the median nerve (high sensitivity). Its TCM function is "calming the mind and soothing the nerves, relieving palpitations". It has a significant effect on physical tension (palpitations, hand tremors) caused by emotions. The corresponding independent coefficient can be set to 0.9. 0.7; (3) The foot muscles where Taichong acupoint is located are thick and the nerves are sparse (low sensitivity). Its TCM function is "to soothe the liver and relieve depression, calm the liver and reduce fire". It has a prominent effect on "irritability and anger", but is weaker than Neiguan acupoint. The corresponding independent coefficient can be set to 0.6; (4) Shenmen acupoint is located on the ulnar side of the wrist, close to the ulnar nerve (extremely high sensitivity). Its TCM function is "to calm the mind and improve sleep". Its effect on regulating emotions is weaker than the previous three. It focuses more on sleep problems related to emotions. The corresponding independent coefficient can be set to 0.55.

[0090] In another optional embodiment, the processing of the single acupoint intensity set and the composite effect value to obtain the modulated intensity set includes: The first judgment result is obtained by determining whether the combined effect value is greater than a preset safety effect threshold. When the first judgment result is yes, the intensity adjustment model is used to adjust the single acupoint intensity set, the synthetic effect value and the safety effect threshold to obtain the adjusted intensity set. When the first judgment result is negative, the N adjustment intensity values ​​are respectively set as the N single-acupoint intensity values.

[0091] Optionally, the above-mentioned safety effect threshold ranges from [1.5, 2.5].

[0092] Preferably, the aforementioned safety effect threshold is 2.0.

[0093] In yet another optional embodiment, the expression for the intensity adjustment model is: .

[0094] In the formula, The first of the set of adjustment intensities k The aforementioned adjustment intensity value; The first of the single acupoint intensity set k The intensity value of each acupoint; LT and These are the synthetic effect value and the safety effect threshold, respectively. ,and k It is an integer.

[0095] As can be seen, the acupuncture-BCI closed-loop neural modulation system based on emotion index feedback described in the embodiments of the present invention can be implemented as follows: (1) By repeatedly executing the closed-loop process of “signal acquisition-emotion judgment-intensity adjustment”, the acupuncture intensity can be dynamically adapted to the changes in emotion in real time, overcoming the problem of “feedback lag” and improving the accuracy of regulation.

[0096] (2) By using the current emotional index, objective physiological indicators can replace subjective judgment, making emotional state quantifiable and traceable, thereby providing a unified basis for regulation, eliminating the influence of "experience differences" on the effect, and greatly improving the stability and repeatability of the regulation effect.

[0097] (3) Utilize the synergistic effect between acupoints to uniformly regulate the stimulation intensity of multiple acupoints, avoid blindly regulating a single acupoint which may lead to failure to achieve the intended effect or over-tolerance of total stimulation, and achieve a balance between regulation efficiency and safety tolerance.

[0098] (4) The initial stimulation intensity value is set to be less than the safe stimulation current threshold of the corresponding acupoint, leaving room for safe adjustment; the total stimulation risk is monitored in real time through the synthetic effect value, and the intensity is automatically reduced if it exceeds the safe threshold. Therefore, through initial safety control and dynamic safety control, the safety risk is blocked twice, effectively avoiding problems such as excessive intensity of a single acupoint and synergistic overtolerance of multiple acupoints, significantly reducing the incidence of adverse reactions such as dizziness and local stinging, and improving the safety of system use.

[0099] Example 2 Please see Figure 3 , Figure 3 This is a flowchart illustrating an acupuncture-BCI closed-loop neural modulation method based on emotion index feedback disclosed in an embodiment of the present invention. Figure 3The described acupuncture-BCI closed-loop neuromodulation method based on emotion index feedback is applied in the field of neuromodulation, such as neuromodulation of emotional disorders like anxiety, tension, and depression. This invention does not limit its application to specific cases. Figure 3 As shown, this acupuncture-BCI closed-loop neural modulation method based on emotion index feedback includes: S1. Wear the EEG acquisition module on the head of the subject; attach the N electrode pads of the multi-channel acupuncture module to the N acupoints to be stimulated on the subject, and set the N stimulation currents of the multi-channel acupuncture module to the N initial stimulation intensity values ​​of the initial stimulation intensity set. S2. Use the EEG acquisition module to acquire EEG signals; S3. Using the EEG processing module, the EEG signal is processed to obtain a first amplitude, a second amplitude, and a third amplitude. S4. Using the emotion index generation module, process the first amplitude, the second amplitude, and the third amplitude to obtain the current emotion index; S5. Using the intensity calculation module, the current emotion index is processed to obtain the set of single acupoint intensity and the composite effect value; S6. Using the intensity adjustment module, the set of intensity of the single acupoint and the composite effect value are processed to obtain the set of adjustable intensity. S7. Set the N stimulation currents of the multi-channel acupuncture module to N adjustment intensity values ​​of the adjustment intensity set respectively; S8. Repeat S2~S7 until the current sentiment index is not lower than the target sentiment index.

[0100] It is evident that implementing the acupuncture-BCI closed-loop neural modulation method based on emotion index feedback described in the embodiments of the present invention can improve the accuracy and stability of modulation and achieve a balance between modulation efficiency and safety tolerance.

[0101] The device embodiments described above are merely illustrative. The modules described as separate components may or may not be physically separate, and the components shown as modules may or may not be physical modules; that is, they may be located in one place or distributed across multiple network modules. Some or all of the modules can be selected to achieve the purpose of this embodiment according to actual needs. Those skilled in the art can understand and implement this without any creative effort.

[0102] Through the detailed description of the above embodiments, those skilled in the art can clearly understand that each implementation method can be implemented by means of software plus necessary general-purpose hardware platforms, and of course, it can also be implemented by hardware. Based on this understanding, the above technical solutions, in essence or the part that contributes to the prior art, can be embodied in the form of a software product. This computer software product can be stored in a computer-readable storage medium, including read-only memory (ROM), random access memory (RAM), programmable read-only memory (PROM), erasable programmable read-only memory (EPROM), one-time programmable read-only memory (OTPROM), electrically-Erasable Programmable Read-Only Memory (EEPROM), compact disc read-only memory (CD-ROM) or other optical disc storage, disk storage, magnetic tape storage, or any other computer-readable medium that can be used to carry or store data.

[0103] Finally, it should be noted that the acupuncture-BCI closed-loop neural regulation system and method based on emotion index feedback disclosed in the embodiments of the present invention are merely preferred embodiments of the present invention, and are only used to illustrate the technical solutions of the present invention, not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. An acupuncture-BCI closed-loop neural modulation system based on emotion index feedback, characterized in that, It includes an EEG acquisition module, an EEG processing module, an emotion index generation module, an intensity calculation module, an intensity adjustment module, and a multi-channel acupuncture module; The EEG acquisition module is connected to the EEG processing module and is worn on the head of the subject to acquire EEG signals. The EEG processing module is connected to the emotion index generation module and is used to process the EEG signal to obtain a first amplitude, a second amplitude, and a third amplitude. The emotion index generation module is data-connected to the intensity calculation module and is used to process the first amplitude, the second amplitude, and the third amplitude to obtain the current emotion index. The intensity calculation module is connected to the intensity adjustment module and is used to process the current emotion index and the preset initial stimulus intensity set to obtain the single acupoint intensity set and the composite effect value. The initial stimulation intensity set includes N initial stimulation intensity values; the single acupoint intensity set includes N single acupoint intensity values; N is an integer greater than 1. The intensity adjustment module is data-connected to the multi-channel acupuncture module and is used to process the single acupoint intensity set and the composite effect value to obtain an adjusted intensity set; the adjusted intensity set includes N adjusted intensity values; The multi-channel acupuncture module is used to output N stimulation currents based on the set of adjustable intensity or the set of initial stimulation intensity.

2. The acupuncture-BCI closed-loop neural modulation system based on emotion index feedback according to claim 1, characterized in that, The process of processing the first amplitude, the second amplitude, and the third amplitude to obtain the current sentiment index includes: A1. Based on a preset set of thresholds, the first amplitude, the second amplitude, and the third amplitude are subjected to amplitude limiting processing to obtain a set of limited amplitudes; The threshold set includes a first threshold. TA Second threshold TB Third threshold TC Fourth threshold TD Fifth threshold TE and the sixth threshold TF The set of restricted amplitude values ​​includes a first restricted amplitude value. ta Second limited amplitude tb and the third limited amplitude tc ; A2. Using an index generation model, process the threshold set and the restricted amplitude set to obtain the current sentiment index; The expression for the exponential generation model is: ； In the formula, EIC The current sentiment index; and These are the preset first and second coefficients, respectively. .

3. The acupuncture-BCI closed-loop neural regulation system based on emotion index feedback according to claim 2, characterized in that, The expression for limiting the amplitude of the first amplitude, the second amplitude, and the third amplitude is as follows: ； In the formula, tx , ty and tz These are the first amplitude, the second amplitude, and the third amplitude, respectively.

4. The acupuncture-BCI closed-loop neural modulation system based on emotion index feedback according to claim 1, characterized in that, The intensity calculation module includes a single acupoint intensity calculation unit, a synergistic effect calculation unit, and a combined effect calculation unit; The single acupoint intensity calculation unit is connected to the emotion index generation module, the intensity adjustment module, the synergistic effect calculation unit, and the synthetic effect calculation unit. It is used to process the current emotion index, the initial stimulus intensity set, the preset target emotion index, and the individual sensitivity using the single acupoint intensity calculation model to obtain the single acupoint intensity set. The synergistic effect calculation unit is data-connected to the synthetic effect calculation unit and is used to process the single acupoint intensity set using the synergistic effect calculation model to obtain the synergistic effect value. The synthetic effect calculation unit is connected to the intensity adjustment module and is used to process the single acupoint intensity set and the synergistic effect value using the synthetic effect calculation model to obtain the synthetic effect value.

5. The acupuncture-BCI closed-loop neural modulation system based on emotion index feedback according to claim 4, characterized in that, The expression for the single acupoint intensity calculation model is as follows: ； In the formula, The first of the single acupoint intensity set i The intensity value of each acupoint; The first of the initial stimulus intensity set i The initial stimulus intensity value; K The individual sensitivity; EIC and EIT These are the current sentiment index and the target sentiment index, respectively. ,and i It is an integer.

6. The acupuncture-BCI closed-loop neural modulation system based on emotion index feedback according to claim 4, characterized in that, The expression for the synergistic effect calculation model is as follows: ； In the formula, LX The synergistic effect value; and The first of the single acupoint intensity set ia and ib The intensity value of each acupoint; For the preset synergy coefficient matrix CC The ia Line number ib The element values ​​of the column; CC It is an N-row, N-column symmetric matrix.

7. The acupuncture-BCI closed-loop neural modulation system based on emotion index feedback according to claim 4, characterized in that, The expression for the calculation model of the combined effect is: ； In the formula, LT The value of the synthetic effect; The first of the single acupoint intensity set ic The intensity value of each acupoint; LX The synergistic effect value; For a pre-defined set of independent coefficients DC The ic Each independent coefficient; the set of independent coefficients DC This includes N independent coefficients.

8. The acupuncture-BCI closed-loop neural modulation system based on emotion index feedback according to claim 1, characterized in that, The process of processing the single acupoint intensity set and the composite effect value to obtain the modulated intensity set includes: The first judgment result is obtained by determining whether the combined effect value is greater than a preset safety effect threshold. When the first judgment result is yes, the intensity adjustment model is used to adjust the single acupoint intensity set, the synthetic effect value and the safety effect threshold to obtain the adjusted intensity set. When the first judgment result is negative, the N adjustment intensity values ​​are respectively set as the N single-acupoint intensity values.

9. The acupuncture-BCI closed-loop neural modulation system based on emotion index feedback according to claim 8, characterized in that, The expression for the intensity adjustment model is: ； In the formula, The first of the set of adjustment intensities k The aforementioned adjustment intensity value; The first of the single acupoint intensity set k The intensity value of each acupoint; LT and These are the synthetic effect value and the safety effect threshold, respectively. ,and k It is an integer.

10. A closed-loop neural modulation method based on emotion index feedback using acupuncture-BCI, characterized in that, The method applied to the acupuncture-BCI closed-loop neural modulation system based on emotion index feedback as described in any one of claims 1 to 9 includes: S1. Wear the EEG acquisition module on the head of the subject; attach the N electrode pads of the multi-channel acupuncture module to the N acupoints to be stimulated on the subject, and set the N stimulation currents of the multi-channel acupuncture module to the N initial stimulation intensity values ​​of the initial stimulation intensity set. S2. Use the EEG acquisition module to acquire EEG signals; S3. Using the EEG processing module, the EEG signal is processed to obtain a first amplitude, a second amplitude, and a third amplitude. S4. Using the emotion index generation module, process the first amplitude, the second amplitude, and the third amplitude to obtain the current emotion index; S5. Using the intensity calculation module, the current emotion index is processed to obtain the single acupoint intensity set and the composite effect value; S6. Using the intensity adjustment module, the set of intensity of the single acupoint and the composite effect value are processed to obtain the set of adjustable intensity. S7. Set the N stimulation currents of the multi-channel acupuncture module to N adjustment intensity values ​​of the adjustment intensity set respectively; S8. Repeat S2~S7 until the current sentiment index is not lower than the target sentiment index.

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