Oral composition

Abstract

The object of this invention is to provide an oral composition that can maintain the stability of the enzyme when an anionic surfactant and the enzyme are used together, and can effectively exhibit foaming properties and foam persistence. This invention provides an oral composition comprising (A) an enzyme, (B) an anionic surfactant comprising (B-1) an alkyl sulfate and / or acylmethyl taurate, and (B-2) one or more anionic surfactants selected from α-olefin sulfonates, acylsarcosinates, acylglutamates, and sulfosuccinates, and (C) glycyrrhizate, wherein the content of component (B) is 0.3 to 1.3% by mass.

Description

Technical Field

[0001] This invention relates to a composition for oral use. Background Technology

[0002] In the past, various enzymes have been incorporated into oral care compositions from the perspectives of preventing and inhibiting the development of tooth decay, preventing halitosis, and further improving the aesthetics of teeth. For example, dextranase is known to achieve a caries-preventing effect by breaking down dental plaque, among other enzymes that can be incorporated into oral care compositions.

[0003] On the other hand, from the viewpoint of improving the user experience and usability, surfactants are usually formulated into oral compositions. Examples of surfactants that can be formulated into oral compositions include anionic surfactants formulated to ensure adequate foaming properties.

[0004] However, anionic surfactants can denature and inactivate enzymes. Therefore, when dextranase is formulated into oral compositions as an enzyme, for example, to ensure the stability of dextranase activity, specific surfactants are formulated together with or in place of anionic surfactants. For example, Patent Document 1 describes the formulation of both anionic and carboxylic acid surfactants, Patent Document 2 describes the formulation of polyoxyethylene alkyl ethers, Patent Document 3 describes the formulation of fatty acid glycerides, and Patent Document 4 describes the formulation of fatty acid diethanolamides.

[0005] [Existing Technical Documents]

[0006] [Patent Documents]

[0007] [Patent Document 1] Japanese Patent Application Publication No. 58-225007

[0008] [Patent Document 2] Japanese Patent Application Publication No. 61-176518

[0009] [Patent Document 3] Japanese Patent Application Publication No. 3-181413

[0010] [Patent Document 4] Japanese Patent Application Publication No. 8-12543 Summary of the Invention

[0011] [The problem the invention aims to solve]

[0012] However, the aforementioned prior art sometimes fails to achieve the desired foaming properties and foam persistence by mixing anionic surfactants. Furthermore, it sometimes fails to adequately suppress enzyme denaturation and inactivation caused by anionic surfactants.

[0013] The object of the present invention is to provide an oral composition that can maintain the stability of the enzyme when an anionic surfactant is used in combination with the enzyme, and can perform well in terms of foaming and foam persistence.

[0014] [Methods for solving the problem]

[0015] This invention provides [1] to [9].

[0016] [1] An oral composition, characterized in that it contains

[0017] Ingredient (A): Enzyme,

[0018] Component (B): An anionic surfactant comprising (B-1) and (B-2),

[0019] (B-1) Alkyl sulfates and / or acylmethyl taurine salts,

[0020] (B-2) is selected from one or more of α-olefin sulfonates, acylsarcosine salts, acylglutamate salts, and sulfosuccinates.

[0021] Ingredient (C): Glycyrrhizic acid salt,

[0022] The content of component (B) is 0.3~1.3 by mass.

[0023] [2] The oral composition according to [1], wherein component (A) comprises one or both of glucanase and protease.

[0024] [3] The oral composition according to [1], wherein component (A) comprises one or more selected from dextranase, polysaccharidease, actinidine, papain and bromelain.

[0025] [4] The oral composition according to [3], wherein component (A) comprises dextranase,

[0026] The enzyme activity of dextranase is 2 U / g to 200 U / g.

[0027] [5] The oral composition according to [3], wherein component (A) comprises papain,

[0028] The enzyme activity of papain is 400 U / g to 40000 U / g.

[0029] [6] The oral composition according to any one of [1] to [5], wherein the content of (B-1) is 0.1 to 0.8 by mass.

[0030] [7] The oral composition according to any one of [1] to [6], wherein the content of (B-2) is 0.1 to 0.8% by mass.

[0031] [8] The oral composition according to any one of [1] to [7], wherein the content of component (B) is 0.3 to 1.0 by mass.

[0032] [9] The oral composition according to any one of [1] to [8], wherein the ratio of the content of (B-1) to the content of (B-2) is 0.15 to 4.

[0033] [Invention Effects]

[0034] According to the present invention, an oral composition is provided that inhibits enzyme inactivation and denaturation, maintains stability, and exhibits good foaming properties and foam persistence. Detailed Implementation

[0035] [1. Ingredients and composition of oral compositions]

[0036] The oral composition of the present invention contains ingredients (A) to (C).

[0037] [1.1 Component A: Enzyme]

[0038] Component (A) is an enzyme. Through component (A), the composition is able to perform functions based on enzyme activity.

[0039] As an enzyme, it is preferred to have enzyme activity that enables the oral composition to perform the functions required by the oral composition, such as decomposing and removing dental plaque (biofilm) from the tooth surface or periodontal pockets and the tongue, preventing tooth decay, and inhibiting the development of caries. Examples of such enzymes include proteases and glucanases. As a glucanase, it is preferred to be an enzyme that acts on polysaccharides related to diseases (e.g., dental caries) in the oral cavity; examples include dextranase, mutagensylase, α-amylase, β-amylase, amylopectinase, glucosylamylase, α-glucosidase, isoamylase, cellulase (including β-glucanase), and hemicellulase, with dextranase being preferred. Dextranase can decompose and remove dental plaque and inhibit its formation.

[0040] The protease can be any type of endopeptidase or exopeptidase (aminopeptidase, carboxypeptidase), but endopeptidase is preferred. Examples of endoproteinases include cysteine ​​proteases such as papain, bromelain, and actinidin, and serine proteases such as nattokinase; cysteine ​​proteases are preferred, papain, bromelain, and actinidin are more preferred, and papain is even more preferred. Papain is effective in removing tongue coating and stains.

[0041] Component (A) may be one enzyme or a combination of two or more enzymes, preferably containing one or more selected from dextranase, polysaccharide enzyme, actinidin, papain and bromelain, more preferably containing dextranase and / or papain.

[0042] The enzyme in component (A) may be an enzyme stabilized using excipients. Excipients may be commonly used substances. Examples include sugar alcohols such as sorbitol, mannitol, and maltitol; polyols such as glycerol and propylene glycol; polysaccharides such as dextrin, starch, and crystalline cellulose; and inorganic powders such as silica. Among these, mannitol, dextrin, crystalline cellulose, and glycerol are preferred.

[0043] The content of excipients relative to enzymes can be adjusted appropriately.

[0044] [Content of ingredient (A)]

[0045] The content of component (A) varies depending on the type of enzyme and cannot be limited in a general sense. As for enzyme activity, it is preferably 1 U / g or more, more preferably 2 U / g or more, further preferably 5 U / g or more, and even more preferably 10 U / g or more. This allows for a better mixing effect. The upper limit is preferably 70,000 U / g or less, more preferably 60,000 U / g or less, further preferably 50,000 U / g or less, even more preferably 40,000 U / g or less, and particularly preferably 30,000 U / g or less. Therefore, it is preferably 1 to 70,000 U / g, more preferably 2 to 60,000 U / g, further preferably 5 to 50,000 U / g, even more preferably 10 to 40,000 U / g, and particularly preferably 10 to 30,000 U / g.

[0046] The content of dextranase as component (A), based on enzyme activity, is preferably 1 U / g or more (in the composition), more preferably 2 U / g or more, further preferably 5 U / g or more, and even more preferably 10 U / g or more. This allows for a better mixing effect. The upper limit is preferably 500 U / g or less, more preferably 200 U / g or less, further preferably 150 U / g or less, and even more preferably 100 U / g or less. Therefore, it is 1 to 500 U / g, more preferably 2 to 200 U / g, further preferably 5 to 150 U / g, and even more preferably 10 to 100 U / g. This suppresses the development of astringent taste during use. When the enzyme activity is 4000 U / g, the content of dextranase is preferably 0.025% by mass or more, more preferably 0.05% by mass or more, further preferably 0.125% by mass or more or 0.055% by mass or more, even more preferably 0.1% by mass or more, and particularly preferably 0.25% by mass or more. This allows for a better formulation effect. When the enzyme activity is 4000 U / g, the upper limit is preferably 12.5% ​​by mass or less, more preferably 5% by mass or less, even more preferably 3.75% by mass or less, and particularly preferably 2.5% by mass or less. This suppresses the development of astringent taste during use. Therefore, when the enzyme activity is 4000 U / g, it is preferably 0.025 to 12.5% ​​by mass, more preferably 0.05 to 5% by mass, even more preferably 0.125 to 3.75% by mass, and particularly preferably 0.25 to 2.5% by mass.

[0047] The content of papain as component (A), based on enzyme activity, is preferably 100 U / g or more (in the composition), more preferably 200 U / g or more, further preferably 300 U / g or more, even more preferably 400 U / g or more, and particularly preferably 500 U / g or more. This allows for a better mixing effect. The upper limit is preferably 70,000 U / g or less, more preferably 60,000 U / g or less, further preferably 50,000 U / g or less, even more preferably 40,000 U / g or less, and particularly preferably 30,000 U / g or less. Therefore, a content of 1 to 500 U / g or more, more preferably 2 to 200 U / g, further preferably 5 to 150 U / g, and even more preferably 10 to 100 U / g, can suppress the formation of astringent taste during use. When the enzyme activity is 800,000 U / g, the papain content is preferably 0.0125% by mass or more, more preferably 0.025% by mass or more, even more preferably 0.0375% by mass or more, even more preferably 0.05% by mass or more, and particularly preferably 0.0625% by mass or more. This allows for a better mixing effect. The upper limit is preferably 8.75% by mass or less, more preferably 7.5% by mass or less, even more preferably 6.25% by mass or less, even more preferably 5% by mass or less, and particularly preferably 3.753% by mass or less. This suppresses the formation of astringent taste during use. Therefore, when the enzyme activity is 800,000 U / g, it is preferably 0.0125 to 8.75% by mass, more preferably 0.025 to 7.5% by mass, even more preferably 0.0375 to 6.25% by mass, even more preferably 0.05 to 5% by mass, and particularly preferably 0.0625 to 3.75% by mass.

[0048] Furthermore, unless otherwise specified, the content of each component in this specification is based on the amount of each component added when manufacturing the oral composition. Additionally, unless otherwise specified, it represents mass% relative to 100% of the total amount of the oral composition.

[0049] [1.2 Component (B): Anionic surfactant]

[0050] Component (B) is an anionic surfactant. Through component (B), the oral composition exhibits good foaming properties and foam persistence. The anionic surfactant comprises (B-1) and (B-2) as described below.

[0051] [Ingredient (B-1)]

[0052] Component (B-1) is selected from one or more alkyl sulfates and acylmethyl taurate. Through (B-1), the composition can improve foaming properties.

[0053] The alkyl group in alkyl sulfates is typically a straight chain, and the number of carbon atoms is preferably 10 to 20, more preferably 12 to 18, and even more preferably 12 to 14. Examples of alkyl sulfates include dodecyl sulfate and tetradecyl sulfate, with dodecyl sulfate being preferred.

[0054] The acyl group of the acylmethyl taurate is usually a straight chain, and the number of carbon atoms is preferably 8 to 20, more preferably 10 to 20, and even more preferably 10 to 18. Examples of acylmethyl taurates include lauroyl methyl taurate and N-cocoyl methyl taurate, with lauroyl methyl taurate being preferred.

[0055] The salts of alkyl sulfates and acylmethyl taurates can be selected from pharmacologically permissible salts such as alkali addition salts and amino acid salts. Examples include inorganic alkali salts such as sodium, potassium, calcium, magnesium, and ammonium salts; organic alkali salts such as triethylammonium, triethanolamine, pyridinium, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic alkali salts are preferred, alkali metal salts (e.g., sodium and potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

[0056] Component (B-1) may be one or a combination of two or more, preferably containing at least sodium dodecyl sulfate and / or sodium lauroyl methyl taurate.

[0057] [Ingredient (B-2)]

[0058] Component (B-2) is selected from one or more of acylsarcosine salts, α-olefin sulfonates, acylglutamate salts, and sulfosuccinates. Through (B-2), the composition can improve foam durability.

[0059] The acyl sarcosine salt typically has a straight-chain acyl group, and preferably has 10 to 20 carbon atoms, more preferably 12 to 18, and even more preferably 12 to 14. Examples of acyl sarcosine salts include lauroyl sarcosine salt and myristyl sarcosine salt, with lauroyl sarcosine salt being the most preferred.

[0060] The α-olefin sulfonate preferably has 10 to 20 carbon atoms, more preferably 12 to 18, and even more preferably 14 to 16. For example, tetradecene sulfonate is preferred as an α-olefin sulfonate.

[0061] The acyl glutamate salt typically has a straight-chain acyl group, and preferably has 8 to 20 carbon atoms, more preferably 10 to 20, and even more preferably 10 to 18. Examples of acyl glutamate salts include cocoyl glutamate and lauroyl glutamate, with lauroyl glutamate being the most preferred.

[0062] The alkyl group in sulfosuccinates is typically straight-chain, preferably with 10 to 20 carbon atoms, more preferably 12 to 18, and even more preferably 12 to 14. For example, lauryl sulfosuccinate is preferred. The alkyl group may also have a polyoxyalkylene group. As a polyoxyalkylene group, a polyoxyethylene group is preferred. As a sulfosuccinate, for example, polyoxyethylene (2)alkyl (12 to 14)sulfosuccinate can be listed.

[0063] Examples of salts possessed by acylsarcosine salts, α-olefin sulfonates, acylglutamate salts, and sulfosuccinates are the same as those in component (B-1).

[0064] Component (B-2) may be one or more combinations of two or more, preferably containing at least one of sodium lauroyl sarcosinate, sodium tetradecene sulfonate, sodium lauroyl glutamate and disodium polyoxyethylene (2)alkyl (12~14)sulfosuccinate.

[0065] [Other anionic surfactants]

[0066] Component (B) may also contain anionic surfactants other than those in (B-1) and (B-2). Examples include acylglycine salts such as cocoyl glycinate; acylalanine salts such as N-dodecyl-β-alanine, N-myristyl-β-alanine, and N-cocoyl-β-alanine; acylmethylalanine salts such as N-dodecyl-N-methyl-β-alanine, N-myristyl-N-methyl-β-alanine, and N-cocoyl-N-methyl-β-alanine; acyl aspartate salts such as lauroyl aspartate; hydrogenated coconut oil fatty acid monoglyceride monosulfate, and dodecyl sulfoacetate. Anionic surfactants other than those in (B-1) and (B-2) may be one or a combination of two or more.

[0067] [Content and mass ratio of components (B), (B-1), and (B-2)]

[0068] The content of component (B) (preferably the total content of components (B-1) and (B-2)) is typically 0.3% by mass or more, preferably 0.4% by mass or more. This allows for a good blending effect of component (B). The upper limit is typically 1.2% by mass or less, preferably 1.1% by mass or less, more preferably 1.0% by mass or less. This suppresses the effect on enzyme activity. Therefore, typically 0.3 to 1.2% by mass, preferably 0.3 to 1.1% by mass, more preferably 0.3 to 1.0% by mass, and even more preferably 0.4 to 1.0% by mass.

[0069] The content of component (B-1) is preferably 0.1% by mass or more, more preferably 0.2% by mass or more, and even more preferably 0.3% by mass or more. This improves the foaming properties. The upper limit is preferably 1% by mass or less, more preferably 0.9% by mass or less, even more preferably 0.8% by mass or less, even more preferably 0.7% by mass or less, and particularly preferably 0.6% by mass or less. This maintains the stability of component (A). Therefore, it is preferably 0.1 to 1% by mass, more preferably 0.1 to 0.9% by mass, even more preferably 0.1 to 0.8% by mass, even more preferably 0.2 to 0.7% by mass, and particularly preferably 0.2 to 0.6% by mass.

[0070] The content of component (B-2) is preferably 0.1% by mass or more, more preferably 0.2% by mass or more. This improves the foam's durability. The upper limit is preferably 1% by mass or less, more preferably 0.9% by mass or less, further preferably 0.8% by mass or less, even more preferably 0.7% by mass or less, and particularly preferably 0.6% by mass or less. This maintains the stability of component (A). Therefore, it is preferably 0.1 to 1% by mass, more preferably 0.1 to 0.9% by mass, more preferably 0.1 to 0.8% by mass, even more preferably 0.2 to 0.7% by mass or more, and particularly preferably 0.2 to 0.6% by mass.

[0071] The ratio (mass ratio) of the content of (B-1) to the content of (B-2) is preferably 0.15 or more, more preferably 0.2 or more, even more preferably 0.3 or more, and even more preferably 0.4 or more, 0.5 or more, or 0.6 or more. This allows for a good balance between foaming properties and foam persistence. The upper limit is preferably 4 or less, more preferably 3.5 or less, even more preferably 3 or less, even more preferably 2 or less, and particularly preferably 1.6 or less. This allows for a good balance between enzyme stability and foam persistence. Therefore, 0.15 to 4 is preferred, more preferably 0.2 to 3.5, even more preferably 0.3 to 3, even more preferably 0.4 to 3, and particularly preferably 0.4 to 2.

[0072] [Mass ratio of component (A) to (B)]

[0073] The ratio of the content (enzyme activity: U / g) of component (A) to the content (B) of component (B) (mass %) is preferably 2 or more, more preferably 5 or more, further preferably 10 or more, and even more preferably 15 or more. When the enzyme is papain, it is preferably 300 or more, 400 or more, or 500 or more. The upper limit is preferably 80,000 or less, more preferably 70,000 or less, and even more preferably 60,000 or less. When the enzyme is dextrinase, it is preferably 500 or less, 400 or less, or 300 or less. Therefore, it is preferably 2 to 80,000, more preferably 5 to 70,000, more preferably 10 to 60,000, and even more preferably 15 to 60,000. By satisfying any of these conditions, a good balance can be achieved between enzyme stability and foam persistence and foaming properties.

[0074] [1.3 Component (C): Glycyrrhizate]

[0075] Component (C) is glycyrrhizic acid salt. Component (C) can improve the stability of component (A).

[0076] Examples of glycyrrhizic acid salts include dipotassium glycyrrhizate and monoammonium glycyrrhizate, with dipotassium glycyrrhizate being preferred.

[0077] Component (C) may be one or a combination of two or more, preferably containing at least dipotassium glycyrrhetinate.

[0078] [Content of component (C)]

[0079] The content of component (C) is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, even more preferably 0.02% by mass or more, even more preferably 0.03% by mass or more, and particularly preferably 0.04% by mass or more. This allows for a good stabilizing effect on component (A). The upper limit is preferably 2% by mass or less, more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.3% by mass or less, and particularly preferably 0.2% by mass or less. This allows for the suppression of bitterness originating from component (C). Therefore, it is preferably 0.005 to 2% by mass, more preferably 0.01 to 1% by mass, even more preferably 0.02 to 0.5% by mass, even more preferably 0.03 to 0.3% by mass, and particularly preferably 0.04 to 0.2% by mass or less.

[0080] [Mass ratio of ingredients (A) to (C)]

[0081] The ratio (mass ratio) of the content (enzyme activity: U / g) of component (A) to the total content (B) and (C) of components (B+C) is preferably 2 or more, more preferably 5 or more, further preferably 10 or more, and even more preferably 12 or more. When the enzyme is papain, it is preferably 300 or more, 400 or more, or 500 or more. The upper limit is preferably 80,000 or less, more preferably 70,000 or less, and even more preferably 60,000 or less. When the enzyme is dextrinase, it is preferably 500 or less, 400 or less, or 300 or less. Therefore, it is preferably 2 to 80,000, more preferably 5 to 70,000, more preferably 10 to 60,000, and even more preferably 12 to 60,000. By satisfying any of these conditions, a good balance can be achieved between enzyme stability and foam persistence and foaming properties.

[0082] [1.4 Any component]

[0083] The oral composition of the present invention may also contain any component other than components (A) to (C) as needed. Examples of such components include abrasives, surfactants, humectants, binders, fragrances, solvents, sweeteners, pharmaceutical ingredients, oily components, preservatives, pH adjusters, and colorants (pigments). Any component may be one or a combination of two or more.

[0084] -Abrasive-

[0085] As abrasives, any type of inorganic or organic abrasive can be used. Examples of inorganic abrasives include silica-based abrasives (abrasive silica), such as precipitated silica, crystalline silica, amorphous silica, silica gel, aluminum silicate, zirconium silicate, and titanium-bonded silica; zeolite; calcium phosphate compounds such as anhydrous calcium phosphate, calcium phosphate dihydrate, calcium phosphate dihydrate or anhydrous calcium phosphate, calcium dihydrogen phosphate, and tetracalcium phosphate; calcium carbonate abrasives such as calcium carbonate; aluminum hydroxide, aluminum oxide, magnesium carbonate, magnesium phosphate, calcium sulfate, and zirconium silicate; apatite materials such as hydroxyapatite, fluorapatite, and calcium-deficient apatite; titanium-based materials such as titanium oxide; and minerals such as bentonite. Examples of organic abrasives include, for example, polymethyl methacrylate and synthetic resin abrasives.

[0086] The abrasive silica is preferably composed of abrasive particles with an average particle size of 1 to 40 μm. Furthermore, the BET specific surface area of ​​the abrasive silica is preferably 80 to 250 m² / g. Here, the average particle size of the abrasive silica is the median diameter (D50) on a volume basis, determined by laser diffraction and scattering.

[0087] There is no particular limitation on the RDA value (Radioactive Dentine Abrasion Values) of the abrasive, but it is preferably 50 to 200.

[0088] The abrasive can also be a granulated material. Examples of granulated materials include particles formed by granulating water-insoluble powders (e.g., silica gel, precipitated silica) into granules. For example, it may contain particles containing pigments such as Red 202, 205, Red 226, Orange-Yellow 203, and Yellow 205. When granulated into granules, any conventionally known preferred binder can also be used.

[0089] The abrasive can be a single type or a combination of two or more types. The content of the abrasive is preferably 7-50% by mass, more preferably 10-30% by mass.

[0090] - Surfactants (other than component (B)) -

[0091] As a surfactant, it is acceptable as long as it is not component (B). For example, nonionic surfactants, amphoteric surfactants, and cationic surfactants can be listed.

[0092] Examples of nonionic surfactants include, for example, polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ethers (e.g., polyoxyethylene stearyl ether), polyoxyethylene-polyoxypropylene alkyl ethers, fatty acid glycerides, polyglycerol fatty acid esters (e.g., decaglycerol fatty acid esters), alkyl glycosides, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), fatty acid alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, sucrose fatty acid esters (e.g., sucrose stearate), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), polyoxyethylene-polyoxypropylene copolymers, and polyoxyethylene-polyoxypropylene fatty acid esters.

[0093] The average molar addition of ethylene oxide to polyoxyethylene hydrogenated castor oil is preferably 5-100 moles, more preferably 5-60 moles. The alkyl chain of polyoxyethylene alkyl ether preferably has 10-26 carbon atoms, and the average molar addition of ethylene oxide is preferably 2-50 moles. The fatty acid of polyglycerol fatty acid ester preferably has 10-20 carbon atoms. The average molar addition of ethylene oxide to polyoxyethylene-polyoxypropylene alkyl ether is preferably 10-300 moles, the average molar addition of propylene oxide is preferably 5-70 moles, and the alkyl group preferably has 10-20 carbon atoms. The alkyl glycoside preferably has 8-20 carbon atoms. The fatty acid of sucrose fatty acid ester preferably has 8-20 carbon atoms. The fatty acid of sorbitan fatty acid ester preferably has 10-18 carbon atoms. The fatty acid of polyoxyethylene sorbitan fatty acid ester preferably has 12-18 carbon atoms, and the average molar addition of ethylene oxide is preferably 20-80 moles. The alkyl chain of fatty acid alkylolamides preferably has 8 to 20 carbon atoms.

[0094] As a nonionic surfactant, polyoxyethylene hydrogenated castor oil is preferred, and polyoxyethylene hydrogenated castor oil with an average addition molar number of ethylene oxide of 5 to 100 moles or 5 to 60 moles is more preferred. The nonionic surfactant can be a single type or a combination of two or more types.

[0095] Examples of amphoteric surfactants include, for example, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazoline betaine, sodium N-dodecyl-N'-carboxymethyl-N'-hydroxyethyl ethylenediamine, alkyl dimethylaminoacetic acid betaine (e.g., lauryl dimethylaminoacetic acid betaine), fatty acid amamidopropyl betaine (e.g., coconut fatty acid amamidopropyl betaine), lauryl imidazoline betaine, alkyl sulfonyl betaine (e.g., lauryl amamidopropyl hydroxysulfonyl betaine), and lecithin. Among these, betaine-type amphoteric surfactants are preferred, fatty acid amamidopropyl betaine is more preferred, and coconut fatty acid amamidopropyl betaine is even more preferred. The amphoteric surfactant can be a single type or a combination of two or more types.

[0096] Examples of cationic surfactants include, for example, quaternary ammonium salt-type cationic surfactants and amino acid-based cationic surfactants. Examples of quaternary ammonium salts include, for example, alkylpyridinium salts, benzalkonium salts, benzalkonium salts, monoalkyltrimethylammonium salts, and dialkyldimethylammonium salts. Examples of salts include, for example, chloride salts and bromide salts. The number of carbon atoms in the alkyl and acyl groups of a cationic surfactant can be, for example, 8 to 22 or 9 to 21. Examples of quaternary ammonium salt-type cationic surfactants include, for example, hexadecylpyridinium chloride, benzalkonium chloride, benzalkonium chloride, stearyltrimethylammonium chloride, hexadecyltrimethylammonium chloride, docosyltrimethylammonium chloride, distearate dimethylammonium chloride, lauryl dimethylbenzylammonium chloride, hexadecyltrimethylammonium bromide, and stearyltrimethylammonium bromide. Examples of amino acid-based cationic surfactants include, for example, mono-N-long-chain acyl basic amino acid lower alkyl ester salts. Amino acids that can constitute cationic surfactants include, for example, basic amino acids (e.g., natural amino acids such as ornithine, lysine, and arginine, and synthetic amino acids such as α,γ-diaminobutyric acid), as well as optically active or racemic forms. The acyl groups that can be present in the cationic surfactant are preferably saturated or unsaturated higher fatty acid residues, such as single higher fatty acid residues like lauroyl, myristoyl, palmitoyl, and stearoyl; and naturally occurring mixed higher fatty acid residues such as coconut oil fatty acid residues and tallow higher fatty acid residues. Lower alkyl esters can be exemplified by alkyl esters with 1 to 8 carbon atoms. Specifically, examples include methyl esters, ethyl esters, propyl esters, butyl esters, pentyl esters, hexyl esters, heptyl esters, and octyl esters. Lower alkyl esters are preferably in the form of salts, specifically, examples include inorganic salts such as hydrochlorides, bromates, sulfates, and phosphates; and organic acid salts such as glycolates, acetates, lactates, succinates, tartrates, citrates, acidic amino acid salts, higher fatty acid salts, L- or DL-pyrrolidone carboxylates, pyroglutamates, and p-toluenesulfonates. As amino acid-based cationic surfactants, examples include N-cocoa fatty acid acyl-L-arginine ethyl·DL-pyrrolidone carboxylates. Cationic surfactants can be a single type or a combination of two or more types.

[0097] The surfactant can be a single type or a combination of two or more types. Furthermore, it is preferable to contain nonionic surfactants, anionic surfactants, or amphoteric surfactants; more preferably, it contains nonionic surfactants and / or amphoteric surfactants.

[0098] The content of surfactant (other than (B)) is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, and even more preferably 0.1% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less. Therefore, it is preferably 0.001 to 10% by mass, more preferably 0.01 to 8% by mass, and even more preferably 0.1 to 5% by mass.

[0099] -Wetting agent-

[0100] Examples of humectants include, for example, sugar alcohols and polyols other than sugar alcohols. Examples of sugar alcohols include, for example, sorbitol, xylitol, erythritol, maltitol, lactitol, and reduced starch saccharides; and polyols include, for example, glycerol, ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycols include, for example, polyethylene glycols with an average molecular weight of 150 to 6000, preferably polyethylene glycols with an average molecular weight of 190 to 4000. Specifically, PEG200, PEG300, PEG400, PEG600, and PEG4000 can be listed. The average molecular weight is the average molecular weight specified in the 2021 Standard for Quasi-Pharmaceutical Raw Materials. One of the above-mentioned humectants can be used alone, or two or more can be used in combination.

[0101] When the total amount of the oral composition is set to 100% by mass, the content of the humectant is preferably 1 to 70% by mass, more preferably 1 to 65% by mass, even more preferably 1 to 60% by mass, and even more preferably 3 to 60% by mass.

[0102] -Adhesive-

[0103] Examples of adhesives include organic adhesives and inorganic adhesives.

[0104] Examples of organic binders include, for example, polysaccharides, cellulose-based binders (e.g., carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, cationic cellulose, and their sodium salts and other pharmacologically permissible salts), other polysaccharide thickeners (e.g., xanthan gum, guar gum, galvanic gum, tragacanth gum, karaya gum, gum arabic, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymers, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Examples of inorganic binders include, for example, thickening silica and aluminum silicate. Binders can be one type alone or in combination of two or more types.

[0105] In the case of an organic binder, the binder content is preferably 0.001% by mass or more, more preferably 0.01% by mass or more. The upper limit is preferably 10% by mass or less, more preferably 8% by mass or less, and even more preferably 5% by mass or less. Therefore, it is preferably 0.001 to 10% by mass or less, more preferably 0.001 to 8% by mass, and even more preferably 0.001 to 5% by mass.

[0106] -spices-

[0107] As spices, examples include peppermint oil, spearmint oil, Japanese peppermint oil, fennel oil, cinnamon oil, eucalyptus oil, wintergreen oil, frankincense oil, orange-flower oil, lemongrass oil, jasmine oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, coriander oil, fennel oil, basil oil, oregano oil, lemon oil, orange oil, pearberry oil, tangerine peel oil, grapefruit oil, orange seed oil, nutmeg oil, lavender oil, para cress oil, vanilla oil, cinnamon oil, allspice oil, and cinnamon oil. Natural essential oils such as perilla oil, wintergreen oil, and rose oil; carvone, eucalyptol (1,8-cineole), anethole, cinnamaldehyde, eugenol, methyl salicylate, thymol, limonene, p-methoxycinnamaldehyde, linalool, linalool oxide, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, genistein, n-decanol, citronellol, α-terpineol, citronellol acetate, ethyl linalool, methyl jasmonate, vanillin (v The fragrance components found in the aforementioned natural essential oils include anillin, geraniol, caryophyllene, and viridiflorol; ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, cis-3-hexenol, trans-2-hexenol, hexyl acetate, ethyl 2-methylbutyrate, benzyl alcohol, linalyl acetate, phenethyl glycidyl ester, phenylethanol, allyl hexanoate, octanol, methyl cinnamate, methyl heptatylacetyl carboxylate, and violet. Ketones, ethyl β-methylthiopropionate, cis-6-nonanol, methyl anthranilate, ethyl methylphenyl glycidyl ester, benzaldehyde, ethyl vanillin, vanillyl butyl ether, furanone, undecanoic acid lactone, decanolone, ethylcyclopentenolone, 3-hydroxy-4,5-dimethylfuran-2-one, methylcyclopentenolone, 2-methylbutyric acid, acetic acid, propionic acid, menthol furan, maltol, ethyl maltol, N-ethyl-2-menthane-3-carboxamide (N-ethyl-2- Flavoring ingredients such as isopropyl-5-methylcyclohexaneformamide, 7-methyl-3,5-dihydro-2H-benzodioxin-3-one, menthol lactate, ethylene glycol carbonate l-menthol ester, and calone; plant extracts such as chili extract, ginger extract, pepper extract, Sichuan pepper extract, cardamom extract, and vanilla extract; and various blended flavors such as mint, fruit, and vanilla, composed of a combination of several flavoring ingredients and natural essential oils.In addition, other fragrances that can function as cooling agents include, for example, menthol, N-ethyl-2-isopropyl-5-methylcyclohexaneformamide, menthyl succinate, menthyl glutarate, isopulegol, menthone glycerol ketal, N-(4-cyanomethylphenyl)-2-menthaneformamide, 3-l-menthoxy-1,2-propanediol, 3-((-)-menthoxy)propane-1,2-diol, 5-methyl-2-propane-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-formamide, ethyl acetate 3-(2-menthane-3-formamide), 2-isopropyl-N,2,3-trimethylbutyramide, and N-[(ethyl [(oxycarbonyl)methyl]-p-menthane-3-carboxamide, N-p-phenylacetonitrile-menthane-carboxamide, N-(2-(pyridin-2-yl)ethyl)-3-p-menthane-carboxamide, N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, 2-(4-methylphenoxy)-N-(1H-pyrazol-3-yl)-N-(thiophen-2-ylmethyl)acetamide, menthol glyceryl ether, menthyl succinate, N-ethyl-2-isopropyl-5-methylcyclohexane-carboxamide, N-ethyl-2,2-diisopropylbutyramide, N-(1,1-dimethyl-2-hydroxyethyl)-2,2-diethylbutyramide, N-(2-hydroxyethyl)-2,3-dimethyl-2-isopropylbutyramide. Fragrances may also contain solvents, such as ethanol, propylene glycol, fatty acid glycerides, and triacetin. Spices can be a single type or a combination of two or more.

[0108] -solvent-

[0109] As solvents, examples include lower monohydric alcohols such as water and ethanol (e.g., those with 1 to 4 carbon atoms).

[0110] -Sweeteners-

[0111] Examples of sweeteners include saccharin, sodium saccharin, aspartame, steviol glycosides, stevia extract, neohesperidin dihydrochalcone, perilla stigma, thaumatin, aspartic acid methyl ester, acesulfame potassium, maltitol, and mannitol. Sweeteners can be one type alone or in combination of two or more.

[0112] -Medicinal ingredients-

[0113] As medicinal ingredients, examples include fluorides such as sodium fluoride, potassium fluoride, sodium monofluorophosphate, and tin fluoride; sensory hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; amino acids such as alanine, pyrrolidone carboxylic acid or their salts (e.g., sodium salts), glycine, proline, arginine, lysine, glutamine, and cysteine; anti-inflammatory agents such as tranexamic acid, allantoin, allantoin hydroxyaluminate, ε-aminocaproic acid, azulene, sodium azulene sulfonate, glycyrrhetinic acid, phellodendron bark, and phellodendron bark extract; cell activators such as sodium chloride and vitamins; and isopropyl methylphenol and hexadecyl chloride. Bactericidal or antibacterial agents such as alkylpyridinium, benzalkonium chloride, benzyl chloride, juniper alcohol, thymol, lysozyme chloride, chlorhexidine, triclosan, zinc gluconate, and zinc citrate; water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar prevention agents such as zeolite, hydroxyethylidene diphosphonates, and polyphosphates; coating agents such as hydroxyethyl cellulose dimethyl diallyl ammonium chloride; vitamins such as vitamin C (e.g., ascorbic acid) and vitamin E (e.g., tocopherol or its derivatives (e.g., tocopheryl acetate)); astringents such as sodium chloride, alum, and lysozyme chloride; peptides such as canine C-peptide; and plant extracts such as thyme, scutellaria baicalensis, clove, and witch hazel. When oral compositions contain pharmaceutical ingredients, their content may be set as an effective amount within a pharmacologically permissible range. Pharmaceutical ingredients may be one or a combination of two or more.

[0114] -Oily ingredients-

[0115] Examples of oily components include, for example, hydrocarbons such as squalane, (light) liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols with 8-22 carbon atoms such as lauryl alcohol, cetearyl alcohol, cetearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids with 8-22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid); vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate. Oily components can be one type alone or in combination of two or more.

[0116] -preservative-

[0117] Examples of preservatives include parabens (e.g., methylparaben, ethylparaben, butylparaben), sodium benzoate, and methylparaben. Preservatives can be one type alone or in combination of two or more.

[0118] -pH adjuster-

[0119] Examples of pH adjusters include, for example, organic acids such as phthalic acid, citric acid, succinic acid, tartaric acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (e.g., sodium citrate); inorganic acids such as phosphoric acid (e.g., orthophosphoric acid), or their salts (e.g., potassium, sodium, and ammonium salts); and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include, for example, disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, sodium carbonate, and sodium bicarbonate. pH adjusters can be one type alone or in combination of two or more.

[0120] -Coloring agents-

[0121] Water-soluble pigments are preferred as colorants due to their high safety profile. Examples include Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105, and Red No. 106.

[0122] Examples of other arbitrary components include inorganic compounds such as zinc oxide, magnesium oxide, and zirconium oxide; natural polymers such as agar, gelatin, starch, and glucomannan; synthetic polymers or copolymers thereof such as polyvinyl acetate, acrylic resin, polyurethane, polyester, polyvinyl chloride, nylon powder, and polyethylene powder; waxes such as carnauba wax, rosin, rice bran wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetyl alcohol and stearyl alcohol; and polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these other arbitrary components can be appropriately set within a range that does not impair the effects of the present invention.

[0123] [2. Dosage Forms and Uses of Oral Compositions]

[0124] The dosage form of oral compositions is not particularly limited. Examples of dosage forms include liquids (solutions, emulsions, suspensions, syrups, etc.), semi-solids (gels, creams, pastes, etc.), and solids (tablets, granules, capsules, films, mixtures, molten solids, waxy solids, elastic solids, soft capsules, etc.). Liquids and semi-solids are preferred dosage forms for oral compositions, with semi-solids being more preferred.

[0125] Oral compositions can be widely used in various oral applications, including food, quasi-drugs, and cosmetics. Examples of solid dosage forms include trochetes, gummies, chewing gum, and dental floss. Examples of semi-solid dosage forms include toothpaste and gel-based dental floss. Examples of liquid dosage forms include mouthwash, liquid dental floss, and mouth sprays.

[0126] The pH (at 25°C) of the oral composition is preferably near neutral, more preferably 5 to 9. The pH can be adjusted by adding pH adjusters, adjusting the composition, etc.

[0127] The viscosity of the oral composition can be adjusted according to the dosage form and intended use. For example, in the case of a paste or gel, the viscosity at 25°C, as measured by a BH viscometer, is preferably 1 to 300 Pa·s, more preferably 20 to 150 Pa·s. Furthermore, in the case of a liquid, the viscosity at 25°C, as measured by a BL viscometer, is preferably 1000 mPa·s or less, particularly more preferably 0.7 to 100 mPa·s or 0.7 to 30 mPa·s.

[0128] [3. Method for manufacturing oral compositions]

[0129] The method for manufacturing the oral composition of the present invention is not particularly limited. In the case of a toothpaste composition, for example, a manufacturing method can be described as follows: after preparing the components that are soluble in a solvent, the insoluble components are mixed, and defoaming is performed as needed, for example, by reducing pressure, and then the mixture is contained in a container.

[0130] There are no particular restrictions on the shape or material of the container. Examples of suitable container materials include plastic containers made of polyethylene, polypropylene, polyethylene terephthalate, and nylon. Containers with an innermost layer of linear low-density polyethylene (LLDPE) or polyethylene (LE) are particularly preferred. Regarding the shape of the container, laminated tubing is preferred for dental cleaning agents, while containers (bottles) capable of holding liquids are preferred for liquids.

[0131]

Example

[0132] The present invention will be specifically described below through examples. These examples are one implementation of the present invention and do not limit the scope of the invention.

[0133] Examples 1-30 and Comparative Examples 1-6

[0134] [Manufacturing of dental cleaning compositions (toothpaste)]

[0135] The toothpaste composition is obtained by mixing the raw materials shown in the table using conventional methods. The resulting toothpaste composition is then contained in any conventionally known preferred container (laminated tube). The obtained toothpaste composition is evaluated according to the following method.

[0136] [Evaluation of dental cleaning compositions]

[0137] (1) Enzyme stability evaluation method

[0138] Each 50g portion of the dental cleaning agent composition was filled into a laminated tube and stored at 45°C and 75% RH for 3 weeks. Then, depending on the type of enzyme mixed in, the dental cleaning agent composition restored to room temperature was supplied for the following tests.

[0139] (i) Determination of dextranase activity

[0140] First, 0.6 g of the dental cleaning agent composition was suspended in 0.1 M phosphate buffer to prepare a suspension. The supernatant obtained by centrifuging the suspension was used as the test solution. The amount of 0.1 M phosphate buffer added when preparing the suspension can be adjusted according to the amount of dextranase mixed in the dental cleaning agent composition. For example, the amount of 0.1 M phosphate buffer is set to 15 mL when the amount of dextranase mixed is 0.5%. 1 mL of the obtained test solution was added to 2 mL of 1% dextran solution and allowed to react accurately in a constant temperature bath at 35°C for 10 minutes. The amount of reducing sugar produced was determined using the Somogyi-Nelson method. One unit of dextranase activity is defined as the amount of dextranase that can produce the equivalent of 1 μmol of free reducing sugar per minute.

[0141] (ii) Determination of papain enzyme activity

[0142] The enzyme activity of papain was determined according to the "Enzyme Activity Assay Method" described in the "Papain" section of the 10th edition of the Japanese Food Additives Standard. Furthermore, regarding the preparation of the test solution used in the enzyme activity assay, firstly, 0.5g of the dental cleaning agent composition was suspended in a diluent to prepare a suspension. The supernatant obtained by centrifuging the resulting suspension was used as the test solution. When preparing the suspension, the amount of diluent added was adjusted according to the amount of papain mixed in the dental cleaning agent composition. For example, when the amount of papain mixed is 0.3%, the amount of diluent was set to 20mL.

[0143] The enzyme activity in the dental cleaning agent composition before and after storage treatment was measured separately, and the enzyme residual rate (unit: %) was calculated according to the following formula.

[0144] Enzyme residual rate (%) = (Enzyme activity after preservation treatment) / (Enzyme activity before preservation treatment) × 100

[0145] In this embodiment, the enzyme residual rate was measured three times, and the enzyme stability was evaluated based on the average of the three results using the following evaluation criteria.

[0146] (Evaluation Criteria)

[0147] ◎ (Good): Enzyme residue rate above 90%

[0148] 〇 (Appropriate): Enzyme residual rate above 80% and below 90%

[0149] × (Not allowed): Enzyme residue rate less than 80%

[0150] (2) Evaluation of the user experience of the foam

[0151] The evaluation was conducted using a sensory test by 10 expert evaluators. Approximately 1g of the dental cleaning composition was placed on a toothbrush (CLINICA Advanced Toothbrush, 4-row Compact Standard, Lion Corporation), and brushed for 3 minutes using the same method as usual. Foaming and foam persistence during use were evaluated according to the following criteria.

[0152] (i) Evaluation of foaming properties

[0153] The foaming properties of the dental cleaning agent composition in the oral cavity at the start of brushing (20 seconds after brushing begins) were evaluated according to the following scoring criteria.

[0154] (Scoring criteria)

[0155] 4 stars: Excellent foaming power and superior user experience.

[0156] 3 stars: The foaming amount is moderate, and the user experience is satisfactory.

[0157] 2 points: Less foaming, slightly less pleasant to use.

[0158] 1 point: Almost no foaming, poor user experience.

[0159] Based on the average score of the evaluation results (ratings) of 10 people, and when evaluated using the following evaluation criteria, the dental cleaning composition that achieves foaming properties rated as ◎ (good) and ○ (acceptable) is evaluated as a good dental cleaning composition.

[0160] (Evaluation Criteria)

[0161] ◎ (Good): Average score above 3.5 and below 4.0

[0162] 〇 (Acceptable): Average score of 3.0 or above, but less than 3.5

[0163] × (Not allowed): Average score less than 3.0 points

[0164] (ii) Evaluation of foam persistence

[0165] The foam persistence of the dental cleaning agent composition in the oral cavity after brushing is evaluated according to the following scoring criteria.

[0166] (Scoring criteria)

[0167] 4 points: Sufficient foam remained in the mouth until the end of brushing, providing an excellent user experience.

[0168] 3 points: By the end of brushing, a moderate amount of foam remained in the mouth, and the user experience was satisfactory.

[0169] 2 points: By the end of brushing, there was relatively little foam in the mouth, resulting in a slightly less pleasant user experience.

[0170] 1 point: By the end of brushing, there was almost no foam in the mouth, resulting in a poor user experience.

[0171] Based on the average score of the evaluation results (ratings) of 10 people, and when evaluated using the following evaluation criteria, the dental cleaning composition that achieves foam persistence rated as ◎ (excellent) and ○ (good) is evaluated as a good dental cleaning composition.

[0172] (Evaluation Criteria)

[0173] ◎ (Good): Average score above 3.5 and below 4.0

[0174] 〇 (Acceptable): Average score of 3.0 or above, but less than 3.5

[0175] × (Not allowed): Average score less than 3.0 points

[0176] Table 1

[0177]

[0178] Table 2

[0179]

[0180] Table 3

[0181]

[0182] Table 4

[0183]

[0184] Table 5

[0185]

[0186] [Footnotes for Tables 1-5]

[0187] *A / B: The ratio of enzyme units (U / g) of component A to the content (mass%) of component B.

[0188] In addition, the values ​​in the table (except for B-1 / B-2, A / B, A / B+C and the average and average scores of the evaluation) are relative to the total amount of the composition in each example, representing 100% by mass (mass%).

[0189] [raw material]

[0190] Dextranase: Manufactured by Mitsubishi Chemical Corporation, trade name "Dextranase 2F", enzyme activity 4000 U / g

[0191] Papain: Manufactured by Mitsubishi Chemical Corporation, trade name "Refined Papain", enzyme activity 800,000 U / g

[0192] Dipotassium glycyrrhizate: Manufactured by Tokyo Chemical Industry Co., Ltd., trade name "Dipotassium Glycyrrhizinate"

[0193] Sodium lauryl sulfate: Manufactured by BASF JAPAN, trade name "Texapon (registered trademark)"

[0194] Sodium lauroyl methyl taurate: Manufactured by Nikko Chemical Co., Ltd., trade name "NIKKOL LMT-P"

[0195] Sodium tetradecenoate: Manufactured by Lion Specialty Chemicals, trade name "K LIPOLAN PJ-400CJ"

[0196] Sodium lauroyl sarcosinate: Manufactured by Sichuan Research Institute of Fine Chemicals, trade name "SOYPON SLP (registered trademark)"

[0197] Sodium lauroyl glutamate: Manufactured by Asahi Kasei Fine Chemicals Co., Ltd., trade name "Aminosurfact (registered trademark) ALMS-P1"

[0198] Disodium polyoxyethylene (2)alkyl (12~14)sulfosuccinate: manufactured by Sanyo Chemical Co., Ltd., trade name "BEAULIGHT ESS"

[0199] Sodium carboxymethyl cellulose: Manufactured by Cailloumec, trade name "CMC1260"

[0200] Abrasive silica: Manufactured by Evonik, trade name "Zeodent (registered trademark) 124"

[0201] Thickening silica: Manufactured by DSL JAPAN, trade name "Carplex (registered trademark) #67"

[0202] Fragrance Composition A: as shown in the table below.

[0203] Compared to the comparative example dental cleaning agent, which showed poor performance in any one of the three aspects—enzyme stability, foaming properties, and foam persistence—the dental cleaning agent of the examples was evaluated as having a good balance in all three aspects. These results indicate that the oral composition of the present invention can maintain enzyme stability and has good foaming properties and foam persistence.

[0204] [Prescription Example]

[0205] Table 6

[0206]

[0207] Table 7

[0208]

[0209] [Footnotes for Tables 6 and 7]

[0210] *1: Coconut oil fatty acid amamidopropyl betaine solution: a liquid solution with a purity of 30%, expressed as the volume of solution mixed.

[0211] *2: Silica particles (average particle size 250μm): Tosoh Silicon Chemical Co., Ltd. NIPGEL (registered trademark) AY-001

[0212] *3: Silica particles (average particle size 100μm): Tosoh Silicon Chemical Co., Ltd. NIPGEL (registered trademark) AY-002

[0213] Furthermore, the values ​​in the table are contents (mass%) relative to the total amount of the composition in each example, representing 100% by mass.

[0214] [Flavor Composition]

[0215] Table 8

[0216]

[0217] Table 9

[0218]

[0219] Table 10

[0220]

[0221] Table 11

[0222]

[0223] Table 12

[0224]

[0225] As can be seen from Examples 1-30 and Formulation Examples 1-11 above, samples with the same composition except that fragrance compositions B-S were used to replace fragrance composition A were prepared. All of these samples maintained enzyme stability and exhibited good foaming properties and foam persistence.

Claims

1. An oral composition containing Ingredient (A): Enzyme, Component (B): An anionic surfactant comprising (B-1) and (B-2), (B-1) Alkyl sulfates and / or acylmethyl taurine salts, (B-2) is selected from one or more of α-olefin sulfonates, acylsarcosinates, acylglutamates, and sulfosuccinates. (C): Glycyrrhizic acid salt, The content of component (B) is 0.3~1.3 by mass.

2. The oral composition according to claim 1, wherein, Component (A) contains one or both of glucanase and protease.

3. The oral composition according to claim 1, wherein, Component (A) contains one or more of the following: dextranase, mutagenase, actinidin, papain and bromelain.

4. The oral composition according to claim 3, wherein, Component (A) contains dextranase. The enzyme activity of dextranase is 2 U / g to 200 U / g.

5. The oral composition according to claim 3, wherein, Ingredient (A) contains papain. The enzyme activity of papain is 400 U / g to 40000 U / g.

6. The oral composition according to any one of claims 1 to 5, wherein, The content of (B-1) is 0.1~0.8% by mass.

7. The oral composition according to any one of claims 1 to 5, wherein, The content of (B-2) is 0.1~0.8% by mass.

8. The oral composition according to any one of claims 1 to 5, wherein, The content of component (B) is 0.3~1.0 by mass.

9. The oral composition according to any one of claims 1 to 5, wherein, The ratio of (B-1) content to (B-2) content is 0.15~4.

10. The oral composition according to claim 1, wherein, The content of component (C) is 0.01~1 by mass.

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