Enteric microbial marker for adolescent autism and application of intestinal microbial marker

By screening and validating six gut microbiota biomarkers, and combining quantitative detection and logistic regression models, the problem of inaccurate diagnosis of autism in adolescents in existing technologies has been solved, achieving highly accurate and non-invasive autism diagnosis.

CN122235344AActive Publication Date: 2026-06-19MEI YI TIAN BIOLOGICAL MEDICINE WUHAN CO LTD
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Patent Information

Application Number
CN202610713203.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-22
Publication Date
2026-06-19
Estimated Expiration
2046-05-22

AI Technical Summary

Technical Problem

In existing technologies, the screening criteria for gut microbiota biomarkers used to diagnose adolescent autism are not strict enough, resulting in inaccurate diagnoses.

Method used

By collecting and screening fecal samples from adolescents with autism and healthy individuals, six gut microbiota biomarkers associated with autism were identified and validated, including active rumenococci, thermophilic streptococci, salivarius streptococci, Enterobacter bartletrium, Corynebacterium davidii, and Prevotella foetida. These biomarkers were used to quantitatively detect the relative abundance of these microorganisms, and metagenomic sequencing and logistic regression models were combined to improve diagnostic accuracy.

Benefits of technology

It achieves highly accurate and non-invasive diagnosis of autism in adolescents. By detecting the relative abundance of these microbial markers, it can accurately assess whether the adolescents under test have autism, providing higher resolution and reliability.

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Abstract

The invention discloses an enteric microbial marker for adolescent autism and application thereof, and belongs to the field of biological medicine. The microbial marker comprises one or more of active ruminococcus, streptococcus thermophilus, streptococcus salivarius, enterobacter butler, anaerobic corynebacterium petagii and fecal bacillus przewalskii. The invention provides a product (such as a kit) comprising a detection reagent for detecting the relative abundance of the microbial marker. The product provided by the invention has good feasibility and accuracy, can effectively evaluate whether teenagers suffer from the risk of autism, and provides a new tool for clinical diagnosis.
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