Pharmaceutical formulations, coated pharmaceutical formulations, methods of preparation and uses

Abstract

This invention relates to a pharmaceutical formulation, a coated pharmaceutical formulation, a method of preparation, and its application. The pharmaceutical formulation comprises a compound of formula I or a solvate thereof or a pharmaceutically acceptable salt thereof or a solvate thereof, a filler, a disintegrant, and a lubricant; based on the total mass of the pharmaceutical formulation, the mass percentage of the compound of formula I is 1%-50%, the mass percentage of the filler is 60%-90%, the mass percentage of the disintegrant is 1%-10%, and the mass percentage of the lubricant is 1%-10%. This formulation is used to prepare a medicament for the treatment and / or prevention of diseases related to GLP-1R. This invention achieves a better form of administration by mixing the active ingredient with excipients and undergoing formulation processing, resulting in a formulation with excellent in vivo absorption.

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