Dressing containing ligusticum wallichii microspheres and preparation method thereof

By preparing PLGA-coated Ligusticum striatum microspheres and semi-encapsulating them with pHEMA hydrogel, the problems of easy oxidation and difficult-to-control release rate of Ligusticum striatum extract in dressings were solved, achieving safe and precise release of Ligusticum striatum extract and wound repair effect.

CN122272875APending Publication Date: 2026-06-26茂名市人民医院
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Patent Information

Application Number
CN202411933625.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-26
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Ligusticum chuanxiong extract or ligustrazine is easily oxidized or decomposed in dressings, and the release rate is difficult to control, affecting efficacy and safety.

Method used

Ligusticum chuanxiong extract or ligustrazine was coated with PLGA to form microspheres, which were then partially encapsulated with pHEMA hydrogel to prepare a dressing containing Ligusticum chuanxiong microspheres. The microspheres were prepared by controlling the ratio of drug to polymer and the spray drying conditions. The sustained-release properties of pHEMA hydrogel were combined to optimize the Ligusticum chuanxiong extraction method to increase the ligustrazine content.

Benefits of technology

This technology enables the safe and precise release of Ligusticum chuanxiong extract, improves drug stability and efficacy, promotes wound repair and antibacterial effects, and enhances the therapeutic effect on wounds.

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Abstract

The invention provides a dressing containing ligusticum wallichii microspheres and a preparation method of the dressing. The dressing is used for solving the problem that a ligusticum wallichii extract or ligustrazine cannot be safely and accurately applied to a wound surface difficult to heal. According to the dressing containing the ligusticum wallichii microspheres and the preparation method of the dressing, the dressing is formed by loading the ligusticum wallichii microspheres with pHEMA hydrogel as a main body, the ligusticum wallichii microspheres are formed by wrapping a ligusticum wallichii extract or ligustrazine with PLGA, and the ligusticum wallichii microspheres are semi-wrapped with the pHEMA hydrogel.
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