A polyvinyl alcohol-fucoidan-keratin ternary hydrogel, a preparation method and application in treating radiation combined injury

By utilizing the network structure of a polyvinyl alcohol-fucose-keratin ternary hydrogel, the multi-level pathological problems of radiation-induced complex injuries were solved, achieving reactive oxygen species scavenging, DNA damage repair, inflammation regulation, and angiogenesis, thus promoting rapid wound healing.

CN122272889APending Publication Date: 2026-06-26CHONGQING UNIV CANCER HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING UNIV CANCER HOSPITAL
Filing Date
2026-05-28
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Existing dressings are unable to effectively eliminate radiation-induced reactive oxygen species, repair DNA damage, regulate inflammatory responses, and promote angiogenesis and collagen maturation when treating radiation-induced complex injuries, resulting in a complex and delayed healing process.

Method used

A ternary hydrogel consisting of polyvinyl alcohol, fucoidan, and keratin is used to form a network structure through cross-linking. Keratin provides a scaffold for cell adhesion and proliferation, fucoidan scavenge free radicals and induce inflammation resolution, and polyvinyl alcohol serves as a mechanical support framework and sustained-release carrier to achieve multi-level pathological intervention.

Benefits of technology

This hydrogel can remove reactive oxygen species from the wound, repair DNA damage, downregulate pro-inflammatory factors, upregulate anti-inflammatory factors, promote angiogenesis and collagen maturation, significantly accelerate the healing process of radiation-induced complex injuries, and avoid the mechanical pressure and chemical toxicity of traditional dressings.

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Abstract

This invention belongs to the field of biomedical materials and repair technology, specifically relating to a polyvinyl alcohol-fucose-keratin ternary hydrogel, its preparation method, and its application in the treatment of radiation-induced injuries. This invention provides a polyvinyl alcohol-fucose-keratin ternary hydrogel, the components of which include polyvinyl alcohol, fucoidan, and keratin; the polyvinyl alcohol, fucoidan, and keratin form a network structure through cross-linking, and this network structure has a porous and interconnected pore structure. The polyvinyl alcohol-fucose-keratin ternary hydrogel can achieve a multi-cascade effect, including ROS scavenging, DNA damage repair, inflammation regulation, angiogenesis promotion, and collagen maturation.
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Citation Information

Patent Citations

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