Process for the synthesis of quinoxalinone-modified gamma-cyanoester / amide derivatives

The synthesis method of γ-cyanoester/amide derivatives modified with quinoxalinone utilizes a visible light-driven three-component cascade reaction, which solves the problems of harsh reaction conditions and catalyst use in the prior art, and realizes the efficient, safe and green synthesis of γ-cyanoester/amide derivatives.

CN122277484APending Publication Date: 2026-06-26TAIZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TAIZHOU UNIV
Filing Date
2026-03-30
Publication Date
2026-06-26

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Abstract

This invention relates to a method for synthesizing quinoxalinone-modified γ-cyano ester / amide derivatives based on visible light induction. The method involves placing a quinoxalinone compound of formula (I), a brominated compound of formula (II), and an unactivated hexadione nitrile of formula (III) in an organic solvent system and reacting under visible light irradiation for 1-24 hours to construct the quinoxalinone-modified γ-cyano ester / amide derivative as shown in formula (IV) in a one-pot reaction. This invention uses visible light as an energy source and leverages the intrinsic photosensitivity of quinoxalinone to achieve a highly efficient three-component construction of quinoxalinone-modified γ-cyano ester / amide derivatives. The method is environmentally friendly, exhibits good selectivity, and has high atom economy.
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