Liquid chromatography and mass spectrometry combined equipment

By setting up low-pressure and high-pressure liquid chromatography channels in the liquid chromatography-mass spectrometry (LC-MS) equipment, the high cost problem caused by high pressure in the existing technology is solved, achieving efficient sample detection and cost reduction.

CN122282976APending Publication Date: 2026-06-26SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
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Patent Information

Application Number
CN202511983193.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2024-12-25
Filing Date
2025-12-25
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

The production and maintenance costs of existing ultra-high performance liquid chromatography-tandem mass spectrometry equipment are high, mainly due to the increased manufacturing difficulty and maintenance costs caused by high pressure.

Method used

A liquid chromatography-mass spectrometry (LC-MS) system is used, with low-pressure and high-pressure liquid chromatography channels. The low-pressure liquid chromatography channel operates at a pressure less than or equal to 20 MPa, while the high-pressure liquid chromatography channel operates at a pressure greater than 20 MPa. These channels are connected in parallel to the same mass spectrometry detection device to achieve low-pressure and high-pressure liquid chromatography elution functions.

Benefits of technology

It reduces the manufacturing difficulty and maintenance cost of liquid chromatography-mass spectrometry (LC-MS) equipment, improves sample detection efficiency, and meets the detection needs of different samples.

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Abstract

The invention is applicable to the field of medical instruments, and discloses liquid chromatography and mass spectrometry combined equipment which comprises a sample storage device, a pretreatment device, a chromatography device, a mass spectrometry detection device and a controller, the chromatographic device comprises a test solution transfer assembly, at least one first liquid chromatography channel and at least one second liquid chromatography channel, and the first liquid chromatography channel is used for driving a liquid phase fluid to elute a first test solution under first working pressure so as to form a first to-be-detected solution; the second liquid chromatogram channel is used for driving the liquid phase fluid to elute a second test solution at a second working pressure so as to form a second to-be-detected solution; the first working pressure is smaller than or equal to 20 MPa, and the second working pressure is larger than 20 MPa. According to the invention, the cost of liquid chromatography and mass spectrometry combined equipment is reduced.
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