Preparation method of core-shell microneedle patch loaded with double nanoparticles

By preparing a core-shell microneedle patch containing silica nanoparticles loaded with oxyhemoglobin and Ce6 and calcium carbonate nanoparticles loaded with aPD-1 antibody, the immune system is activated, solving the problems of large trauma to normal tissue and poor treatment effect of existing melanoma treatments, and achieving efficient and non-invasive tumor treatment.

CN122297364APending Publication Date: 2026-06-30NORTHWEST UNIV
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Patent Information

Application Number
CN202610491283.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-14
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing treatments for melanoma, such as surgery, chemotherapy, and radiotherapy, cause damage to normal tissues and are often ineffective due to drug resistance. Immunotherapy has limited effectiveness and benefits only a small number of patients.

Method used

Core-shell microneedle patches were prepared using silica nanoparticles loaded with oxyhemoglobin and Ce6 and calcium carbonate nanoparticles loaded with aPD-1 antibody. By constructing the core-shell structure of the microneedles, the nanoparticles were used to activate the immune system in response to the tumor microenvironment, thereby achieving tumor therapy.

Benefits of technology

Ultrasound-assisted therapy can effectively treat large or deep-seated tumors, reduce damage to normal tissues, improve the therapeutic efficiency of immune checkpoint inhibitors, alleviate the problems of high glutathione content and low pH in the tumor microenvironment, and protect the activity of aPD-1 antibodies.

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Abstract

The invention discloses a preparation method of a core-shell microneedle patch loaded with double nanoparticles. The preparation method comprises the following steps: preparing silicon dioxide nanoparticles loaded with oxyhemoglobin and chlorin e6; preparing calcium carbonate nanoparticles loaded with an aPD-1 antibody; the preparation method comprises the following steps: dispersing silicon dioxide nanoparticles loaded with oxyhemoglobin and chlorin e6 into a polyvinyl alcohol solution to prepare a shell structure of the microneedle; preparing a polymer hydrogel; dispersing the calcium carbonate nanoparticles loaded with the aPD-1 antibody into polymer hydrogel to prepare a core structure of the microneedle; and pouring a polyvinyl alcohol solution on the backing of the microneedle to finally obtain the core-shell microneedle patch loaded with the double nanoparticles. According to the core-shell microneedle patch loaded with the double nano particles, the nano particles can be delivered to a tumor part, the nano particles respond to a tumor microenvironment, human body autoimmunity is activated, and therefore the effect of treating tumors is achieved.
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