A dry eye disease atomizing liquid containing vitamin B12, a preparation method and application thereof

Abstract

This invention discloses a vitamin B-containing 12 Dry eye nebulizer solution, its preparation method and application, with vitamin B 12 Using physiological saline or water for injection as the main ingredient, a vitamin B-containing product was prepared. 12 This dry eye nebulizer solution is an effective preparation for treating dry eye syndrome using nebulization, and it also contains vitamin B. 12 This has pioneered a new application of effective formulations for treating dry eye syndrome through atomization therapy, which differs from existing technologies that improve the skin through internal absorption, thus opening up a new technological route.

Description

Technical Field

[0001] This invention relates to the field of ophthalmology, specifically, to a substance containing vitamin B. 12 Dry eye nebulizer solution, its preparation method and application. Background Technology

[0002] Dry eye syndrome patients often experience symptoms such as dry and painful eyes, blurred vision, and decreased visual acuity, which seriously affect their daily life, work, and social interactions. This is inevitably related to the use of medications, treatment methods, and understanding.

[0003] Its causes are closely related to abnormal tear secretion, ocular surface inflammation, prolonged improper use of the eyes, and environmental factors. Early scientific intervention and avoiding common eye care mistakes are crucial.

[0004] Dry eye syndrome is a common, chronic, relapsing, ocular surface metabolic disease.

[0005] Dry eye syndrome is closely related to abnormal tear secretion, tear film instability, chronic ocular surface inflammation, prolonged excessive use of the eyes, and dry environmental irritation. Abnormalities in the quality or quantity of tears lead to an imbalance in ocular surface homeostasis, resulting in a prolonged course of disease that is prone to recurrence, accompanied by multiple eye discomforts, and seriously affecting the quality of life. Summary of the Invention

[0006] The purpose of this invention is to provide a product containing vitamin B. 12 A dry eye nebulizer solution, its preparation method, and its application are disclosed. The dry eye nebulizer solution is an effective preparation for treating dry eye syndrome using nebulization as a therapeutic method. The preparation method can produce a solution containing vitamin B1. 12 Dry eye nebulizer; the application is vitamin B. 12 This has pioneered a new application of effective formulations for treating dry eye syndrome through atomization therapy, which differs from existing technologies that improve the skin through internal absorption, thus opening up a new technological route.

[0007] This invention is achieved through the following technical solution: a vitamin B-containing... 12 A dry eye nebulizer, said dry eye nebulizer may be composed of vitamin B. 12 Composed of physiological saline, or of vitamin B 12 It consists of water for injection.

[0008] Vitamin B 12 Chemical name: Coa-[a-(5,6-dimethylbenzimidazolyl)]-Coß: cyanocobalaminamide.

[0009] Molecular formula: C 63 H 88 CoN 14 O 14 P; Molecular weight: L355.38; Contains vitamin B 12 The characteristics of the dry eye nebulizer solution: a clear liquid ranging from pink to red.

[0010] Vitamin B 12 Its chemical composition is a class of complex organic compounds containing cobalt.

[0011] 1. Its chemical structure contains a corrin ring system with a central cobalt atom, which is also linked to different groups to form different forms of vitamin B. 12 .

[0012] 2. Common forms include cyanocobalamin (a synthetic pharmaceutical form), methylcobalamin (one of the naturally occurring and biologically active forms), and adenosylcobalamin (one of the naturally occurring and biologically active forms).

[0013] Vitamin B 12 Skincare products have a variety of effects and functions, including moisturizing, anti-oxidation, repairing and improving skin tone.

[0014] 1. Moisturizing: Vitamin B 12 It can help the skin retain moisture, enhance the skin barrier function, reduce moisture loss, and make the skin more hydrated.

[0015] 2. Antioxidant: It has antioxidant properties, which can remove free radicals in the skin, delay skin aging, and keep the skin youthful.

[0016] 3. Repair: It has a certain repairing effect on the skin. By activating the sympathetic nerve endings in the hair follicles, it improves microcirculation and skin inflammation, and promotes the regeneration and repair of skin cells.

[0017] 4. Improves skin tone: It can promote skin metabolism, help remove dead skin cells, make the skin smoother and more delicate, improve dull skin tone, improve microcirculation, and reduce dark circles.

[0018] Contains vitamin B 12 The dry eye nebulizer primarily activates the function of proteases in the membranes of sympathetic nerve endings in the hair follicles, promoting improved skin microcirculation through neuroregulation, accelerating tissue cell repair, and relieving symptoms such as eye and peri-eye fatigue and dryness. Its main ingredient is vitamin B. 12 It is a neurotrophic drug that can promote the metabolism and regeneration of sympathetic nerve cells and has a certain effect on the recovery of nerve cell function.

[0019] Contains vitamin B 12 This dry eye nebulizer has unique effects on the skin. It participates in cell metabolism, promoting skin cell renewal and repair. In terms of precise spot reduction, it penetrates deep into the skin to inhibit melanin production, thereby reducing the formation of dark spots. Vitamin B12 It can improve blood circulation in the skin, making the skin healthier and creating a favorable environment for fading dark spots.

[0020] Vitamin B is beneficial for skin repair. 12 It's a natural moisturizer for the skin, increasing its moisture content and improving dryness. In dry seasons, skin is prone to peeling and itching, and vitamin B... 12 Applying a face mask can effectively relieve these symptoms, restoring skin to a moist and smooth state. Moreover, it offers excellent value for money, delivering significant benefits and making it a cost-effective choice compared to expensive skincare products.

[0021] Vitamin B 12 Also known as cobalamin, it is the only vitamin in the human body that contains a metallic element. It plays an important role in improving dry eye syndrome. The concentration of the nebulized solution is 0.01mg-2mg / ml, and the number of nebulizations per day is 3-5 times or the number of nebulizations is determined according to the severity of symptoms.

[0022] To further achieve the purpose of this invention, a vitamin B-containing... 12 The dry eye nebulizer solution is specifically formulated as follows: by weight of product, the dry eye nebulizer solution may contain 0.01 to 2 parts of vitamin B. 12 It consists of 998-999.99 parts physiological saline, or 0.01-2 parts vitamin B. 12 It consists of 998 to 999.99 parts of water for injection.

[0023] To further achieve the purpose of this invention, a vitamin B-containing... 12 The dry eye nebulizer solution is specifically formulated as follows: by weight of product, the dry eye nebulizer solution may consist of 0.01 parts of vitamin B. 12 It consists of 999.99 parts physiological saline, or 0.01 parts vitamin B. 12 It consists of 999.99 parts of water for injection.

[0024] To further achieve the purpose of this invention, a vitamin B-containing... 12 The dry eye nebulizer solution is specifically formulated as follows: by weight of product, the dry eye nebulizer solution may consist of 2 parts of vitamin B... 12 It consists of 998 parts physiological saline, or 2 parts vitamin B. 12 It consists of 998 parts of water for injection.

[0025] A type containing vitamin B 12 A method for preparing a dry eye nebulizer solution, used to prepare the aforementioned solution containing vitamin B. 12 For dry eye nebulizers, according to the formula, take the required amount of Vitamin B.12 It will dissolve in an appropriate amount of physiological saline solution in water for injection.

[0026] To further achieve the purpose of this invention, a vitamin B-containing... 12 The preparation method of the dry eye nebulizer solution adopts the following setup: the prepared dry eye nebulizer solution is bottled separately using a dispensing and filling machine.

[0027] Vitamin B 12 In the preparation of a nebulizing solution for dry eye, the nebulizing solution for dry eye may include vitamin B. 12 And physiological saline, or containing vitamin B 12 and water for injection.

[0028] Furthermore, to better achieve the vitamin B content described in this invention 12 In the preparation of nebulizing solutions for dry eye, the following configuration is specifically adopted: the vitamin B... 12 Vitamin B 12 Tablets, powders, or liquids.

[0029] Compared with the prior art, the present invention has the following advantages and beneficial effects: The dry eye nebulizer solution described in this invention is an effective preparation for treating dry eye syndrome using nebulization as a treatment method.

[0030] The preparation method described in this invention can prepare products containing vitamin B. 12 Dry eye nebulizer solution.

[0031] The application described in this invention is vitamin B. 12 This has pioneered a new application of effective formulations for treating dry eye syndrome through atomization therapy, which differs from existing technologies that improve the skin through internal absorption, thus opening up a new technological route. Detailed Implementation

[0032] The present invention will be further described in detail below with reference to embodiments, but the implementation of the present invention is not limited thereto.

[0033] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of the present invention. Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without inventive effort are within the scope of protection of the present invention.

[0034] Example 1: A type containing vitamin B 12 The dry eye nebulizer solution is an effective preparation for treating dry eye syndrome using nebulization therapy. The dry eye nebulizer solution may be composed of vitamin B. 12 Composed of physiological saline, or of vitamin B 12 It consists of water for injection.

[0035] Vitamin B 12 Chemical name: Coa-[a-(5,6-dimethylbenzimidazolyl)]-Coß: cyanocobalaminamide.

[0036] Molecular formula: C 63 H 88 CoN 14 O 14 P; Molecular weight: L355.38; Contains vitamin B 12 The characteristics of the dry eye nebulizer solution: a clear liquid ranging from pink to red.

[0037] Vitamin B 12 Its chemical composition is a class of complex organic compounds containing cobalt.

[0038] 1. Its chemical structure contains a corrin ring system with a central cobalt atom, which is also linked to different groups to form different forms of vitamin B. 12 .

[0039] 2. Common forms include cyanocobalamin (a synthetic pharmaceutical form), methylcobalamin (one of the naturally occurring and biologically active forms), and adenosylcobalamin (one of the naturally occurring and biologically active forms).

[0040] Vitamin B 12 Skincare products have a variety of effects and functions, including moisturizing, anti-oxidation, repairing and improving skin tone.

[0041] 1. Moisturizing: Vitamin B 12 It can help the skin retain moisture, enhance the skin barrier function, reduce moisture loss, and make the skin more hydrated.

[0042] 2. Antioxidant: It has antioxidant properties, which can remove free radicals in the skin, delay skin aging, and keep the skin youthful.

[0043] 3. Repair: It has a certain repairing effect on the skin. By activating the sympathetic nerve endings in the hair follicles, it improves microcirculation and skin inflammation, and promotes the regeneration and repair of skin cells.

[0044] 4. Improves skin tone: It can promote skin metabolism, help remove dead skin cells, make the skin smoother and more delicate, improve dull skin tone, improve microcirculation, and reduce dark circles.

[0045] Contains vitamin B 12 The dry eye nebulizer primarily activates the function of proteases in the membranes of sympathetic nerve endings in the hair follicles, promoting improved skin microcirculation through neuroregulation, accelerating tissue cell repair, and relieving symptoms such as eye and peri-eye fatigue and dryness. Its main ingredient is vitamin B. 12 It is a neurotrophic drug that can promote the metabolism and regeneration of sympathetic nerve cells and has a certain effect on the recovery of nerve cell function.

[0046] Contains vitamin B 12 This dry eye nebulizer has unique effects on the skin. It participates in cell metabolism, promoting skin cell renewal and repair. In terms of precise spot reduction, it penetrates deep into the skin to inhibit melanin production, thereby reducing the formation of dark spots. Vitamin B 12 It can improve blood circulation in the skin, making the skin healthier and creating a favorable environment for fading dark spots.

[0047] Vitamin B is beneficial for skin repair. 12 It's a natural moisturizer for the skin, increasing its moisture content and improving dryness. In dry seasons, skin is prone to peeling and itching, and vitamin B... 12 Applying a face mask can effectively relieve these symptoms, restoring skin to a moist and smooth state. Moreover, it offers excellent value for money, delivering significant benefits and making it a cost-effective choice compared to expensive skincare products.

[0048] Vitamin B 12 Also known as cobalamin, it is the only vitamin in the human body that contains a metallic element. It plays an important role in improving dry eye syndrome. The concentration of the nebulized solution is 0.01mg-2mg / ml, and the number of nebulizations per day is 3-5 times or the number of nebulizations is determined according to the severity of symptoms.

[0049] Example 2: This embodiment is a further optimization based on the above embodiments. The parts identical to the aforementioned technical solutions will not be repeated here. Further improvements are made to better realize the vitamin B-containing... 12 The dry eye nebulizer solution is specifically formulated as follows: by weight of product, the dry eye nebulizer solution may contain 0.01 to 2 parts of vitamin B. 12 It consists of 998-999.99 parts physiological saline, or 0.01-2 parts vitamin B. 12 It consists of 998 to 999.99 parts of water for injection.

[0050] Example 3: This embodiment is a further optimization based on any of the above embodiments. The parts identical to the aforementioned technical solutions will not be repeated here. Further improvements are made to better realize the vitamin B-containing... 12 The dry eye nebulizer solution is specifically formulated as follows: by weight of product, the dry eye nebulizer solution may consist of 0.01 parts of vitamin B. 12 It consists of 999.99 parts physiological saline, or 0.01 parts vitamin B. 12 It consists of 999.99 parts of water for injection.

[0051] Example 4: This embodiment is a further optimization based on any of the above embodiments. The parts identical to the aforementioned technical solutions will not be repeated here. Further improvements are made to better realize the vitamin B-containing... 12 The dry eye nebulizer solution is specifically formulated as follows: by weight of product, the dry eye nebulizer solution may consist of 2 parts of vitamin B... 12 It consists of 998 parts physiological saline, or 2 parts vitamin B. 12 It consists of 998 parts of water for injection.

[0052] Example 5: A type containing vitamin B 12 A method for preparing a dry eye nebulizer solution, used to prepare the aforementioned solution containing vitamin B. 12 For dry eye nebulizers, according to the formula, take the required amount of Vitamin B. 12 Dissolved in an appropriate amount of physiological saline solution in water for injection. In the treatment of dry eye syndrome, the prepared vitamin B-containing solution... 12 The dry eye nebulizer solution is applied to the eyes via an automatic nebulizer or sprayer, and the treatment lasts for about 1 minute to achieve the desired therapeutic effect.

[0053] Example 6: This embodiment is a further optimization based on the above embodiments. The parts identical to the aforementioned technical solutions will not be repeated here. Further improvements are made to better realize the vitamin B-containing... 12 The preparation method of the dry eye nebulizer solution adopts the following setup: the prepared dry eye nebulizer solution is bottled separately using a dispensing and filling machine.

[0054] Example 7: Vitamin B 12 In the preparation of a nebulizing solution for dry eye, the nebulizing solution for dry eye may include vitamin B. 12 And physiological saline, or containing vitamin B 12 and water for injection.

[0055] Example 8: This embodiment is a further optimization based on the above embodiments. The parts identical to the aforementioned technical solutions will not be repeated here. Further improvements are made to better realize the vitamin B content of this invention. 12 In the preparation of nebulizing solutions for dry eye, the following configuration is specifically adopted: the vitamin B... 12 Vitamin B 12 Tablets, powders, or liquids.

[0056] Experimental verification, technical effects and conclusions: After nebulization treatment in nearly 1000 subjects, containing vitamin B 12 This dry eye nebulizer, after two weeks of continuous nebulization, reduced inflammatory factor levels, significantly increased tear production, and substantially relieved dry eye symptoms. It contains vitamin B. 12 Nebulized treatment with a dry eye solution confirms that this therapy not only relieves discomfort but also has the ability to repair the lacrimal glands. All patients receiving treatment containing vitamin B... 12 Patients experiencing dry eye discomfort after nebulization treatment with this dry eye nebulizer reported no discomfort. Pre-existing dryness and itching were eliminated, and wrinkles around the eyes were significantly improved or eliminated. Existing dark circles were also significantly improved or eliminated. Vision improved noticeably, with objects and text appearing clearer than before treatment. The feeling of pressure subsided, and intraocular pressure decreased. It also has a protective and improving effect on the cornea.

[0057] Contains vitamin B 12 A new dry eye nebulizer solution has been developed, offering an effective treatment for dry eye syndrome. With ongoing research and continuous optimization of formulation technology, this therapy will benefit more patients suffering from dry eye, blurred vision, and other symptoms. It repairs ocular surface damage, stabilizes tear film structure, and corrects ocular surface inflammation, addressing the root cause of dry eye and significantly improving patients' visual health and quality of life.

[0058] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Any simple modifications or equivalent changes made to the above embodiments based on the technical essence of the present invention shall fall within the protection scope of the present invention.

Claims

1. A dry eye misting solution comprising vitamin B 12 characterized in that: The dry eye nebulizer may be composed of vitamin B. 12 Composed of physiological saline, or of vitamin B 12 It consists of water for injection.

2. The vitamin B 12 of claim 1, wherein the vitamin B Based on product weight, the dry eye nebulizer may contain 0.01 to 2 parts of vitamin B. 12 It consists of 998-999.99 parts physiological saline, or 0.01-2 parts vitamin B. 12 It consists of 998 to 999.99 parts of water for injection.

3. The vitamin B 12 of claim 1, wherein the vitamin B The dry eye mist liquid consists of 0.01 parts of vitamin B 12 and 999.99 parts of physiological saline by product quality parts, or consists of 0.01 parts of vitamin B 12 and 999.99 parts of water for injection.

4. The vitamin B 12 spray liquid for dry eye according to claim 1, characterized by: The dry eye misting solution consists of 2 parts of vitamin B 12 and 998 parts of physiological saline, or consists of 2 parts of vitamin B 12 and 998 parts of water for injection.

5. A substance containing vitamin B 12 A method for preparing a nebulizing solution for dry eye, characterized in that: A dry eye misting solution containing vitamin B 12 as claimed in claims 1 to 4 is prepared by dissolving the required vitamin B 12 in the required amount of physiological saline in water for injection.

6. A vitamin B6-containing dry eye mist liquid according to claim 5, wherein the vitamin B6 is pyridoxine hydrochloride. 12 The preparation method of the dry eye mist liquid according to claim 5, wherein the vitamin B6 is pyridoxine hydrochloride. The prepared dry eye atomized liquid is filled into bottles by a separate filling machine.

7. Vitamin B 12 In the use of preparing the atomized liquid for dry eye, characterized in that: The dry eye mist liquid or the vitamin B 12 and physiological saline, or the vitamin B 12 and water for injection.

8. The vitamin B of claim 7 12 The use for preparing the dry eye disease atomizing liquid is characterized in that: said vitamin B 12 is vitamin B 12 Tablets or powders or water preparations.