Application of cPGES as target spot in development, screening or preparation of medicine for preventing and / or treating osteoarthritis

By targeting cPGES and knocking down viral expression, drugs for the prevention and treatment of osteoarthritis were developed. This approach addresses the safety and efficacy issues of existing osteoarthritis treatments, significantly relieving pain, improving bone metabolism, and inhibiting the release of inflammatory factors.

CN122321141APending Publication Date: 2026-07-03XUZHOU MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202610450213.7
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-08
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Current technologies lack radical means to safely and effectively reverse or block the progression of osteoarthritis, and existing treatments such as nonsteroidal anti-inflammatory drugs and chondroprotective agents have adverse reactions. The pathogenesis of osteoarthritis is complex and the core molecular regulatory network is unclear.

Method used

Using cytoplasmic prostaglandin E synthase (cPGES) as a target, drugs for the prevention and treatment of osteoarthritis can be developed by knocking down the virus through local intra-articular injection of cPGES, including cPGES or downregulators of its encoding gene and pharmaceutically acceptable vectors.

Benefits of technology

It significantly reduces joint pain, protects cartilage, improves bone metabolism imbalance, inhibits the release of inflammatory factors, and improves osteoarthritis symptoms, making it of great significance for drug development and prevention and treatment.

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Abstract

The invention discloses an application of cPGES as a target spot in developing, screening or preparing a medicine for preventing and / or treating osteoarthritis. The invention proposes that cPGES is a drug target of osteoarthritis for the first time. Experiments show that the cPGES knock-down virus is locally injected into an articular cavity, so that arthralgia of mice can be remarkably relieved, cartilage abrasion is protected, bone metabolism imbalance is improved, and release of inflammatory factors is inhibited. The results show that the cPGES has a remarkable effect on improving osteoarthritis, can be used as a target for treating osteoarthritis, and has important significance on drug development and prevention and treatment of the diseases in the future.
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