Dual-target transcranial alternating current stimulation method
By identifying dual targets in children with ASD through imaging and functional connectivity analysis, and using a transcranial alternating current stimulation device to enhance the rhythmic coupling between the primary visual cortex and the supplementary motor area, the treatment of ASD in existing technologies has been found to be inadequate, and significant improvements have been achieved in social impairment and repetitive stereotyped behaviors.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INSTITUTE OF MENTAL HEALTH OF PEKING UNIVERSITY (SIXTH HOSPITAL OF PEKING UNIVERSITY)
- Filing Date
- 2026-05-22
- Publication Date
- 2026-07-03
AI Technical Summary
Current technologies lack effective methods for stimulating abnormal neural network targets in children with autism spectrum disorder (ASD), especially stimulation patterns with dual-target phase coupling and rhythmic interventions for long-distance functional connectivity disorders, resulting in limited treatment efficacy.
By using imaging data and functional connectivity analysis, the primary visual cortex and supplementary motor area, which are associated with core symptoms of ASD, were identified as dual targets. A transcranial alternating current stimulation device was used to output sinusoidal alternating current signals in the theta band to enhance the rhythmic coupling and network synergy efficiency of these two brain regions. Conductive rubber electrode patches and the international 10–20 EEG cap were used for positioning to achieve non-invasive neuromodulation.
It significantly improves social impairment and repetitive stereotyped behaviors in children with ASD, enhances the targeting and safety of neuromodulation, and is simple to operate and easy to promote and apply.
Smart Images
Figure CN122321338A_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the technical field of EEG / neuroelectric stimulation control, and in particular to a dual-target transcranial alternating current stimulation method. Background Technology
[0002] Autism spectrum disorder (ASD) is primarily characterized by social communication impairments and repetitive, stereotyped behaviors. Current clinical treatment options are limited, lacking effective medications and interventions targeting the core symptoms. While some physical therapy methods, such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), have been studied for application in ASD, these primarily affect conventional cognitive-related areas (such as the dorsolateral prefrontal cortex) rather than brain networks highly correlated with the core symptoms of ASD identified through large-sample imaging data.
[0003] Transcranial alternating current stimulation (tACS), a non-invasive neuromodulation technique that can regulate nerve rhythms, has shown significant effects in studies on depression, insomnia, and cognitive impairment. However, there is currently no published literature or mature technology that applies tACS to the treatment of children with ASD, especially lacking ASD-specific stimulation targets identified from neural network abnormalities, stimulation patterns with dual-target phase coupling, and rhythmic intervention methods based on long-distance functional connectivity disorders.
[0004] Therefore, it remains unclear whether tACS stimulation of specific brain regions targeting the abnormal brain networks of ASD can improve core symptoms such as social impairment in children with the condition. Summary of the Invention
[0005] In view of the aforementioned existing problems, the present invention is proposed.
[0006] To solve the above-mentioned technical problems, the present invention provides the following technical solution:
[0007] In a first aspect, the present invention provides a dual-target transcranial alternating current stimulation method, which includes identifying two key brain regions related to the core symptoms of children with autism spectrum disorder based on imaging data and functional connectivity analysis: the primary visual cortex and the supplementary motor area.
[0008] Using a transcranial electrical stimulation device, electrodes are attached to the anatomical locations of the primary visual cortex and the supplementary motor area on the scalp via electrode patches.
[0009] The transcranial electrical stimulation device outputs a sinusoidal alternating current signal in the theta band for continuous stimulation.
[0010] During stimulation, the current forms an alternating electric field through the scalp-skull-brain tissue, causing the neuronal membrane potential to oscillate slightly around the resting potential, thereby enhancing the rhythmic coupling and network coordination efficiency between the primary visual cortex and the supplementary motor area.
[0011] By periodically monitoring and assessing behavioral symptoms, the effectiveness of transcranial electrical stimulation (TCS) in improving core symptoms of autism spectrum disorder can be determined.
[0012] As a preferred embodiment of the dual-target transcranial alternating current stimulation method of the present invention, the electrode patch is made of conductive rubber and the electrode position is assisted by the international 10–20 EEG cap standard system.
[0013] In a preferred embodiment of the dual-target transcranial alternating current stimulation method of the present invention, the primary visual cortex is denoted as V1, and the auxiliary motor area is denoted as SMA.
[0014] V1 corresponds to the Oz position in the brain, and SMA corresponds to the FCz position in the brain.
[0015] As a preferred embodiment of the dual-target transcranial alternating current stimulation method of the present invention, the transcranial electrical stimulation device outputs a sinusoidal alternating current signal in the theta band, with a stimulation frequency of 6 Hz, a peak current intensity of 2 mA, a current rise and fall time of 30 seconds, and a stimulation duration of 20 minutes.
[0016] As a preferred embodiment of the dual-target transcranial alternating current stimulation method of the present invention, the membrane potential is rhythmically changed around the resting potential in accordance with the frequency of the applied current by periodically changing the potential difference across the neuronal membrane, thereby achieving rhythmic remodeling of the brain functional connectivity of children with ASD.
[0017] As a preferred embodiment of the dual-target transcranial alternating current stimulation method of the present invention, the transcranial stimulation device improves the social impairment and repetitive stereotyped behaviors of children with ASD by synchronously regulating the functional connection of V1 and SMA through dual targets.
[0018] As a preferred embodiment of the dual-target transcranial alternating current stimulation method of the present invention, wherein: the Oz position represents the electrode point located at the midline of the occipital lobe, which is located slightly below the center of the back of the head, close to the scalp centerline at the occipital protuberance.
[0019] As a preferred embodiment of the dual-target transcranial alternating current stimulation method of the present invention, wherein: the FCz position represents the midline electrode point between the frontal region and the central region, located on the anterior midline of the top of the head, between the Fz frontal midline and the Cz central midline.
[0020] As a preferred embodiment of the dual-target transcranial alternating current stimulation method of the present invention, wherein:
[0021] In a second aspect, the present invention provides a computer device including a memory and a processor, wherein the memory stores a computer program, wherein when the computer program is executed by the processor, it implements any step of the dual-target transcranial alternating current stimulation method as described in the first aspect of the present invention.
[0022] Thirdly, the present invention provides a computer-readable storage medium having a computer program stored thereon, wherein: when the computer program is executed by a processor, it implements any step of the dual-target transcranial alternating current stimulation method as described in the first aspect of the present invention.
[0023] The beneficial effects of this invention are as follows: By selecting two brain regions closely related to the core symptoms of autism as joint stimulation targets and employing transcranial alternating current synchronous stimulation, abnormal brain functional connectivity is modulated. Compared with traditional single-region stimulation methods, this approach can improve the specificity and overall effectiveness of neuromodulation while ensuring safety, thus helping to improve patients' social communication abilities and repetitive stereotyped behaviors. Furthermore, this method uses standardized scalp localization and fixed stimulation parameters, making it simple to operate, highly repeatable, and low-risk. It is easily promoted and applied in clinical and rehabilitation institutions, demonstrating good practical value and application prospects. Attached Figure Description
[0024] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the following description of the embodiments will be briefly introduced. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.
[0025] Figure 1 This is a flowchart of a dual-target transcranial alternating current stimulation method.
[0026] Figure 2 This is a schematic diagram of the tACS treatment model using a dual-target transcranial alternating current stimulation method.
[0027] Figure 3 This is a schematic diagram of the therapeutic target layout for the dual-target transcranial alternating current stimulation method.
[0028] Figure 4 Electric field diagram for current modeling of the dual-target transcranial alternating current stimulation method.
[0029] Figure 5 This is the most discriminative brain region map of whole-brain functional connectivity in children with ASD and children with typical development, using the dual-target transcranial alternating current stimulation method.
[0030] Figure 6 The differential functional connectivity (V1-SMA) most relevant to the autism diagnostic scale is the dual-target transcranial alternating current stimulation method.
[0031] Figure 7 This is a diagram showing the experimental grouping of the dual-target transcranial alternating current stimulation method.
[0032] Figure 8 The marginal mean trajectory of the Childhood Autism Rating Scale (CARS) over time for each group in the dual-target transcranial alternating current stimulation method (baseline adjusted).
[0033] Figure 9 A bar chart showing the reduction rate of the Childhood Autism Rating Scale (CARS) at different follow-up time points in the dual-target transcranial alternating current stimulation method. Detailed Implementation
[0034] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.
[0035] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.
[0036] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.
[0037] Example 1, referring to Figures 1-4 As one embodiment of the present invention, this embodiment provides a dual-target transcranial alternating current stimulation method, comprising the following steps:
[0038] Based on a systematic analysis of the circuits related to the core symptoms of ASD in children, and utilizing the ABIDE database and functional connectivity studies, two key brain regions significantly associated with core symptoms (V1 primary visual cortex and SMA supplementary motor cortex) were identified through differential functional connectivity calculations. Figure 3 As shown.
[0039] Studies have found that children with ASD exhibit abnormal brain connectivity, with particularly prominent abnormalities in the theta band. Based on these neural circuit characteristics, a transcranial electrical stimulation (tES) device was used to implement simultaneous dual-target modulation.
[0040] The transcranial electrical stimulation device includes a stimulation unit, electrode leads, and conductive electrode patches. Two electrodes connected to the same output channel are respectively attached to the anatomical projection positions of V1 and SMA on the scalp surface of the subject. Figure 2 ).
[0041] Brain region localization was achieved with the aid of an EEG cap conforming to the international 10–20 system standard, where V1 corresponds to the Oz position and SMA corresponds to the FCz position. The electrode patches are made of conductive rubber. During stimulation, the tES device outputs a sinusoidal alternating current signal in the theta band, with a stimulation frequency of 6 Hz and a peak current intensity of 2 mA.
[0042] The output signals from the two electrode channels cause the current to create a stable alternating electric field between the scalp, skull, and brain tissue, such as... Figure 4 This process involves periodically altering the potential difference across the neuronal membrane, causing the membrane potential to oscillate around the resting potential at a frequency consistent with the applied current. This increases the probability of phase locking of the neuronal population to specific frequency oscillations, enhances the rhythmic coupling stability and network coordination efficiency of distant brain regions, and achieves rhythmic reshaping of abnormal functional connectivity patterns.
[0043] This modulation process is a non-invasive neuromodulation method. The current density is below the safe threshold range, and the subject usually only experiences a slight tingling or warming sensation during the stimulation process.
[0044] Example 2, refer to Figures 5-9 As an embodiment of the present invention, a load balancing method for a computing platform based on particle swarm genetic algorithm is provided. To verify the beneficial effects of the present invention, scientific demonstration is carried out through economic benefit calculation and simulation experiments.
[0045] Target identification process: First, this study screened children and adolescents aged 5-13 years from the ABIDII database, ultimately including 136 patients with ASD and 116 healthy controls. Subsequently, whole-brain functional connectivity analysis was performed to screen key brain regions. The results showed significant differences in the primary visual cortex (V1), supplementary motor area (SMA), and prefrontal cortex. Figure 5 Further analysis revealed that the most differentially functioning connections associated with the total score of the Autism Diagnostic Observation Scale, social skills score, and repetitive and stereotyped behavior score were the V1 and SMA connections, both of which were negatively correlated with the scale scores. Figure 6 The results suggest that asynchrony in brain activity is related to the severity of autism symptoms. Therefore, V1-SMA was ultimately identified as the core circuit for ASD treatment. Electroencephalography (EEG) caps were used to determine the location of the stimulating electrodes. The SMA target was located at FCz, and the V1 target was located at Oz, constructing a dual-target intervention site. Current modeling was used to verify that the stimulation field strength covered the target cortical area.
[0046] This study was designed as a randomized, controlled, double-blind trial, with blinding procedures applied to both patients and assessors. The specific process is as follows:
[0047] (1) Obtain informed consent. Before enrollment, the doctor conducts a safety screening for the patient to ensure that the patient can be treated with tACS.
[0048] (2) Understand the patient’s medical history, clinical manifestations, behavioral interventions and drug use information.
[0049] (3) Behavioral assessments were conducted upon enrollment, and MRI and magnetoencephalography (MEG) were collected.
[0050] (4) Determine electrode location: Determine the stimulation site based on the anatomical location of the brain and the EEG 10-20 system location.
[0051] (5) The patients were given 20 treatments over 5 days, four times a day, according to a randomized grouping scheme.
[0052] (6) Outcome assessment and follow-up: MRI and magnetoencephalography were performed one day after the end of 20 treatments. During the treatment period, adverse reactions were monitored and reported one day after the end of treatment and 4 weeks after the end of treatment. Behavioral symptoms were assessed to determine the improvement of ASD core symptoms by tACS.
[0053] The treatment portion of this study utilized the neuroConn DC-STIMULATOR MC multichannel tES device. The DC-STIMULATOR MC provides up to 16 freely programmable, microprocessor-controlled constant current sources using independent channels. Due to multi-level monitoring of the current path using both hardware and software, it meets the highest safety standards. By continuously monitoring electrode impedance, it can accurately maintain the user-defined current amplitude while also detecting insufficient skin contact. The DC-STIMULATOR MC automatically terminates stimulation to ensure subject safety. This device has been deployed in major hospitals and research institutions. The specific treatment protocols for each group are described below:
[0054] Dual-target tACS parameter design: A dual-channel tACS is used, synchronously outputting a 6Hz sine wave with a current intensity of 2mA. The stimulation duration is 20 minutes, the stimulation intensity is 2mA, the time for the stimulation current to rise from 0mA to 2mA is 30 seconds, and the current drop time at the end of treatment is also 30 seconds. The tACS treatment cycle is five consecutive days, four times a day, with an interval of ≥70 minutes between each treatment, for a total of 20 treatments. Electrode placement: V1, SMA, right mastoid process. The effective output electrodes are V1 and SMA.
[0055] The tACS parameter design for the sham stimulation group was the same as that for the dual-target group: the placement of the sham stimulation electrodes, the stimulation frequency band, the current intensity, and the rise and fall times of the stimulation current. The difference was that the duration of the sham stimulation current was only 30 seconds. Electrode placement: V1, SMA, and right ear mastoid process. The effective output electrodes were V1 and SMA.
[0056] SMA group tACS parameter design: Dual-channel tACS was used, synchronously outputting a 6Hz sine wave with a current intensity of 2mA. The stimulation duration was 20 minutes, the stimulation intensity was 2mA, the time for the stimulation current to rise from 0mA to 2mA was 30 seconds, and the time for the current to drop at the end of treatment was also 30 seconds. The tACS treatment cycle was five consecutive days, four times a day, with an interval of ≥70 minutes between each treatment, for a total of 20 treatments. Electrode placement: V1, SMA, right mastoid process. The effective output electrodes were the SMA and the right mastoid process.
[0057] V1 group tACS parameter design: Dual-channel tACS was used, synchronously outputting a 6Hz sine wave with a current intensity of 2mA. The stimulation duration was 20 minutes, the stimulation intensity was 2mA, the time for the stimulation current to rise from 0mA to 2mA was 30 seconds, and the time for the current to drop at the end of treatment was also 30 seconds. The tACS treatment cycle was five consecutive days, four times a day, with an interval of ≥70 minutes between each treatment, for a total of 20 treatments. Electrode placement: V1, SMA, right mastoid process. The effective output electrodes were V1 and the right mastoid process.
[0058] Grouping as Figure 7 As shown.
[0059] Currently, 48 children with ASD have been included. All demographic data are presented as mean ± standard deviation. For details, please refer to Table 1.
[0060] Table 1. Demographic data and baseline information for each group
[0061] spurious stimulation group Dual-target group SMA Group V1 Group P Age (years) 8.6±2.0 8.3±1.7 8.4±1.6 8.9±2.4 0.894 Gender (Female%) 15.40% 7.10% 18.20% 0.00% 0.498 ADOS 11.3±6.0 14.6±7.4 15.1±7.3 14.4±6.7 0.561 Wechsler Intelligence Scale 110.9±23.9 100.9±39.0 100.0±22.6 93.6±31.2 0.728 CARS 32.3±5.2 36.0±4.1 33.6±6.2 32.3±5.6 0.241 SRS_RRB 19.0±6.6 21.6±6.7 18.3±7.3 18.0±7.2 0.536 SRS_SCI 79.0±13.6 88.8±19.9 80.5±19.8 76.4±23.8 0.410 SRS_Total 98.0±19.2 110.4±25.9 98.7±24.6 94.4±30.3 0.406 RBS-R 22.8±11.9 24.3±14.4 23.5±7.4 25.0±23.1 0.986 AQ 82.2±10.4 86.3±13.9 85.2±19.1 79.1±19.6 0.699
[0062] Note: ADOS: Diagnostic Observational Scale for Autism, CARS: Childhood Autism Rating Scale, SRS: Social Response Scale (including three dimensions: SRS_RRB (behavioral), SRS_SCI (social score), and SRS_Total (total score), RBS-R: Dimensional Assessment of Repetitive Behaviors, AQ: Autism Spectrum Quotient. Results are expressed as mean ± standard deviation.
[0063] A mixed-effects repeated measures (MMRM) analysis was conducted to examine changes in CARS scores at different follow-up time points. Baseline CARS scores were included as covariates to construct an interaction model between group and time. The results showed a significant group × time interaction effect (W=27.78, df=6, P=0.0001), indicating differences in the trends of CARS score changes among different intervention groups during the follow-up period. Figure 8 ).
[0064] Figure caption: Spurious stimulation group (blue), dual-target group (red), SMA group (green), V1 group (yellow). Baselines have been adjusted, and error bars represent 95% confidence intervals.
[0065] After baseline adjustment, the estimated marginal means of all groups showed a decreasing trend at the end of treatment and during follow-up, but the magnitude of the decrease differed. Specifically, the dual-target group (red) showed a greater decrease in CARS after treatment than the sham stimulation group (blue) (difference = 0.96, 95% CI: -0.20–2.12, P = 0.104, marginally significant), which further increased one week after the end of treatment (difference = 1.95, 95% CI: 0.80–3.11, P = 0.001), and the difference became more significant at the 4-week follow-up (difference = 3.47, 95% CI: 2.31–4.63, P < 0.001). No significant differences were observed between the SMA group (green) and the sham stimulation group at any time point; similarly, no significant differences were found between the V1 group (yellow) and the sham stimulation group.
[0066] In addition, such as Figure 9 As shown, the CARS score reduction rate was calculated at each follow-up stage as a supplementary analysis: score reduction rate (%) = (score at follow-up - baseline score) / baseline score × 100%. Significant differences in CARS score reduction rates were observed among the four groups at different follow-up time points. After treatment, the dual-target group showed significant symptom improvement, with a score reduction rate significantly better than the sham stimulation group (P=0.005), SMA group (P=0.001), and V1 group (P=0.003). At the 1-week follow-up after treatment, the efficacy of the dual-target group remained stable and significantly better than the sham stimulation group (P=0.023) and V1 group (P=0.002), showing a marginally significant difference compared to the SMA group (P=0.066). At the 4-week follow-up after treatment, the efficacy of the dual-target group further expanded, significantly better than the sham stimulation group (P=0.003) and V1 group (P=0.004); the difference compared to the SMA group was nearly significant (P=0.053). Overall, the dual-target group showed stable and significant improvement at all three follow-up time points.
[0067] This embodiment also provides a computer device applicable to the dual-target transcranial alternating current stimulation method, comprising: a memory and a processor; the memory is used to store computer-executable instructions, and the processor is used to execute the computer-executable instructions to realize the dual-target transcranial alternating current stimulation method as proposed in the above embodiment.
[0068] The computer device can be a terminal, comprising a processor, memory, communication interface, display screen, and input devices connected via a system bus. The processor provides computing and control capabilities. The memory includes non-volatile storage media and internal memory. The non-volatile storage media stores the operating system and computer programs. The internal memory provides an environment for the operation of the operating system and computer programs stored in the non-volatile storage media. The communication interface is used for wired or wireless communication with external terminals; wireless communication can be achieved through Wi-Fi, carrier networks, NFC (Near Field Communication), or other technologies. The display screen can be an LCD screen or an e-ink screen. The input devices can be a touch layer covering the display screen, buttons, a trackball, or a touchpad on the computer device's casing, or an external keyboard, touchpad, or mouse.
[0069] This embodiment also provides a storage medium storing a computer program that, when executed by a processor, implements the dual-target transcranial alternating current stimulation method as proposed in the above embodiments. The storage medium can be implemented by any type of volatile or non-volatile storage device or a combination thereof, such as Static Random Access Memory (SRAM), Electrically Erasable Programmable Read-Only Memory (EEPROM), Erasable Programmable Read Only Memory (EPROM), Programmable Red-Only Memory (PROM), Read-Only Memory (ROM), magnetic storage, flash memory, magnetic disk, or optical disk.
[0070] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.
Claims
1. A dual-target transcranial alternating current stimulation method, characterized in that: This includes identifying two key brain regions associated with core symptoms of autism spectrum disorder, namely the primary visual cortex and the supplementary motor area, based on imaging data and functional connectivity analysis. Using a transcranial electrical stimulation device, electrodes are attached to the anatomical locations of the primary visual cortex and the supplementary motor area on the scalp via electrode patches. The transcranial electrical stimulation device outputs a sinusoidal alternating current signal in the theta band for continuous stimulation. During stimulation, the current forms an alternating electric field through the scalp-skull-brain tissue, causing the neuronal membrane potential to oscillate slightly around the resting potential, thereby enhancing the rhythmic coupling and network coordination efficiency between the primary visual cortex and the supplementary motor area. By periodically monitoring and assessing behavioral symptoms, the effectiveness of transcranial electrical stimulation (TCS) in improving core symptoms of autism spectrum disorder can be determined.
2. The dual-target transcranial alternating current stimulation method as described in claim 1, characterized in that: The electrode patches are made of conductive rubber and are positioned using the international 10–20 EEG cap standard system.
3. The dual-target transcranial alternating current stimulation method as described in claim 2, characterized in that: The primary visual cortex is denoted as V1, and the auxiliary motor area is denoted as SMA; V1 corresponds to the Oz position in the brain, and SMA corresponds to the FCz position in the brain.
4. The dual-target transcranial alternating current stimulation method as described in claim 3, characterized in that: The transcranial electrical stimulation device outputs a sinusoidal alternating current signal in the theta band, with a stimulation frequency of 6 Hz, a peak current intensity of 2 mA, a current rise and fall time of 30 seconds, and a stimulation duration of 20 minutes.
5. The dual-target transcranial alternating current stimulation method as described in claim 4, characterized in that: By periodically altering the potential difference across the neuronal membrane, the membrane potential undergoes rhythmic changes around the resting potential that are consistent with the frequency of the applied current, thereby achieving rhythmic remodeling of the brain functional connections in children with ASD.
6. The dual-target transcranial alternating current stimulation method as described in claim 5, characterized in that: The transcranial stimulation device improves social impairments and repetitive stereotyped behaviors in children with ASD by simultaneously modulating the functional connection between V1 and SMA at two targets.
7. The dual-target transcranial alternating current stimulation method as described in claim 6, characterized in that: The Oz position refers to the electrode point located at the midline of the occipital lobe, which is located slightly below the center of the back of the head, close to the center line of the scalp at the occipital protuberance.
8. The dual-target transcranial alternating current stimulation method as described in claim 7, characterized in that: The FCz position represents the midline electrode point between the forehead region and the central region, located on the frontal midline of the head, between the Fz frontal center and the Cz central center.
9. A computer device comprising a memory and a processor, wherein the memory stores a computer program, characterized in that: When the processor executes the computer program, it implements the steps of the dual-target transcranial alternating current stimulation method according to any one of claims 1 to 8.
10. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by the processor, it implements the steps of the dual-target transcranial alternating current stimulation method according to any one of claims 1 to 8.