Enhanced permeability branched cationic polymers, methods of making, and degradation and use in nucleic acid delivery applications

By preparing branched cationic polymers with multiple terminal groups and three-dimensional topological structures, the problem of cationic polymer carriers being unable to penetrate the skin barrier was solved, achieving efficient nucleic acid delivery and controllable degradation, which is suitable for clinical applications in gene therapy.

CN122356471APending Publication Date: 2026-07-10BINZHOU MEDICAL COLLEGE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BINZHOU MEDICAL COLLEGE
Filing Date
2026-04-17
Publication Date
2026-07-10

AI Technical Summary

Technical Problem

Existing cationic polymer carriers have difficulty penetrating the skin barrier when delivering nucleic acids, resulting in low transfection efficiency and cytotoxicity issues, which limit their application in gene therapy.

Method used

A branched cationic polymer with enhanced permeability was prepared by Michael addition reaction of small molecule amine monomers, acrylate monomers and branched small molecule organic amines. The polymer was then reacted with functionalized small molecule amine end-capping agents and finally acrylate transdermal monomers were added to form a branched cationic polymer with multiple terminal groups and a three-dimensional topological structure, which enabled controlled degradation.

Benefits of technology

Enhanced permeability branched cationic polymers exhibit excellent biocompatibility and in vivo permeability, high transfection efficiency, controllable degradation process, suitability for industrial production, and high safety of degradation products, making them suitable for clinical applications.

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Abstract

This invention discloses a class of permeability-enhancing branched cationic polymers, their preparation method, degradation, and applications in nucleic acid delivery, belonging to the field of biomedical materials technology. Using small molecule amine monomers, acrylate monomers, branched small molecule polyamines, functionalized amine-terminated monomers, and permeability-enhancing functionalized monomers as raw materials, a one-pot method is employed to prepare functional permeability-enhancing branched cationic polymers. The synthesis is simple and efficient, suitable for industrial-scale production. The complex nanoparticles formed by the permeability-enhancing branched cationic polymers and nucleic acids exhibit relatively uniform distribution, good stability, and biodegradability, demonstrating good biocompatibility. Transfection results show that the permeability-enhancing branched cationic polymers and their degradation products have broad application prospects in nucleic acid delivery and gene therapy.
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