Use of clopidogrel for the preparation of a medicament for preventing radiation-induced damage to the hematopoietic system
By using clopidogrel to prevent radiation-induced hematopoietic system damage and inhibit the ferroptosis pathway, the problem of radiation-induced hematopoietic system damage was solved, achieving the protection of hematopoietic stem and progenitor cells and the restoration of blood cell counts.
CN122398792APending Publication Date: 2026-07-17THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
- Filing Date
- 2026-04-30
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Current technology lacks effective drugs to prevent radiation-induced hematopoietic system damage, especially drugs that inhibit ferroptosis, which increases the risk of hematologic diseases such as leukemia.
Method used
Clopidogrel was used as the drug to inhibit ferroptosis induced by ferroptosis inducers such as RSL3 or IKE by administering the drug 24 hours in advance, and to prevent radiation-induced hematopoietic system damage by utilizing the CHMP5 pathway.
Benefits of technology
It significantly reduces radiation-induced damage to mouse stem and progenitor cells, salvages cell survival, restores the number of blood cells, and reduces the risk of hematopoietic system damage after radiation.
✦ Generated by Eureka AI based on patent content.
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Figure CN122398792A_ABST
Abstract
本发明涉及一种氯吡格雷在防治辐射诱发造血系统损伤中的应用，所述药物提前24h给药可以预防小鼠造血系统辐射损伤，在2Gy‑6Gy辐射剂量下可预防辐射引起的小鼠干祖细胞损伤，同时挽救小鼠血常规。体外细胞实验表明，该药效是通过抑制铁死亡诱导剂（如 RSL3）所诱导的铁死亡实现的，氯吡格雷可部分恢复铁死亡所引起的细胞脂质过氧化和胞内Fe2+含量的增加。本发明所述氯吡格雷用于抑制细胞铁死亡效果明显，有利于预防辐射引起的造血系统损伤。
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