Application of radix morindae officinalis oligosaccharide and composition thereof in preparation of product for preventing, delaying or treating vascular depression

By using Morinda officinalis oligosaccharides and their combinations to regulate neurotransmitters and promote synaptic remodeling, the limitations of existing drugs for treating vascular depression and their significant side effects have been addressed, achieving a safe and effective neuroprotective effect.

CN122398823APending Publication Date: 2026-07-17BEIJING TONGRENTANG CO LTD
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Patent Information

Application Number
CN202610295843.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-11
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing medications for treating vascular depression have limited efficacy, significant side effects, high costs, and inconvenience of use. Current physical and psychological treatments cannot fundamentally address the depressive symptoms caused by cerebrovascular lesions and neuronal damage.

Method used

Morinda officinalis oligosaccharides and their combinations are used as novel neuroprotective drugs. Through multi-target mechanisms such as regulating neurotransmitters, protecting mitochondria, inhibiting inflammation, and promoting synaptic remodeling, they are prepared into suitable dosage forms such as oral preparations, injections, and transdermal patches for administration.

Benefits of technology

It significantly improves symptoms of vascular depression, lowers blood pressure, reduces pathological damage to brain tissue, restores neurotransmitter levels, has few side effects, improves patient compliance, and provides continuous and effective treatment.

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Abstract

The invention provides application of radix morindae officinalis oligosaccharide and a composition thereof in preparation of products for preventing, delaying or treating vascular depression, and relates to the technical field of medicines. The application of the radix morindae officinalis oligosaccharide and the composition thereof in preparation of products for preventing, delaying or treating vascular depression has the potential advantages of multi-target effect, high safety, low cost, convenience in use and the like, animal experiments find that the radix morindae officinalis oligosaccharide has a remarkable treatment effect on rats suffering from vascular depression, can improve depression-like behaviors and reduce blood pressure, and can be used for preventing, delaying or treating vascular depression. The pathological injury of brain tissues is relieved, the neurotransmitter level is recovered, and the side effect is small. And cell experiments are further carried out to define that the radix morindae officinalis oligosaccharide can promote neuronal synaptic remodeling, improve the activity of a BDNF-TrkB-CREB signal channel and enhance the neuroprotective effect of the BDNF-TrkB-CREB signal channel, so that a new idea is provided for the treatment of neuronal injury, and a new choice is provided for the treatment of vascular depression.
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