Use of polymyxins and tetracycline antibiotics in the prevention and treatment of ocular diseases in dogs caused by bacterial infections

The combined use of polymyxins and tetracycline antibiotics has solved the problems of narrow antibacterial spectrum and drug resistance in the treatment of bacterial eye infections in dogs, providing a broad-spectrum treatment plan with significant synergistic effects and enhancing antibacterial efficacy against both Gram-negative and Gram-positive bacteria.

CN122398992APending Publication Date: 2026-07-17JINHE BIOTECHNOLOGY CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JINHE BIOTECHNOLOGY CO LTD
Filing Date
2026-05-14
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In the current technology, the treatment of bacterial eye infections in dogs mainly relies on single antibacterial drugs, which have problems such as limited antibacterial spectrum, easy development of drug resistance and poor treatment effect. There is a lack of broad-spectrum drug combinations with significant synergistic effects.

Method used

The combined use of polymyxins and tetracycline antibiotics, through different proportions of drug combinations, targets Gram-negative and Gram-positive bacterial infections, and is formulated into ophthalmic dosage forms such as eye drops and ointments, which are used in combination to enhance the antibacterial effect.

Benefits of technology

It significantly enhances the antibacterial spectrum against bacterial eye infections in dogs, reduces the emergence of drug-resistant strains, and provides a more effective treatment option.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明提供多黏菌素和四环素类抗生素在预防和治疗因细菌感染导致的犬类眼部疾病中的应用。本发明通过棋盘法最小抑菌浓度试验、体外时间杀菌曲线证明盐酸金霉素和硫酸多黏菌素B联合具有明显的协同抗细菌活性作用,解决目前单一药物抗菌谱窄,无法同时覆盖革兰氏阳性菌与阴性菌的问题,适配混合感染;并且可减少单药用量,延缓耐药菌株产生;本发明还通过小鼠伪中间葡萄球菌感染建立的眼结膜炎模型,证明了盐酸金霉素和硫酸多黏菌素B联合使用,具有明显的协同抗菌作用。本发明为多黏菌素和四环素类抗生素的联合用药开辟了一种新用途,在治疗犬眼部疾病方面具有重要的应用价值。
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