Safflower active ingredient loaded wound repair hydrogel and preparation method thereof
By preparing ZV@F composite hydrogels that combine rutin zinc nanoparticles with safflower vesicles and poloxamer PF127 hydrogels, the problem of limited functionality in existing wound repair materials has been solved, achieving diversified wound repair effects and promoting tissue regeneration and healing.
CN122399095APending Publication Date: 2026-07-17TIANJIN UNIV OF SCI & TECH
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- TIANJIN UNIV OF SCI & TECH
- Filing Date
- 2026-06-03
- Publication Date
- 2026-07-17
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Figure CN122399095A_ABST
Abstract
本发明公开了一种红花有效成分负载的创面修复水凝胶及其制备方法，属于生物医药材料技术领域。本发明首先通过改进的细胞外囊泡分离方法从干燥红花中提取纯化红花纳米囊泡（CDNVs）；再采用自组装配位法制备芦丁锌纳米颗粒（ZnR NPs）；将二者共负载于质量分数为 20%–30% 的泊洛沙姆 PF127 温敏水凝胶中，制得 ZV@F 复合水凝胶。该水凝胶在 35℃–38℃发生溶胶 ‑ 凝胶转变，具有均匀致密网状结构、良好组织黏附性。动物实验表明，ZV@F 水凝胶能显著降低炎症反应、促进血管生成与胶原沉积，有效减少瘢痕形成，实现感染创面高质量愈合。本发明工艺温和、操作简便、生物相容性好，为中药活性成分的局部精准递送与创面修复提供了新型制剂，具有良好的临床应用前景。
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