Cyclohexylquinoxalinone derivatives, methods of making and use in alleviating hypertriglyceridemic pancreatitis
Cyclohexylquinoxalone derivatives were successfully synthesized via visible light-catalyzed free radical addition reactions, solving the high-temperature and high-oxidation problems of traditional methods, realizing a green and environmentally friendly synthetic route, and demonstrating potential therapeutic effects on hypertriglyceridemic pancreatitis.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NINGXIA MEDICAL UNIVERSITY GENERAL HOSPITAL
- Filing Date
- 2026-05-29
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies for synthesizing cyclohexylquinoxalone derivatives typically require high temperatures and strong oxidation systems, resulting in harsh conditions, complex operations, and a lack of environmental friendliness. Furthermore, their application in alleviating hypertriglyceridemic pancreatitis has not been fully explored.
A visible-light-catalyzed radical addition reaction was employed, using 1-methylquinoxalin-2(1H)-one as the acceptor substrate and 2-cyclohexyl-2-methyl-2,3-dihydroquinoxalin-4(1H)-one as the cyclohexyl radical precursor. Cesium bromide and the photocatalyst were irradiated with visible light in dichloroethane to achieve regioselective cyclohexylation at the C3 position, avoiding high temperature and strong oxidation systems.
A green synthesis of cyclohexylquinoxalone derivatives was achieved under mild, simple, and efficient conditions, with broad substrate applicability, few byproducts, high yield, and easy preparation in high purity. It also showed potential therapeutic effects on hypertriglyceridemic pancreatitis.
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Figure CN122404239A_ABST