A method for synthesizing furan-3(2H)-one compounds
By using a one-step reaction of diazonium ketones and diazonium esters under visible light, the problems of harsh synthesis conditions and narrow substrate range of furanones in the prior art have been solved, realizing the efficient and economical synthesis of furan-3(2H)-ketones, which are suitable for the synthesis of pharmaceuticals and natural products.
CN122404263APending Publication Date: 2026-07-17FUYANG NORMAL UNIVERSITY +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- FUYANG NORMAL UNIVERSITY
- Filing Date
- 2026-03-12
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing synthetic methods for furanone compounds require the use of metals and ligands, are subject to harsh conditions, have a narrow substrate range, and are difficult to efficiently prepare 5-acylated 2-pyridinone compounds.
Method used
Furan-3(2H)-ketone compounds were constructed from diazonium ketones and diazonium esters in a single reaction under visible light. The reaction used readily available solvents and mild reaction conditions, avoiding the use of catalysts.
Benefits of technology
The efficient, economical, and diversified synthesis of furan-3(2H)-ketone compounds has been achieved, exhibiting good functional group tolerance and substrate universality, and is suitable for the synthesis of pharmaceuticals and natural products.
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Figure CN122404263A_ABST
Abstract
本发明属于有机合成技术领域，公开了一种呋喃‑3（2H）‑酮类化合物的合成方法，包括以下步骤：在氮气保护下，将2‑重氮‑2‑苯乙酸甲酯类化合物、1‑重氮酮类化合物溶于有机溶剂中，在400~800nm波长可见光范围内搅拌反应0‑80小时，反应后分离提纯，即得呋喃‑3（2H）‑酮类化合物。本发明主要以重氮酮类化合物与重氮酯类化合物为原料进行反应，该方法反应条件温和，具有良好的官能团容忍性和底物普适性，可克级规模生产；且无需额外添加配体，具有极好的化学选择性，有望在相关的药物化学的合成中得到应用。
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