An alpha-carboline-3-ketone compound and a preparation method thereof
A one-pot synthesis method for α-carboline-3-one compounds was developed by reacting 3-benzylidene-2-p-toluenesulfonyliminoindoline and enaminoketone compounds in the presence of a basic substance. This method overcomes the problems of narrow substrate range, low yield, and harsh reaction conditions in the preparation of α-carboline-3-one compounds in existing technologies, and achieves an efficient and convenient preparation method.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- ZHEJIANG NORMAL UNIV
- Filing Date
- 2026-05-14
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for preparing α-carboline-3-one compounds suffer from problems such as narrow substrate applicability, low yield, harsh reaction conditions, and poor functional group compatibility, lacking efficient and convenient synthetic methods.
α-Carblin-3-one compounds were prepared by a one-pot reaction in the presence of an alkaline substance using 3-benzylidene-2-p-toluenesulfonyliminoindoline and enaminoketone compounds as raw materials. The reaction conditions were mild and no transition metal catalysis was required.
The method achieves the preparation of α-carboline-3-one compounds with high yield and high purity. It is simple to operate, the raw materials are readily available, it has a wide range of applications, and it is suitable for large-scale production.
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Figure CN122404331A_ABST