Preparation and application of a purified synthetic phospholipid-monoterpene traditional Chinese medicine penetration enhancer associated composition
By reacting acid anhydrides with monoterpene chemical penetration enhancers to generate active esters, which are then combined with phosphatidylethanolamine, modified phospholipid-monoterpene lipid carriers are prepared. This solves the problems of easy volatility and low modification rate of monoterpene traditional Chinese medicine penetration enhancers, and realizes efficient transdermal drug delivery and brain-targeted application.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- INST OF MATERIA MEDICA CHINESE ACAD OF MEDICAL SCI
- Filing Date
- 2025-01-17
- Publication Date
- 2026-07-17
AI Technical Summary
Existing monoterpenoid-based traditional Chinese medicine penetration enhancers are volatile, and the physical modification rate of lipid carriers is not high, making it difficult to effectively improve their penetration effect in transdermal drug delivery.
An active ester is generated by reacting anhydride with a monoterpene chemical penetration enhancer in an organic solvent. This ester is then combined with phosphatidylethanolamine (PE) and modified phospholipid-monoterpene lipid carriers are prepared by thin-film dispersion or reverse evaporation to form solid lipid nanoparticles or ethanol bodies. Surfactants are added to improve film-forming properties.
It improved the modification rate of monoterpenoid traditional Chinese medicine penetration enhancers, enhanced the permeability of transdermal drug delivery, reduced cell toxicity at high concentrations, and improved the potential for brain-targeted applications.
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