Nanobodies specifically binding aav8 and aav9 and uses thereof
By developing nanobodies that specifically bind to AAV8 and AAV9 and utilizing the characteristics of camel-derived nanobodies, we have achieved efficient purification and accurate detection of AAV8 and AAV9, solving the problems of complex purification and high detection costs in existing technologies, and making it suitable for large-scale preparation and quality control in the field of gene therapy.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- XIAMEN UNIV
- Filing Date
- 2026-04-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are insufficient for efficient and low-cost purification and accurate detection of AAV8 and AAV9 dual serotypes. Traditional methods are complex and rely on imported antibodies, which cannot meet the needs of large-scale preparation and quality control in the field of gene therapy.
We developed nanobodies that specifically bind to AAV8 and AAV9, utilizing the properties of camel-derived nanobodies to achieve efficient purification and detection via affinity chromatography. These nanobodies are designed with specific amino acid sequences to bind to AAV8 and AAV9, avoiding cross-reactivity and making them suitable for industrial applications.
It achieves efficient purification and accurate detection of AAV8 and AAV9, reduces production costs, improves the accuracy of product quality control, adapts to the needs of large-scale production, and ensures the independent control of the supply chain.
Smart Images
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