Normal temperature liquid nucleic acid quality control
By combining metal ion chelators, protease inhibitors, and full-chain thiophosphate-modified oligonucleotides, the problem of instability of nucleic acid quality control products at room temperature was solved, achieving high stability and PCR compatibility of the quality control products at room temperature and expanding their application range.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Filing Date
- 2026-05-23
- Publication Date
- 2026-07-17
AI Technical Summary
Existing nucleic acid quality control products are unstable at room temperature and are easily degraded by nucleases and proteases. Furthermore, magnesium-containing PCR reagents are chemically unstable at room temperature, resulting in high storage and transportation costs and limited applications.
A triple synergistic protection mechanism is formed by combining metal ion chelators, protease inhibitors, and full-chain thiophosphate-modified oligonucleotides. Combined with a complex buffer system, this ensures the stability of the quality control products at room temperature.
It achieves high stability and PCR compatibility of quality control products at room temperature, significantly improves tolerance to nucleases and proteases, reduces storage and transportation costs, and expands the scope of application.
Smart Images
Figure CN122405902A_ABST