A bifunctional capillary sers sensor and a preparation method and application thereof
By designing a dual-function capillary SERS sensor, non-invasive collection and simultaneous detection of micro-liter specific tears were achieved, solving the sensitivity and rapid screening problems of micro-tear detection in existing technologies and providing an efficient diagnostic method for ophthalmic diseases.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- BEIJING UNIV OF TECH
- Filing Date
- 2026-04-29
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies are insufficient for the direct collection and rapid analysis of microliter-sized tears, especially in the immediate diagnosis and rapid screening of ophthalmic diseases, where they suffer from insufficient sensitivity and sample utilization. Traditional methods are complex and time-consuming.
A dual-function capillary SERS sensor was designed, employing a flexible sampling head and a capillary solid-phase carrier. The inner wall is uniformly distributed with a layer of gold nanoparticles and a gold nanoparticle/4-MBA composite layer, enabling non-invasive collection of tears and simultaneous acquisition of Raman fingerprint spectrum and tear pH response. Changes in 4-MBA characteristic signals are detected to reflect ocular lesions.
It enables dual detection of minute amounts of tears, with high accuracy and simple operation, making it suitable for rapid in-situ screening in clinical settings. It features non-invasive sampling, rapid response, and high sensitivity, making it suitable for immediate diagnosis of ophthalmic diseases.
Smart Images
Figure CN122409616A_ABST