A cyclic electrophoresis chip system and its application
By combining a cyclic electrophoresis chip system with a laser-induced fluorescence detector, the problems of cumbersome operation and large errors in chip electrophoresis diffusion coefficient measurement are solved, enabling rapid and accurate diffusion coefficient determination and qualitative identification of substances.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SUN YAT SEN UNIV
- Filing Date
- 2026-04-24
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for measuring diffusion coefficients using chip electrophoresis are cumbersome and inefficient. Furthermore, multiple independent sample injections lead to sample adsorption and channel contamination, introducing systematic errors and making it difficult to achieve rapid and accurate qualitative detection of substances.
A cyclic electrophoresis chip system is used, which periodically switches the direction of the electric field by a high-voltage power supply to make the sample reciprocate within the separation channel. Combined with a laser-induced fluorescence detector to record the fluorescence signal, the operation process is simplified, errors introduced by multiple sample injections are avoided, and dynamic diffusion coefficient determination is achieved.
It improves the accuracy and stability of measurement results, simplifies the operation process, and enables rapid, online determination of diffusion coefficients. It is suitable for qualitative identification of various fluorescent dyes and amino acids.
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