A method for preparing a myofibrillar protein-based double gel

By using myofibrillar protein as the main structural material, combined with emulsion template method and transglutaminase crosslinking technology, the interfacial compatibility and stability issues of the dual-gel system were solved, achieving efficient encapsulation and sustained-release delivery of active substances.

CN122439852APending Publication Date: 2026-07-24MINJIANG UNIVERSITY +1
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Patent Information

Application Number
CN202610840280.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-11
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing bigel systems rely on small molecule oleogel agents, resulting in complex compositions, poor interfacial compatibility between the hydrogel phase and the oleogel phase, difficulty in forming structurally stable bigel networks, and a tendency for phase separation and network discontinuity.

Method used

Using myofibrillar protein as the main structural material, oleogels were prepared by emulsion template method, and enzymatic covalent cross-linking with transglutaminase was used to enhance the interfacial compatibility and structural stability of hydrogels and oleogels.

Benefits of technology

It significantly improves the interfacial compatibility and structural stability of the bigel, reduces phase separation and network discontinuity, and enhances the encapsulation efficiency and sustained-release delivery performance of active substances.

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Abstract

The application relates to a preparation method of a myofibrillar protein-based double gel, which comprises the following steps: S1, preparing a myofibrillar protein-based hydrogel through one-time thermal induction by taking a first myofibrillar protein and a first salt solution as raw materials; S2, preparing a myofibrillar protein-based oil gel through an emulsion template method by taking a second myofibrillar protein, edible oil and a second salt solution as raw materials; and S3, mixing and shearing and dispersing the myofibrillar protein-based hydrogel and the myofibrillar protein-based oil gel, and adding a transglutaminase for cross-linking, so that the myofibrillar protein-based double gel is obtained. The application constructs two phases of a hydrogel and an oil gel by taking myofibrillar protein as a main structural material, and the double gel is prepared through transglutaminase cross-linking, so that the interface compatibility and the structural stability are significantly enhanced, and the phase separation and network discontinuity phenomenon are effectively reduced; the myofibrillar protein-based double gel prepared by the method has excellent embedding efficiency of active substances, processing stability and slow-release delivery performance.
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