A safe and detachable microstructure hydrogel electrode patch and a preparation method thereof

Abstract

The present application relates to the technical field of hydrogel patch, and particularly relates to a microstructure hydrogel electrode patch capable of safe peeling, which comprises a substrate layer, a conductive electrode and a hydrogel adhesive layer, and further comprises a slow-release cavity and a linkage. The slow-release cavity is arranged on the circumferential edge of the other surface of the substrate layer, a first cavity of the slow-release cavity encapsulates a basic soothing substance, and a second cavity encapsulates a functional soothing substance. The linkage comprises a fracture control part and a sensing part arranged in parallel, the fracture control part is integrally formed with the first cavity and extends along a peeling direction, and is used for controlling the release of the first cavity; and the sensing part is a pH-sensitive polymer film attached to the side wall of the second cavity, and is used for controlling the release of the second cavity. The soothing substance is triggered to release through the linkage when the patch is peeled, the pain of peeling is reduced, the safety and comfort are improved, and the physiological signal monitoring and electric stimulation treatment are applicable.

Description

Technical Field

[0001] This invention relates to the field of electrode patch technology, and more specifically, to a microstructured hydrogel electrode patch that can be safely detached and its preparation method. Background Technology

[0002] Electrocardiogram (ECG) monitoring requires electrode patches to be attached to the skin for extended periods to reliably acquire ECG signals. Currently, commonly used ECG electrode patches rely on strong adhesives or medical tape for stable attachment, but this presents a challenge in balancing adhesion: if the adhesion is too weak, the patch may loosen or shift during movement, leading to signal artifacts and increased noise, potentially causing misdiagnosis; conversely, if the adhesion is too strong, it may tear the skin's stratum corneum during electrode removal, causing local skin pain, irritation, or even inflammation. During prolonged wear, strong adhesives may also trigger skin allergies or redness. This "pain / skin peeling" problem when removing the patch severely impacts user experience and safety. Therefore, there is an urgent need for a technological solution that ensures a secure patch fit while avoiding pain and skin damage during removal.

[0003] To address these contradictions, recent years have seen research into smart-responsive adhesive materials, namely novel hydrogel adhesives that adjust their adhesive properties according to changes in external stimuli. Existing methods have attempted to use chemical triggers (such as solvents or specific ions) to separate the adhesive interface on demand; however, chemical triggering carries the risk of additional reagents irritating the skin, and unintended detachment due to bodily secretions. In contrast, separable hydrogels triggered by physical stimuli (such as light, magnetic fields, and temperature) have attracted considerable attention, avoiding the side effects of chemical reagents. In summary, a suitable ECG electrode patch that maintains stable adhesion under normal wearing conditions but rapidly detaches only under specific active triggering conditions is still lacking. Summary of the Invention

[0004] The technical problem to be solved by this invention is that the adhesive stability is poor and the adhesive cannot be quickly detached after active triggering. In view of the above-mentioned defects of the prior art, this invention provides a microstructured hydrogel electrode patch with safe detachment and its preparation method.

[0005] The technical solution adopted by this invention to solve its technical problem is: on the one hand A safe-release microstructured hydrogel electrode patch includes a flexible thin-film substrate, a conductive electrode attached to one main surface of the substrate, and a hydrogel adhesive layer covering the conductive electrode on the side away from the substrate. It also includes a release chamber and a linkage mechanism. The release chamber is located at the circumferential edge region of another main surface of the substrate. The release chamber has a first chamber and a second chamber. The first chamber encapsulates a basic soothing substance, and the second chamber encapsulates a functional soothing substance. The linkage is connected to the sustained-release chamber, and the linkage is used to drive the sustained-release chamber to release basic soothing substances and functional soothing substances.

[0006] By adopting the above technical solution, the patch uses a flexible film as its base layer. Through the combination of conductive electrodes and a hydrogel adhesion layer, stable adhesion to the skin and effective acquisition of physiological electrical signals are ensured. Based on this, a controllable biphasic substance release mechanism is constructed by setting a sustained-release chamber containing a first chamber and a second chamber in the circumferential edge region of the base layer and introducing a linkage mechanism connected to it. The basic soothing substance encapsulated in the first chamber can be used to soften the stratum corneum and reduce adhesion during the initial use of the patch or before removal, while the functional soothing substance encapsulated in the second chamber can be used to repair specific skin conditions (such as inflammation). By uniformly controlling the release of the two chambers through the linkage mechanism, safe removal and skin care functions are integrated into one unit without increasing operational complexity, significantly improving user experience and product medical safety.

[0007] Preferably, the linkage includes a fracture control unit and a sensing unit arranged in parallel, the fracture control unit being used to control the release of the first chamber, and the sensing unit being used to control the release of the second chamber.

[0008] By adopting the above technical solution, and setting the linkage components as a parallel and functionally independent fracture control unit and sensing unit, the triggering mechanisms of the two chambers are decoupled. Specifically, the fracture control unit focuses on physical external force triggering, used to actively control the release of basic soothing substances, facilitating manual operation by the user when the patch needs to be removed, reflecting the immediate need for safe removal; while the sensing unit focuses on environmental response, used to automatically trigger the release of functional soothing substances under specific physiological conditions (such as changes in skin pH), providing a slow-release effect on the skin. This parallel setting not only ensures the basic control function of the linkage components over the two chambers, but also expands the application dimensions of the patch by distinguishing between physical and chemical triggering mechanisms, giving it the dual effects of immediate intervention and long-term conditioning.

[0009] Preferably, the fracture control part is a strip-shaped or strip-shaped weak connection bridge, the end of the fracture control part is connected to the outer wall of the first chamber, and a tearing part is provided at the connection between the fracture control part and the first chamber.

[0010] By employing the above technical solution, a low-resistance directional tearing guide structure is constructed by specifying the fracture control part as a strip-shaped or band-shaped weak connecting bridge and setting a tear section at its connection with the first chamber. When the user applies tearing force, the stress is concentrated at the pre-designed tear section, allowing the connecting bridge to precisely tear open the first chamber with minimal force, avoiding overall patch displacement or skin tearing due to excessive force. This design utilizes the principle of stress concentration in mechanics, transforming the user's tearing action into a controllable, localized destructive force, achieving precise and low-pain release of basic soothing substances, and further enhancing the technical effect of safe patch removal.

[0011] Preferably, the sensing element is attached to the side wall of the second chamber, and the sensing element is a polymer film sensitive to a specific pH range.

[0012] By employing the above technical solution, and using a polymer film sensitive to a specific pH range as the sensing element, which is attached to the sidewall of the second chamber, the release mechanism acquires environmental responsiveness. When human skin experiences inflammation, allergies, or prolonged periods of occlusion, the surface pH value typically changes. When the sensing element detects that the environmental pH value deviates from the normal range and enters a preset threshold, the polymer film undergoes physical or chemical changes (such as dissolution, swelling, or pore opening), thereby automatically breaking the seal of the second chamber and releasing functional soothing substances. This allows for automatic activation of the care program when skin conditions are abnormal without user intervention, making it highly practical for nighttime monitoring or patients with limited mobility.

[0013] Preferably, the fracture control unit is a tear strip with a preset fracture point. One end of the tear strip is fixed to the base layer, and the other end of the tear strip is connected to the side wall of the second chamber. The preset fracture point is located on the tear strip near the connection point of the second chamber. The tear strip is integrally formed with the second chamber, and the extension direction of the tear strip is the same as the expected tearing direction of the patch.

[0014] By adopting the above technical solution, and by setting the breakage control unit as a tear strip integrally molded with the second chamber, with a preset breakage point on it near the connection point, while limiting the extension direction of the tear strip to be consistent with the expected tearing direction, an intuitive operating system is formed. When the user tears the patch in the usual direction, the force is directly transmitted to the preset breakage point through the tear strip, using leverage or direct pulling to break the second chamber. Because the tear strip is integrally molded with the chamber, the risk of connection failure is reduced; and the limitation of the position of the preset breakage point and the tearing direction ensures that each tear breaks accurately at the expected position, avoiding problems such as failure to release or accidental tearing of other structures due to incorrect force direction, thus improving the reliability and ease of operation of the product.

[0015] Preferably, the linkage further includes a removable protective cover that covers the linkage and the base layer, the protective cover being used to protect the linkage.

[0016] By adopting the above technical solution, a removable protective cover is placed over the linkage and base layer, providing a physical barrier for the precise sustained-release control structure. This effectively prevents accidental triggering of the linkage during transportation, storage, or preparation, ensuring the integrity of the product before use. Simultaneously, the protective cover also serves to prevent dust and bacteria, maintaining the sterility of the encapsulated material inside the patch. During use, the user only needs to remove the protective cover to expose the intact linkage for operation, ensuring both product functional reliability and compliance with the stringent hygiene and safety requirements for medical devices.

[0017] Preferably, the protective cover is affixed to the side of the fracture control section and the base layer.

[0018] By adopting the above technical solution, and instead of covering the entire surface, the protective cover is adhered to the side of the fracture control section and the base layer, a balance between reliable fixation and easy removal is achieved. This dotted or linear side-adhesion method utilizes localized adhesive force to firmly position the protective cover above the linkage, preventing it from sliding off. Furthermore, because the adhesive area is small and located on the side, users can easily peel it off from the opposite side, avoiding tearing damage to the fragile hydrogel layer or linkage structure caused by large-area adhesion. This design reflects meticulous consideration of manufacturing processes and user experience, ensuring that the protective cover effectively performs its protective function without affecting the main structure.

[0019] Preferably, the sustained-release cavity is a closed cavity formed by a flexible sealing film, and the breakage control part is integrally connected to the shell of the closed cavity; the sustained-release cavity is capsule-shaped, ring-shaped, strip-shaped or sheet-shaped.

[0020] By employing the above technical solution, a flexible sealing film is used to form a closed cavity, ensuring the stable storage of the encapsulated material (soothing agent) while maintaining the overall flexibility of the patch, avoiding any impact on wearing comfort due to the addition of a rigid cavity. Integrating the fracture control unit with the shell of the closed cavity simplifies the manufacturing process and eliminates the risk of stress concentration or leakage at assembly connection points, improving structural strength and airtightness. Furthermore, limiting the shape of the sustained-release cavity to capsule, ring, strip, or sheet shape allows for flexible adjustment of the cavity's layout and appearance according to different application sites (such as joints, face, and torso) and dosage requirements of the loaded material, thus adapting to diverse clinical needs and demonstrating the universality and scalability of this patented solution.

[0021] on the other hand A method for preparing a safe and detachable microstructured hydrogel electrode patch, used to prepare the hydrogel electrode patch according to any one of the claims, includes the following steps: Step 1: Preparation of temperature-responsive conductive hydrogel adhesion layer: N-isopropylacrylamide and acrylamide monomer are mixed in a mass ratio, and deionized water, electrolyte, crosslinking agent and initiator are added. After stirring and dissolving, the mixture is poured into a mold and polymerized by ultraviolet light irradiation or thermal initiation to form a conductive hydrogel film with temperature response characteristics. The thickness is controlled to be 0.5 mm to 2.0 mm, and the film is fully swollen and balanced at 4°C to obtain a hydrogel adhesion layer. Step 2: Preparation of the substrate layer and conductive electrode composite: A flexible medical film is used as the base layer, and a conductive electrode is set on one of its main surfaces. The conductive electrode is an Ag / AgCl electrode sheet or a conductive coating, which is fixed to the base layer by lamination or printing. Step 3: Constructing the sustained-release cavity structure: A slow-release cavity is provided in the circumferential edge region of another main surface of the base layer. The slow-release cavity includes a first chamber and a second chamber, which respectively encapsulate the basic soothing substance and the functional soothing substance. The cavity is composed of a flexible sealing film or an integrally molded shell. Step 4: Prepare the linkage and connect the sustained-release chamber: A linkage component is prepared, and the fracture control part is connected to the first chamber and the sensing part is connected to the second chamber by hot pressing, ultrasonic welding or bonding; the fracture control part is a tear strip with a preset fracture point. Step 5: Assemble the layers of the patch: The hydrogel adhesive layer prepared in step one is applied to the side of the conductive electrode away from the substrate layer, ensuring that the hydrogel completely covers the electrode and extends slightly beyond the electrode edge to form an adhesive interface that contacts the skin; the sustained-release cavity and linkage constructed in steps three and four are fixed to another main surface of the substrate layer to complete the overall assembly of the patch. Step Six: Packaging and Sterilization The assembled patch is aseptically encapsulated to ensure that the substance in the sustained-release chamber is not released prematurely and that the linkage remains operable, thus obtaining a microstructured hydrogel electrode patch with controllable adhesion and safe detachment functions.

[0022] The beneficial effects of this invention are as follows: The patch uses a flexible film as its base layer, and the combination of conductive electrodes and a hydrogel adhesive layer ensures stable adhesion to the skin and effective acquisition of physiological electrical signals. Based on this, a controllable biphasic substance release mechanism is constructed by setting a sustained-release chamber containing a first chamber and a second chamber in the circumferential edge region of the base layer and introducing a linkage mechanism connected to it. The basic soothing substance encapsulated in the first chamber can be used to soften the stratum corneum and reduce adhesion during the initial application of the patch or before removal, while the functional soothing substance encapsulated in the second chamber can be used to repair specific skin conditions (such as inflammation). By controlling the release of the two chambers through the linkage mechanism, safe removal and skin care functions are integrated into one unit without increasing operational complexity, significantly improving user experience and product medical safety. Attached Figure Description

[0023] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the present invention will be further described below in conjunction with the accompanying drawings and embodiments. The drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort: Figure 1 This is a schematic diagram of the overall structure of the microstructured hydrogel electrode patch that can be safely detached according to an embodiment of this application.

[0024] Figure 2 This is a schematic diagram of the structure of the sustained-release cavity in an embodiment of this application.

[0025] Explanation of reference numerals in the attached drawings: 1. Base layer; 2. Conductive electrode; 3. Hydrogel adhesion layer; 4. Sustained release chamber; 41. First chamber; 42. Second chamber; 5. Linkage component; 51. Fracture control unit; 52. Sensing unit; 6. Protective cover. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, a clear and complete description will be provided below in conjunction with the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the protection scope of the present invention.

[0027] Example 1 Preferred embodiments of the present invention, for example Figures 1 to 2 As shown, a microstructured hydrogel electrode patch that can be safely detached includes a base layer 1, a conductive electrode 2, a hydrogel adhesion layer 3, a sustained-release cavity 4, a linkage 5, and a protective cover 6.

[0028] The substrate 1 is a flexible thin film. The conductive electrode 2 is attached to one main surface of the substrate 1. The hydrogel adhesion layer 3 covers the side of the substrate 1 away from the conductive electrode 2. As an optional embodiment, the substrate 1 is made of medical thermoplastic polyurethane film with a thickness of 0.05 mm to 0.2 mm. The hydrogel adhesion layer 3 can be set as a temperature-responsive conductive hydrogel adhesion layer 3, which is peeled off after the temperature of the hydrogel adhesion layer 3 is raised above a threshold temperature by an external heating medium and the adhesion force decays. The conductive electrode 2 is a silver / silver chloride electrode sheet. The hydrogel adhesion layer 3 is composed of a copolymer network of acrylamide monomers and N-isopropylacrylamide monomers and contains an electrolyte.

[0029] The sustained-release cavity 4 is located on the circumferential edge region of the base layer 1 near the hydrogel adhesion layer 3. The sustained-release cavity 4 is provided with a first chamber 41 and a second chamber 42. The first chamber 41 encapsulates a basic soothing substance, and the second chamber 42 encapsulates a functional soothing substance. As an optional embodiment, the basic soothing substance may be menthol, and the functional soothing substance may be one or more soothing agents selected from aloe vera extract, panthenol, dipotassium glycyrrhizate, and bisabolol, as well as a moisturizer.

[0030] Linkage component 5 is connected to the sustained-release chamber 4. Linkage component 5 is used to drive the sustained-release chamber 4 to release the basic soothing substance and the functional soothing substance. Linkage component 5 includes a break control unit 51 and a sensing unit 52 arranged in parallel. The break control unit 51 is used to control the release of the first chamber 41, and the sensing unit 52 is used to control the release of the second chamber 42.

[0031] The breakage control unit 51 is a tear strip with a preset breakage point. One end of the tear strip is fixed to the base layer 1 and has a free end extending to the outside of the base layer 1. The other end of the tear strip is connected to the side wall of the second chamber 42. The preset breakage point is located on the tear strip near the connection point of the second chamber 42. The tear strip and the second chamber 42 are integrally formed. The extension direction of the free end is the same as the expected tearing direction of the patch. Reinforcing ribs or thickened areas are provided on both sides of the length direction of the tear strip to resist shearing force perpendicular to the length direction. Textures or protrusions that increase friction are provided at the free end for the user to grip.

[0032] The sensing element 52 is attached to the side wall of the second chamber 42, and the sensing element 52 is a polymer film that is sensitive to a specific pH value.

[0033] The protective cover 6 covers and protects the breakage control section 51 during the use of the patch. When it is necessary to remove the patch, the protective cover 6 can be removed first and then the tearing action can be performed to remove the patch from the side of the breakage control section 51. The patch is connected to the base layer 1 by easy-tear lines or weak adhesive.

[0034] When the patch needs to be removed, external heating is applied to the patch to raise the temperature of the hydrogel adhesion layer 3 above its phase transition temperature; a tearing force exceeding a preset threshold is applied to the mechanical linkage structure or the edge of the patch in a direction parallel to the skin surface; the tearing force causes the breakage control part 51 to break, thereby triggering the rupture of the sustained-release cavity 4 and releasing the soothing substance to the skin, while the patch detaches from the skin.

[0035] Example 2 A method for preparing a safe and detachable microstructured hydrogel electrode patch, used to prepare the hydrogel electrode patch of any of the embodiments in Example 1, includes the following steps: Step 1: Preparation of temperature-responsive conductive hydrogel adhesion layer 3: N-isopropylacrylamide and acrylamide monomer were mixed in a mass ratio, and deionized water, electrolyte, crosslinking agent and initiator were added. After stirring and dissolving, the mixture was injected into a mold and polymerized by ultraviolet light irradiation or thermal initiation to form a conductive hydrogel film with temperature response characteristics. The thickness was controlled to be 0.5 mm to 2.0 mm, and the film was fully swollen and balanced at 4°C to obtain hydrogel adhesion layer 3.

[0036] Step 2: Preparation of the composite material of substrate layer 1 and conductive electrode 2: A flexible medical film is used as the substrate layer 1, and a conductive electrode 2 is disposed on one of its main surfaces. The conductive electrode 2 is an Ag / AgCl electrode sheet or a conductive coating, which is fixed to the substrate layer 1 by pressing or printing.

[0037] Step 3: Constructing the sustained-release cavity structure 4: A sustained-release cavity 4 is provided in the circumferential edge region of another main surface of the base layer 1. The sustained-release cavity 4 includes a first chamber 41 and a second chamber 42, which respectively encapsulate the basic soothing substance and the functional soothing substance. The cavity is composed of a flexible sealing film or an integrally molded shell.

[0038] Step 4: Prepare linkage component 5 and connect it to the sustained-release chamber 4: The linkage component 5 is prepared, and the fracture control unit 51 is connected to the first chamber 41 by hot pressing, ultrasonic welding or bonding, and the sensing unit 52 is connected to the second chamber 42; the fracture control unit 51 is a tear strip with a preset fracture point.

[0039] Step 5: Assemble the layers of the patch: The hydrogel adhesion layer 3 prepared in step one is placed on the side of the conductive electrode 2 away from the base layer 1, ensuring that the hydrogel completely covers the electrode and slightly extends beyond the edge of the electrode to form an adhesion interface that contacts the skin; the sustained-release cavity 4 and the linkage 5 constructed in steps three and four are fixed to the other main surface of the base layer 1 to complete the overall assembly of the patch.

[0040] Step Six: Packaging and Sterilization The assembled patch is aseptically encapsulated to ensure that the substance in the sustained-release chamber 4 is not released prematurely and that the linkage 5 remains in an operable state, thus obtaining a microstructured hydrogel electrode patch with controllable adhesion and safe detachment functions.

[0041] It should be understood that those skilled in the art can make improvements or modifications based on the above description, and all such improvements and modifications should fall within the protection scope of the appended claims.

Claims

1. A microstructured hydrogel electrode patch with safe detachment, comprising a flexible thin-film substrate (1), a conductive electrode (2) attached to a main surface of the substrate (1), and a hydrogel adhesion layer (3) covering the conductive electrode (2) away from the substrate (1); characterized in that, It also includes a sustained-release chamber (4) and a linkage (5). The sustained-release chamber (4) is located in the circumferential edge region of another main surface of the base layer (1). The sustained-release chamber (4) is provided with a first chamber (41) and a second chamber (42). The first chamber (41) contains a basic soothing substance, and the second chamber (42) contains a functional soothing substance. The linkage (5) is connected to the sustained-release chamber (4), and the linkage (5) is used to drive the sustained-release chamber (4) to release basic soothing substances and functional soothing substances.

2. The microstructured hydrogel electrode patch with safe detachment according to claim 1, characterized in that, The linkage (5) includes a fracture control unit (51) and a sensing unit (52) arranged in parallel. The fracture control unit (51) is used to control the release of the first chamber (41), and the sensing unit (52) is used to control the release of the second chamber (42).

3. The microstructured hydrogel electrode patch with safe detachment according to claim 2, characterized in that, The sensing element (52) is attached to the side wall of the second chamber (42), and the sensing element (52) is a polymer film that is sensitive to a specific pH range.

4. The microstructured hydrogel electrode patch with safe detachment according to claim 2, characterized in that, The fracture control unit (51) is a tear strip with a preset fracture point. One end of the tear strip is fixed to the base layer (1), and the other end of the tear strip is connected to the side wall of the second chamber (42). The preset fracture point is located on the tear strip near the connection of the second chamber (42). The tear strip is integrally formed with the second chamber (42), and the extension direction of the tear strip is the same as the expected tearing direction of the patch.

5. The microstructured hydrogel electrode patch with safe detachment according to claim 2, characterized in that, The linkage (5) also includes a removable protective cover (6), which covers the linkage (5) and the base layer (1), and the protective cover (6) is used to protect the linkage (5).

6. The microstructured hydrogel electrode patch with safe detachment according to claim 5, characterized in that, The protective cover (6) is attached to the side of the fracture control part (51) and the base layer (1).

7. The microstructured hydrogel electrode patch with safe detachment according to claim 2, characterized in that, The sustained-release cavity (4) is a closed cavity formed by a flexible sealing film, and the fracture control part (51) is integrally connected to the shell of the closed cavity; the sustained-release cavity (4) is capsule-shaped, ring-shaped, strip-shaped or sheet-shaped.

8. A method for preparing a safe-detachable microstructured hydrogel electrode patch, used to prepare the hydrogel electrode patch as described in any one of claims 1-7, characterized in that, Includes the following steps: Step 1: Preparation of temperature-responsive conductive hydrogel adhesion layer: N-isopropylacrylamide and acrylamide monomer were mixed in a mass ratio, and deionized water, electrolyte, crosslinking agent and initiator were added. After stirring and dissolving, the mixture was injected into a mold and polymerized by ultraviolet light irradiation or thermal initiation to form a conductive hydrogel film with temperature response characteristics. The thickness was controlled to be 0.5 mm to 2.0 mm, and the film was fully swollen and balanced at 4°C to obtain a hydrogel adhesion layer (3). Step 2: Preparation of the substrate layer and conductive electrode composite: A flexible medical film is used as the base layer (1), and a conductive electrode (2) is set on one of its main surfaces. The conductive electrode (2) is an Ag / AgCl electrode sheet or a conductive coating, which is fixed on the base layer (1) by pressing or printing. Step 3: Constructing the sustained-release cavity structure: A slow-release cavity (4) is provided in the circumferential edge region of another main surface of the base layer (1). The slow-release cavity (4) includes a first chamber (41) and a second chamber (42), which respectively encapsulate the basic soothing substance and the functional soothing substance. The cavity is composed of a flexible sealing film or an integrally molded shell. Step 4: Prepare the linkage and connect the sustained-release chamber: Prepare a linkage component (5), and connect the fracture control part (51) to the first chamber (41) by hot pressing, ultrasonic welding or bonding, and connect the sensing part (52) to the second chamber (42); the fracture control part (51) is a tear strip with a preset fracture point; Step 5: Assemble the layers of the patch: The hydrogel adhesive layer (3) prepared in step one is covered on the side of the conductive electrode (2) away from the base layer (1), ensuring that the hydrogel completely covers the electrode and slightly extends beyond the edge of the electrode to form an adhesive interface that contacts the skin; the sustained-release cavity (4) and linkage (5) constructed in steps three and four are fixed to the other main surface of the base layer (1) to complete the overall assembly of the patch. Step Six: Packaging and Sterilization The assembled patch is aseptically packaged to ensure that the substance in the sustained-release chamber (4) is not released in advance and the linkage (5) remains in an operable state, thus obtaining a microstructured hydrogel electrode patch with controllable adhesion and safe detachment function.

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