Wine stewed dogwood oligosaccharide as well as preparation method and application thereof

By developing a method for preparing oligosaccharides from Cornus officinalis stewed in wine, the problems of inconsistent processing standards for Cornus officinalis and potential safety concerns regarding drugs used to treat type 2 diabetes have been resolved. This method produces highly active oligosaccharides that significantly improve insulin resistance and provide a new treatment option for type 2 diabetes.

CN122444795APending Publication Date: 2026-07-24HEBEI UNIVERSITY
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Patent Information

Application Number
CN202610605351.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-06
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

The existing processing standards for Cornus officinalis are not uniform, and the effects of active ingredients are unclear. There are potential safety risks and drug resistance risks in drugs for the treatment of type 2 diabetes. Existing drugs such as metformin hydrochloride, glimepiride, and acarbose have side effects or are inconvenient to use.

Method used

The preparation method of oligosaccharides from Cornus officinalis stewed in rice wine includes steps such as soaking in rice wine, stewing, extraction with anhydrous ethanol, water bath heating, filtration and freeze drying. Highly active oligosaccharides were prepared, and the material basis for the enhanced efficacy of the processing method was identified as the oligosaccharide fraction.

Benefits of technology

The oligosaccharide of Cornus officinalis stewed in wine significantly improves insulin resistance, with effects comparable to metformin hydrochloride. It is a natural product with no risk of hypoglycemia, providing a new candidate drug for the treatment of type 2 diabetes and improving the standardization of traditional Chinese medicine processing.

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Abstract

The invention relates to the technical field of traditional Chinese medicine processing, in particular to wine stewed dogwood oligosaccharide and a preparation method and application thereof. The preparation method comprises the following steps: moistening dogwood with yellow wine, stewing in a water-isolated manner, degreasing, extracting with water, removing protein, decolorizing and purifying to obtain a total sugar extract, and carrying out alcohol precipitation grading and freeze drying to obtain the wine stewed dogwood oligosaccharide. Experimental results show that the ratio of the oligosaccharide in the total sugar of the dogwood can be remarkably increased through the wine stewing process, the insulin resistance state of IR-HepG2 cells can be remarkably improved through the obtained oligosaccharide, and the effect is equivalent to that of metformin hydrochloride. The invention also discloses an application of the oligosaccharide in preparation of drugs for improving insulin resistance and treating type 2 diabetes mellitus.
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