A synergistic pesticidal composition

Abstract

A synergistic insecticidal composition comprising (A) isothiazolyl amide; (B) one insecticide selected from the group consisting of chlorantraniliprole, cyantraniliprole, cyclaniliprole, tetraniliprole, pyridalyl, pymetrozine, chlorfenapyr, sulfoxaflor, flubrocythrinate, sulfoxaflor; and (C) one or more insecticides selected from the given list. The invention also relates to a process for the preparation of said composition in specific amounts. The invention also relates to a process for the preparation of said composition together with at least one formulation excipient, and to the formulation of said composition. The invention also relates to a synergistic composition, wherein the active ingredients present in fixed amounts exhibit a synergistic effect in terms of insecticidal activity.

Description

Technical Field

[0001] This invention relates to a synergistic insecticidal composition comprising (A) isoxazolam; (B) at least one insecticidal compound selected from chlorantraniliprole, bromonitrile acetamiprid, cyclobromhizometrid, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, chlorfluazuron, flubendiamide, flufenoxuron, and thiophanate-methyl; and (C) at least one other insecticide. The invention also relates to a method for preparing the composition together with at least one inactive excipient, and to formulations thereof. Background Technology

[0002] Combinations of insecticides and isoxaflutole are used to broaden the control spectrum against pests and mites, improving pest control through synergistic effects, reducing dosage and thus environmental impact, decreasing the likelihood of resistance development, and enhancing sustained control, thereby reducing the number of sprays for crop protection and minimizing pesticide loads in the ecosystem. Combinations of insecticides and isoxaflutole sometimes exhibit additive or synergistic effects, resulting in improved control of pests and mites.

[0003] Many combinations of isoxazolidinamide with other insecticides are known in the art for the control of pests. For example, WO2022018745A1 relates to a synergistic agricultural composition in which active ingredients present in a fixed ratio exhibit a synergistic effect in insecticidal activity, the agricultural composition comprising (A) a diamide insecticide, such as brofenoxuron, chlorantraniliprole, brofenoxuron, cyclobromin, chlorfluazuron, cyprofenoflavone, flubendiamide, tetrachlorantraniliprole, pyrimethanil, tetrazolium, fluoxazolidinamide, or isoxazolidinamide, and mixtures thereof; (B) one or more plant health additive compounds, such as chitosan, chitin, humic acid, potassium polysaccharide, jasmonic acid (methyl jasmonic acid), silicon compounds-silicic acid (H2SiO3), and mixtures thereof; and (C) another insecticide, such as a carbamate acetylcholinesterase inhibitor, an organophosphate acetylcholinesterase inhibitor, or a GABA-gated chloride channel antagonist.

[0004] CA3199551A1 relates to a composition comprising isoxazolidinone. The composition comprises: (a) isoxazolidinone, (b) a polyoxyethylene copolymer, (c) an acrylic acid graft copolymer, and (d) an oxygenated hydrocarbon compound. More specifically, the invention relates to grinding matrices, or to formulations such as suspension concentrates (SC), fluid suspensions (FS), emulsions (SE), suspension-microcapsule suspension blends (ZC), ready-to-use baits (RB), water-soluble granules (SG), water-dispersible granules (WG), and water-dispersible tablets (WT), to diluents or dispersions of these formulations, more specifically to diluents or dispersions in a farmer's spray can; and to the use of such compositions in combating and / or controlling animal pests.

[0005] WO2022207887A1 relates to a bait composition comprising an insecticidally effective amount of isoxazolidinone and bait material comprising insect food attractants and / or insect food flavorings. Furthermore, the present invention relates to a method for controlling pests or pest populations, the method comprising applying an insecticidally effective amount of the bait composition to a location or environment where insect activity is known or likely to occur.

[0006] US20230292757A1 relates to a synergistic insecticidal composition comprising a bioactive amount of (A) at least one insecticide selected from diamides, m-diamides, isoxazolines, isoxazoline, or mixtures thereof; (B) at least one plant growth regulator or mixture thereof; and (C) at least one other insecticide from a variety of classes or mixtures thereof. The invention also relates to a method for preparing the composition together with at least one inactive excipient, and to formulations thereof.

[0007] WO2023282140A1 relates to a composition with excellent pest control efficacy and a method for pest control. The composition comprises at least one pest control compound selected from group (A), at least one pest control compound selected from group (B), and at least one pest control compound selected from group (C), in a weight ratio of 1:1000:1000 to 1:0.001:0.001. Groups (A), (B), and (C) are as follows: Group (A): composed of bromuconazole, nicotinamide, fluoxazolamide, and isoxazolamide; Group (B): composed of propargite and cypermethrin; Group (C): composed of permethrin, cypermethrin, deltamethrin, fenvalerate, deltamethrin, and cyhalothrin.

[0008] CN110250186A relates to an invention that discloses a synergistic pesticide composition containing pyridinequinazoline. The composition comprises active components A and B, wherein A is selected from pyridinequinazoline, and B is selected from fatty acids, chlorpyrifos, pyrimethanil, tetrazolium, dichlorvos, pyraclostrobin, methoxypiperazine, cyclopyridazine, isoxaflutole, spinosad, and flupyrflufenone. The composition includes common adjuvants, active components A and B, and A and B, when combined in a certain proportion, have a synergistic effect on the target, making it suitable for controlling agricultural pests, especially whiteflies and aphids.

[0009] However, there is still a need for improvement in these compositions. Prolonged use of single-active-ingredient compositions has led to resistance. With the emergence of resistance in certain pests, there is a need in the art for an active-ingredient composition that can reduce the likelihood of resistance development and improve the control spectrum against pests and mites.

[0010] The present invention also relates to a method for preparing the composition together with at least one inactive formulation excipient and to formulations thereof, the method overcoming some existing problems and being readily prepared without requiring highly complex preparation methods.

[0011] In general applications, insecticide active ingredients are used in diluted aqueous compositions to achieve good interaction with target organisms. However, most active insecticide compounds used as pesticides are only slightly soluble in water or even insoluble in water. This low solubility presents a challenge for formulation engineers: how to formulate pesticide compounds into stable formulations that can be stored stably for extended periods while maintaining high stability and efficacy before use. This problem is particularly prone to occur and can be exacerbated if the composition contains more than one active compound.

[0012] Therefore, one object of the present invention is to provide an improved composition of an insecticide and isoxaflutole for the control of pests and mites. Another object of the present invention is to provide a method and composition for the control of pests and mites.

[0013] Another object of the present invention is to provide an improved composition of an insecticide and isoxazoline, which can enhance insecticidal activity and increase plant or crop yield.

[0014] Another object of the present invention is to provide a method for preparing a stable and non-phytotoxic formulation.

[0015] The embodiments of the present invention can improve one or more of the above-mentioned problems.

[0016] The inventors of this invention have unexpectedly discovered that an insecticidal composition consisting of isoxaflutole, an insecticide selected from chlorantraniliprole, bromonitrile acetamiprid, cyclobromhizometrid, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, chlorfluazuron, flubendiamide, flufenoxuron, chlorantraniliprole, and thiofenoxuron; and another insecticide selected from the group thereof, exhibits a synergistic effect. This invention also relates to a method for preparing the composition together with at least one inactive excipient, as described above, and to formulations thereof, which provide a solution to the aforementioned problems. Summary of the Invention

[0017] Therefore, one aspect of the present invention provides an insecticidal composition comprising a bioactive amount of (A) isoxazolam; (B) at least one insecticide selected from chlorantraniliprole, bromonitrile acetamiprid, cyclobromhizosinamide, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, chlorfluazuron, flubendiamide, fluchlorfenapyr, and thiophanate-methyl; and (C) at least one other insecticide.

[0018] Another aspect of the invention provides a synergistic composition comprising (A) isoxazolam; (B) at least one insecticide selected from chlorantraniliprole, bromonitrile acetamiprid, cyclobromhizosinamide, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, chlorfluazuron, flubendiamide, fluchlorfenapyr, and thiophanate-methyl; and (C) at least one compound selected from the group of insecticides.

[0019] The insecticidal compound (C) is selected from the following group: (1) selected from carbamates (AChE-acetylcholinesterase inhibitors): carbaryl, carbofuran, thiocarbamate, sec-butylcarbamate, methomyl, chlorpyrifos, pirimicarb, thiamethoxam; (2) selected from organophosphates (AChE-acetylcholinesterase inhibitors): acephate, thion, chlorpyrifos, methyl chlorpyrifos, methyl demeton-methyl, dimethoate, ethion, fenpyrophos, fenitrothion, fenthion, thiamethoxam, methamidophos, phorate, sulfonylurea, parathion, methyl parathion, phorate, phorate, phosmet, fenpyrophos, fenpyrophos, quinalphos, triazophos; (3) selected from phenylpyrazole-flufenicol (GABA-gated chloride channel blockers): acetamiprid, fipronil, tebufenozide, fenpyroxene. Amide, pyrazosulfuron, pyrazosulfuron; (4) Selected from meta-bisamides and isoxazolines (GABA-gated chloride channel allosteric modulators): meta-bisamides - bromoxynil, cyprofen; isoxazolines - fluoxazolamide, afralanar, essolana, fleraranar, loteranar, saloranar; (5) Selected from pyrethroids (sodium channel modulators): bifenthrin, cypermethrin, β-cypermethrin, cypermethrin, λ-cypermethrin, γ-cypermethrin, cypermethrin, α-cypermethrin, β-cypermethrin, θ-cypermethrin, ζ-cypermethrin, deltamethrin, cypermethrin, fenvalerate, τ-cypermethrin, permethrin, fenvalerate, acetamiprid, propargyl, propargyl 1. Pyrethroids (pyrethrum); (6) Selected from neonicotinoid insecticides (competitive regulators of nicotinic acetylcholine receptors (nAChR): acetamiprid, thiamethoxam, fipronil, imidacloprid, acetamiprid, thiamethoxam, flufenoxuron, epoxuron, piperazine, pendimethalin, epoxuron; sulfoxides - flupyridine; butenolates - flupyrflufenone; metronidazoles - trifluralin, dichlorvos, dithiazolinone; (7) Selected from nereistoxin analogs (nicotinic acetylcholine receptor (nAChR) channel blockers): chlorfenapyr, chlorfenapyr mononitrate, chlorfenapyr hydrochloride, chlorfenapyr ring, chlorfenapyr oxalate, chlorfenapyr hydrochloride, chlorfenapyr dichlorvos; (8) Selected from spinosads (nicotinic acetylcholine receptor (nAChR) allosteric compounds (9) Selected from avermectin and milbemycin (glutamate-gated chloride channel (GluCl) allosteric regulators): avermectin-avermectin, emamectin benzoate, ivermectin, rapamectin; milbemycin-milbemycin; (10) Selected from juvenile hormone analogs: acetamiprid, acetamiprid, acetamiprid, dioxane, pyriproxyfen; (11) Selected from non-specific multisite inhibitors: chloropicrin, dazomet, fenpropathrin; (12) Selected from string organ regulators: pymetrozine, flufenoxuron, difenoconazole, flonicamid; (13) Selected from mite growth inhibitors affecting CHS1: tetradifon, thiamethoxam, flufenoxuron or etoxazole;(14) Selected from benzoylurea (inhibitors of chitin biosynthesis affecting CHS1): bis(triflufenoxuron), flufenoxuron, diflubenzuron, flucyclobenzuron, flufenoxuron, flufenoxuron, lufenuron, diphenylfluorourea, polyfluorourea, flufenoxuron, chlorfenapyr; (15) Selected from thiamethoxam (type 1 chitin biosynthesis inhibitors): thiamethoxam; (16) Selected from cyclopropamine (molting interference agents for dipteran insects): cyclopropamine; (17) Selected from insect midgut membrane microbial disruptors: Bacillus thuringiensis (; Bacillus thuringiensis (18) Selected from oxidative phosphorylation uncoupling agents: chlorfenapyr, DNOC or fipronil; (19) Selected from dihydrazides (ecdysone receptor agonists): dihydrazides - methoxyfenozide, tebufenozide, chlorfenapyr, furazolidone or cyclotebufenozide; (20) Selected from octopamine receptor agonists: amitraz; (21) Selected from mitochondrial ATP synthase inhibitors: bufenozide, triazole tin, tricyclic tin, phenbutyltin, propargite or triazole tin (22) Selected from METI (mitochondrial complex I) inhibitors: quinclorac, azoxystrobin, pyrimethanil, pyridaben, pyrimethanil, rotenone, pyrimethanil, pyrimethanil; (23) Selected from METI (mitochondrial complex II) inhibitors: cyprodinil, fenfluroxyfen, pyrimethanil; (24) Selected from METI (mitochondrial complex III) inhibitors: flufenoxuron, fenfluroxyfen, pyrimethanil, bifenazate, flufenoxuron Toquine; (25) Selected from METI (mitochondrial complex IV) inhibitors: phosphides and cyanides; (26) Selected from voltage-dependent sodium channel blockers: indoxacarb, cyfluthrin; (27) Selected from lipid synthesis inhibitors (acetyl-CoA carboxylase inhibitors): spirodiclofen, spirodiclofen, spirotetramat, spirotetramat, methoxypiperidine, spirodiclofen diester; (28) Selected from baculoviruses: granuloviruses and nucleopolyhedroviruses; (29) Selected from calcium-activated potassium channel (KCa2) regulators: flufenoxuron; (30) compounds with unknown or uncertain mechanisms of action: azadirachtin, bensulfuron, bromopropylate, pyrimethanil, fenpyroxane, trichlorfon, acetamiprid, oxazolidinyl sulfadiazine, fenpyroxonamide, indoxonamide, flufenoxuron, etoxonil, flufenoxuron thiophanate, flufenoxuron, trifluralin, triflupyridine, trifluralinamide, thiazoxafen, thiofluridine, thiofluridine, ledprona.

[0020] Therefore, in another aspect, the present invention provides a method for protecting plant propagation material, plants, plant parts and / or later-growing plant organs from pests, the method being achieved by applying a composition comprising the insecticidal composition described in the first aspect to the plant propagation material.

[0021] According to one embodiment, the formulation of the composition is selected from microcapsule suspensions (CS), dispersible liquids (DC), emulsifiable concentrates (EC), water-in-oil emulsions (EO), oil-in-water emulsions (EW), Jambo spheres or bags (bags in water-soluble sachets), microemulsions (ME), oil dispersants (OD), oil miscible flow concentrates (oil suspensions (OF)), oils (OL), suspensions (SC), emulsions (SE), soluble concentrates (SL), wettable granules / water-dispersible granules (WG / WDG), water-soluble granules (SG), water-soluble powders (SP), wettable powders (WP), mixtures of CS and SC (ZC), mixtures of CS and SE (ZE), mixtures of CS and EW (ZW), granules (GR) / soil-applied granules (SAG), and controlled-release granules (CR).

[0022] The remainder of the aqueous formulation is preferably entirely water, but may also contain other materials, such as inorganic salts. The formulation is preferably completely free of organic solvents.

[0023] Therefore, in a first aspect, the present invention provides a synergistic composition comprising (A) isoxazolam; (B) at least one insecticide selected from chlorantraniliprole, bromonitrile acetamiprid, cyclobromhizosinamide, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, chlorfluazuron, flubendiamide, fluchlorfenapyr, and thiophanate-methyl; and (C) at least one other insecticide. Detailed Implementation

[0024] Therefore, one aspect of the present invention provides a composition comprising: (A) isoxazolam; (B) at least one insecticide selected from chlorantraniliprole, bromonitrile acetamiprid, cyclobromhizoprospora, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, chlorfluazuron, flubendiamide, fluchlorfenapyr, and thiophanate-methyl; and (C) at least one other insecticide.

[0025] In one embodiment of the present invention, the insecticide of compound (C) is selected from the group consisting of: (1) carbamates (AChE-acetylcholinesterase inhibitors): carbaryl, carbofuran, thiocarbofuran, sec-butylcarbide, methomyl, chlorpyrifos, pirimicarb, thiamethoxam; (2) organophosphates (AChE-acetylcholinesterase inhibitors): acephate, thion, chlorpyrifos, methyl chlorpyrifos, methyl demeton-methyl, dimethoate, ethion, fenpyrophos, fenitrothion, fenthion, thiamethoxam, methamidophos, phorate, methyl parathion, phorate, phorate, phosphamidon, phosmet, fenpyrophos, phosphamidon, phosmet, phosphamidon, fenpyrophos, triazophos; (3) phenylpyrazole-flufenoxam (GABA-gated chlorides) (4) Selected from meta-diamides and isoxazoline derivatives (GABA-gated chloride channel allosteric modulators): meta-diamides - bromoxynil, cyprodinil; isoxazoline derivatives - fluoxazolamide, afralanar, essolana, fleraranar, lotelanar, saloranarar; (5) Selected from pyrethroids (sodium channel modulators): bifenthrin, cypermethrin, β-cypermethrin, cypermethrin, λ-cypermethrin, γ-cypermethrin, cypermethrin, α-cypermethrin, β-cypermethrin, θ-cypermethrin, ζ-cypermethrin, fenpyrocyanide, deltamethrin, cypermethrin, cypermethrin, fenvalerate. Pyrethroids, flufenacetate, permethrin, fenpyrethrin, propargite, pyrethrin (pyrethrum); (6) Selected from neonicotinoid insecticides (nicotinoid acetylcholine receptor (nAChR) competitive modulators): acetamiprid, thiamethoxam, dinotefuran, imidacloprid, acetamiprid, thiamethoxam, fipronil, epoxim, pipemidone, pendimethalin, epoxim; sulfoxides - flupyridine; butenolates - flupyrflufenoxuron; metronidazoles - trifluorophenylpyrimidine, dichlorvos, dithiazoxazine; (7) Selected from nereistoxin analogs (nicotinoid acetylcholine receptor (nAChR) channel blockers): chlorfenapyr, chlorfenapyr, pyridaben hydrochloride, chlorfenapyr ring, chlorfenapyr oxalate, chlorfenapyr hydrochloride, (8) Selected from spinosads (nicotinic acetylcholine receptor (nAChR) allosteric modulators - site I): spinosad, ethyl spinosad; (9) Selected from avermectins and milbemycins (glutamate-gated chloride channel (GluCl) allosteric modulators): avermectins - avermectin, emamectin benzoate, ivermectin, rapamectin; milbemycins - milbemycin; (10) Selected from juvenile hormone analogs: tebufenozide, tebufenozide, tebufenozide, dioxane, pyriproxyfen; (11) Selected from non-specific multisite inhibitors: chloropicrin, dazomet, fenpropathrin; (12) Selected from string organ modulators: pymetrozine, flufenoxuron, difenoconazole, flonicamid;(13) Selected from mite growth inhibitors affecting CHS1: tetradifon, thiamethoxam, flufenoxuron, or etoxazole; (14) Selected from benzoylurea (chitin biosynthesis inhibitors affecting CHS1): bis(triflufenoxuron), flufenoxuron, diflubenzuron, flucyclobenzuron, flufenoxuron, flufenoxuron, lufenuron, diphenylfluorourea, polyfluorourea, flufenoxuron, chlorfenapyr; (15) Selected from thiamethoxam (type 1 chitin biosynthesis inhibitors): thiamethoxam; (16) Selected from cyproheptadine (dipteran insect molting interference agents): cyproheptadine; (17) Selected from insect midgut membrane microbial disruptors: Bacillus thuringiensis and its products Insecticidal proteins; (18) selected from oxidative phosphorylation uncoupling agents: chlorfenapyr, DNOC or fipronil; (19) selected from dihydrazides (ecdysone receptor agonists): dihydrazides - methoxyfenozide, chlorfenapyr, chlorfenapyr, furazolidone, cyclofenozide; (20) selected from octopamine receptor agonists: amitraz; (21) selected from mitochondrial ATP synthase inhibitors: bufenozide, triazotin, tricyclic tin, fenbutatin, propargite or trichlorfon; (22) selected from METI (mitochondrial complex I) inhibitors: quinfenozide, azoxystrobin, pyrimethanil, pyridaben, pyridaben, pyrimethanil, pyrimethanil, pyrimethanil (23) Selected from METI (mitochondrial complex II) inhibitors: cypermethrin, fenfluroxyfen, pyrimethanil; (24) Selected from METI (mitochondrial complex III) inhibitors: flufenoxuron, fenfluroxyfen, pyrimethanil, bifenazate, flumettoquinone; (25) Selected from METI (mitochondrial complex IV) inhibitors: phosphides and cyanides; (26) Selected from voltage-dependent sodium channel blockers: indoxacarb, cyfluthrin; (27) Selected from lipid synthesis inhibitors (acetyl-CoA carboxylase inhibitors): spirodiclofen, spirodiclofen, spirodiclofen Ethyl methoxyfenozide, spirodiclofen, methoxyfenozide, spirodiclofen diester; (28) selected from baculoviruses: granuloviruses and nucleopolyhedroviruses; (29) selected from calcium-activated potassium channel (KCa2) regulators: flufenoxuron; (30) compounds with unknown or uncertain mechanisms of action: azadirachtin, benzalkonium chloride, bromodifenozide, pyrimethanil, fenpyroximate, trichlorfon, acetamiprid, oxazolidinyl sulfadiazine, fenazate, indoxacin, flufenoxuron, etoxacin, flufenoxuron sulfadiazine, flufenoxuron, trifluralin, triflupyridine, trifluralinamide, thiazoxafen, thioflurperidone, ledprona.

[0026] Isoxazolidinone is an isoxazoline insecticide and acaricide active against Lepidoptera, Hemiptera, Coleoptera, Thysanoptera, and Diptera pests. Isoxazolidinone selectively targets the Rdl GABA receptor in invertebrates, a site of action distinct from fipronil and organochlorine insecticides. The widely distributed cyclodiene resistance mutant A301S does not affect susceptibility to isoxazolidinone, either in vitro or in vivo, indicating its suitability for controlling pests with this resistance mechanism. Isoxazolidinone is a diastereomer mixture containing 80% to 100% of the (4R,5S)- isomer and 0% to 20% of the (4R,5R)-, (4S,5R)-, and (4S,5S)- isomers. It is a broad-spectrum insecticide and acaricide developed by Syngenta Crop Protection, active against a variety of pests, including Lepidoptera, Hemiptera, and Diptera. Its functions include that of an insecticide, acaricide, GABA-gated chloride channel antagonist, and agrochemical. It comprises (4R,5S)-isoxazolide, (4R,5R)-isoxazolide, (4S,5R)-isoxazolide, and (4S,5S)-isoxazolide. The IUPAC name for isoxazolidinamide is 4-[5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazolide-3-yl]-N-(2-ethyl-3-oxoisoxazolide-4-yl)-2-methylbenzamide.

[0027] Bromnipotent is a ryanodine-based insecticide, specifically a diamide insecticide. Its IUPAC name is 4-bromo-1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-1H-pyrazole-5-carboxamide.

[0028] The inventors believe that the combination of the present invention unexpectedly produces a synergistic effect. The combination of the present invention provides broad-spectrum control of insects, pests, and mites. It also provides sustained control, i.e., a longer duration of control, thereby reducing the number of applications. The broad-spectrum nature of the combination of the present invention also provides a solution for preventing the development of resistance.

[0029] Synergistic compositions of specific active ingredients possess the unique advantage of high activity against pests and mites. The inventors believe that the combinations of the present invention unexpectedly produce a synergistic effect. The combinations of the present invention provide broad-spectrum pest control. This broad-spectrum nature of the combinations also offers a solution for preventing the development of resistance.

[0030] The synergistic composition has highly advantageous insecticidal properties for protecting cultivated plants from pests and mites. As described above, the active ingredient composition can be used to inhibit or kill pests and mites appearing on plants or parts of various crops or useful plants, while also protecting later-growing plant parts from such pests and mites.

[0031] Synergistic compositions of insecticides are used to protect crops and plants from pests and mites. A list of major crops includes, but is not limited to: cotton (…). Gossypium spp. ), rice ( White rice ),wheat( Wheat summer ),barley( Barley ),corn( Corn ), sorghum ( Sorghum bicolor ),oat( Oats ), Pearl Millet ( Pennisetum glaucus ),sugar cane( Sugarcane ),beet( Beetroot ), soybeans Glycine max ), groundnut / peanut ( Peanut ),sunflower( Sunflower ),mustard( Brassica juncea ), rapeseed ( Brassica napus ),Sesame( Sesame indigo ),green beans( Radiant vine ), black beans ( I am milking the vineyard. ), chickpeas ( Chickpea ),cowpea( Unguiculata vine ), pigeon pea ( Cajanus cajanus ),kidney bean( Common bean ), lentils ( Lablab purple ), horse beans ( Macrotyloma uniflorum ),pea( Pea ), guar beans ( Cyamopsis tetragonal lobe ), lentils ( Culinary lens ),eggplant( Solanum aubergine ),cabbage( Brassica oleracea var. capitata ),brocoli( Brassica oleracea var. botrytis Okra Abelmoschus esculentus ),onion( Allium cepa L. ),tomato( Solanum lycopersicum ),potato( Solanum tuberosum ),sweet potato( Sweet potato ),chili( Capsicum annum ), bell peppers ( Capsicum annum ),garlic( Allium sativum ),cucumber( Cucumber ),melon( Cucumber with melon ),watermelon( Citrullus woolly ),gourd( Lagenaria siceraria ),Momordica charantia( Momordica charantia charity ),radish( Radish ),carrot( Dacus carrot subsp. sativus ),turnip( Brassica turnip turnip ),apple( Domestic badger ),banana( Musa spp. ),Tangerine( Citrus spp. ),Grape( Wine grapevine guava ( Psidium guajava ),mango( Mangosteen ),pawpaw( Papaya ),Pineapple( Pineapple is delicious. ),Pomegranate( Pomegranate ), sapodilla ( Manilkara sapote ),Tea( Camellia sinensis ),coffee( Arabica coffee ),turmeric( Curcuma longa ), ginger ( Ginger officinalis ),cumin( Cumin, cumin ), black pepper ( Black pepper ),Mint( Mint spp. ),Rose( Rosa spp. ), Jasmine ( Jasminum spp. ),marigold( Marigolds spp. ),daisy( Wars perennial ), Dahlia ( Dahlia hortensia ), Gerbera ( Gerbera jamesonii Carnation ( Carnation carnation GMO (genetically modified organism) and non-GMO traits, hybrids and conventional varieties.

[0032] Crops should be understood to also include those crops that have been made tolerant to herbicides or herbicide classes (e.g., ALS-, GS-, EPSPS-, PPO-, ACCase-, and HPPD inhibitors) through conventional breeding methods or genetic engineering. An example of a crop that has been made tolerant to imidazolinones (e.g., methoxyfenozide) through conventional breeding methods is Clearfield® canola. Examples of crops that have been made tolerant to herbicides through genetic engineering include, for example, commercially available glyphosate-resistant and glufosinate-resistant maize varieties.

[0033] Crops should also be understood as those that have been genetically engineered to be resistant to harmful insects, such as Bt corn (resistant to the European corn borer), Bt cotton (resistant to the boll weevil), and Bt potatoes (resistant to the Colorado beetle). Bt corn is an example. Bt toxin is produced by the soil bacterium Bacillus thuringiensis (Bt). Bacillus Thuringian Naturally occurring proteins. Examples of genetically modified plants include plants containing one or more genes encoding insecticidal resistance and expressing one or more toxins. Plant crops or their seed material can be resistant to both herbicides and insect predation (“superimposed” transgenic events). For example, seeds can have the ability to express the insecticidal Cry3 protein while also being resistant to glyphosate.

[0034] Crops should also be understood to include those obtained through conventional breeding or genetic engineering methods and that contain so-called productive traits (such as improved storage stability, higher nutritional value, and improved flavor).

[0035] Other useful plants include lawn grasses, such as those used on golf courses, lawns, parks, and roadsides, or commercially grown for turfgrass, as well as ornamental plants such as flowers or shrubs.

[0036] The compositions of the present invention are used to control the following major pests and plant parasitic mites that infest crops.

[0037] The main pests belong to the order Hemiptera (Hemiptera) Hemiptera ), for example, the rice leafhopper / green leafhopper (GLH) ( Nephotettix painted black ), brown planthopper (BPH) Nilaparvata mourns. ), rice back planthopper (WBPH) Sogatella fork-bearer Apple mealybug ( Phenococcus aceris ), bean aphids ( Bean aphid ), orange black aphid ( Toxoptera orange ), Citrus black scale ( Saissetia olives ), cabbage aphid ( Brassica oleracea Radish aphid ( Lipaphis erysimi ), Citrus red scale ( Aonidiella aurantii ), Yellow round scale ( Aonidiella lemon ), citrus mealybug ( Planococcus citri ), corn aphids ( Rhopalosiphum maidis ), cotton aphids ( Aphid gossip ), cotton leafhopper ( Amrasca biguttula biguttla ), genus Mealybug ( Planococcus spp. and Pseudococcus spp. ), cotton red bug ( Dysdercus suturellus ), whiteflies ( Bemisia tabaci ), cowpea aphid ( Aphis crassivora ), wheat aphid ( Sitobion oat ), Aphid genus ( Uroleucon spp. Grape mealybug ( Pseudococcus maritimus ), Peach aphid ( Myzus persica Greenhouse whiteflies ( Trialeurodes vaporizers Papaya mealybug ( Red-crowned crane ), pea aphid ( Acyrthosiphon pea Sugarcane mealybug ( Saccharicoccus sacchari ), potato aphid ( Myzus persica ), potato leafhopper ( Empoasca beans ), cotton whitefly ( Bemisia tabaci ), pasture mirid bug ( Lygus lineolaris Apple woolly aphid ( Eriosoma woolen Mango leafhopper ( Amritodus atkinsoni ), genus *Platybeak* ( Idioscopus spp. ); Lepidoptera ( Lepidoptera ), slime bugs ( Mythimna unipuncta ), stem borer ( Chilo suppressalis ), Bean pod borer ( Glazed maruca ), beet armyworm ( Spodoptera small ), small cutworm ( Agrotis ipsilon ), cotton bollworm ( Helicoverpa armigera ), Powdered Noctuid moth ( Trichoplusia ni Apple codling moth ( Cydia pomonella ), castor bean moth ( Achaea janata Diamondback moth ( Plutella xylostella ),cabbage butterfly( Pieris turnips ), pink bollworm ( Pectinophora gossypiella ), sugarcane borer ( Diatraea saccharalis ), sugarcane two-spotted stem borer ( Kilo little black box ), tobacco shoot moth ( Heliothis virescens ), corn ear worm ( Helicoverpa zea ), soybean noctuid moth ( Anticarsia gemmatalis ), rice stem borer ( Scirpophaga incertulas ), Jadeite Diamond ( Airy calf ), rice leaf roller ( Cnaphalocrocis medinalis ), genus *Malus* ( Sesamia spp. ), Spodoptera litura ( Spodoptera litura ), eggplant moth ( Leucinodes orbonalis ), Bean pod borer ( Glazed maruca ), Maruca testicle Armyworms ( Separate myths ), pink bollworm ( Pectinophora gossypiella citrus leafminer ( Phyllocnistis citrella ),cabbage butterfly( Pieris brasicae Diamondback moth ( Small boat xylostella ), white rice moth ( Scirpophaga excerptalis ), rice stem borer ( Scirpophaga incertulas ), the hidden grain borer ( Scirpophaga innotata ), giant borer ( Bringing sesame seeds ), wheat moth ( Sitotroga cereal ), dust moths ( Spilosoma oblique Fall armyworm ( Spodoptera frugiperda ), sea gray-winged moth ( Spodoptera littoralis ), Spodoptera litura ( Spodoptera litura ), Powdered Noctuid moth ( Trichoplusia ni Sugarcane white moth ( Tryporyza nivella ), rice stem borer ( Tryporyza incertulas Tomato leafminer ( Absolutely safe ). Coleoptera ( Beetles For example: *Leptochloa* genus ( Amphicerus spp. ), corn root firefly beetle ( Diabrotica virgifera ), Cucumber Leaf Beetle ( Diabrotica striata ), Cotton Boll Weevil ( Anthonomus grandis ), grape flea beetle ( High steel ), grape root leaf beetle ( Grapevine Grape vine borers ( Clytoleptus albofasciatus ), Carrot Flea Beetle ( Phyllotreta armoraciae ), corn weevil ( Sitophilus zeamais ), Northern corn root firefly beetle ( Diabrotica barberi ), rice water weevil ( Lissorhoptrus oryzophilus ), Cotton Boll Weevil ( Anthonomus grandis ), lentil weevil ( Beetle lens ), striped leaf beetle ( Diabrotica semipunctata ), corn root firefly beetle ( Diabrotica virgifera ), rice iron beetle ( Dicladispa armigera ), Mexican bean ladybug ( Epila-chna varivestis ), various grubs (including the two-colored scarab beetle ( Holotrichia bicolor ), same-colored gill beetle ( Holotrichia consanguinea ), serrated gill beetle ( Holotrichia serrata ), potato beetle ( Leptinotarsa ​​ten-lineata ), rapeseed blue flea beetle ( Phyllotreta chrysocephala ), Japanese beetle ( Japanese popillia ) etc.; from Orthoptera ( Orthoptera For example: the genus *Mole Cricket* (… Gryllotalpa spp. ), locust genus ( Locust spp. ) and the desert locust genus ( Schistocerca spp. ); from the order Thysanoptera ( Thysanoptera For example: Thrips ( ) Frankliniella spp. Palm thrips ( Palm thrips ), thrips ( Tobacco thrips ), small spotted thrips ( Thrips small-thorned ) and tea thrips ( Scirtothrips dorsalis );termite( Isoptera For example: Yellow-necked wood termites ( Yellow-necked Calotermes ), house termites ( Coptotermes formosanus ), golden termite ( Heterotermes aureus Yellow-legged termites ( Leucotermes flavipes Wheat termites ( Microterms obese ), Fat-toothed termites ( Odontotermes obesus ), yellow-limbed subterranean termites ( Reticulitermes flavipes ), Natal termites ( Natal's thermal baths ); from Hemiptera ( Heteroptera For example: the genus *Cotton Red Bug* (… Dysdercus spp. ), genus *Rhizophora* ( Leptocorisa spp. ); from Hymenoptera ( Hymenoptera For example: Fire ants (genus) Solenopsis spp. ); from Diptera ( Diptera For example: sorghum fly ( Antherigona soccata ), Fruit fly genus ( Dacus spp. ), genus *Leymus* ( Liriomyza spp. ), Black leafminer ( ) Melanagromyza spp. ).

[0038] The main plant parasitic mites come from the order Acari ( ). Acarine ), such as mango gall mite ( Acer mango trees ), genus *Bristylus* ( Brevipalpus spp. ), genus *Gallus* ( Eriophyes spp. Mango claw mite ( Oligonychus mangiferus ), pomegranate claw mite ( Oligonychus punicae ), Citrus red claw mite ( Panonychus citri ), elm spider mite ( Panonychus elm ), Lateral polyphagous tarsiformis ( Polyphagotarsonemus side ), Tarsiformes ( Tarsonemus spp. Two-spotted spider mite ( Spider mite ), Cinnabar Tetranychus ( Cinnabar spider mite ).

[0039] In a particularly preferred embodiment of the invention, the yield of the treated plants is increased. In another preferred embodiment of the invention, the yield of the plants treated according to the method of the invention is synergistically increased. According to the invention, "increased yield" of plants, particularly agricultural, forestry, and / or horticultural plants, means that the yield of the product of the corresponding plant is increased by a measurable amount compared to the yield of the same product produced by the plant under the same conditions but without the application of the mixture described in the invention. Increased yield can be characterized by improved plant characteristics, including: increased plant weight, increased plant height, increased biomass such as higher total fresh weight (FW), increased number of flowers per plant, higher grain yield, more tillers or lateral branches (branches), larger leaves, enhanced branch growth, increased protein content, increased oil content, increased starch content, increased pigment content, and increased leaf area index.

[0040] Another indicator of plant condition is plant vitality. Plant vitality is reflected in several aspects, such as overall visual appearance. In another particularly preferred embodiment of the invention, the plant vitality of the treated plants is increased. In another preferred embodiment of the invention, the plant vitality of the plants treated according to the method of the invention is synergistically increased. The improvement in plant vitality can be characterized by the following improved plant characteristics, including: increased plant vitality, improved plant growth, improved plant development, improved visual appearance, improved plant site stability (reduced lodging), improved emergence, enhanced root growth and / or more developed root system, enhanced nodulation (especially rhizobium nodulation), larger leaves, larger leaf size, increased plant weight, increased plant height, increased number of tillers, increased number of lateral branches, increased number of flowers per plant, enhanced branch growth, enhanced root growth (developed root system), increased yield when growing in poor soil or adverse climate, enhanced photosynthetic activity (e.g., based on increased stomatal conductance and / or increased CO2 assimilation rate), increased stomatal conductance, increased CO2 assimilation rate, increased pigment content (e.g., chlorophyll content), earlier flowering, and more abundant fruit set. Earlier fruiting, earlier and improved germination, earlier grain maturity, improved self-defense mechanisms, enhanced plant stress tolerance and resistance to biotic and abiotic stresses (e.g., fungi, bacteria, viruses, insects, heat stress, cold stress, drought stress, UV stress, and / or salt stress), reduced ineffective tillering, reduced basal leaf dieback, reduced input requirements (e.g., fertilizer or water), greener leaves, full maturity within a shortened vegetation growing season, reduced fertilizer requirements, reduced seed requirements, easier harvesting, faster and more uniform maturity, longer shelf life, longer ears, delayed senescence, stronger and / or higher tillering, better extractability of components, improved seed quality (for sowing in the following season to produce seeds), better nitrogen uptake, improved reproduction, reduced ethylene production and / or inhibition of ethylene absorption by plants.

[0041] The improvement in plant vigor according to the invention specifically means an improvement in any one, several, or all of the aforementioned plant characteristics, and such improvement is unrelated to the insecticidal effect of the mixture or active ingredient (component).

[0042] Another indicator of plant condition is the "quality" of the plant and / or its products. In a particularly preferred embodiment of the invention, the quality of the treated plants is improved.

[0043] In another preferred embodiment of the invention, the quality of plants treated according to the method of the invention is synergistically improved.

[0044] The formulations of this invention may be selected from any of the following: microcapsule suspensions (CS), dispersible liquids (DC), emulsifiable concentrates (EC), water-in-oil emulsions (EO), oil-in-water emulsions (EW), Jambo spheres or bags (bags in water-soluble sachets), microemulsions (ME), oil dispersants (OD), oil miscible flow concentrates (oil suspensions (OF)), oils (OL), suspensions (SC), emulsions (SE), soluble concentrates (SL), wettable granules / water-dispersible granules (WG / WDG), water-soluble granules (SG), water-soluble powders (SP), wettable powders (WP), mixtures of CS and SC (ZC), mixtures of CS and SE (ZE), mixtures of CS and EW (ZW), granules (GR) / soil-applied granules (SAG), and controlled-release granules (CR).

[0045] The other composition comprises (A) isoxazolam; (B) at least one insecticide selected from chlorantraniliprole, bromonitrile acetamiprid, cyclobromhizopromycin, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, chlorfluazuron, flubendiamide, fluchlorfenapyr, and thiophanate-methyl; and (C) at least one other insecticide present in the composition in a specific fixed proportion.

[0046] In another aspect, the present invention relates to synergistic compositions comprising (A) 1% to 20% w / w of the composition; (B) 0.5% to 30% w / w of the composition; and (C) 0.5% to 30% w / w of the composition. In addition to bioavailable amounts of the active ingredient, the compositions of the present invention also contain inactive excipients, including but not limited to superwetting-spreading-penetrating agents, solvents, dispersants or dispersants, antifreeze agents, emulsifiers, defoamers, preservatives, and buffers.

[0047] A wetting agent is a substance that, when added to a liquid, enhances the spreading or penetrating ability of the liquid by reducing the interfacial tension between the liquid and the surface it is spread on. Wetting agents serve two main functions in agrochemicals: during processing and production, they are used to increase the wetting rate of powders in water to prepare concentrates of soluble or suspending agents; and when mixing products with water in spray cans or other containers, they are used to reduce the wetting time of wettable powders and improve the penetration of water into water-dispersible granules.

[0048] Suspension (SC) Formulations: Examples of wetting agents used in suspension (SC) formulations herein include, but are not limited to: ethylene oxide / propylene oxide (EO / PO) block copolymers, polyarylphenyl ether phosphates, polyalkoxylated butyl ethers, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, and alkyl naphthalene sulfonates. Ethoxylated alcohols include natural fatty alcohols (lauryl alcohol polyoxyethylene ether, lauryl alkoxy ether) and synthetic alcohol polyoxyethylene ethers (tetranol polyoxyethylene ether, 2-ethylhexanol, 2-propylheptanol, isodecanol).

[0049] Examples of wetting-spreading-penetrating agents used in this article for suspension (SC) formulations include, but are not limited to: trisiloxane polyoxyethylene ether, heptamethyltrisiloxane, modified forms including polyoxyethylene-modified heptamethyltrisiloxane, polyether-modified polysiloxane, polyoxyethylene-modified trisiloxane, and polyoxyethylene-modified polydimethylsiloxane, which may be in liquid or powder form.

[0050] Examples of dispersants used in suspension (SC) formulations in this article include, but are not limited to: sodium salt of naphthalene sulfonate formaldehyde condensate, sodium salt of alkyl naphthalene sulfonate, sodium salt of naphthalene sulfonate condensate, sodium lignin sulfonate, sodium polycarboxylate, EO / PO based copolymers, phenol sulfonates, sodium methyl oleoyl taurate, styrene-acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyrene phenyl ether, tristyrene phenol polyethylene glycol ether phosphate, tristyrene phenol containing 16 moles of EO, tristyrene phenol polyethylene glycol ether phosphate, oleyl alcohol polyethylene glycol ether (containing ethylene oxide), tallow fatty amine polyoxyethylene ether, and nonylphenol polyethylene glycol ether (containing 9 to 10 moles of ethylene oxide).

[0051] Examples of suspending agents used in this article for suspending (SC) formulations include, but are not limited to: magnesium aluminum silicate, bentonite, silica, and attapulgite clay.

[0052] Examples of defoamers used in suspension (SC) formulations in this article include, but are not limited to: silicone defoaming emulsions, dimethylsiloxane, polydimethylsiloxane, vegetable oil-based defoamers, and tallow-based fatty acids.

[0053] Examples of antifreeze agents used in suspension (SC) formulations in this article include, but are not limited to: ethylene glycol, propylene glycol, glycerin or urea, glycols (ethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride, etc.

[0054] Examples of preservatives used in suspension (SC) formulations in this article include, but are not limited to: sodium salt of 1,2-benzisothiazolin-3(2H)-one, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenolate, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.

[0055] Examples of thickeners used in suspension (SC) formulations in this article include, but are not limited to: xanthan gum, PVK, carboxymethyl cellulose, polyvinyl alcohol, gelatin, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium polyacrylate, modified starch, and gum arabic.

[0056] Examples of humectants used in suspension (SC) formulations in this article include, but are not limited to: urea, humic acid, glycerin, and lactose.

[0057] ZC formulations are a mixture of microcapsule suspensions (CS) and suspensions (SC).

[0058] Examples of wall-forming materials 1 used in microcapsule suspension (CS) formulations herein include, but are not limited to: tetramethylene diisocyanate, pentamethylene diisocyanate, hexamethylene diisocyanate, toluene diisocyanate, 4,4-diphenylmethane diisocyanate (MDI), polymethylene polyphenyl isocyanate, 2,4,4'-diphenyl ether triisocyanate, 3,3'-dimethyl-4,4'-diphenyl diisocyanate, 3,3'-dimethoxy-4,4'-diphenyl diisocyanate, 1,5-naphthalene diisocyanate and 4,4',4''-triphenylmethane triisocyanate, toluene diisocyanate or polymethylene polyphenyl isocyanate, and polyurethanes comprising polyfunctional isocyanates and polyamines in polarized forms.

[0059] Examples of wall-forming materials 2 used in microcapsule suspension (CS) formulations include, but are not limited to: diethylenetriamine, ammonia, hexamethylenetetramine, ethylenediamine, 1,3-propanediamine, tetramethylenediamine, pentamethylenediamine, 1,6-hexamethylenediamine, diethylenetriamine, triethylenetetramine, tetraethylenepentamine, pentaethylenehexamine, 4,9-dioxadodecane-1,12-diamine, 1,3-phenylenediamine, 2,4- and 2, 6-Toluenediamine, 4,4'-diaminodiphenylmethane, 1,3-phenylenediamine, 2,4- and 2,6-toluenediamine, 4,4'-diaminodiphenylmethane, 1,5-diaminonaphthalene, 1,3,5-triaminobenzene, 2,4,6-triaminotoluene, 1,3,6-triaminonaphthalene, 2,4,4'-triaminodiphenyl ether, 3,4,5-triamino-1,2,4-triazole, and 1,4,5,8-tetraaminoanthraquinone.

[0060] Examples of dispersants used in microcapsule suspension (CS) formulations in this article include, but are not limited to: ethoxylated lignin sulfonate, lignin sulfonate, oxidized lignin, lignin salt, styrene-maleic anhydride copolymer salt, polyvinyl alcohol, styrene-maleic anhydride copolymer metaester salt, polyacrylic acid metasalt, and polyacrylic acid terpolymer metasalt. The surfactant is calcium lignosulfonate or sodium lignosulfonate or a mixture thereof, or high-sulfonic acid group modified sulfate lignin, dibutylnaphthalene sulfonic acid, fatty acids, alkyl sulfonates and alkyl aryl sulfonates, alkyl sulfates, lauryl ether sulfates and fatty alcohol sulfates, as well as salts of sulfated hexadecyl alcohol, heptadecanol, octadecyl alcohol and fatty alcohol glycol ethers, condensates of sulfonated naphthalene and its derivatives with formaldehyde, condensates of naphthalene or naphthalene sulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenol ether, ethoxylated isooctylphenol, ethoxylated octylphenol or ethoxylated nonylphenol, alkylphenyl polyethylene glycol ether, tributylphenyl polyethylene glycol ether, alkyl aryl polyether alcohol, isotretinoin, fatty alcohol / ethylene oxide condensate, castor oil polyoxyethylene ether Polyoxyethylene alkyl ethers or polyoxypropylene alkyl ethers, lauryl glycol ether acetate, sorbitan esters, sulfite lignin waste liquid, and ammonium salts of proteins, denatured proteins, polysaccharides, sulfonates, sulfates, phosphates or carboxylates, alkyl aryl sulfonates, diphenyl sulfonates, α-olefin sulfonates, sulfonates of fatty acids and oils, sulfonates of ethoxylated alkylphenols, sulfonates of condensed naphthalenes, sulfonates of dodecylbenzene and tridecylbenzene, sulfonates of naphthalene and alkylnaphthalenes, sulfosuccinates or sulfosuccinates, alkoxylates, N-alkylated fatty acid amides, amine oxides, esters or glycosyl surfactants, alkylphenols, amines (such as tallow amine), amides, arylphenols, fatty acids or fatty acid esters (hexyloxylated). Alkoxylation can be performed using ethylene oxide and / or propylene oxide, preferably ethylene oxide, polyoxyethylene and polyoxypropylene, polybasic acids or polybasic bases.

[0061] Examples of wetting agents used in microcapsule suspension (CS) formulations include, but are not limited to: ethylene oxide / propylene oxide block copolymers, polyarylphenyl ether phosphates, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates, octylphenol polyoxyethylene ether, and alkylphenol polyoxyethylene ether.

[0062] Examples of wetting-spreading-penetrating agents used in microcapsule suspension (CS) formulations include, but are not limited to: silicone surfactants, including trisiloxane polyoxyethylene ether, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyepoxide-modified heptamethyltrisiloxane, polyether-modified polysiloxane, and octylphenol added to 10 moles of ethylene oxide; the above substances may be in modified or unmodified form, and may be in liquid or powder form or mixtures thereof.

[0063] Examples of solvents used in this article for microcapsule suspension (CS) formulations include, but are not limited to: hydrocarbon solvents, such as aliphatic hydrocarbons, cyclic hydrocarbons, and aromatic hydrocarbons (e.g., toluene, xylene, paraffin, tetrahydronaphthalene, alkylated naphthalene or their derivatives, medium to high boiling point mineral oil fractions (e.g., kerosene, diesel, coal tar)); vegetable oils such as corn oil and rapeseed oil; fatty acid esters, such as C1-C10 alkyl esters of C10-C22 fatty acids; or methyl or ethyl esters of vegetable oils, such as rapeseed oil methyl ester or corn oil methyl ester, acetophenone, 2-heptanone, 3-heptanone, 2-hexanone, 5-methyl-2-hexanone, 5-methyl-3-heptanone, 3-methyl-2-hexanone, 4-methyl-2-hexanone, 2-methyl-3-hexanone, 4-methyl-3-hexanone, 5-methyl-3-hexanone, 3-ethyl-2-pentanone, 3,3-dimethyl... 2-Pentanone, 3,4-Dimethyl-2-Pentanone, 4,4-Dimethyl-2-Pentanone, 2,2-Dimethyl-3-Pentanone, 2,4-Dimethyl-3-Pentanone, 2-Octanone, 2,5-Dimethyl-3-Hexanone, 2,2-Dimethyl-3-Hexanone, 3,3-Dimethyl-2-Hexanone, 3,4-Dimethyl-2-Hexanone, 4,4-Dimethyl-3-Hexanone, 3-Ethyl- 4-Methyl-2-pentanone, 2-methyl-3-heptanone, 2-methyl-4-heptanone, 3-methyl-2-heptanone, 3-methyl-4-heptanone, 5-methyl-3-heptanone, 6-methyl-2-heptanone, 6-methyl-3-heptanone, 3-octanone, 4-octanone, 2,2,4-trimethyl-3-pentanone, 3-ethyl-3-methyl-2-pentanone, 5-methyl-2-heptanone, isoprene.

[0064] Examples of thickeners used in microcapsule suspension (CS) formulations include, but are not limited to: xanthan gum, carboxymethyl cellulose, attapulgite clay, and bentonite.

[0065] Examples of suspending agents used in microcapsule suspension (CS) formulations in this article include, but are not limited to: magnesium aluminum silicate, bentonite, silica, and attapulgite clay.

[0066] Examples of defoamers used in microcapsule suspension (CS) formulations in this article include, but are not limited to: silicone oil, organosilicon compounds, C10-C20 saturated fatty acid compounds or C8-C10 aliphatic alcohol compounds, organosilicon defoaming emulsions, dimethylsiloxane, polydimethylsiloxane, vegetable oil-based defoamers, tallow-based fatty acids, and polyepoxide-modified polydimethylsiloxane.

[0067] Examples of antifreeze agents used in microcapsule suspension (CS) formulations include, but are not limited to: ethylene glycol, propylene glycol, glycerin or urea, glycols (monoethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride, etc.

[0068] Examples of preservatives used in microcapsule suspension (CS) formulations include, but are not limited to: sodium 1,2-benzisothiazolin-3(2H)-one, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenolate, 5-chloro-2-methyl-4-isothiazolin-3-one, and 2-methyl-4-isothiazolin-3-one.

[0069] Examples of buffers used in microcapsule suspension (CS) formulations include, but are not limited to: sodium hydroxide, potassium hydroxide, acetic acid, sulfuric acid, hydrochloric acid, orthophosphoric acid, and ammonium hydroxide.

[0070] Examples of wetting agents used in oil dispersant (OD) formulations in this article include, but are not limited to: ethylene oxide / propylene oxide block copolymers, polyarylphenyl ether phosphates, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, and alkyl naphthalene sulfonates.

[0071] Examples of superwetting-spreading-penetrating agents used in oil dispersant (OD) formulations include, but are not limited to: silicone surfactants, including trisiloxane polyoxyethylene ether, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyepoxide-modified heptamethyltrisiloxane, polyether-modified polysiloxane, the above substances may be in modified or unmodified form, and may be in liquid or powder form or mixtures thereof, etc.

[0072] Examples of dispersants used in oil dispersant (OD) formulations in this article include, but are not limited to: alkyl sulfonates, alkylbenzene sulfonates, alkylaryl sulfonates, alkylphenol alkoxylates, tristyrylphenol polyoxyethylene ethers, natural or synthetic fatty alcohol polyoxyethylene ethers, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohol alkoxylates, alkoxylated alcohols (e.g., n-butanol polyethylene glycol ether), block copolymers (e.g., ethylene oxide-propylene oxide block copolymers and ethylene oxide-butane oxide block copolymers), fatty acid polyalkylene glycol condensates, and polyamine fatty acid condensates. Polyester condensates, polyolefin condensate salts, sodium lignosulfonate, sodium polycarboxylate, EO / PO based copolymers, phenol sulfonates, sodium methyl oleoyl taurate, styrene-acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyrene phenyl ether, tristyrene phenol polyethylene glycol ether phosphate, tristyrene phenol containing 16 moles of EO, tristyrene phenol polyethylene glycol ether phosphate, oleyl alcohol polyethylene glycol ether (containing ethylene oxide), tallow fatty amine polyoxyethylene ether, nonylphenol polyethylene glycol ether (containing 9 to 10 moles of ethylene oxide).

[0073] The emulsifiers used in this article for oil dispersant (OD) formulations include, but are not limited to: castor oil polyoxyethylene ether, alcohol polyoxyethylene ether, fatty acid polyoxyethylene ester, polyoxyethylene sorbitan ester, sulfosuccinate, calcium dodecylbenzene sulfonate, alkylbenzene sulfonate alkylammonium salt, alkyl sulfosuccinate, ethylene oxide-propylene oxide block copolymer, ethoxylated alkylamine, ethoxylated alkylphenol, polyoxyethylene sorbitan hexaoleate, polyoxyethylene sorbitan monolaurate, etc.

[0074] Examples of defoamers used in oil dispersant (OD) formulations in this article include, but are not limited to: silicone oil, organosilicon compounds, C10-C20 saturated fatty acid compounds or C8-C10 aliphatic alcohol compounds, organosilicon defoaming emulsions, dimethylsiloxane, polydimethylsiloxane, vegetable oil-based defoamers, tallow-based fatty acids, and polyepoxide-modified polydimethylsiloxane.

[0075] Examples of antifreeze agents used in oil dispersant (OD) formulations include, but are not limited to: ethylene glycol, propylene glycol, glycerin or urea, glycols (ethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride, etc.

[0076] The preservatives used in this article for oil dispersant (OD) formulations include, but are not limited to: sodium salt of 1,2-benzisothiazolin-3(2H)-one, sodium benzoate, 2-bromo-2-nitropropane-1,3-diol, formaldehyde, sodium o-phenylphenol, 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one.

[0077] Examples of stabilizers or rheology modifiers used in this article for oil dispersant (OD) formulations are selected from: lithium montmorillonite, magnesium aluminum silicate, bentonite, silica, and attapulgite clay.

[0078] Examples of solvents used in oil dispersant (OD) formulations include, but are not limited to, vegetable oils (of plant, seed, or tree origin) or their alkylated, ethoxylated, or esterified forms. Alkylated vegetable oils can be methylated or ethylated. These vegetable oils include olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, rapeseed-mustard oil, linseed oil, tung oil, sunflower oil, safflower oil, and coconut oil. Alkyl esters of vegetable oils include methyl, ethyl, propyl, or butyl esters. Some examples include methylated vegetable oils, polyepoxide-modified polydimethylsiloxane alkylphenol polyoxyethylene ethers, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl ester, rapeseed oil butyl ester, soybean oil methyl ester, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cottonseed oil methyl ester, cottonseed oil ethyl ester, cottonseed oil butyl ester, cottonseed oil propyl ester, tallow fatty acid esters, tallow methyl ester, tallow Ethyl acetate, propyl tallow, biodiesel, mineral oil (aromatic solvent, isoparaffin, base solvent), fatty acid amides (e.g., amides formed from C1-C3 amines, alkylamines, or alkanolamines and C6-C18 carboxylic acids), fatty acids, fatty acid alkyl esters, methyl oleate and ethyl oleate, methyl soyate and ethyl soyate, alkylbenzenes and alkylnaphthalenes, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, alkylene carbonates, ketones, and alcohols. The above oil-based carriers / diluents can be used alone or, if desired, in mixtures of two or more.

[0079] The cosolvents used in this article for oil dispersant (OD) formulations include, but are not limited to: cyclohexanone, acetophenone, NMP, dimethyl sulfoxide, benzyl alcohol, butanol, n-octanol, n-propanol, 2-ethylhexanol, tetrahydrofurfuryl alcohol, isophorone, fatty acid dimethylamide, 2-hexylethyl lactate, and propylene carbonate.

[0080] Examples of dispersants used in wettable granules (WG) / water-dispersible granules (WDG) formulations include, but are not limited to: sodium alkyl naphthalene sulfonate, sodium polycarboxylate, sodium naphthalene sulfonate formaldehyde condensate, polyalkoxylated alkylphenol, naphthalene sulfonate formaldehyde condensate, sodium methylnaphthalene formaldehyde condensate, naphthalene condensate, lignin sulfonate, polyacrylate and phosphate esters, calcium lignin sulfonate, and sodium lignin sulfonate.

[0081] Examples of wetting agents used in this article for wettable granule (WG) / water-dispersible granule (WDG) formulations include, but are not limited to: sodium N-methyl-N-oleoyl taurate, sodium alkyl naphthalene sulfonate, a mixture of dibutyl naphthalene sulfonate isomers, sodium diisopropyl naphthalene sulfonate, sodium dodecyl sulfate, dioctyl sulfate, alkyl naphthalene sulfonates, phosphate esters, sulfosuccinates, and nonionic wetting agents (e.g., tridecyl alcohol polyoxyethylene ether), alkyl or alkylaryl sulfonates (e.g., alkylbenzene sulfonates, α-olefin sulfonates, and alkyl naphthalene sulfonates), ethoxylated or nonethoxylated alkyl or alkylaryl carboxylates, alkyl or alkylaryl phosphate esters, alkyl polysaccharides, dialkyl or monoalkyl sulfosuccinate derivatives, α-olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulfosuccinates, butyl, dibutyl, isopropyl, and diisopropyl naphthalene sulfonates, C 12 Alkylbenzene sulfonates or C 10 -C 16 Alkylbenzene sulfonates and organosilicon surfactants (including trisiloxane polyoxyethylene ether, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyepoxide-modified heptamethyltrisiloxane, and polyether-modified polysiloxane), the above substances may be in modified or unmodified form, and may be in liquid or powder form or mixtures thereof.

[0082] Examples of defoamers used in wettable granules (WG) / water-dispersible granules (WDG) formulations include, but are not limited to, polydimethylsiloxane.

[0083] Examples of carriers used in this article for wettable granules (WG) / water-dispersible granules (WDG) formulations include, but are not limited to: clay, silica, anhydrous lactose, ammonium sulfate, anhydrous sodium sulfate, corn starch, urea, EDTA, urea-formaldehyde resin, diatomaceous earth, kaolin, bentonite, diatomaceous earth, bleaching clay, attapulgite clay, red clay, loess, talc, chalk, dolomite, limestone, quicklime, calcium carbonate, magnesium oxide powder, magnesium oxide, magnesium sulfate, sodium chloride, gypsum, calcium sulfate, pyrophyllite, silicates and silica gel; fertilizers such as ammonium sulfate, ammonium phosphate, ammonium nitrate and urea; natural products of plant origin such as cereal flour and wheat flour, bark flour, wood flour, nut shell flour and cellulose powder; and synthetic polymers such as ground or pulverized plastics and resins, bentonite, zeolite, titanium dioxide, iron oxides and hydroxides, aluminum oxides and hydroxides, or organic materials such as bagasse, charcoal or synthetic organic polymers.

[0084] Examples of disintegrants used in this article for wettable granule (WG) / water-dispersible granule (WDG) formulations include, but are not limited to, citric acid, succinic acid, or sodium bicarbonate.

[0085] Examples of humectants used in wettable granules (WG) / water-dispersible granules (WDG) formulations include, but are not limited to, urea, humic acid, glycerin, and lactose.

[0086] Examples of solvents used in suspension (SE) formulations include, but are not limited to, water, water-soluble alcohols, and dihydroxy alcohol ethers. Water-soluble alcohols or lower alcohols (1 to 4 carbon atoms) include methanol, ethanol, n-propanol, isopropanol, n-butanol, and tert-butanol. High molecular weight alcohols include polyethylene glycol, sorbitol, and glucosyl alcohol, etc. Dihydroxy alcohol ethers include dihydroxy alkyl ethers or dihydroxy aryl ethers. Examples of dihydroxy alkyl ethers include ethylene glycol methyl ether, diethylene glycol methyl ether, propylene glycol methyl ether, dipropylene glycol methyl ether, ethylene glycol ethyl ether, diethylene glycol ethyl ether, propylene glycol ethyl ether, dipropylene glycol ethyl ether, etc. Examples of dihydroxy aryl ethers include ethylene glycol phenyl ether, diethylene glycol phenyl ether, propylene glycol phenyl ether, dipropylene glycol phenyl ether, etc. Any of the above solvents can be used alone or in combination.

[0087] Hydrocarbons include solvents such as naphtha, n-pentane, hexane (or similar), cyclohexane, methylcyclohexane, heptane, isooctane, benzene, toluene, xylene (or similar), isophorone, as well as ester solvents (e.g., methyl oleate), dimethylamides and morpholinamide derivatives of C6-C16 fatty acids, monoalkylene carbonates (e.g., ethylene carbonate, propylene carbonate, and butene carbonate), dimethyl sulfoxide (DMSO), 2-ethylhexanol and n-butanol, n-alkylpyrrolidones, dimethyl fatty acid esters, fatty acid esters, diesters, aromatic hydrocarbons and / or aliphatic hydrocarbons, and one or more dimethylamides (e.g., C6-C16 methyl ether). 8-Dimethylamide, C10-Dimethylamide, C12-Dimethylamide), ethylene glycol, propylene glycol, polyalkylene glycol, aromatic hydrocarbons, N-methylpyrrolidone (NMP), dimethylformamide (DMF), dimethyl isosorbide (DMI), isophorone, acetophenone, 1,3-dimethyl-2-imidazolinone, lactates, dimethyl carbonate and diethyl carbonate, alcohols (including methanol, ethanol, isopropanol, n-propanol, n-butanol, isobutanol and tert-butanol), L-methyl lactate, L-2-ethylhexyl lactate, L-ethyl lactate, L-n-butyl lactate, octylphenol polyoxyethylene ether.

[0088] Examples of emulsifiers used in suspension (SE) formulations include, but are not limited to: dodecylbenzene sulfonates (e.g., calcium or amine salts) and other C11-C16 alkylbenzene sulfonates, alkyl ether sulfates, alkylphenol ether phosphates, and phosphates; nonionic surfactants, such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils (e.g., castor oil polyoxyethylene ether), fatty acid esters (e.g., sorbitan fatty acid esters) and their ethoxylated derivatives, ethoxylated amines, and glycerol condensates; and anionic and cationic emulsifiers (e.g., cationic amines), optionally used in combination with: alkyl sulfonates or ether sulfonates or ether phosphates, alkoxylated alcohols, alkoxylated alkylphenols; ethoxylated fatty acids; ethoxylated vegetable oils; and ethoxylated triphenylene. Tristyrylphenol (containing 16 moles of EO), tristyrylphenol polyethylene glycol ether phosphate, sorbitan fatty acid esters and their ethoxylated derivatives, ethoxylated amines and glycerol condensates, alkylbenzene sulfonates and their salts in the C11-C16 range, alkyl ether sulfates, alkyl ether phosphates, alkylphenol ether phosphates, or combinations thereof, ethoxylated tristyrylphenol phosphate salts, ethoxylated tristyrylphenol sulfated ether salts; or anionic and cationic systems wherein the cationic amine is present in combination with alkyl sulfonates, alkyl ether sulfonates, ether sulfates or ether phosphates (e.g., alkyl ether phosphates), nonylphenol polyoxyethylene ether, castor oil polyethylene glycol ether, polyadditions of ethylene oxide and polypropylene, tributylphenoxy polyoxyethylene ether, and octylphenoxy polyoxyethylene ether.

[0089] Examples of stabilizers used in suspension (SE) formulations in this article include, but are not limited to: butylated hydroxytoluene (BHT) and epoxidized soybean oil (ESBO), epichlorohydrin.

[0090] Examples of antifreeze agents used in suspension (SE) formulations in this article include, but are not limited to: ethylene glycol, propylene glycol, glycerin or urea, glycols (ethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, and sodium chloride.

[0091] Examples of defoamers used in suspension emulsion (SE) formulations in this article include, but are not limited to: silicone oil, organosilicon compounds, C10-C20 saturated fatty acid compounds or C8-C10 aliphatic alcohol compounds, organosilicon defoaming emulsions, dimethylsiloxane, polydimethylsiloxane, vegetable oil-based defoamers, tallow-based fatty acids, polyepoxide-modified polydimethylsiloxane, etc.

[0092] Examples of defoamers used in suspension (SE) formulations in this article include, but are not limited to: magnesium aluminum silicate, bentonite, silica, silicate dioxide, and attapulgite clay.

[0093] Examples of wetting agents used in suspension (SE) formulations in this article include, but are not limited to: ethylene oxide / propylene oxide block copolymers, polyarylphenyl ether phosphates, ethoxylated fatty alcohols, sodium dioctyl sulfosuccinate, sodium dodecyl sulfate and sodium dodecylbenzene sulfonate, alkyl diphenyl sulfonates, sodium isopropyl naphthalene sulfonate, alkyl naphthalene sulfonates, octylphenol polyoxyethylene ether, and alkylphenol polyoxyethylene ether.

[0094] Examples of wetting-spreading-penetrating agents used in suspension (SE) formulations include, but are not limited to: silicone surfactants, including trisiloxane polyoxyethylene ether, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyepoxide-modified heptamethyltrisiloxane, heptamethyltrisiloxane polyoxyethylene ether, polyether-modified polysiloxane, and 10 moles of ethylene oxide-added octylphenol. These substances may be in modified or unmodified form, and may be in liquid or powder form or mixtures thereof.

[0095] Examples of preservatives used in suspension (SE) formulations include, but are not limited to: propionic acid and its sodium salt, sorbic acid and its sodium or potassium salt, benzoic acid and its sodium salt, sodium para-hydroxybenzoate; methyl para-hydroxybenzoate; and biocides such as sodium benzoate, 1,2-benzisothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, 5-chloro-2-methyl-4-isothiazolin-3-one, potassium sorbate, para-hydroxybenzoate, or mixtures thereof.

[0096] Examples of thickeners used in suspension (SE) formulations are categorized into two types: water-insoluble microparticles and water-soluble polymers. Suspension formulations can be prepared using clay and silica. Examples of these types of materials include, but are not limited to, montmorillonite (e.g., bentonite), magnesium aluminum silicate, and attapulgite clay. Water-soluble polysaccharides have been used as thickeners / gelling agents for many years. The most commonly used types of polysaccharides are natural extracts from seeds and 15 seaweed species, synthetic derivatives of cellulose, or mixtures thereof. Examples of these types of materials include, but are not limited to, guar gum, locust bean gum, carrageenan, xanthan gum, alginate, methylcellulose, sodium carboxymethyl cellulose (SCMC), hydroxyethyl cellulose (HEC), or mixtures thereof. Other types of antisettling agents are based on modified starch, polyacrylates, polyvinyl alcohol, and polyoxyethylene, or mixtures thereof.

[0097] Examples of dispersants used in suspension (SE) formulations herein include, but are not limited to: polyesters, polyamides, polycarbonates, polyureas and polyurethanes, acrylic polymers, acrylic graft copolymers, styrene copolymers, butadiene copolymers, polysaccharides (e.g., starch and cellulose derivatives), vinyl alcohol polymers and copolymers, vinyl acetate polymers and copolymers, vinylpyrrolidone polymers and copolymers, polyethers, epoxy resins, phenolic resins and melamine resins, polyolefins and their defined copolymers, and mixtures thereof. Preferred examples of polymers include: acrylate polymers (e.g., poly(methacrylate), poly(ethyl methacrylate), poly(methyl methacrylate)), acrylate copolymers and styrene-acrylic acid copolymers as defined below, poly(styrene-copoly-maleic anhydride), cellulose polymers (e.g., ethyl cellulose, cellulose acetate, cellulose acetate butyrate), acetylated monoglycerides, acetylated diglycerides and acetylated triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycols), styrene-butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more thereof. In this invention, biodegradable polymers are also useful. As used herein, a polymer is biodegradable if it is insoluble in water but degrades within weeks of being placed in the application environment. Examples of biodegradable polymers that can be used in this invention include: biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly(n-pentyl methacrylate), rosin, polyanhydride, polyvinyl alcohol, polyhydroxybutyrate valerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof. Examples of dispersants include sodium alkyl naphthalene sulfonate, sodium naphthalene sulfonate condensate, sodium alkyl naphthalene sulfonate, sodium lignin sulfonate, sodium polycarboxylate, EO / PO block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene-acrylic acid copolymer, propylene oxide-ethylene oxide copolymer, polyethylene glycol 2,4,6-tristyrene phenyl ether, tristyrene phenol polyethylene glycol ether phosphate, tristyrene phenol containing 16 moles of EO, tristyrene phenol polyethylene glycol ether phosphate, oleyl alcohol polyethylene glycol ether (containing ethylene oxide), tallow fatty amine polyoxyethylene ether, and nonylphenol polyethylene glycol ether (containing 9 to 10 moles of ethylene oxide).

[0098] Examples of buffers used in suspension (SE) formulations in this article include, but are not limited to: calcium hydroxyapatite, potassium dihydrogen phosphate, sodium hydroxide, carbonated apatite, calcium carbonate, sodium bicarbonate, tricalcium phosphate, calcium phosphate, carbonated calcium phosphate, amine monomers, lactate dehydrogenase, and magnesium hydroxide.

[0099] Examples of humectants used in suspension (SE) formulations in this article include, but are not limited to, urea, humic acid, glycerin, and lactose.

[0100] The synergistic composition comprises (A) isoxazolam, present in an amount of 1% to 20% w / w of the composition; (B) at least one insecticide selected from chlorantraniliprole, broflanilide, cyclobromoxyfenozide, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, chlorfluazuron, flubendiamide, flufenoxuron, thiophanate-methyl, and (C) at least one other insecticide (0.5% to 30% w / w of the composition), which exhibits: ● A single application can effectively control both pests and mites.

[0101] ● Long-lasting protection, meaning a longer duration of protection, providing immediate protection for crops.

[0102] ● It slows down the development of resistance and effectively controls difficult-to-kill and resistant pests and mites.

[0103] ● Increased yields of treated plants (cereals, legumes, oilseeds, fiber crops, sugar crops, leafy vegetables, tuber crops, fruit crops, flowers, ornamental plants, etc.).

[0104] ● Production increased due to pest and mite control.

[0105] ● Increased yield due to more tillers, more branches and sub-branches, more flowers, and more fruits.

[0106] ● Improve plant vitality.

[0107] ● Enhances tolerance to pests and mites.

[0108] The method for preparing the novel synergistic composition of the present invention can be modified accordingly by those skilled in the art based on their knowledge of formulation preparation. However, all such changes and modifications are still covered within the scope of the present invention.

[0109] While the foregoing written description of the present invention enables those skilled in the art to prepare and use what is currently considered the best mode thereof, those skilled in the art will understand and recognize that variations, combinations, and equivalents exist in the specific embodiments, methods, and examples described herein. Therefore, the present invention should not be limited to the foregoing embodiments, methods, and examples, but should be limited to all embodiments and methods within the scope and spirit of the present invention. The present invention is now described with reference to the following specific examples. It should be noted that the following examples are illustrative rather than limiting, and those skilled in the art can devise many alternative embodiments without departing from the scope of the present invention.

[0110] These and other aspects of the invention will become clearer through the embodiments described below. These embodiments are provided merely as illustrative of the invention and are not intended to constitute a limitation thereof.

[0111] Example 1: 1% isoxaflutole + 0.64% chlorantraniliprole + 6.4% fenitrothion hydrochloride GR (granules) The active ingredients are based on 100% purity.

[0112] Storage stability - 1% isoxaflutole + 0.64% chlorantraniliprole + 6.4% fenitrothion hydrochloride GR (granules) The composition of 1% isoxaflutole + 0.64% chlorantraniliprole + 6.4% fenitrothion hydrochloride GR (granules) meets all internal standards for laboratory storage stability studies (14 days at 54±2 °C and 0±2 °C) and room temperature storage stability studies (12 months).

[0113] A method for preparing 100 kg batches of 1% isoxaflutole + 0.64% chlorantraniliprole + 6.4% fenitrothion hydrochloride GR (granules). Example 2: A composition of 9% isoxaflutole + 6% chlorantraniliprole + 1.8% abamectin SC The active ingredients are based on 100% purity.

[0114] Storage stability - 9% isoxaflutole + 6% chlorantraniliprole + 1.8% abamectin SC The composition of 9% isoxaflutole + 6% chlorantraniliprole + 1.8% abamectin SC meets all internal standards for laboratory storage stability studies (14 days at 54±2℃ and 0±2℃) and room temperature storage stability studies (12 months).

[0115] Preparation method of 100 kg batch of 9% isoxaflutole + 6% chlorantraniliprole + 1.8% abamectin SC Example 3: 7.5% isoxaflutole + 7.5% bromocyanamide + 12% oxaflutole SC The active ingredients are based on 100% purity.

[0116] Storage stability - 7.5% isoxaflutole + 7.5% bromocyanamide + 12% oxaflutole SC The composition of 7.5% isoxaflutole + 7.5% bromocyanamide + 12% oxaflutole SC meets all internal standards for laboratory storage stability studies (14 days at 54±2 °C and 0±2 °C) and room temperature storage stability studies (12 months).

[0117] Preparation method of 100 kg batch of 7.5% isoxaflutole + 7.5% bromocyanamide + 12% oxaflutole SC Example 4: A composition of 5% isoxaflutole + 10% tetrazolium acetamiprid + 5% thiamethoxam SE The active ingredients are based on 100% purity.

[0118] Storage stability - 5% isoxazoline + 10% tetrazolium + 5% thiamethoxam SE The composition of 5% isoxazoline + 10% tetrazolium + 5% thiamethoxam SE meets all internal standards for laboratory storage stability studies (14 days at 54±2 °C and 0±2 °C) and room temperature storage stability studies (12 months).

[0119] Preparation method of 100 kg batch of 5% isoxazolam + 10% tetrazolium acetamiprid + 5% thiamethoxam SE Example 5: A composition of 8% isoxazolidinone + 6.67% cyclobrombutamide + 5% fluoxazolidinone DC The active ingredients are based on 100% purity.

[0120] Storage stability - 8% isoxazolidinamide + 6.67% cyclobrombutamide + 5% fluoxazolidinamide DC The composition of 8% isoxazolidinamide + 6.67% cyclobrombutamide + 5% fluoxazolidinamide DC meets all internal standards for laboratory storage stability studies (14 days at 54±2 °C and 0±2 °C) and room temperature storage stability studies (12 months).

[0121] Preparation method of 100 kg batch of 8% isoxazolidinamide + 6.67% cyclobrombutamide + 5% fluoxazolidinamide DC Example 6: A composition of 7.5% isoxazolidinone + 7.5% bromocyanamide + 5% fluoxazolidinone OD The active ingredients are based on 100% purity.

[0122] Storage stability - 7.5% isoxazolidinamide + 7.5% bromocyanamide + 5% fluoxazolidinamide OD. The composition of 7.5% isoxazolidinamide + 7.5% bromocyanamide + 5% fluoxazolidinamide OD meets all internal standards for laboratory storage stability studies (14 days at 54±2 °C and 0±2 °C) and room temperature storage stability studies (12 months).

[0123] Preparation method of 100 kg batch of 7.5% isoxazolidinamide + 7.5% bromocyanamide + 5% fluoxazolidinamide OD Example 7: A composition of 12% isoxaflutole + 6% flubendiamide + 30% pymetrozine WG The active ingredients are based on 100% purity.

[0124] Storage stability - 12% isoxaflutole + 6% flubendiamide + 30% pymetrozine WG. The composition of 12% isoxaflutole + 6% flubendiamide + 30% pymetrozine WG meets all internal standards for laboratory storage stability studies (14 days at 54±2 °C and 0±2 °C) and room temperature storage stability studies (12 months).

[0125] Preparation method of 100 kg batch of 12% isoxaflutole + 6% flubendiamide + 30% pymetrozine WG Example 8: The preferred composition of the present invention is: The active ingredients are based on 100% purity.

[0126] Biological Example: The synergistic insecticidal effect of the mixtures of the present invention can be confirmed through the following experiments. A synergistic effect exists as long as the combined effect of the active ingredients (i.e., the mixture) or the canned mixture is greater than the sum of the individual effects of each ingredient. Therefore, the synergistic effective amount or the effective amount of the synergistic composition / combination refers to the amount by which its insecticidal activity is greater than the sum of the insecticidal activities of each component.

[0127] In agriculture, the term "synergistic" is generally understood according to the definition given by Colby SR in his 1967 article "Calculation of the synergistic and antagonistic responses of herbicide combinations" published in the journal Weeds (1967, 15, pp. 20–22), which is incorporated herein by reference in its entirety. For a specific combination of two or three active components, the expected effect can be calculated as follows: Colby formula for calculating the synergistic effect between two active ingredients Where E = expected / calculated efficacy of compound A and compound B mixed or combined at a determined dose. X = the observed protective effect of compound A, Y = the observed protective effect of compound B.

[0128] Colby formula for calculating the synergistic effect among three active ingredients Where E = expected / calculated efficacy of compound A, compound B and compound C after mixing or combining at a determined dose; X = the observed protective effect of compound A, Y = the observed protective effect of compound B, and Z = the observed protective effect of compound C.

[0129] If the Colby ratio > 1, a synergistic effect is observed; if the Colby ratio < 1, an antagonistic effect is observed; if the Colby ratio = 1, it indicates a simple additive effect.

[0130] A higher ratio indicates a stronger synergistic effect; a lower ratio indicates a weaker synergistic effect.

[0131] The purpose of this study is to investigate the synergistic effects and benefits of the compositions of the present invention.

[0132] Example 1: Bioactivity against pests that damage chili pepper crops.

[0133] Crop: Chili pepper Location: Warangar, Telangana Number of processes: 28 Community area: 50 sq.m (m 2 ) Crop growth period: 92 days after transplanting Application method: Use an electric backpack sprayer for foliar spraying. Water consumption: 520 liters / hectare Observation method: Thrips (mixed infestation by yellow thrips and small spotted thrips): The number of live thrips was counted by tapping branches on black paper. At 7 and 14 DAA (days after application), 3 branches per plant were surveyed, and 10 plants per plot were surveyed, and the results were recorded. Thrips control efficacy (%) was calculated based on the observed values, and synergistic effects were calculated using the Colby formula.

[0134] Bollworm larvae: Count the number of live larvae on each plant. Record observations from 10 plants per plot and calculate the larval control efficacy (%) using the given formula.

[0135] Healthy fruit count: Count the number of healthy, marketable fruits on each plant. Record observations from 10 plants per plot and calculate the yield increase (%) of healthy, marketable fruits relative to UTC (untreated control).

[0136] Table 1: Processing Details SE: suspension emulsion, SC: suspension agent, ZC: zeon concentrate, OD: oil dispersant, EC: emulsifiable concentrate, T1 to T8: compositions of the present invention, T9 to T20: known formulations.

[0137] Table 2a: Control efficacy against thrips on chili pepper crops. DAA: Number of days after administration, Y: Yes, N: No.

[0138] Compared to all known formulations (T9 to T20) and commercially available products (T21 to T27), all compositions of the present invention (T1 to T8) provide synergistic protection and sustained protection for up to 14 days. All compositions of the present invention (T1 to T8) have a Colby ratio greater than 1, indicating a stronger synergistic effect.

[0139] Table 2b: Control efficacy against fruit borer larvae and pepper fruit yield. All of the compositions of the present invention (T1 to T8) provide synergistic control against fruit borer larvae and result in the highest number of marketable fruits per plant (a yield increase of <206% relative to UTC (T28)).

[0140] Conclusion: Among the various compositions shown in Table 1, treatments T1 to T8 are considered to be the compositions of this invention, exhibiting excellent synergistic effects and control efficacy against pepper thrips and fruit borer larvae on pepper crops. At 7 DAA (days after application), the observed thrips control efficacy of T1 to T8 was >96%, with a Colby ratio >1, indicating a strong synergistic effect. At 14 DAA, the observed thrips control efficacy was greater than 88%. In particular, compared with other known and commercially available products, T7 (99%) showed the highest thrips control efficacy at 14 DAA, followed by T8 (98.8%) and T6 (98.4%), with a Colby ratio >1, demonstrating an effective synergistic effect.

[0141] Furthermore, T1 to T8 all demonstrated 100% control efficacy against fruit borer larvae over 14 DAA, with each plant producing more than 54 healthy fruits. T7 had the highest number of healthy fruits at 54.3, followed by T6 (54.1) and T8 (53.6). In addition, compared to other known and commercially available products, T1 to T8 showed a significant increase in fruit yield relative to UTC (untreated control) of more than 206%, with T7 showing a yield increase of 225.1%, followed by T6 (224%) and T8 (221%).

[0142] Example 2: Control efficacy against pests on eggplant crops.

[0143] Crop: Eggplant Location: Sonpat, Haryana Number of processes: 28 Apartment size: 40 sq.m Crop age: 75 days after transplanting Application method: Use an electric backpack sprayer for foliar spraying. Water consumption: 500 liters / hectare Observation method: Young shoot and fruit borers (eggplant yellow spot moth) Leucinoides orbonalis Damage caused by the shoot and fruit borer larvae: This insect damages the shoots and fruits of eggplant crops. It is an internal feeder, meaning it burrows into the shoots and fruits to cause damage. Control effectiveness can be assessed by counting the number of healthy and damaged shoots, healthy and damaged fruits per plant. Ten plants were randomly selected from each plot, and the observations were recorded.

[0144] Fruit count: The number of healthy, marketable fruits from 5 plants per plot was counted, and the yield increase of healthy fruits relative to UTC was calculated. Two-spotted spider mite (Tetranychus urticae): The number of active mite stages per unit area was counted using a 10X pocket microscope. Leaves (new young leaves) were randomly selected from each plant, and observations were recorded at 5 observation points. Ten plants were observed per plot. Mite control efficacy (%) was calculated using the formula for thrips control efficacy.

[0145] Table 3: Processing Details T1 to T8: Compositions of the present invention; T9 to T20: Known compositions; T21 to T27: Commercially available products.

[0146] Table 4a: Control efficacy against two-spotted spider mites on eggplant. All of the compositions of the present invention (T1 to T8) provide synergistic control against two-spotted spider mites.

[0147] Table 4b: Control efficacy and yield of eggplant crop against borer damage to tender shoots and fruits. All of the compositions of the present invention (T1 to T8) provide excellent control over shoot and fruit borers and produce the highest number of commercially viable fruits per plant.

[0148] Conclusion: Among the various compositions shown in Table 3, T1 to T8 are the compositions of this invention, which exhibit excellent synergistic effects and control efficacy against two-spotted spider mites, shoot borers, and fruit borers on eggplant crops. At 7 DAA (days after application), the control efficacy against two-spotted spider mites was observed to be greater than 97% for all compositions T1 to T8. Furthermore, compared with known and commercially available products, T6 showed the highest control efficacy against two-spotted spider mites, reaching 99.2%, followed by T7 (98.4%) and T5 (98.2%), while their Colby ratios were >1, demonstrating effective synergistic effects.

[0149] Furthermore, compared with other known and commercially available products, T1 to T8 exhibited excellent control efficacy against shoot and fruit borers, with 0% damage rates to shoots and fruits. In addition, T1 to T8 produced more than 72 healthy fruits per five plants, with T1 having the highest number of healthy fruits (78.4 per five plants), followed by T3 (78.1) and T2 (77.3). Moreover, T1 to T8 showed the highest fruit yield increase relative to UTC (untreated control) (>154%). Specifically, compared with other known and commercially available products, T1 showed a fruit yield increase of 146.5% relative to UTC, followed by T3 (145.6%) and T2 (143.1%).

[0150] Example 3: Control efficacy and yield against pigeon pod borer larvae on pigeon pods Crop: Pigeon pea Location: Amlauti, Maharashtra Number of processes: 21 Crop age: 110 days after sowing Spray water consumption: 500 liters / hectare Application method: Use an electric backpack sprayer equipped with a hollow cone nozzle for foliar spraying.

[0151] Observation method: Control efficacy (%) of bean pod borer (cotton bollworm) larvae: count the number of live larvae on each plant. On day 14 after application, record the observations from 10 plants in each plot.

[0152] Pod counting: Count the number of healthy pods on each pigeon pea plant. Record the observations from 10 plants per plot.

[0153] Table 5: Processing Details T1 to T12: Compositions of the present invention; T13 to T20: Commercially available products.

[0154] Table 6: Control efficacy against pod borer larvae on pigeon peas and pod yield. Compared to all known compositions, farm barrel mixes, and commercially available products, all compositions of the present invention (T1 to T12) provide synergistic and sustained control against bean pod borer larvae and produce a higher number of healthy pods per plant.

[0155] Conclusion: Among the various compositions shown in Table 6, treatments T1 to T12 are considered to be the compositions of the present invention, exhibiting excellent synergistic effects and efficacy against the pod borer larvae on pigeon peas. Furthermore, compared to other known compositions, farm barrel mixes, and commercially available products, they achieved 100% control efficacy against the pod borer at 14 DAA (days after application). In addition, T1 to T12 showed more than 310 healthy pods per plant. Specifically, T10 had the highest number of healthy pods per plant at 115.3, followed by T2 (314.5) and T1 (313.7). Moreover, T1 to T12 showed a yield increase of more than 139% in healthy pods relative to UTC (untreated control). Specifically, compared to commercially available products (T13 to T20), T10 showed a yield increase of 142.9% in healthy pods relative to UTC, followed by T2 (142.3%) and T1 (141.7%).

[0156] Example 4: Control efficacy and yield of whitefly and fruit borer larvae on tomatoes.

[0157] Crop: Tomato Location: Gujarat, Anand, Tarapour Number of treatments: 19 (including untreated controls (UTC)).

[0158] Crop age: 80 days after transplanting.

[0159] Spray water consumption: 480 liters / hectare.

[0160] Application method: Use an electric backpack sprayer equipped with a hollow cone nozzle for foliar spraying.

[0161] Observation method: Whiteflies (Tobacco whiteflies) Tobacco Bemesia Control efficacy (%): Count the number of live whiteflies (nymphs and adults) on each trifoliate leaf. Investigate 3 leaves per plant and 10 plants per plot, and record the observation results.

[0162] Control efficacy (%) of fruit borer (cotton bollworm) larvae: Count the number of live larvae on each plant. Record the observations from 10 plants per plot. Calculate the control efficacy (%) of fruit borer larvae.

[0163] Healthy fruit count: Count the number of healthy, marketable fruits on each plant. Record observations from 10 plants per plot and calculate the yield increase (%) of healthy, marketable fruits relative to UTC (untreated control).

[0164] Table 7: Control efficacy against fruit borer larvae and whiteflies on tomato crops. DC: Dispersible liquid, WG: Wettable granules, T1 to T10 are innovative compositions, and T11 to T18 are commercially available products.

[0165] Table 8: Control efficacy against fruit borer larvae and whiteflies on tomatoes. All of the compositions of the present invention (T1 to T10) provide synergistic control against whiteflies and fruit borers, and produce a higher number of healthy fruits per plant on tomatoes.

[0166] Conclusion: Among the various compositions shown in Table 8, treatments T1 to T10 are considered to be the compositions of this invention, exhibiting excellent synergistic effects and control efficacy against whitefly and fruit borer larvae on tomatoes. The observed control efficacy against whiteflies for T1 to T10 was greater than 90%. Specifically, compared to commercially available products, T1 showed the highest control efficacy at 99%, followed by T2 (98.8%) and T5 (98.4%), with a Colby ratio >1, demonstrating effective synergistic effects. Furthermore, T1 to T10 achieved 100% control efficacy against fruit borer larvae. In addition, T1 to T10 resulted in more than 40 healthy fruits per plant, with T9 having the highest number of healthy fruits at 45.2 per plant, followed by T3 (43.8) and T8 (43.1). Moreover, T1 to T10 showed a yield increase of more than 115% for healthy fruits compared to the UTC (untreated control). Specifically, compared to commercially available products, T9 showed a 139.2% increase in yield of healthy fruit relative to UTC, followed by T3 (131.7%) and T8 (128%).

[0167] Example 5: Control efficacy against fruit borer larvae on okra.

[0168] Crop: Okra Location: Sonpat, Haryana Number of processes: 19 Crop plant age: 70 days after sowing Spray water consumption: 450 liters / hectare Application method: Use an electric backpack sprayer equipped with a hollow cone nozzle for foliar spraying.

[0169] Observation method: Control efficacy (%) against fruit borer larvae (mixed infestation by cotton bollworm and beet armyworm): same as in Example 4.

[0170] Table 9: Processing Details T1 to T4: Compositions of the present invention; T5 to T13: Known compositions; T14 to T19: Commercially available products.

[0171] Table 9: Control efficacy against fruit borer larvae on okra crops. All of the compositions of the present invention (T1 to T10) provide synergistic control against fruit borer larvae that infest okra crops.

[0172] Conclusion: Among the various compositions shown in Table 9, treatments T1 to T10 are considered to be the compositions of the present invention, which exhibit excellent synergistic effects and control efficacy against fruit borer larvae on okra. Furthermore, compared with commercially available products, T1 to T10 showed 100% superior fruit borer control efficacy, and a Colby ratio >1, indicating an effective synergistic effect.

[0173] Example 6: Control efficacy and yield of chickpea pod borer larvae.

[0174] Crop: Chickpeas Location: Dewas, Madhya Pradesh Number of treatment groups: 20 Crop age: 88 days after sowing Spray water consumption: 400 liters / hectare Application method: Use an electric backpack sprayer equipped with a hollow cone nozzle for foliar spraying.

[0175] Observation method: Control efficacy against cotton bollworm larvae: as described in Example 4.

[0176] Table 10: Processing details. T1 to T4: Compositions of the present invention; T5 to T13: Known formulations; T14 to T19: Commercially available products.

[0177] Table 11: Control efficacy against chickpea pod borer larvae. All of the compositions of the present invention (T1 to T4) provide synergistic control against pod borer larvae that infest chickpea crops.

[0178] Conclusion: Among the various compositions shown in Table 11, treatments T1 to T4 are considered to be the compositions of the present invention, which exhibit excellent synergistic effects and control efficacy against chickpea pod borer larvae. Furthermore, compared with known compositions (T5 to T13) and commercially available products (T14 to T19), T1 to T4 showed 100% superior control efficacy against the chickpea pod borer, and a Colby ratio >1, indicating an effective synergistic effect.

[0179] Example 7: Control efficacy against rice stem borers.

[0180] Crop: Rice Location: Rajim, Chhattisgarh Number of processes: 24 Application methods: Manual application 20 days after rice transplanting (T1 to T22), or dissolving in water first and then mixing with sand before application (T23).

[0181] Observation method: Rice stem borer control efficacy: The symptoms of stem borer damage were observed as follows: dead heart (DH) appeared during the vegetative growth and tillering stages, and white ears (WE) appeared during crop maturity. The incidence of stem borer was calculated by counting the number of dead hearts (damaged tillers plus healthy tillers) per hill and counting the number of white ears and effective tillers per hill at maturity.

[0182] The DH rate and WE incidence rate are calculated using the following formula: Effective tiller count: Count the number of effective tillers per hill. At harvest, record the observations from 10 hills per plot.

[0183] Table 12: Processing Details T1 to T5: Compositions of the present invention; T6 to T16: Known compositions; T17 to T23: Commercially available products.

[0184] Table 13: Control efficacy against stem borer on rice crops and number of effective tillers. All of the compositions of the present invention (T1 to T5) provide complete protection against rice stem borers (in terms of dead heart and whitehead) and also produce a higher number of effective tillers per hill, which directly contributes to increased grain yield.

[0185] Conclusion: Among the various compositions shown in Table 13, treatments T1 to T5 are considered to be the compositions of the present invention, exhibiting excellent synergistic effects and control efficacy against stem borers (dystocia and whiteheads) on rice plants. Furthermore, the stem borer incidence (dystocia and whiteheads) of T1 to T5 was 0% compared to other known compositions and commercially available products. In addition, the number of effective tillers per square meter for T1 to T5 was 301 to 308. Specifically, compared to other known compositions and commercially available products, T2 had 308.5 effective tillers per square meter, followed by T1 (305.7) and T4 (304.2). Furthermore, the effective tiller growth rate relative to T24 was 60% to 65%.

Claims

1. A synergistic insecticidal composition comprising: a. Isoxazolidinamide, which exists in amounts from 1% to 20% w / w; b. Insecticides selected from the following, present in amounts from 0.5% to 30% w / w: chlorantraniliprole, broflanilide, cyclobromhizolide, tetrazolium acetamiprid, tetrachlorantraniliprole, chlorpyrifos, cyfluthrin, flubendiamide, fluchlorfenapyr, thiofenoxam; and c. Insecticides selected from the following, present in amounts from 0.5% to 30% w / w: carbaryl, carbofuran, thiamethoxam, sec-butylcarbide, methomyl, chlorpyrifos, pirimicarb, thiamethoxam, acephate, chlorpyrifos, methyl chlorpyrifos, methyl demeton-methyl, dimethoate, ethion, fenpyrophos, fenitrothion, fenthion, thiamethoxam, methamidophos, monocrotophos, sulfonylurea, parathion, methyl parathion, isoprothiolane, phorate, phosmet, phosmet, fenpropathrin, quinalphos, triazophos, acetamiprid, fipronil, difenoconazole, nicotineamide, etc. Pyrazosulfuron, Pyrazosulfuron, Brofenoxam, Cyprodinil, Fluoxazolamide, Afralanar, Essolana, Freranar, Loteranar, Saloranar, Bifenthrin, Cypermethrin, β-Cypermethrin, Lambda-cyhalothrin, Lambda-cyhalothrin, λ-Cypermethrin, γ-Cypermethrin, Cypermethrin, α-Cypermethrin, β-Cypermethrin, θ-Cypermethrin, ζ-Cypermethrin, Lambda-cyhalothrin, Deltamethrin, Cypermethrin, Cypermethrin, τ-Flumethoxyfenozide, Cypermethrin Ester, fenpyrethrin, propargyl, propargyl, pyrethrin, acetamiprid, thiamethoxam, dinotefuran, imidacloprid, acetamiprid, thiamethoxam, thiamethoxam, flufenoxuron, cyclopyridamole, imidacloprid, pendimethalin, cyclopyridamole, flupyrrolidone, trifluralin, dichlorvos, dithiamethoxam; chlorfenapyr, chlorfenapyr mononitrate, fenitrothion hydrochloride, chlorfenapyr ring, chlorfenapyr oxalate, chlorfenapyr hydrochloride, chlorfenapyr, spinosad, ethyl spinosad, abamectin, Emamectin benzoate, ivermectin, rapamycin, milbemycin; tebufenozide, tebufenozide, tebufenozide, dioxin, pyriproxyfen, chloropicrin, dazomet, fenpropathrin, pymetrozine, flufenoxuron, difenoconazole, thiamethoxam, flufenoxuron or etoxazole, diflubenzuron, flufenoxuron, diflubenzuron, flufenoxuron, flufenoxuron, lufenuron, difenoconazole, polyfluorourea, flufenoxuron, chlorfenapyr, thiamethoxam, cyprodinil, Bacillus thuringiensis Bacillus thuringiensis And the insecticidal proteins they produce; chlorfenapyr, DNOC or fipronil, methoxyfenozide, chlorfenapyr, chlorfenapyr, furazolidone or cyclofenozide, amitraz, buprofen, triazophos, tricyclic tin, fenbutatin, propargite or trichlorfon, quinclorac, azoxystrobin, pyrimethanil, pyridaben, pyrimethanil, rotenone, pyrimethanil, pyrimethanil, cyprodinil, pyrimethanil, pyrimethanil, pyrimethanil, pyrimethanil, pyrimethanil, pyrimethanil, pyrimethanil, flufenoxuron, fenfluridine, fenfluridine, fenfluridine, pyrimethanil, bifenazate, flumetoquinone, phosphates and cyanides, indica The following are listed: cyfluthrin, spirodiclofen, spirodiclofen, spirodiclofen ethyl ester, spirodiclofen, methoxypiperidine ethyl ester, spirodiclofen diester, granulovirus and nucleopolyhedrovirus, flufenoxuron, azadirachtin, bensulfuron, bromodifen, pyrimethanil, fenpyroxane, trichlorfon, acetamiprid, oxazolidinyl sulfadiazine, fenpyroxenamide, indoxuronamide, flufenoxuron, etoxazole, flufenoxuron, flufenoxuron, trifluralin, triflupyridine, trifluralinamide, thiazoxafen, thioflurperidone, ledprona.

2. The synergistic insecticidal composition according to claim 1, wherein the formulation of the composition is selected from suspension concentrates (SC), wettable granules (WG) / water-dispersible granules (WDG), granules (GR), oil dispersants (OD), and emulsions (SE), and one or more inactive excipients are selected from suspension concentrates, dispersants, wetting agents, emulsifiers, defoamers, antifreeze agents, stabilizers, preservatives, thickeners, diluents, and solvents.

3. The synergistic insecticidal composition according to claim 2, wherein the suspension concentrate (SC) formulation comprises: i. Isoxazolidinamide, which is present in amounts from 1% to 20% w / w; ii. Insecticides selected from the following, present in amounts from 0.5% to 30% w / w: chlorantraniliprole, bromocyanamide, tetrazolium acetamiprid, cyclobrombutamide, flubendiamide; and iii. Insecticides selected from the following, present in amounts from 0.5% to 30% w / w: azoxystrobin, bifenthrin, abamectin, fipronil, difenoconazole, spirodiclofen, azoxystrobin, etoxazole, cyproconazole, methoxyfenozide, spinosad, indoxacarb, emamectin benzoate, flufenoxuron, trifluralin, emamectin benzoate, bromoxynil, fluoxazolamide; iv. A wetting agent, which is present in an amount of 2% to 6% by weight; v. A dispersant, which exists in an amount of 1% to 6% by weight; vi. A suspending agent, which exists in an amount of 0.1% to 4.0% by weight; vii. Defoamer, which is present in an amount of 0.1% to 1.5% by weight; viii. Antifreeze, which is present in an amount of 2% to 6% by weight.

4. The synergistic insecticidal composition according to claim 2, wherein the wettable granule formulation comprises: i. Isoxazolidinamide, which is present in amounts from 1% to 20% w / w; ii. Insecticides selected from the following, present in amounts from 0.5% to 30% w / w: chlorantraniliprole, cyantraniliprole, tetrazolium acetamiprid, cyclobrombutamide, flubendiamide; and iii. Insecticides selected from the following, present in amounts from 0.5% to 30% w / w: acetamiprid, pymetrozine, methoxyfenozide, flonicamid, emamectin benzoate, flufenoxuron, and fipronil; iv. A wetting agent, which is present in an amount of 2% to 6% by weight; v. A dispersant, which is present in an amount of 2% to 8% by weight; vi. Defoamer, which is present in an amount of 0.1% to 2.0% by weight.

5. The synergistic insecticidal composition according to claim 2, wherein the suspension emulsion (SE) formulation comprises: i. Isoxazolidinamide, which is present in amounts from 1% to 20% w / w; ii. Insecticides selected from the following, present in amounts from 0.5% to 30% w / w: chlorantraniliprole, broflanilide, tetrazolium acetamiprid, cyclobrombutamide; and iii. Insecticides selected from the following, present in amounts of 0.5% to 30% w / w: cypermethrin, pyriproxyfen, thiamethoxam; iv. A solvent, present in an amount of 10% to 20% by weight; v. Emulsifier, which is present in an amount of 1.0% to 4% by weight; vi. A dispersant, which exists in an amount of 2% to 6% by weight; vii. A suspending agent, which exists in an amount of 0.1% to 1.0% by weight; viii. Preservatives, which are present in amounts of 0.01% by weight to 1.0% by weight; ix. Antifreeze, which is present in an amount of 4.0% to 6.0% by weight.

6. The synergistic insecticidal composition according to claim 2, wherein the oil dispersant (OD) formulation comprises: i. Isoxazolidinamide, which is present in amounts from 1% to 20% w / w; ii. Selected from the following insecticides, present in amounts of 0.5% to 30% w / w: cyclobrombutamide, chlorantraniliprole, brofenacin; as well as iii. Insecticides selected from the following, present in amounts of 0.5% to 30% w / w: spirodiclofen, fluoxazolamide, emamectin benzoate; iv. Solvent, present in amounts of 40% to 70% w / w; v. Dispersant, which exists in amounts of 1% to 8% w / w; vi. Emulsifier, which is present in an amount of 2% to 12% w / w; vii. Stabilizers or rheology modifiers present in amounts of 0.5% to 3.0% w / w.

7. The synergistic insecticidal composition according to claim 2, wherein the granule (GR) formulation comprises: i. Isoxazolidinamide, which is present in amounts from 1% to 20% w / w; ii. Insecticides selected from the following, present in amounts from 0.5% to 30% w / w: chlorantraniliprole, cyclobrombutamide, flubendiamide; and iii. Insecticides selected from the following, present in amounts of 0.5% to 30% w / w: fenitrothion hydrochloride, cyclooxam, thiamethoxam, fipronil, and emamectin benzoate; iv. Phosphoric acid (buffer), which is present in amounts of 0.1% to 1.0% w / w; v. Alcohol phosphates, which are present in amounts of 1.0% to 2.0% w / w; vi. Alcohol alkoxylates, which are present in amounts of 1.0% to 2.0% w / w.

8. The synergistic insecticidal composition according to claims 3 and 4, wherein the suspending agent is selected from: magnesium aluminum silicate, bentonite, silica, attapulgite clay.

9. The synergistic insecticidal composition according to claims 3 and 4, wherein the antifreeze is selected from: ethylene glycol, propylene glycol, glycerin or urea, glycols (ethylene glycol, diethylene glycol, polypropylene glycol, polyethylene glycol), glycerin, urea, magnesium sulfate heptahydrate, sodium chloride.

10. The synergistic insecticidal composition according to claims 3 and 4, wherein the dispersant is selected from: sodium polycarboxylate (sodium polyacrylate), sodium naphthalene sulfonate formaldehyde condensate, polyalkoxylated alkylphenol, naphthalene sulfonate formaldehyde condensate, sodium methylnaphthalene formaldehyde condensate, naphthalene condensate, lignin sulfonate, calcium lignin sulfonate, sodium lignin sulfonate, sodium alkyl naphthalene sulfonate, sodium naphthalene sulfonate formaldehyde condensate, sodium alkyl naphthalene sulfonate, sodium naphthalene sulfonate condensate, sodium lignin sulfonate, sodium polycarboxylate, based on EO / PO copolymers, phenol sulfonates, sodium methyl oleoyl taurate, styrene-acrylic acid copolymers, propylene oxide-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyryl phenyl ether, tristyryl phenol polyethylene glycol ether phosphate, tristyryl phenol containing 16 moles of EO, tristyryl phenol polyethylene glycol ether phosphate, oleyl alcohol polyethylene glycol ether containing ethylene oxide, tallow fatty amine polyoxyethylene ether, and nonylphenol polyethylene glycol ether containing 9 to 10 moles of ethylene oxide.

11. The synergistic insecticidal composition according to claims 3 and 4, wherein the wetting agent is selected from: sodium N-methyl-N-oleoyl taurate, sodium alkyl naphthalene sulfonate, a mixture of isomers of sodium dibutyl naphthalene sulfonate, sodium diisopropyl naphthalene sulfonate, sodium dodecyl sulfate, dioctyl sulfate, alkyl naphthalene sulfonate, phosphate esters, sulfosuccinates, and nonionic wetting agents such as tridecyl alcohol polyoxyethylene ether, alkyl or alkylaryl sulfonates such as alkylbenzene sulfonates, α-olefin sulfonates and alkyl naphthalene sulfonates, ethoxylated or nonethoxylated alkyl or alkylaryl carboxylates, alkyl or alkylaryl phosphate esters, alkyl polysaccharides, dialkyl or monoalkyl sulfosuccinate derivatives, α-olefin sulfonates, alkyl naphthalene sulfonates, dialkyl sulfosuccinates, butyl, dibutyl, isopropyl and diisopropyl naphthalene sulfonates, C 12 Alkylbenzene sulfonates or C 10 -C 16 Alkylbenzene sulfonates and organosilicon surfactants include trisiloxane polyoxyethylene ether, polydimethylsiloxane, polyoxyethylene methyl polysiloxane, polyoxyalkylene methyl polysiloxane, polyether polymethylsiloxane copolymer, heptamethyltrisiloxane, polyepoxide-modified heptamethyltrisiloxane, polyether-modified polysiloxane, and heptamethyltrisiloxane. Modified forms include polyepoxide-modified heptamethyltrisiloxane, polyether-modified polysiloxane, polyepoxide-modified trisiloxane, and polyepoxide-modified polydimethylsiloxane, and can be in liquid or powder form.

12. The synergistic insecticidal composition according to claims 3 and 4, wherein the defoamer is selected from: polyester, polyamide, magnesium aluminum silicate, bentonite, silica, attapulgite clay, polydimethylsiloxane, organosilicon defoaming emulsion, dimethylsiloxane, polydimethylsiloxane, vegetable oil-based defoamer, tallow-based fatty acid, polydimethylsiloxane, organosilicon defoaming emulsion, dimethylsiloxane, polydimethylsiloxane, vegetable oil-based defoamer, tallow-based fatty acid.

13. The synergistic insecticidal composition according to claims 5 and 6, wherein the dispersant is selected from: alkyl sulfonates, alkylbenzene sulfonates, alkylaryl sulfonates, alkylphenol alkoxylates, tristyrylphenol polyoxyethylene ethers, natural or synthetic fatty alcohol polyoxyethylene ethers, natural or synthetic fatty acid alkoxylates, natural or synthetic fatty alcohol alkoxylates, alkoxylated alcohols (e.g., n-butanol polyethylene glycol ether), block copolymers (e.g., ethylene oxide-propylene oxide block copolymers and ethylene oxide-butane oxide block copolymers), fatty acid polyalkylene glycol condensates, polyamine fatty acid condensates, polyester condensates, polyolefin condensate salts, sodium lignin sulfonate, sodium polycarboxylate, EO / PO based copolymers, phenol sulfonates, sodium methyl oleoyl taurate, styrene-acrylic acid copolymers, epoxy propylene oxide, etc. Alkyl-ethylene oxide copolymers, polyethylene glycol 2,4,6-tristyrene phenyl ether, tristyrene phenol polyethylene glycol ether phosphate, tristyrene phenol containing 16 mol EO, tristyrene phenol polyethylene glycol ether phosphate, oleyl alcohol polyethylene glycol ether containing ethylene oxide, tallow fatty amine polyoxyethylene ether, nonylphenol polyethylene glycol ether containing 9 to 10 mol ethylene oxide, polyesters, polyamides, polycarbonates, polyureas and polyurethanes, acrylic polymers, acrylic graft copolymers, styrene copolymers, butadiene copolymers, polysaccharides such as starch and cellulose derivatives, vinyl alcohol polymers and copolymers, vinyl acetate polymers and copolymers, vinylpyrrolidone polymers and copolymers, polyethers, epoxy resins, phenolic resins and melamine resins, polyolefins and their defined copolymers, and mixtures thereof. Examples of preferred polymers include: acrylate polymers such as poly(methacrylate), poly(ethyl methacrylate), poly(methyl methacrylate), acrylate copolymers and styrene-acrylic acid copolymers as defined below, poly(styrene-copoly-maleic anhydride), cellulose polymers such as ethyl cellulose, cellulose acetate, cellulose acetate butyrate, acetylated monoglycerides, acetylated diglycerides and acetylated triglycerides, poly(vinylpyrrolidone), vinyl acetate polymers and copolymers, poly(alkylene glycols), styrene-butadiene copolymers, poly(orthoesters), alkyd resins, and mixtures of two or more thereof. Biodegradable polymers are also useful in this invention. As used herein, a polymer is biodegradable if it is insoluble in water but degrades within weeks of being placed in the application environment. Examples of biodegradable polymers that can be used in this invention include: Biodegradable polyesters, starch, polylactic acid starch blends, polylactic acid, poly(lactic acid-glycolic acid) copolymers, polydioxanone, cellulose esters, ethyl cellulose, cellulose acetate butyrate, starch esters, starch ester aliphatic polyester blends, modified corn starch, polycaprolactone, poly(n-pentyl methacrylate), rosin, polyanhydride, polyvinyl alcohol, polyhydroxybutyrate valerate, biodegradable aliphatic polyesters, and polyhydroxybutyrate or mixtures thereof. Examples of dispersants include sodium alkyl naphthalene sulfonate, sodium salt of naphthalene sulfonic acid condensate, sodium alkyl naphthalene sulfonate, sodium lignin sulfonate, sodium polycarboxylate, EO / PO block copolymer, phenol sulfonate, sodium methyl oleoyl taurate, styrene-acrylic acid copolymer, propylene oxide-ethylene oxide copolymer, polyethylene glycol 2,4,6-tristyrene phenyl ether, tristyrene phenol polyethylene glycol ether phosphate, tristyrene phenol containing 16 moles of EO, tristyrene phenol polyethylene glycol ether phosphate, oleyl alcohol polyethylene glycol ether containing ethylene oxide, tallow fatty amine polyoxyethylene ether, and nonylphenol polyethylene glycol ether containing 9 to 10 moles of ethylene oxide.

14. The synergistic insecticidal composition according to claims 5 and 6, wherein the emulsifier is selected from: castor oil polyoxyethylene ether, alcohol polyoxyethylene ether, fatty acid polyoxyethylene ester, polyoxyethylene sorbitan ester, sulfosuccinate, calcium dodecylbenzene sulfonate, alkylbenzene sulfonate alkylammonium salt, alkyl sulfosuccinate, ethylene oxide-propylene oxide block copolymer, ethoxylated alkylamine, ethoxylated alkylphenol, polyoxyethylene sorbitan hexaoleate, polyoxyethylene sorbitan monolaurate, dodecylbenzene sulfonate such as calcium salt or amine salt, and other C11-C16 alkylbenzene sulfonates, alkyl ether sulfates, alkylphenol ether phosphates and phosphates; nonionic surfactants such as alkoxylated alcohols and alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils such as castor oil polyoxyethylene ether, fatty acid esters such as sorbitan fatty acid esters and their ethoxylated derivatives, ethoxylated amines, and glycerol condensates; and cationic and anionic emulsifiers such as cationic amines, optionally. It may be used in combination with the following substances: alkyl sulfonates or ether sulfonates or ether phosphates, alkoxylated alcohols, alkoxylated alkylphenols, ethoxylated fatty acids, ethoxylated vegetable oils, ethoxylated tristyrylphenol (tristyrylphenol containing 16 moles of EO), tristyrylphenol polyethylene glycol ether phosphate, sorbitan fatty acid esters and their ethoxylated derivatives, ethoxylated amines and glycerol condensates, alkylbenzene sulfonates and their salts in the C11-C16 range, alkyl ether sulfates, alkyl ether phosphates, alkylphenol ether phosphates, or combinations thereof, ethoxylated tristyrylphenol phosphate salts, ethoxylated tristyrylphenol sulfated ether salts; or anionic and cationic systems in which cationic amines are combined with alkyl sulfonates, alkyl ether sulfonates, ether sulfates or ether phosphates such as alkyl ether phosphates, nonylphenol polyoxyethylene ether, castor oil polyethylene glycol ether, polyadditions of ethylene oxide and polypropylene, tributylphenoxy polyoxyethylene ether, octylphenoxy polyoxyethylene ether.

15. The synergistic insecticidal composition according to claim 6, wherein the solvent is selected from: vegetable oils (plants, seeds, or trees) or their alkylated, ethoxylated, or esterified products; the alkylated vegetable oil may be methylated or ethylated vegetable oil; the vegetable oil includes olive oil, kapok oil, castor oil, papaya oil, camellia oil, sesame oil, corn oil, rice bran oil, cottonseed oil, soybean oil, peanut oil, rapeseed-mustard oil, flaxseed oil, tung oil, sunflower seed oil, safflower oil, and coconut oil; the alkyl esters of the vegetable oil include methyl ester, ethyl ester, propyl ester, or butyl ester of the vegetable oil; methylated seed oil, polyoxyethylene modified polydimethylsiloxane alkylphenol polyoxyethylene ether, rapeseed oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl ester, rapeseed oil butyl ester, soybean oil methyl ester, rapeseed oil ethyl ester, rapeseed oil propyl ester, rapeseed oil butyl ester, and soybean oil methyl ester. Esters, soybean oil ethyl ester, soybean oil propyl ester, soybean oil butyl ester, castor oil methyl ester, castor oil ethyl ester, castor oil propyl ester, castor oil butyl ester, cottonseed oil methyl ester, cottonseed oil ethyl ester, cottonseed oil butyl ester, cottonseed oil propyl ester, tallow fatty acid esters, tallow methyl ester, tallow ethyl ester, tallow propyl ester, biodiesel, mineral oil (aromatic solvent, isoparaffin, base solvent), fatty acid amides (e.g., amides formed by C1-C3 amines, alkylamines or alkanolamines with C6-C18 carboxylic acids), fatty acids, fatty acid alkyl esters, methyl oleate and ethyl oleate, soybean oil methyl ester and soybean oil ethyl ester, alkylbenzene and alkylnaphthalene, polyalkylene glycol ethers, fatty acid diesters, fatty alkylamides and diamides, alkylene carbonates, ketones and alcohols; used alone or as mixtures thereof.

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