Compositions comprising platelet-derived extracellular vesicles

By combining platelet-derived extracellular vesicles with immunosuppressive and anti-inflammatory drugs, the problems of poor treatment efficacy and severe side effects in existing technologies have been solved, achieving highly effective treatment for immune and inflammatory diseases while reducing unwanted side effects and resource requirements.

CN122459000APending Publication Date: 2026-07-24LYSAT PHARMA GMBH
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Patent Information

Application Number
CN202480082413.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2023-12-28
Filing Date
2024-12-19
Publication Date
2026-07-24

AI Technical Summary

Technical Problem

Existing technologies have problems with poor treatment efficacy or severe side effects in the treatment of immune and inflammatory diseases, especially for patients who do not respond well to existing drug regimens, and the resource requirements for preparing therapeutic compositions are high.

Method used

The combination of extracellular vesicles containing platelets with immunosuppressive and/or anti-inflammatory drugs is used to prevent and treat immune and inflammatory diseases, including graft-versus-host disease, transplant rejection, autoimmune diseases, and neuroinflammatory-related diseases.

Benefits of technology

It provides highly effective immunosuppression and anti-inflammatory effects, reduces unwanted side effects, and improves treatment efficacy and resource utilization efficiency.

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Abstract

The present invention relates to a composition comprising platelet-derived extracellular vesicles, such as human platelet lysate-derived extracellular vesicles, for use in the prevention and / or treatment of immune and / or inflammatory diseases in a subject wherein the composition is administered to the subject.
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