A traditional Chinese medicine formula for treating gout in a warm-yang and dampness-reducing mode

Abstract

This invention relates to the field of traditional Chinese medicine (TCM) composition technology. It discloses a TCM formula for treating gout using a warming and dampness-eliminating approach. The TCM composition is made from the following raw materials: kudzu root, yam, cinnamon twig, dioscorea hypoglauca, corydalis rhizome, poria cocos, atractylodes macrocephala, cistanche deserticola, morinda officinalis, and licorice root. Cistanche deserticola and morinda officinalis are the principal herbs to warm and tonify kidney yang, while poria cocos and atractylodes macrocephala are the assistant herbs to strengthen the spleen and eliminate dampness. This warming and dampness-eliminating TCM formula for gout breaks through the limitations of traditional heat-clearing and dampness-eliminating methods, focusing on the pathogenesis of spleen and kidney yang deficiency and internal dampness, treating both the root cause and symptoms, and significantly reducing the recurrence of gout attacks. The entire formula is warming without being drying, does not harm spleen and kidney yang, has high safety, and is suitable for long-term use. The formula is carefully formulated, quickly relieving pain and lowering uric acid, while improving yang deficiency symptoms, with side effects far lower than Western medicine. It has various dosage forms, simple processing, and is easy to produce and promote, providing a safe and effective new solution for gout treatment.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, specifically a traditional Chinese medicine formula for treating gout with a warming and dampness-eliminating type. Background Technology

[0002] Gout is a metabolic disease caused by purine metabolism disorders, leading to elevated blood uric acid levels and the deposition of urate crystals in the joints, soft tissues, and kidneys. Currently, the main Western medicines used to treat gout include nonsteroidal anti-inflammatory drugs (NSAIDs), colchicine, allopurinol, and febuxostat. While these drugs can quickly relieve acute symptoms or lower blood uric acid, they have significant side effects such as gastrointestinal reactions, liver and kidney damage, and cardiovascular risks. Furthermore, long-term adherence to these medications is poor for patients with recurrent chronic gout.

[0003] Traditional Chinese medicine (TCM) offers advantages in treating gout through multi-target and holistic regulation. Current TCM formulas often follow the principles of "clearing heat and promoting diuresis," "activating blood circulation and removing blood stasis," or "draining turbidity and unblocking the meridians," commonly using herbs such as Phellodendron bark, Atractylodes rhizome, Coix seed, Smilax glabra rhizome, and Alisma rhizome. However, current techniques generally overlook the fundamental pathogenesis of gout, which lies in "spleen and kidney yang deficiency." Simply using cold and cooling herbs to clear heat and promote diuresis may temporarily alleviate symptoms, but it easily damages the spleen and kidney yang, leading to internal dampness and turbidity, resulting in recurrent attacks and a prolonged, difficult-to-cure condition. Therefore, we propose a TCM formula for treating gout that warms yang and promotes diuresis to address these problems. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine formula for treating gout using a warming and dampness-eliminating approach. This formula solves many of the deficiencies of existing gout medications: Western medicines have significant side effects, easily damage the gastrointestinal tract and liver and kidney function, and have poor long-term adherence; traditional Chinese medicines are mostly based on cold and cooling methods to clear heat and eliminate dampness, which easily damages the spleen and kidney yang, and cannot address the root cause of spleen and kidney yang deficiency, leading to recurrent gout attacks and difficulty in achieving a complete cure.

[0005] To achieve the above objectives, the present invention is implemented through the following technical solution: a traditional Chinese medicine formula for treating gout with a warming and dampness-eliminating type, wherein the traditional Chinese medicine composition is made from the following raw materials: kudzu root, yam, cinnamon twig, dioscorea hypoglauca, corydalis rhizome, poria cocos, atractylodes macrocephala, cistanche deserticola, morinda officinalis, and licorice; wherein the traditional Chinese medicine composition uses cistanche deserticola and morinda officinalis as the principal herbs to warm and tonify kidney yang, and poria cocos and atractylodes macrocephala as the assistant herbs to strengthen the spleen and eliminate dampness, and dioscorea hypoglauca, corydalis rhizome, kudzu root, and cinnamon twig as adjuvant herbs to separate clear and turbid substances, unblock the meridians and relieve pain, and licorice is used to harmonize the various herbs.

[0006] Preferably, the traditional Chinese medicine composition is a clinically acceptable preparation, including decoctions, granules, capsules, tablets, or pills.

[0007] Preferably, the preparation method of the formulation includes the following steps: extracting the raw material drug with water or ethanol, concentrating the extract, and adding pharmaceutically acceptable excipients to prepare the formulation.

[0008] Preferably, the weight ratio of the raw materials is as follows: 10-30 parts of kudzu root, 10-30 parts of yam, 5-15 parts of cinnamon twig, 10-20 parts of dioscorea hypoglauca, 5-15 parts of corydalis rhizome, 10-20 parts of poria cocos, 10-20 parts of atractylodes macrocephala, 10-20 parts of cistanche deserticola, 10-20 parts of morinda officinalis, and 3-10 parts of licorice root.

[0009] Preferably, the weight ratio of the raw materials is as follows: 20 parts of kudzu root, 20 parts of yam, 10 parts of cinnamon twig, 15 parts of dioscorea hypoglauca, 10 parts of corydalis rhizome, 15 parts of poria cocos, 15 parts of atractylodes macrocephala, 15 parts of cistanche deserticola, 15 parts of morinda officinalis, and 6 parts of licorice.

[0010] Preferably, the water extraction involves adding water at a rate of 6-10 times the total weight of the raw material, extracting 2-3 times, with each extraction lasting 40 minutes to 2 hours.

[0011] Preferably, the ethanol extraction is performed by reflux extraction with 60%-80% ethanol by volume, the extraction is performed twice, and the extraction time is 1-1.5 hours each time.

[0012] The present invention also provides the use of any of the above-mentioned traditional Chinese medicine compositions in the preparation of drugs for treating gout.

[0013] Beneficial effects

[0014] This invention provides a traditional Chinese medicine formula for treating gout using the warming and dampness-eliminating method. Compared with existing technologies, it has the following beneficial effects:

[0015] This traditional Chinese medicine formula for treating gout, focusing on warming yang and eliminating dampness, breaks through the limitations of traditional Chinese medicine's simple heat-clearing and dampness-eliminating approach. It addresses the root cause of gout—spleen and kidney yang deficiency and internal dampness—by tonifying the kidneys and strengthening the spleen and eliminating dampness. This approach achieves both symptomatic and root-cause treatment, reducing the recurrence of gout attacks and resolving the persistent and difficult-to-cure nature of chronic gout. The formula is warming without being drying and tonifying without being drastic, avoiding large amounts of cold and dampness-eliminating drugs to prevent further damage to the spleen and kidney yang. This makes it more suitable for long-term use by chronic patients, ensuring higher medication safety. The formula's precise combination of principal, assistant, and adjuvant herbs works synergistically to target multiple points, quickly relieving symptoms such as joint redness, swelling, heat, pain, and difficulty in flexion and extension. It also promotes uric acid excretion, lowers blood uric acid levels, and improves symptoms of yang deficiency such as lower back and knee weakness, and cold limbs.

[0016] Compared with Western medicine and conventional Chinese medicine, this invention has significant advantages. All the medicinal materials used are commonly used Chinese medicinal herbs in clinical practice, with no obvious side effects such as gastrointestinal irritation or liver and kidney damage, greatly improving patient adherence to long-term medication. The formula can be prepared into various dosage forms such as decoctions, granules, capsules, tablets, and pills to meet the medication habits of different groups. The preparation process is simple and low-cost, suitable for industrial production and large-scale clinical application, providing a safer and more effective new option for long-term management and cure of gout. Detailed Implementation

[0017] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0018] Example 1

[0019] A traditional Chinese medicine decoction for treating gout with a warming and dampness-eliminating type is made from the following raw materials: 20 parts of kudzu root, 20 parts of yam, 10 parts of cinnamon twig, 15 parts of dioscorea hypoglauca, 10 parts of corydalis rhizome, 15 parts of poria cocos, 15 parts of atractylodes macrocephala, 15 parts of cistanche deserticola, 15 parts of morinda officinalis, and 6 parts of licorice root.

[0020] Preparation method: Weigh each raw material according to the above weight proportions, add 8 times the amount of water and soak for 30 minutes, bring to a boil over high heat and then simmer over low heat for 1 hour, filter to obtain the first extract; add 6 times the amount of water to the dregs and continue to simmer for 40 minutes, filter to obtain the second extract; combine the two extracts and mix well to obtain the decoction.

[0021] Dosage and administration: One dose per day, taken twice daily (morning and evening) with warm water. One course of treatment is four weeks.

[0022] Example 2

[0023] A traditional Chinese medicine granule for treating gout with a warming and dampness-eliminating type is made from the following raw materials: 30 parts of kudzu root, 30 parts of yam, 15 parts of cinnamon twig, 20 parts of dioscorea hypoglauca, 15 parts of corydalis rhizome, 20 parts of poria cocos, 20 parts of atractylodes macrocephala, 20 parts of cistanche deserticola, 20 parts of morinda officinalis, and 10 parts of licorice root.

[0024] Preparation method: Weigh the raw material according to the weight parts, add 70% ethanol and reflux extract twice, 1.5 hours each time, combine the extracts, recover the ethanol and concentrate under reduced pressure to a clear extract with a relative density of 1.20; add 3 times the amount of dextrin and an appropriate amount of sucrose to the clear extract, mix well, granulate, dry and granulate to obtain granules.

[0025] Dosage and administration: Take one packet each time, twice a day, dissolved in warm water.

[0026] Example 3

[0027] A traditional Chinese medicine capsule for treating gout with a warming and dampness-eliminating type is made from the following raw materials: 10 parts of kudzu root, 10 parts of yam, 5 parts of cinnamon twig, 10 parts of dioscorea hypoglauca, 5 parts of corydalis rhizome, 10 parts of poria cocos, 10 parts of atractylodes macrocephala, 10 parts of cistanche deserticola, 10 parts of morinda officinalis, and 3 parts of licorice root.

[0028] Preparation method: Weigh the raw material according to the weight parts, extract it twice with water, combine the extracts and concentrate them into a dry paste, then pulverize it into a fine powder; add an appropriate amount of starch, mix well, and fill the capsule shell to obtain the capsule.

[0029] Dosage and administration: 4 capsules each time, 3 times a day, orally.

[0030] Clinical validation cases

[0031] Sixty patients with gout of the spleen and kidney yang deficiency type were randomly divided into a treatment group and a control group, with 30 patients in each group. The treatment group received the decoction described in Example 1 of this invention, while the control group received a conventional heat-clearing and dampness-removing traditional Chinese medicine decoction. The treatment course for both groups was 8 weeks. The results showed that the total effective rate in the treatment group was 93.3%, the average decrease in serum uric acid level was 38.6%, and the gout recurrence rate was 6.7%; the total effective rate in the control group was 73.3%, the average decrease in serum uric acid level was 21.2%, and the gout recurrence rate was 33.3%. The formula of this invention is significantly superior to the control group in relieving symptoms, reducing uric acid, and reducing recurrence, and has no obvious adverse reactions.

[0032] The above clinical results demonstrate that the warming and dampness-eliminating traditional Chinese medicine formula of this invention is effective and safe in treating gout, and has good clinical application value.

[0033] This treatment plan breaks through the limitations of traditional Chinese medicine's simple heat-clearing and dampness-removing methods. It addresses the root cause of gout—spleen and kidney yang deficiency and internal dampness—by focusing on warming yang and tonifying the kidneys, strengthening the spleen and removing dampness. This approach achieves both symptomatic and root-cause treatment, reducing recurrent gout attacks and resolving the persistent and difficult-to-cure nature of chronic gout. The formula is warming without being drying and tonifying without being drastic, avoiding a large amount of cold and dampness-removing drugs to prevent further damage to the spleen and kidney yang. This makes it more suitable for long-term use by chronic patients and ensures higher medication safety. The formula's composition is rigorous, with multiple targets working synergistically. It can quickly relieve symptoms such as joint redness, swelling, heat, pain, and difficulty in flexion and extension, while also promoting uric acid excretion, lowering blood uric acid levels, and improving symptoms of yang deficiency such as lower back and knee weakness, and cold limbs.

[0034] Compared with Western medicine and conventional Chinese medicine, this invention has significant advantages. All the medicinal materials used are commonly used Chinese medicinal herbs in clinical practice, with no obvious side effects such as gastrointestinal irritation or liver and kidney damage, greatly improving patient adherence to long-term medication. The formula can be prepared into various dosage forms such as decoctions, granules, capsules, tablets, and pills to meet the medication habits of different groups. The preparation process is simple and low-cost, suitable for industrial production and large-scale clinical application, providing a safer and more effective new option for long-term management and cure of gout.

[0035] Finally, it should be noted that the above descriptions are merely preferred embodiments of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine formula for treating gout using the warming and dampness-eliminating type, characterized in that: The traditional Chinese medicine composition is made from the following raw materials: Kudzu root, Chinese yam, cinnamon twig, Dioscorea hypoglauca, Corydalis yanhusuo, Poria cocos, Atractylodes macrocephala, Cistanche deserticola, Morinda officinalis, licorice; The herbal composition uses Cistanche deserticola and Morinda officinalis as the principal herbs to warm and tonify kidney yang, Poria cocos and Atractylodes macrocephala as the assistant herbs to strengthen the spleen and promote diuresis, and Dioscorea hypoglauca, Corydalis yanhusuo, Pueraria lobata and Cinnamomum cassia as adjuvant herbs to separate clear from turbid, unblock the meridians and relieve pain, and Glycyrrhiza uralensis as the harmonizing agent to harmonize the herbs.

2. The traditional Chinese medicine formula for treating gout of the warming-yang and dampness-eliminating type according to claim 1, characterized in that: The traditional Chinese medicine composition is a clinically acceptable preparation, which includes decoctions, granules, capsules, tablets or pills.

3. The traditional Chinese medicine formula for treating gout of the warming-yang and dampness-eliminating type according to claim 1, characterized in that: The preparation method of the formulation includes the following steps: The active pharmaceutical ingredient is extracted with water or ethanol, the extract is concentrated, and pharmaceutically acceptable excipients are added to prepare the formulation.

4. The traditional Chinese medicine formula for treating gout of the warming-yang and dampness-eliminating type according to claim 2, characterized in that: The weight ratio of the raw materials is as follows: 10-30 parts of kudzu root, 10-30 parts of yam, 5-15 parts of cinnamon twig, 10-20 parts of dioscorea hypoglauca, 5-15 parts of corydalis rhizome, 10-20 parts of poria cocos, 10-20 parts of atractylodes macrocephala, 10-20 parts of cistanche deserticola, 10-20 parts of morinda officinalis, and 3-10 parts of licorice root.

5. The use of the traditional Chinese medicine composition according to any one of claims 1 to 4 in the preparation of a drug for treating gout.