Sample analyzer

Abstract

The utility model discloses a sample analyzer which comprises an amplification module, a first driving module, a second driving module and a detection module, the amplification module comprises a base, a heating assembly and a gland assembly, the heating assembly is used for heating a nucleic acid sample contained in a sample container, and the gland assembly is used for pressing the nucleic acid sample. The first driving module is used for driving the gland to rotate between a first position and a second position relative to the base; the second driving module is used for driving the gland to move downwards from a second position to a third position relative to the base in the vertical direction, so that the sample container is tightly pressed between the crimping surface of the gland and the heating assembly, and when the gland is located at the first position, the angle of the crimping surface relative to the horizontal plane is a first angle; when the gland is in the second position, the angle of the crimping surface relative to the horizontal plane is a second angle which is larger than the first angle. According to the utility model, the problem of non-uniform pressing force of the gland can be improved.

Description

Technical Field

[0001] The utility model relates to the field of medical equipment, in particular to a sample analyzer. Background Art

[0002] With the development of technology, sample analyzers based on polymerase chain reaction (PCR) are increasingly used in the field of medical testing. The amplification module is the core component of molecular diagnostic equipment, which can significantly increase trace amounts of DNA. The amplification module includes a cover body, which is used to press the reaction tube during the amplification reaction to ensure that the reaction tube can fully contact the heating device. The pressure cover in the related technology has the problem of uneven pressing force, which affects the fixation of the reaction tube. Utility Model Content

[0003] The utility model aims to at least solve the technical problems existing in the prior art. To this end, the utility model provides a sample analyzer that can improve the problem of uneven pressing force of the gland.

[0004] According to the sample analyzer in the first embodiment of the utility model, it includes:

[0005] The amplification module comprises a base, a heating component and a pressure cover component, wherein the heating component is connected to the base and is used to place a sample container and heat the nucleic acid sample contained in the sample container, and the pressure cover component comprises a pressure cover having a pressing surface for pressing the sample container;

[0006] A first driving module, used for driving the pressing cover to rotate relative to the base between a first position and a second position;

[0007] A second driving module, used for driving the pressing cover to move downward from the second position to a third position along a vertical direction relative to the base, so as to press the sample container tightly between the pressing surface of the pressing cover and the heating component;

[0008] A detection module, used for detecting the amplified nucleic acid sample;

[0009] When the pressure cover is in the first position, the angle of the crimping surface relative to the horizontal plane is a first angle, and when the pressure cover is in the second position, the angle of the crimping surface relative to the horizontal plane is a second angle, and the first angle is greater than the second angle.

[0010] The sample analyzer according to the first embodiment of the utility model has at least the following beneficial effects:

[0011] The pressure cover first rotates from the first position to the second position, and then moves in the second position to contact the sample container, which can reduce the possibility of the sample container being skewed due to local force and improve the problem of uneven pressing force of the pressure cover.

[0012] In some other embodiments, the amplification module further includes a transmission assembly, the transmission assembly includes a connecting rod, a first sliding seat and a second sliding seat, the gland is rotatably connected to the second sliding seat, and the connecting rod is rotatably connected to the gland and the first sliding seat respectively;

[0013] The first driving module drives the first sliding seat to move downward in a vertical direction relative to the base, so as to drive the pressure cover to rotate from the first position to the second position through the connecting rod;

[0014] The second driving module is used to drive the first sliding seat and the second sliding seat to move downward along the vertical direction, so as to drive the pressing cover to move downward along the vertical direction from the second position to the third position.

[0015] In some other embodiments, the first driving module and the second driving module are the same module, the first sliding seat has a first abutting portion, and the second sliding seat has a second abutting portion, and when the pressure cover is located at the second position, the first abutting portion abuts against the second abutting portion in a vertical direction, and when the first driving module drives the first sliding seat to move downward in the vertical direction, the first sliding seat drives the second sliding seat to move downward in the vertical direction, so that the pressure cover moves from the second position to the third position.

[0016] In some other embodiments, the amplification module also includes a locking component, the first sliding seat has a butt contact surface, and the sample analyzer also includes a third driving module, and the third driving module is used to drive the locking component to move relative to the base between a fourth position and a fifth position, and when the locking component is at the fourth position, the locking component abuts against the butt contact surface of the first sliding seat to limit the upward movement of the first sliding seat in the vertical direction, and when the locking component is at the fifth position, the locking component disengages from the butt contact surface.

[0017] In some other embodiments, the amplification module also includes a reset component, and the reset component includes a first elastic member and a second elastic member, the first elastic member is connected between the first sliding seat and the base, and the second elastic member is connected between the second sliding seat and the base, when the pressure cover is located at the third position, the first elastic member and the second elastic member both have a deformation amount, when the locking part is separated from the abutment surface, the first elastic member drives the first sliding seat to move upward by its own elastic force, and the second elastic member drives the second sliding seat to move upward by its own elastic force.

[0018] In some other embodiments, the amplification module also includes a reset component, which includes a second elastic member and a fifth elastic member, the second elastic member is connected between the second sliding seat and the base, the fifth elastic member is connected between the pressure cover and the second sliding seat, when the pressure cover is located at the third position, the second elastic member and the fifth elastic member both have a deformation amount, when the locking part is disengaged from the abutment surface, the second elastic member drives the second sliding seat to move upward by its own elastic force, and the fifth elastic member drives the pressure cover to rotate in the opposite direction of the rotation direction from the first position to the second position by its own elastic force.

[0019] In some other embodiments, the amplification module also includes a fourth elastic member, which is connected between the locking component and the base. When the locking component is in the fifth position, the fourth elastic member has a deformation amount. When the pressure cover moves to the third position, the fourth elastic member drives the locking component from the fifth position to the fourth position through its own elastic force.

[0020] In some other embodiments, the locking component is rotatably connected to the base, and has a fifth abutting portion for abutting against the first sliding seat, the fifth abutting portion can be rotated to a first side of the rotation axis of the locking component, and rotated to a second side opposite to the first side, when the fifth abutting portion is located at the first side, the locking component is in the fourth position, and when the fifth abutting portion is located at the second side, the locking component is in the fifth position;

[0021] The first sliding seat has a first limiting portion. When the fifth abutting portion rotates to the fourth position, the fifth abutting portion abuts against the first sliding seat to keep the pressure cover in the third position, and the locking component abuts against the first limiting portion to limit the rotation of the locking component in the direction from the fifth position to the fourth position.

[0022] In some other embodiments, the amplification module further includes a transfer device for transferring the sample container, the first driving module, the second driving module and the third driving module are the same module, and the first driving module is further configured to drive the transfer device to move in a vertical direction and in a horizontal direction between a sixth position and a seventh position;

[0023] Wherein, when the transfer device is in the sixth position and the pressure cover is in the first position, the first driving module drives the transfer device to move downward in the vertical direction to abut against the first sliding seat, and after abutting against the first sliding seat, the first sliding seat is driven by the transfer device to move downward in the vertical direction, so that the pressure cover rotates from the first position to the second position; when the pressure cover is in the second position, the first driving module drives the first sliding seat and the second sliding seat to move downward in the vertical direction through the transfer device, so that the pressure cover moves from the second position to the third position;

[0024] Furthermore, when the transfer device is in the seventh position and the locking part is in the fourth position, the first driving module drives the transfer device to move downward in the vertical direction to abut against the locking part, and drives the transfer device to move downward in the vertical direction after abutting against the locking part to drive the fifth abutment part to rotate from the first side to the second side.

[0025] In some other embodiments, the amplification module also includes a transfer device for transferring the sample container, and the third driving module is also configured to drive the transfer device to move in a vertical direction, wherein when the locking part is in the fourth position and the transfer device abuts against the locking part, the third driving module drives the transfer device to move downward in the vertical direction to drive the fifth abutment portion to rotate from the first side to the second side.

[0026] In some other embodiments, the amplification module also includes a transfer device for transferring the sample container, the first driving module and the second driving module are the same module, and the first driving module is also configured to drive the transfer device to move in a vertical direction, wherein, when the pressure cover is in the first position and the transfer device abuts against the first sliding seat, the first driving module drives the first sliding seat to move downward in the vertical direction through the transfer device, so that the pressure cover rotates from the first position to the second position; when the pressure cover is in the second position, the first driving module drives the first sliding seat and the second sliding seat to move downward in the vertical direction through the transfer device, so that the pressure cover moves from the second position to the third position.

[0027] In some other embodiments, the amplification module further includes a reset component, the first driving module and the second driving module are the same module, the first driving module includes a first power device and a power output part, the first power device can drive the power output part to move in the vertical direction, wherein, when the pressure cover is in the first position and the power output part abuts against the first sliding seat, the power output part is driven by the first power device to drive the first sliding seat to move downward in the vertical direction, so that the pressure cover rotates from the first position to the second position, when the pressure cover rotates to the second position, the power output part is driven by the first power device to drive the first sliding seat and the second sliding seat to move downward in the vertical direction, so that the pressure cover moves to the third position, and, after the pressure cover moves to the third position, the power output part is stationary and remains abutted against the first sliding seat, so that the pressure cover remains in the third position;

[0028] The reset assembly includes a first elastic member and a second elastic member, the first elastic member is connected between the first sliding seat and the base, and the second elastic member is connected between the second sliding seat and the base. When the pressure cover is located at the third position, the first elastic member and the second elastic member both have a deformation amount. When the power output part is driven by the first power device to move upward in the vertical direction, the first elastic member drives the first sliding seat to move upward by its own elastic force, and the second elastic member drives the second sliding seat to move upward by its own elastic force.

[0029] In some other embodiments, the amplification module further includes a reset component, the first driving module and the second driving module are the same module, the first driving module includes a first power device and a power output part, the power output part is connected to the first sliding seat, wherein when the pressure cover is in the first position, the power output part can be driven by the first power device to drive the first sliding seat to move in the vertical direction, so that the pressure cover rotates from the first position to the second position, when the pressure cover rotates to the second position, the power output part is driven by the first power device to drive the first sliding seat and the second sliding seat to move downward in the vertical direction, so that the pressure cover moves to the third position, and after the pressure cover moves to the third position, the power output part is stationary, so that the pressure cover remains in the third position;

[0030] The reset assembly includes a second elastic member, which is connected between the second sliding seat and the base. When the pressure cover is located at the third position, the second elastic member has a deformation amount. When the power output part is driven by the first power device to drive the first sliding seat to move upward in the vertical direction, the second elastic member drives the second sliding seat to move upward through its own elastic force.

[0031] In some other embodiments, the pressure cover includes a first main body, a pressure block and a third elastic member, the pressure block is connected to one side of the first main body, and the pressure surface is provided at an end of the pressure block away from the first main body, and the third elastic member is connected between the pressure block and the first main body, and when the pressure cover is in the third position, the pressure block can abut against the sample container and compress the third elastic member.

[0032] In some other embodiments, when the pressing block is in the initial state, the third elastic member is configured to have a set preload force, and the pressing cover also includes an adjusting component, which is connected to the first main body, and the third elastic member is connected between the first main body and the adjusting component, and the adjusting component is used to move relative to the first main body to adjust the preload force of the third elastic member.

[0033] In some other embodiments, the pressure cover assembly includes a plurality of the pressure blocks and a plurality of the third elastic members, and the plurality of the pressure blocks are connected in parallel to the same side of the first main body.

[0034] In some other embodiments, the pressing cover is configured such that: when in the second position, the pressing surface is perpendicular to the axis of the sample container.

[0035] In some other embodiments, the heating component includes a semiconductor heater, a heat sink, a heat conducting mechanism and a pressing mechanism, the heat sink is in contact with the first side of the semiconductor heater, the heat conducting mechanism is in contact with the second side of the semiconductor heater, the first side and the second side are arranged opposite to each other, the heat conducting mechanism has a accommodating hole for accommodating a sample container, and the pressing mechanism is used to press the heat conducting mechanism between the semiconductor heater and the pressing mechanism.

[0036] In some other embodiments, the clamping mechanism includes a first substrate and a plurality of clamping components, the first substrate is connected to the heat sink, and the plurality of clamping components are connected to the same side of the first substrate and are all abutted against the heat conducting mechanism to press the heat conducting mechanism between the semiconductor heater and the clamping mechanism, wherein at least the clamping component is made of heat insulating material.

[0037] In some other embodiments, the pressing mechanism further includes a fastener, and the first substrate is connected to the heat sink via the fastener;

[0038] Wherein, the clamping mechanism further includes a heat insulating pad, and the heat insulating pad is arranged between the head of the fastener and the first substrate;

[0039] And / or, the fastener is made of a heat insulating material.

[0040] In some other embodiments, the heating component also includes a limit seat made of a thermal insulation material, the limit seat includes a second main body and a plurality of second limit portions, the second main body has a receiving groove, the second limit portion is connected to the second main body and at least partially extends into the receiving groove, the semiconductor heater is arranged in the receiving groove, and the side surface of the semiconductor heater abuts against each of the second limit portions to form a thermal insulation gap between the side surface of the semiconductor heater and the groove wall of the receiving groove.

[0041] In some other embodiments, the clamping mechanism includes a first substrate and a plurality of clamping components, the first substrate is connected to the heat sink, and the plurality of clamping components are connected to the same side of the first substrate and are all abutted against the heat conducting mechanism to press the heat conducting mechanism between the semiconductor heater and the clamping mechanism, wherein along the direction in which the clamping component abuts against the heat conducting mechanism, the first substrate abuts against the limit seat.

[0042] In some other embodiments, the heat-conducting mechanism includes a second substrate and a heat-conducting component connected to the second substrate, the second substrate is attached to the second side of the semiconductor heater, and the clamping mechanism presses the second substrate between the semiconductor heater and the clamping mechanism, and the heat-conducting component has the accommodating hole at one end away from the second substrate.

[0043] According to the sample analyzer in the second embodiment of the utility model, it includes:

[0044] An amplification module, comprising a base, a heating component and a pressure cover component, wherein the heating component is connected to the base and is used to place a sample container and heat the nucleic acid sample contained in the sample container, the pressure cover component comprises a pressure cover that can move between an eighth position and a ninth position relative to the base, the pressure cover comprises a first main body, a plurality of pressure blocks and a plurality of third elastic members, the plurality of pressure blocks are connected in parallel to the same side of the first main body, and the third elastic member is connected between the first main body corresponding to the pressure blocks;

[0045] a fourth driving module, used for driving the pressing cover to move between an eighth position and a ninth position relative to the base;

[0046] A detection module, used for detecting the amplified nucleic acid sample;

[0047] When the fourth driving module drives the pressing cover to move to the ninth position, each pressing block abuts against the corresponding sample container and independently moves relative to the first main body to press each sample container tightly between the heating component and the pressing cover;

[0048] When the pressing cover moves from the ninth position to the eighth position to separate the pressing block from the sample container, the third elastic member drives the pressing block to return to an initial state.

[0049] The sample analyzer according to the second embodiment of the utility model has at least the following beneficial effects:

[0050] Each pressing block is provided with a corresponding third elastic member so that it can abut against the corresponding sample container and move independently relative to the pressure cover. In this way, even if the heights of the tubes in the multi-tube are inconsistent, the pressing block can adaptively adjust the third elastic member to ensure uniform pressing force of each tube.

[0051] In some other embodiments, when the pressing block is in the initial state, the third elastic member is configured to have a set preload force, the pressing cover also includes an adjusting component, the adjusting component is connected to the first main body, the third elastic member is connected between the first main body and the adjusting component, and the adjusting component is used to move relative to the pressing cover to adjust the preload force of the third elastic member.

[0052] The sample analyzer according to the third embodiment of the utility model comprises:

[0053] The amplification module comprises a base, a heating component and a pressure cover component, wherein the heating component is connected to the base and is used to place a sample container and heat the nucleic acid sample contained in the sample container, and the pressure cover component comprises a pressure cover having a pressing surface for pressing the sample container;

[0054] a fifth driving module, used for driving the pressing cover to move downward from the tenth position to the eleventh position along the vertical direction relative to the base, so as to press the sample container between the pressing surface of the pressing cover and the heating component;

[0055] The detection module is used to detect the amplified nucleic acid sample.

[0056] The sample analyzer according to the third embodiment of the utility model has at least the following beneficial effects:

[0057] The pressing cover moves downward from the tenth position to the eleventh position to press the sample container, which can reduce the possibility of the sample container being skewed due to local force and improve the problem of uneven pressing force of the pressing cover.

[0058] In some other embodiments, the pressing cover is configured such that when in the tenth position and the eleventh position, the pressing surface is perpendicular to the axis of the sample container.

[0059] Additional aspects and advantages of the present invention will be given in part in the following description, and in part will become apparent from the following description, or will be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0060] The present invention is further described below with reference to the accompanying drawings and embodiments, wherein:

[0061] Figure 1 This is a three-dimensional schematic diagram of an amplification module in an embodiment of the utility model;

[0062] Figure 2 for Figure 1 A three-dimensional schematic diagram of the amplification module in another direction;

[0063] Figure 3 for Figure 1 Schematic diagram of the decomposition of the amplification module;

[0064] Figure 4 for Figure 1 A front view of the amplification module, in which the gland is in the first position;

[0065] Figure 5 for Figure 1 A front view of the middle amplification module, in which the gland is in the third position;

[0066] Figure 6 for Figure 1 A side view of the amplification module, in which the gland is in a first position;

[0067] Figure 7 for Figure 1 A side view of the middle amplification module, in which the gland is in the third position;

[0068] Figure 8 A schematic diagram of a mechanism for switching the pressure cover from a first position to a third position;

[0069] Fig. 9 for Figure 1 Exploded diagram of the middle gland assembly;

[0070] Fig.10 for Figure 1 A rear view of the amplification module, in which the gland is in the first position;

[0071] Fig.11 for Figure 1 A rear view of the middle amplification module, in which the gland is in the third position;

[0072] Fig.12 Schematic diagrams of the mechanism with the locking component being in the fourth position and the fifth position respectively;

[0073] Fig.13 It is a three-dimensional schematic diagram of a heating component in an embodiment of the utility model;

[0074] Fig.14 for Fig.13 A cross-sectional view of the heating assembly, wherein the cross-sectional plane is arranged along the left-right direction;

[0075] Fig.15 for Fig.13 A cross-sectional view of the heating assembly, wherein the cross-sectional plane is arranged along the front-rear direction;

[0076] Fig.16 for Fig.13 Schematic diagram of the exploded view of the heating assembly;

[0077] Fig.17 It is a three-dimensional schematic diagram of a heating component in another embodiment of the utility model.

[0078] Reference numerals:

[0079] Amplification module 10;

[0080] Base 100, slide rail 110, first slide block 120, second slide block 130;

[0081] Transfer device 200, inclined plane 210;

[0082] The gland assembly 300, the gland 310, the mounting seat 311, the mounting plate 312, the pressing block 320, and the third elastic member 330;

[0083] Transmission assembly 400, connecting rod 410, first sliding seat 420, first abutting portion 421, first limiting portion 422, guide surface 423, second sliding seat 430, second abutting portion 431;

[0084] Reset assembly 500, first elastic member 510, second elastic member 520;

[0085] Self-locking assembly 600, locking component 610, fourth elastic member 620;

[0086] Heating component 700, semiconductor heater 710, first side 711, second side 712, heat sink 720, heat conducting mechanism 730, second substrate 731, heat conducting component 732, accommodating hole 733, clamping mechanism 740, first substrate 741, clamping component 742, first threaded fastener 743, thermal insulation pad 744, limiting seat 750, second main body 751, accommodating groove 7511, second limiting portion 752, second threaded fastener 753. DETAILED DESCRIPTION

[0087] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0088] In the description of the present invention, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0089] In the description of the present utility model, "several" means more than one, "many" means more than two, "greater than", "less than", "exceed" etc. are understood to exclude the number itself, and "above", "below", "within" etc. are understood to include the number itself. If there is a description of "first" or "second", it is only used to distinguish the technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0090] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0091] In the description of the utility model, the description with reference to the terms "one embodiment", "some embodiments", "illustrative embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0092] The present utility model embodiment proposes a sample analyzer, which mainly includes an amplification module 10 and a detection module, wherein the amplification module 10 is used to amplify the nucleic acid sample extracted from the biological sample by polymerase chain reaction, so as to significantly increase the trace nucleic acid sample in a short time, and the detection module is used to detect the amplified sample. In some embodiments, the nucleic acid sample is first extracted from the biological sample by a separate step, and the sample analyzer is a PCR detection device mainly used for amplification and detection of nucleic acid samples. In other embodiments, the sample analyzer also includes a sample module, wherein the sample module is used for pre-treatment of biological samples and extraction of nucleic acid samples, that is, the sample analyzer is an integrated machine integrating the pre-treatment of biological samples and the extraction, amplification, and detection of nucleic acid samples. When the sample analyzer is an integrated machine, in addition to the aforementioned sample module, amplification module 10 and detection module, it also includes a transport device 200, and the transport device 200 includes one or more manipulators, which are driven by a driving module to realize the transportation of sample containers between modules, thereby cooperating with each module to realize the automation of the entire process.

[0093] It should be noted that the sample container referred to in the present invention can be different types of containers according to different stages. For example, when the user puts the biological sample into the sample injection position of the sample analyzer, the corresponding sample container is a test tube; when nucleic acid is extracted from the biological sample, the corresponding sample container is an extraction tube; when the nucleic acid sample is amplified, the corresponding sample container is a reaction tube.

[0094] It should also be noted that the sample module, detection module and manipulator involved in the present invention can all adopt known technologies, which can be understood and implemented by those skilled in the art.

[0095] It should also be noted that when the present invention involves the description of the position, it is based on the amplification module 10 in Figure 1 The description is based on the normal usage posture shown. When the amplification module 10 is placed in other postures, the various directions are also adjusted accordingly, which is understandable to those skilled in the art.

[0096] The amplification of nucleic acid samples needs to be carried out in a heating environment, so the sample container containing the nucleic acid sample will be placed in the heating component for heating. In order to ensure that the sample container is in close contact with the heating component to ensure heating efficiency and uniformity, the amplification module 10 is also provided with a pressure cover, which can press the sample container so that the sample container can maintain good thermal conductivity with the heating component. Therefore, the pressing force of the pressure cover will affect the amplification effect of the nucleic acid sample. The amplification module 10 of this embodiment can ensure that the pressure cover has sufficient pressing force, and can also improve the problem of uneven pressing force to a certain extent.

[0097] The sample analyzer of the first embodiment of the utility model includes an amplification module, a detection module, a first driving module and a second driving module. Figure 1 The amplification module 10 includes a base 100, a heating component and a pressure cover component 300, wherein the base 100 is used as the main bearing structure, and the heating component and the pressure cover component 300 are directly or indirectly connected to the base 100. Figure 3 In the illustrated embodiment, the base 100 is shown as a plate-like structure extending along the height direction (or referred to as the vertical direction and the up-down direction).

[0098] The heating assembly (not shown) is fixedly connected to the base 100 by means of a threaded fastener or other structure, wherein one or more heating chambers are arranged therein for accommodating a single tube or multiple tubes, and the heating assembly also includes a heating device capable of generating heat, such as an electric heating device, to heat the sample in the sample container. The gland assembly 300 is connected to the base 100 by means of a transmission assembly 400, specifically located on the upper side of the heating assembly, and the gland assembly 300 can press the sample container into the heating assembly or release the compression of the sample container by corresponding movement.

[0099] The pressure cover assembly 300 has a pressure cover 310, and the pressure cover 310 has a crimping surface, and the crimping surface is used to press the sample container. The first driving module is used to drive the pressure cover 310 to rotate from the first position to the second position relative to the base 100. After the pressure cover 310 rotates to the second position, the second driving module is used to drive the pressure cover 310 to move to the third position along the first direction (for example, the downward direction, which will be described in the following as the downward direction) to press the sample container between the heating component and the pressure cover 310. The angle of the crimping surface relative to the horizontal plane when the pressure cover 310 is in the first position is defined as the first angle, and the angle of the crimping surface relative to the horizontal plane when the pressure cover 310 is in the third position is defined as the second angle. In this embodiment, the first angle is greater than the second angle, for example, the first angle is 30°, 45°, 60°, etc., and the second angle is 0, 1°, 3°, etc. In the related art, the pressure cover 310 can only rotate, so it will first contact a part of the sample container during the pressing process, causing the sample container to be skewed due to the local force, and then causing the problem of uneven pressing force. The pressure cover 310 of this embodiment first rotates from the first position to the second position, and then moves at the second position to contact the sample container. In this way, when the pressure cover 310 is in the first position, it can be suitable for placing the sample container. When the pressure cover 310 is in the third position, it can press the sample container and reduce the possibility of the sample container being skewed due to the local force, thereby improving the problem of uneven pressing force of the pressure cover 310.

[0100] Specifically, in this embodiment, the pressure cover 310 is in the initial state (for example Figure 4 , Figure 6as well as Figure 8 When the pressure cover 310 needs to press the sample container, the pressure cover 310 can be driven by the first driving module to rotate from the first position to the second position, that is, from Figure 8 The state a in the diagram is changed to the state b. In the second position, the pressure cover 310 is suitable for pressing the sample container. Specifically, the angle between the pressure cover 310 and the upper end surface of the sample container is reduced compared with the first position. When the pressure cover 310 is in the second position, the pressure cover 310 can be further driven by the second driving module to move from the current position to the third position, that is, from Figure 8 The b state in the figure is changed to the c state, and the pressing cover 310 in the third position can press the sample container.

[0101] It should be noted that the first driving module drives the cover 310 to rotate, including: the first driving module directly drives the cover 310 to rotate, or drives the cover 310 to rotate through other structures (such as the transfer device 200 and the transmission assembly 400 described below); the second driving module drives the cover 310 to move, including: the second driving module directly drives the cover 310 to move, or drives the cover 310 to move through other structures (such as the transfer device 200 and the transmission assembly 400 described below). The first driving module and the second driving module can be the same module or different modules.

[0102] In some embodiments, the amplification module 10 further includes a transmission assembly 400, and the first drive module and the second drive module can drive the pressure cover 310 to rotate and move through the transmission assembly 400. The transmission assembly 400 includes a connecting rod 410 and a first sliding seat 420. The first sliding seat 420 is slidably connected to the base 100. One end of the connecting rod 410 is rotatably connected to the pressure cover 310 through a rotating shaft, and the other end is rotatably connected to the first sliding seat 420 through a rotating shaft. In this way, as the first sliding seat 420 slides relative to the base 100, the pressure cover 310 can be switched from the first position to the second position. Figure 3 In the illustrated embodiment, a slide rail 110 extending in the height direction is provided on the base 100 , a first slider 120 is connected to the slide rail 110 , and the first slide seat 420 is fixedly connected to the first slider 120 , so that the first slide seat 420 can slide relative to the base 100 .

[0103] As a specific arrangement of the first sliding seat 420, Figure 3In the illustrated embodiment, the first sliding seat 420 includes a horizontally arranged sliding connection portion and a vertically arranged rotating connection portion. The aforementioned first slider 120 is fixedly connected to the sliding connection portion. The two rotating connection portions are respectively connected to the two ends of the sliding connection portion and are located on both sides of the base 100. Correspondingly, two connecting rods 410 are provided, which are respectively rotatably connected to the rotating connection portions on both sides, so that the force on the pressure cover 310 is more balanced.

[0104] It should be noted that this embodiment does not limit the sliding direction of the first sliding seat 420. In some embodiments, the first sliding seat 420 slides in the vertical direction, in other embodiments, the first sliding seat 420 slides in the horizontal direction, and in other embodiments, the first sliding seat 420 slides in the inclined direction.

[0105] In some embodiments, the transmission assembly 400 further includes a second sliding seat 430, which is also slidably connected to the base 100, so that the pressure cover 310 can move relative to the base 100 and can rotate relative to the base 100. When the pressure cover 310 rotates from the first position to the second position, the first sliding seat 420 and the second sliding seat 430 can move a second distance along the first direction, so that the pressure cover 310 moves to the third position, thereby pressing the sample container.

[0106] In some specific embodiments, the sliding directions of the first sliding seat 420 and the second sliding seat 430 are the same, both along the vertical direction. Figure 3 In the illustrated embodiment, the aforementioned slide rail 110 is disposed on the base 100 , the slide rail 110 is connected to the second slider 130 , and the second slide seat 430 is fixedly connected to the second slider 130 , so that the second slide seat 430 can slide relative to the base 100 .

[0107] As a specific configuration of the second sliding seat 430, refer to Figure 3 The structure of the second sliding seat 430 is similar to that of the first sliding seat 420, and also includes a horizontally arranged sliding connection part and a vertically arranged rotating connection part. The two sides of the pressure cover 310 are respectively rotatably connected to the two sliding connections of the second sliding seat 430. In this way, the rotating connection part of the first sliding seat 420, the base 100 and the rotating connection part of the second sliding seat 430 are arranged in parallel, and the overall structure is more compact.

[0108] Based on the above structure, the specific movement of the pressure cover 310 in this embodiment is described below. Figures 4 to 7 , and combined with Figure 8 The schematic diagram of the mechanism movement is as follows: the pressing process of the pressure cover 310 is as follows: the pressure cover 310 is in the initial state (for example Figure 4 , Figure 6 as well as Figure 8When the pressure cover 310 needs to press the sample container, the first driving module first drives the first sliding seat 420 to move a first distance in a first direction (for example, a downward direction, and the following descriptions are all based on the downward direction), and the first sliding seat 420 pulls the pressure cover 310 to rotate relative to the second sliding seat 430 through the connecting rod 410, thereby rotating from the first position to the second position, that is, from the first position to the second position. Figure 8 The state a in the diagram is changed to the state b. In the second position, the pressure cover 310 is suitable for pressing the sample container. Specifically, the angle between the pressure cover 310 and the upper end surface of the sample container is reduced relative to the first position. When the pressure cover 310 is in the second position, the second driving module drives the first sliding seat 420 and the second sliding seat 430 to continue to move the second distance in the downward direction synchronously, and the pressure cover 310 maintained in the second position also moves downward the second distance synchronously, thereby moving from the current position to the third position, that is, from Figure 8 The state b in the figure is changed to the state c, and the cover 310 in the third position can press the sample container. In this embodiment, the cover 310 is rotated and moved by the cooperation of the connecting rod 410, the first sliding seat 420 and the second sliding seat 430, and the structure is relatively simple.

[0109] When a transmission assembly 400 including a first sliding seat 420 and a second sliding seat 430 is provided, in some embodiments, the first driving module and the second driving module are the same module, and the first driving module is used as an example for explanation, and the first driving module indirectly drives the second sliding seat 430 to move a second distance in the downward direction through the first sliding seat 420, referring to Figure 4 , Figure 5 The first sliding seat 420 has a first abutting portion 421, and the second sliding seat 430 has a second abutting portion 431. The first abutting portion 421 can abut against the second abutting portion 431 in a downward direction, so that the first sliding seat 420 drives the second sliding seat 430 to move a second distance in a downward direction. When the pressure cover 310 is reset, the first abutting portion 421 can separate upward from the second abutting portion 431, and will not hinder the first sliding seat 420 from moving upward by itself for the first distance. Figure 3 In the illustrated embodiment, the first abutting portion 421 is a convex block with an abutting surface at the bottom, which can be connected to the rotating connection portion on one side of the first sliding seat 420, and the second abutting portion 431 is a convex block with an abutting surface at the top, which can be connected to the rotating connection portion on one side of the second sliding seat 430. The first abutting portion 421 is located above the second abutting portion 431. When the pressure cover 310 is in Figure 4In the first position shown in FIG. 1 , the first abutting portion 421 and the second abutting portion 431 are spaced a certain distance apart, and the distance is substantially equal to the aforementioned first distance. Figure 5 In the third position shown, the first abutting portion 421 and the second abutting portion 431 abut against each other.

[0110] It should be noted that, in other embodiments, there is no mutual abutment relationship between the first sliding seat 420 and the second sliding seat 430, the first driving module and the second driving module are the same module, and the first driving module drives the first sliding seat 420 and the second sliding seat 430 to move downward, for example, the first driving module drives the transfer device 200 for transferring the sample container to move downward, the transfer device 200 is provided with a third abutting portion and a fourth abutting portion, the third abutting portion is located below the fourth abutting portion, when the transfer device 200 moves downward, the third abutting portion first abuts against the first sliding seat 420, drives the first sliding seat 420 to move downward by a first distance, then the fourth abutting portion abuts against the second sliding seat 430, the third abutting portion continues to drive the first sliding seat 420 to move downward by a second distance, and at the same time, the fourth abutting portion drives the second sliding seat 430 to move downward by a second distance. Of course, the first driving module may also be provided with a third abutting portion and a fourth abutting portion, so as to directly push the first sliding seat 420 and the second sliding seat 430.

[0111] In some embodiments, the sample analyzer further includes a third driving module, the amplification module further includes a self-locking assembly 600, the self-locking assembly 600 includes a locking component 610, the locking component 610 is connected to the base 100, the third driving module can drive the locking component 610 to move relative to the base 100 to switch between the fourth position and the fifth position, and the first sliding seat 420 has an abutting surface, such as the top surface of the first sliding seat 420. When the locking component 610 is in the fourth position and the pressure cover 310 is in the third position, the locking component 610 can keep the pressure cover 310 in the third position by abutting the abutting surface of the first sliding seat 420; when the locking component 610 is in the fifth position, the locking component 610 is separated from the abutting surface, and the first sliding seat 420 can move in a second direction opposite to the first direction (for example, an upward direction, and the following description is based on the upward direction).

[0112] It should be noted that the third driving module and the aforementioned first driving module and / or second driving module may be the same module or may be different modules.

[0113] When the amplification module also includes a self-locking component 600, in some embodiments, the amplification module also includes a reset component 500, and the reset component 500 includes an elastic component, which is respectively connected to the first sliding seat 420 and the second sliding seat 430. When the self-locking component 600 is in the fifth position, the elastic component drives the first sliding seat 420 and the second sliding seat 430 to move upward to reset the pressure cover 310 to the first position.

[0114] Specifically, the reset process of the pressure cover 310 is as follows: the first sliding seat 420 and the second sliding seat 430 move a second distance along a second direction (for example, an upward direction, which will be described in the following as an upward direction), so that the pressure cover moves upward from the third position, that is, from Figure 8 The state c in the figure is changed to the state b, and then the second sliding seat 430 is relatively stationary, and the first sliding seat 420 continues to move the first distance in the upward direction, and the pressing cover 310 is pulled by the connecting rod 410 to rotate relative to the second sliding seat 430, thereby rotating from the second position to the first position, that is, from Figure 8 The b state in the process is changed to the a state to complete the resetting of the pressure cover 310.

[0115] It should be noted that the reset assembly 500 can be a reset assembly without active power, such as a reset assembly using an elastic member to reset, so that the pressure cover 310 does not need to be reset by an additional active power source. In addition, the reset assembly 500 can also be a reset assembly with active power, such as a reset assembly using a motor to reset.

[0116] It should also be noted that the reset of the pressing cover 310 may not strictly follow the aforementioned process. For example, the pressing cover 310 may also start to rotate and reset during the process of moving upward.

[0117] When the amplification module further includes a reset component 500 and a self-locking component 600, in some embodiments, Figure 4 , Figure 5 The elastic component includes a first elastic member 510 and a second elastic member 520. The first elastic member 510 is connected between the first sliding seat 420 and the base 100, and is configured to drive the first sliding seat 420 to reset upward after the self-locking component 600 switches to the fifth position. Specifically, the first elastic member 510 is selected as a compression spring. The first sliding seat 420 can compress the first elastic member 510 during the downward movement, so that it has a deformation amount. The second elastic member 520 is connected between the second sliding seat 430 and the base 100, and is configured to drive the second sliding seat 430 to reset along the second direction after the self-locking component 600 switches to the fifth position. Specifically, the second elastic member 520 is selected as a compression spring. The second sliding seat 430 can compress the second elastic member 520 during the downward movement, so that it has a deformation amount. Figure 4As shown, the compression amount of the first elastic member 510 and the second elastic member 520 is small, and the pressure cover 310 is in the initial first position, such as Figure 5 As shown, the compression amount of the first elastic member 510 and the second elastic member 520 is relatively large, and the pressure cover 310 is in the second position of pressing the sample container and is located in the third position. In this embodiment, the first sliding seat 420 needs to move downward by a first distance first, so the reset stroke of the second elastic member 520 is smaller than the reset stroke of the first elastic member 510.

[0118] In other embodiments, the elastic component includes a fifth elastic member and the aforementioned second elastic member 520, the second elastic member 520 is connected between the second sliding seat 430 and the base 100, and is configured to drive the second sliding seat 430 to reset along the second direction after the self-locking component 600 switches to the fifth position. Specifically, the second elastic member 520 is selected as a compression spring, and the second sliding seat 430 can compress the second elastic member 520 during the downward movement, so that it has a deformation amount. The fifth elastic member is connected between the pressure cover 310 and the second sliding seat 430, and is configured to drive the pressure cover 310 to rotate to the first position after the self-locking component 600 switches to the fifth position. Specifically, the fifth elastic member is selected as a torsion spring, and the pressure cover 310 can compress the fifth elastic member during the rotation from the first position to the second position, so that it has a deformation amount. The difference between this embodiment and the aforementioned embodiment lies in that: in the aforementioned embodiment, the first elastic member 510 is used to drive the first sliding seat 420 to reset, and then the first sliding seat 420 drives the pressure cover 310 to reset, while in this embodiment, the pressure cover 310 is directly driven to reset by the fifth elastic member, and the first sliding seat 420 is driven to reset during the process of the pressure cover 310 resetting.

[0119] It should be noted that the number of elastic members in the above embodiments is not limited, and can be as follows: Figure 4 , Figure 5 As shown, each is set to one to save cost, or it can be symmetrically set to two to make the force on the sliding seat or the pressure cover more balanced.

[0120] In some embodiments, two limiting structures are disposed on the base 100 , and the two limiting structures are disposed in the up-down direction. The second sliding seat 430 limits the end point of the travel in the up-down direction through the two limiting structures.

[0121] When the amplification module further includes a self-locking component 600, in some embodiments, the sample analyzer drives the transfer device 200 for transferring the sample container to move in the vertical direction through the third driving module, and then drives the locking component 610 to switch from the fourth position to the fifth position through the transfer device 200, that is, the third driving module is an existing driving module of the sample analyzer for driving the sample container to perform the transfer action. In addition to being used for the transfer of the sample container, the transfer device 200 can also be used for the state switching of the locking component 610. When the locking component 610 is in the fourth position and the transfer device 200 abuts against the locking component 610, the transfer device 200 can be driven by the third driving module to move downward, and the locking component 610 is driven to switch from the fourth position to the fifth position during the downward movement of the transfer device 200. It should be noted that the transfer device 200 can abut against the locking component 610 by, for example, moving downward or in other directions, and then push the locking component 610 to switch the state after the abutment.

[0122] Since the locking component 610 has a fourth position for locking the pressure cover 310 in the third position, when the first driving module drives the pressure cover 310 to be in the third position, the self-locking component 600 in the fourth position keeps the pressure cover 310 in the third position. That is, the first driving module and the transfer device 200 of this embodiment are mainly used for switching the state of the pressure cover 310, and the third position of the pressure cover 310 is maintained by the self-locking component 600, so it will not affect the transfer device 200 to perform normal transfer actions.

[0123] When the amplification module further includes a self-locking component 600, in some specific embodiments, the amplification module further includes a reset component 500. After the locking component 610 moves to the fifth position, the reset component 500 drives the first sliding seat 420 and the second sliding seat 430 to move the second distance in the upward direction, and then drives the first sliding seat 420 to move the first distance in the upward direction, so that the pressure cover 310 is reset to the first position. In this way, the third driving module and the transfer device 200 of this embodiment are mainly used for switching the state of the locking component 610. The reset of the pressure cover 310 is maintained by the self-locking component 600, which will not affect the normal transfer operation of the transfer device 200. The reset component 500 of this embodiment can be the aforementioned reset component that uses an elastic member for reset. Since the third driving module is an existing module of the sample analyzer for driving the transfer device 200 to perform the transfer operation, in this way, the pressure cover 310 does not need to be provided with an additional active power source whether in the pressing process or the resetting process.

[0124] When the amplification module also includes a transmission assembly 400, in some embodiments, the first drive module and the second drive module are the same module and are existing modules of the sample analyzer for driving the transfer device 200 to perform a transfer operation. The present embodiment also uses the first drive module as a power source for driving the pressure cover 310 to move. That is, in addition to being used for the transfer of sample containers, the transfer device 200 can also be used for position switching of the pressure cover 310. For example, when the pressure cover 310 is in the first position and the transfer device 200 is in contact with the first sliding seat 420, the first drive module drives the transfer device 200 to move downward by a first distance. During the downward movement of the transfer device 200, the first sliding seat 420 is pushed to synchronously move downward by a first distance, so that the pressure cover 310 rotates from the first position to the second position; when the pressure cover 310 is in the second position, the first drive module drives the transfer device 200 to continue to move downward by a second distance. During the downward movement of the transfer device 200, the first sliding seat 420 and the second sliding seat 430 are pushed to synchronously move by a second distance, so that the pressure cover moves to the third position. As mentioned above, the first driving module is an existing driving module of the sample analyzer, so there is no need to set up an independent power source for the movement of the pressing cover 310, thereby simplifying the structure and significantly reducing the cost.

[0125] It should be noted that the transfer device 200 referred to here drives the first sliding seat 420 and the second sliding seat 430 to move the second distance along the first direction, which includes the situation where the transfer device 200 indirectly drives the second sliding seat 430 through the first sliding seat 420, and also includes the situation where the transfer device 200 directly drives the first sliding seat 420 and the second sliding seat 430.

[0126] When the amplification module also includes a transmission assembly 400, in some specific embodiments, the amplification module also includes a self-locking assembly 600, and the pressing of the sample container by the pressure cover assembly 300 is completed by the self-locking assembly 600, the transfer device 200 and the driving module. Since the locking component 610 has a fourth position for locking the pressure cover 310 in the third position, when the first driving module drives the pressure cover 310 to be in the third position, the self-locking assembly 600 in the fourth position keeps the pressure cover 310 in the third position. That is, the first driving module and the transfer device 200 of this embodiment are mainly used for switching the state of the pressure cover 310, and the third position of the pressure cover 310 is maintained by the self-locking assembly 600, so it will not affect the transfer device 200 to perform normal transfer actions.

[0127] When the self-locking assembly includes the aforementioned locking component 610, in some embodiments, refer to Figures 10 to 12The self-locking assembly 600 further includes a fourth elastic member 620, which is connected between the locking member 610 and the base 100. When the locking member 610 is in the fifth position, the fourth elastic member has a deformation amount. When the third driving module drives the gland 310 to move to the third position, the fourth elastic member 620 drives the locking member 610 to switch from the fifth position to the fourth position to automatically lock the gland 310. The fourth elastic member can be selected as a tension spring, a tension spring or a torsion spring.

[0128] Specifically, in some embodiments, the locking component 610 switches between states by rotating, referring to Figures 10 to 12 The locking component 610 is selected as a locking rod, one end of which is rotatably connected to the base 100, and the other end can abut against the first sliding seat 420, and the fourth elastic member 620 is selected as a tension spring, one end of which is connected to the locking component 610, and the other end is connected to the base 100.

[0129] Combination Fig.12 In the embodiment, the locking component 610 can be rotated to different positions relative to the base 100, and the locking component 610 has a fifth abutting portion for abutting against the first sliding seat 420. For example, the fifth abutting portion can be the lower end of the locking component 610. With the rotation axis of the locking component 610 and the base 100 as a reference, when the fifth abutting portion is rotated to the first side of the rotation axis of the locking component 610 along the first direction (for example, Fig.12 When the locking member 610 is in the fourth position, the fifth abutting portion rotates to the opposite second side (eg, Fig.12 When the locking member 610 is in the fifth position (as shown in the right side of the state f), the locking member 610 is in the fifth position. As mentioned above, the locking member 610 can be driven by the fourth elastic member 620 to rotate from the second side to the first side.

[0130] The first sliding seat 420 has a first limiting portion 422, referring to Figure 2 and Fig.12 The first limiting portion 422 may be a protrusion disposed on the top surface of the first sliding seat 420 and located on the first side of the rotation axis. When the locking component 610 rotates to the first side, the fifth abutting portion abuts against the top surface of the first sliding seat 420 to keep the pressure cover 310 at the third position. In addition, the locking component 610 can also abut against the first limiting portion 422 (the fifth abutting portion can abut against the first limiting portion 422, or other structures can abut against each other) to limit the rotation of the locking component 610 toward the first side. Fig.12 Describe, refer to Fig.12e state, at this time, the fifth abutment portion is located on the first side, and it abuts against the top of the first sliding seat 420, and at the same time the locking component 610 abuts against the first limiting portion 422. If the pressure cover 310 needs to be reset, the first sliding seat 420 needs to move upward, and the corresponding locking component 610 needs to continue to rotate toward the first side. However, the rotation of the locking component 610 toward the first side is restricted by the first limiting portion 422. If there is no external force driving the locking component 610 to switch states, the pressure cover 310 will always remain in the current state, thereby achieving self-locking.

[0131] When it is necessary to release the lock of the locking component 610 on the pressure cover 310, it is necessary to apply an external force to the locking component 610 to destroy its self-locking state. As mentioned above, the external force comes from the third driving module. In this embodiment, the first driving module, the second driving module and the third driving module are the same module. Taking the first driving module as an example, the first driving module can drive the locking component 610 to move to the right to switch to the fifth position by applying a force to the locking component 610 to move toward the second side. In some embodiments, the first driving module achieves unlocking by driving the transfer device 200 to move along the first direction. Specifically, the transfer device 200 can move along the third direction to switch between the sixth position and the seventh position. The third direction intersects with the first direction. In some embodiments, the third direction is perpendicular to the first direction. For example, when the first direction is a downward direction, the third direction is Fig.10 When the transfer device 200 is in the sixth position, it can move in the first direction to drive the first sliding seat 420 and the second sliding seat 430 to move, so that the pressure cover 310 moves to the third position; when the transfer device 200 is in the seventh position, it can move in the first direction to drive the locking component 610 to rotate from the first side to the second side.

[0132] In order to facilitate the conversion of the movement of the transfer device 200 along the first direction into the rotation of the locking component 610 toward the second side, refer to Fig.10 , Fig.11 The transfer device 200 has a slope 210, and the transfer device 200 abuts against the locking component 610 through the slope 210, thereby driving the locking component 610 to rotate toward the second side during the downward movement. In addition, the locking component 610 can also be provided with a guide wheel, and the guide wheel contacts the slope 210 as the aforementioned fifth abutment portion, thereby reducing the friction between the transfer device 200 and the locking component 610.

[0133] On the other hand, in order to facilitate the rotation of the locking member 610 toward the second side, refer to Figures 10 to 12The first sliding seat 420 is also provided with a guide surface 423, and the guide surface 423 is arranged on the second side of the rotation axis. When the locking component 610 rotates to the second side, the locking component 610 has lost its self-locking ability, and the first sliding seat 420 can move upward to reset. The locking component 610 contacts the guide surface 423 and continues to rotate toward the second side, and at the same time, the stretching amount of the fourth elastic member 620 increases.

[0134] Based on the above structure, the locking and unlocking process of the self-locking assembly 600 will be described below: Fig.11 When the pressure cover 310 is in the initial first position, the fifth abutment of the locking component 610 is located on the second side (e.g., the right side) of the rotation axis, and the bottom end is in contact with the guide surface 423, and the transfer device 200 is in the sixth position. As the transfer device 200 moves downward, the first sliding seat 420 moves downward according to the above process, and the fifth abutment rotates toward the first side (e.g., the left side) along the guide surface 423 under the drive of the fourth elastic member 620. When the first sliding seat 420 moves downward to the set position, the fifth abutment rotates to the first side, and the locking component 610 abuts against the first limiting portion 422. Subsequently, the transfer device 200 is reset upward, and the first sliding seat 420 abuts against the fifth abutment to achieve self-locking. It should be noted that when the transfer device 200 is in the sixth position, it will not contact the locking component 610, and therefore will not hinder the locking component 610 from rotating toward the first side.

[0135] When unlocking, the transfer device 200 first moves rightward from the sixth position to the seventh position, that is, a position closer to the locking component 610, and then moves downward, and the inclined surface 210 of the transfer device 200 contacts the locking component 610, for example, contacts the roller at the bottom end of the locking component 610, thereby driving the locking component 610 to rotate toward the second side. When the fifth abutting portion rotates to the second side, the transfer device 200 resets upward, the first sliding seat 420 also resets upward, and the locking component 610 finally resets to Fig.11 Status shown.

[0136] The first driving module of the present embodiment drives the pressure cover 310 and unlocks the self-locking component 600 by driving the transfer device 200 to move along the first direction and the third direction. The control is simple. The first driving module can be an existing driving module of the sample analyzer for driving the transfer device 200 to perform the sample transfer action, so there is no need to set up an additional power source.

[0137] It should be noted that the transfer device 200 is not limited to moving in the aforementioned direction to unlock. For example, the transfer device 200 can directly move along the third direction to push the locking component 610 to rotate toward the second side.

[0138] In the aforementioned embodiments, the pressing and releasing of the sample container by the pressure cover 310 is completed by driving the transfer device 200 through the driving module, that is, the pressing and releasing of the pressure cover 310 is achieved by the existing driving module of the sample analyzer for driving the transfer device 200 to perform the sample transfer action. In other embodiments, the pressing and releasing of the sample container by the pressure cover 310 are completed by a separate driving module, that is, the driving module in this embodiment is different from the driving module used to drive the transfer device 200 to move. Since the driving module in this embodiment does not need to drive the transfer device 200, it can keep the pressure cover 310 in the third position, so that there is no need to set a self-locking component 600.

[0139] In addition, the amplification module further includes a reset component, which is used to reset the pressure cover 310 after the driving module releases the pressure.

[0140] In some specific embodiments, the first driving module and the second driving module are the same module, the first driving module includes a first power device and a power output part, the first power device can drive the power output part to move in the vertical direction, the reset assembly includes a second elastic member 520, the power output part is connected to the first sliding seat 420, and the second elastic member 520 is connected between the second sliding seat 430 and the base 100, wherein the first power device can drive the first sliding seat 420 to move a first distance in the first direction through the power output part so that the pressure cover 310 rotates from the first position to the second position, and, after the pressure cover 310 rotates to the second position, drive the first sliding seat 420 and the second sliding seat 430 to move a second distance in the first direction so that the pressure cover 310 moves to the third position, and after the pressure cover 310 is in the third position, the power output part stops to keep the pressure cover 310 in the third position.

[0141] When the pressure cover 310 needs to be reset, the first power device is also used to drive the power output part to move along the second direction, the first sliding seat 420 is driven by the power output part and moves synchronously along the second direction, and the second elastic member 520 drives the second sliding seat 430 to move along the second direction, so that the pressure cover 310 is reset to the first position.

[0142] Specifically, the first power device is selected as a motor. When the drive shaft of the motor is connected to the first sliding seat 420 through a transmission mechanism such as a synchronous belt, the power output part is a structure in the transmission mechanism connected to the first sliding seat 420. When pressing is required, the motor drives the first sliding seat 420 to move downward, so that the pressure cover moves to the third position. When the pressure cover 310 is in the third position, the motor stops moving and the pressure cover 310 remains in the third position. When resetting is required, the motor drives the first sliding seat 420 to move upward, so that the pressure cover 310 is reset to the first position.

[0143] The second elastic member 520 is used to drive the second sliding seat 430 to move and reset along the second direction. The second elastic member 520 can be selected as a compression spring with reference to the above-mentioned embodiment. When the first sliding seat 420 moves upward, the second sliding seat 430 can be reset upward under the drive of the second elastic member 520.

[0144] When the first driving module includes the first power device and the second elastic member 520, in some embodiments, the first power device indirectly drives the second sliding seat 430 to move the second distance in the downward direction through the first sliding seat 420, for example, the first abutting portion 421 and the second abutting portion 431 cooperate to drive the second sliding seat 430. In other embodiments, the first driving module can also directly drive the first sliding seat 420 and the second sliding seat 430 to move the second distance in the downward direction, for example, the first driving module is provided with the third abutting portion and the fourth abutting portion.

[0145] In some specific embodiments, the first driving module and the second driving module are the same module, the first driving module includes a first power device and a power output part, the first power device can drive the power output part to move in the vertical direction, and the reset assembly includes a second elastic member 520, and the second elastic member 520 is connected between the second sliding seat 430 and the base 100. The difference between this embodiment and the previous embodiment includes: the reset assembly also includes a first elastic member 510, and the power output part in the previous embodiment can drive the first sliding seat 420 to move downward and can drive the first sliding seat 420 to move upward. In this embodiment, the power output part can drive the first sliding seat 420 to move downward, and the force for the first sliding seat 420 to move upward is provided by the first elastic member 510.

[0146] Specifically, the first elastic member 510 is connected between the first sliding seat 420 and the base 100. When the pressure cover 310 is in the first position, the power output part can abut against the first sliding seat 420, and is driven by the first power device to drive the first sliding seat 420 to move a first distance along the first direction, so that the pressure cover 310 rotates from the first position to the second position, and, after the pressure cover 310 rotates to the second position, drives the first sliding seat 420 and the second sliding seat 430 to move a second distance along the first direction, so that the pressure cover 310 moves to the third position, and after the pressure cover 310 is in the third position, the power output part stops and remains in abutment with the first sliding seat 420, so that the pressure cover 310 remains in the third position.

[0147] When the pressure cover 310 needs to be reset, the first power device is used to drive the power output part to move along the second direction, the first elastic member 510 drives the first sliding seat 420 to move along the second direction, and the second elastic member 520 drives the second sliding seat 430 to move along the second direction, so that the pressure cover 310 is reset to the first position.

[0148] Specifically, the first power device can be selected as a motor. When the driving shaft of the motor is connected to the first sliding seat 420 through a transmission mechanism, the power output part is a structure in the transmission mechanism that is in contact with the first sliding seat 420.

[0149] The first elastic member 510 and the second elastic member 520 can be selected as compression springs with reference to the above-mentioned embodiment. When the first sliding seat 420 moves upward, the second sliding seat 430 can be reset upward under the drive of the second elastic member 520 .

[0150] When the first driving module includes the first power device, the first elastic member 510 and the second elastic member 520, in some embodiments, the first power device indirectly drives the second sliding seat 430 to move the second distance in the downward direction through the first sliding seat 420, for example, the first abutting portion 421 and the second abutting portion 431 cooperate to drive the second sliding seat 430. In other embodiments, the first power device can also directly drive the first sliding seat 420 and the second sliding seat 430 to move the second distance in the downward direction, for example, the first power device is provided with the third abutting portion and the fourth abutting portion.

[0151] In the above embodiments, the case where the first driving module and the second driving module are the same module is described. In other embodiments, the first driving module and the second driving module may also be different modules. For example, the first driving module is slidably connected to the base 100 through the mounting seat, the pressure cover 310 is connected to the driving end of the first driving module, and the second driving module is connected to the base 100, and its driving end is connected to the mounting seat, which can drive the mounting seat to slide in the vertical direction. In this way, the first driving module first rotates the pressure cover 310 from the first position to the second position, and then the second driving module causes the pressure cover 310, the mounting seat and the first driving module to move synchronously, so that the pressure cover 310 moves from the second position to the third position. The first driving module includes but is not limited to driving the pressure cover 310 to rotate by a rotary motor, or is a linear driving module, and converts the linear movement into the rotation of the pressure cover 310 through, for example, the aforementioned sliding seat-connecting rod system.

[0152] In addition, the third driving module may also be an independent module.

[0153] In some embodiments, the capping assembly 300 presses the sample container tightly by means of a pressing block 320 that can move elastically. Fig. 9The pressure cover 310 includes a first main body, a pressure block 320 and a third elastic member 330. The pressure block 320 is connected to one side of the first main body, specifically the side facing the sample container, such as the lower side. In the illustrated embodiment, the lower end of the pressure block 320 extends from the first main body, so that the pressure block 320 can first contact the sample container during the pressing process. Adapting to the shape of the sample container, the pressure block 320 can be a cylindrical structure. The end of the pressure block 320 away from the first main body is provided with the aforementioned crimping surface.

[0154] The third elastic member 330 is connected between the pressing block 320 and the first main body. The third elastic member 330 can be selected as a compression spring. Specifically, one end of the third elastic member 330 abuts against the pressing block 320, and the other end abuts against the first main body. After the pressing block 320 abuts against the sample container, as the pressure cover 310 moves, the pressing block 320 can move relative to the first main body, while compressing the third elastic member 330. When the pressing block 320 is separated from the sample container as the pressure cover 310 is reset, the third elastic member 330 drives the pressing block 320 to reset to the initial state. In this way, it can adapt to the height change of the sample container and ensure the compression effect of the pressure cover assembly 300 on the sample container. In addition, the third elastic member 330 can also ensure that the pressing block 320 can apply sufficient compression force to the sample container.

[0155] As a specific installation method of the pressing block 320, the first main body includes a mounting seat 311 and a mounting plate 312. The mounting seat 311 is provided with a through mounting hole. The mounting plate 312 is fixedly connected to the mounting seat 311 by a threaded fastener, thereby closing the upper end opening of the mounting hole. The pressing block 320 is installed in the mounting hole, and the lower end extends out of the mounting hole. The pressing block 320 can be abutted against the mounting seat 311 through a flange for limiting. One end of the third elastic member 330 abuts against the pressing block 320, and the other end abuts against the mounting plate 312.

[0156] When the pressure cover assembly 300 is provided with a pressure block 320 capable of elastic movement, in some embodiments, when the pressure block 320 is in the initial state, the third elastic member 330 is configured to have a set preload force. For example, for the compression spring, the third elastic member 330 has a certain amount of compression. On the one hand, it can press the pressure block 320 in the initial state to prevent the pressure block 320 from shaking relative to the pressure cover 310. On the other hand, since the third elastic member 330 has a certain preload force, the third elastic member 330 only needs to continue to deform slightly to meet the clamping force requirement. That is, it can shorten the moving distance of the pressure block 320 relative to the first main body and reduce the thickness of the pressure cover assembly 300.

[0157] When the gland assembly 300 is provided with a compression block 320 capable of elastic movement, in some embodiments, the gland 310 includes a plurality of compression blocks 320 and a plurality of third elastic members 330, so as to be adapted to a multi-tube. Fig. 9 , multiple pressing blocks 320 are connected in parallel on the same side of the first main body. Specifically, the multiple pressing blocks 320 are evenly distributed along the length direction of the first main body. Each pressing block 320 is correspondingly provided with a third elastic member 330, so that it can abut against the corresponding sample container and move independently relative to the pressure cover 310. In this way, even if the heights of the tubes in the multi-tube are inconsistent, the pressing block 320 can ensure uniform pressing force of each tube through adaptive adjustment of the third elastic member 330.

[0158] When the pressure cover 310 is provided with a pressure block 320 capable of elastic movement, in some embodiments, the preload force of the third elastic member 330 can also be adjusted. Specifically, the pressure cover 310 further includes an adjustment component, the adjustment component is connected to the first main body, the third elastic member 330 is connected between the first main body and the adjustment component, and the adjustment component is used to move relative to the first main body to adjust the preload force of the third elastic member 330. Fig. 9 Taking the example shown, the adjustment component can be understood with reference to the mounting plate 312. When the adjustment component moves upward relative to the first main body, the compression amount of the third elastic component 330 becomes smaller, and the preload force becomes smaller. Conversely, when the adjustment component moves downward relative to the first main body, the compression amount of the third elastic component 330 becomes larger, and the preload force becomes larger, thereby being able to adjust the corresponding preload force according to sample containers of different heights.

[0159] In some embodiments, reference Figure 7 When the pressure cover 310 is in the third position, the pressing surface of the pressure cover 310 is perpendicular to the axis of the sample container. Usually, the sample container is placed vertically in the heating component. Therefore, when the pressure cover 310 is in the third position, the pressing surface is parallel to the horizontal direction, that is, parallel to the upper end surface of the sample container. In this way, various parts of the upper end of the sample container can contact the pressure cover 310 at the same time. The pressure cover 310 is applied to the sample container and faces vertically downward, so that the sample container can be evenly pressurized.

[0160] In some embodiments, reference Figures 13 to 16 The heating component 700 includes a semiconductor heater 710, a heat sink 720, a heat conduction mechanism 730 and a pressing mechanism 740, wherein the semiconductor heater 710 is used to generate heat to heat the sample, the heat sink 720 is used to dissipate the heat of the semiconductor heater 710, the heat conduction mechanism 730 is used to transfer heat to the sample container, and the pressing mechanism 740 is used to keep the heat conduction mechanism 730 in close contact with the semiconductor heater 710 to improve the heat conduction efficiency.

[0161] The heating assembly 700 of this embodiment is used for incubating samples, so its heating temperature needs to be adjusted within a certain temperature range, for example, between 50°C and 90°C. The semiconductor heater 710 has two sides arranged opposite to each other. When heating at a higher temperature, one side is used as a hot end and the other side is used as a cold end. Fig.15 Taking the example shown, the first side 711 of the semiconductor heater 710 is the cold end, and the second side 712 is the hot end. When the semiconductor heater 710 needs to drop from a higher temperature to a lower temperature, the direction of the current in the semiconductor heater 710 is changed so that the semiconductor heater 710 switches its hot end and the cold end, for example, making the first side 711 the hot end and the second side 712 the cold end, so that the temperature of the second side 712 can drop rapidly.

[0162] Reference Fig.14 and Fig.15 The heat sink 720 is attached to the first side 711 of the semiconductor heater 710. When the first side 711 serves as a hot end, the heat sink 720 is used to accelerate the dissipation of heat. The heat conducting mechanism 730 is attached to the second side 712 of the semiconductor heater 710, and the heat conducting mechanism 730 has a receiving hole 733. The sample container can be held on the heat conducting mechanism 730 by inserting the bottom into the receiving hole 733. In this way, the heat conducting mechanism 730 can transfer the heat of the second side 712 to the sample container to achieve sample incubation.

[0163] In this embodiment, the pressing mechanism 740 is connected to the heat sink 720 and presses the heat conducting mechanism 730 against the second side 712 of the semiconductor heater 710, thereby achieving close contact between the heat conducting mechanism 730 and the semiconductor heater 710 and ensuring heat conduction between the heat conducting mechanism 730 and the semiconductor heater 710.

[0164] Based on the aforementioned heating component, in some embodiments, in order to ensure the working efficiency of the semiconductor heater 710, heat conduction should be avoided between the first side 711 and the second side 712 of the semiconductor heater 710. Since the clamping mechanism 740 is connected to the radiator, and the heat conducting mechanism 730 is connected to the second side 712 of the semiconductor heater 710, if the heat can be smoothly conducted between the clamping mechanism 740 and the heat conducting mechanism 730, it may affect the heat isolation between the first side 711 and the second side 712. Based on this, the clamping mechanism 740 of this embodiment clamps the heat conducting mechanism 730 through a plurality of clamping parts 742. Compared with the method of clamping the heat conducting mechanism 730 through an entire flat plate structure, clamping through a plurality of clamping parts 742 can reduce the contact area between the clamping mechanism 740 and the heat conducting mechanism 730, thereby reducing the heat transfer between the two, thereby ensuring the heating effect of the semiconductor heater 710.

[0165] Specifically, refer to Figures 13 to 16 The pressing mechanism 740 includes a first substrate 741 and a plurality of pressing parts 742. The first substrate 741 is connected to the heat sink 720. For example, the first substrate 741 is provided with a through hole, the heat sink 720 is provided with a threaded hole, and the first threaded fastener 743 passes through the through hole and is threadedly connected to the threaded hole of the heat sink 720. The plurality of pressing parts 742 are connected to the same side of the first substrate 741, for example, the lower side in the figure, and are all in contact with the heat conduction mechanism 730. As the fastening device such as the first threaded fastener 743 is locked, the pressing part 742 applies a force to the heat conduction mechanism 730, so that the heat conduction mechanism 730 is pressed against the semiconductor heater 710.

[0166] In this embodiment, the pressing member 742 is made of a heat-insulating material, which can further reduce the heat transfer between the pressing member 742 and the heat-conducting mechanism 730. In some embodiments, the pressing member 742 and the first substrate 741 are independent components, and the first substrate 741 and the pressing member 742 are made of different materials. For example, the first substrate 741 is made of stainless steel or other materials, which has sufficient strength and can reduce deformation, so that multiple pressing members 742 can abut against the heat-conducting mechanism 730 at the same time and apply sufficient force to the semiconductor heater 710. In other embodiments, the pressing member 742 and the first substrate 741 are connected as an integrated structure.

[0167] When the clamping mechanism 740 includes a first substrate 741 and a plurality of clamping components 742, in some embodiments, the plurality of clamping components 742 are distributed along the circumference of the heat conducting mechanism 730. For example, when the heat conducting mechanism 730 includes a second substrate 731, the plurality of clamping components 742 are distributed along the circumference of the second substrate 731. In this way, the clamping mechanism 740 can achieve multi-point clamping of the heat conducting mechanism 730, and the clamping force is more uniform.

[0168] When the pressing mechanism 740 includes a first substrate 741 and a plurality of pressing components 742, in some embodiments, refer to Fig.15 , Fig.16 The clamping mechanism 740 further includes a first threaded fastener 743, and the first substrate 741 is connected to the heat sink 720 through the first threaded fastener 743. As mentioned above, the first threaded fastener 743 is threadedly connected to the heat sink 720. The common first threaded fastener 743 is made of metal material with poor thermal conductivity. In order to reduce the heat transferred between the heat sink 720 and the clamping mechanism 740 through the first threaded fastener 743, in this embodiment, the clamping mechanism 740 further includes a heat insulation pad 744, which is arranged between the head of the first threaded fastener 743 and the first substrate 741, thereby reducing the heat transfer between the first threaded fastener 743 and the first substrate 741.

[0169] In other embodiments, the first threaded fastener 743 is entirely made of heat-insulating material, which can also reduce heat transfer between the heat sink 720 and the clamping mechanism 740 .

[0170] Based on the aforementioned heating component, in some embodiments, the heating component 700 also includes a limit seat 750 made of a heat-insulating material. The limit seat 750 can limit the displacement of the semiconductor heater 710, such as displacement in the horizontal direction. Combined with the clamping of the clamping mechanism 740, the semiconductor heater 710 can be fully positioned.

[0171] Reference Figures 14 to 16 The limiting seat 750 includes a second main body 751 and a plurality of second limiting parts 752. The second main body 751 has a receiving groove 7511. The shape and size of the receiving groove 7511 are suitable for installing the semiconductor heater 710. For example, the receiving groove 7511 is a rectangular groove, and its length and width are greater than the length and width of the semiconductor heater 710. The second main body 751 is connected to the heat sink 720. For example, the second main body 751 is provided with a through hole, and the heat sink 720 is provided with a threaded hole. The second threaded fastener 753 passes through the through hole of the second main body 751 and is threadedly connected to the threaded hole of the heat sink 720.

[0172] The second limiting portion 752 is connected to the second main body portion 751 and at least partially extends into the receiving groove 7511. For example, the second limiting portion 752 is disposed on the groove wall of the receiving groove 7511. A plurality of second limiting portions 752 are distributed along the circumference of the receiving groove 7511. For example, the second limiting portions 752 are disposed on both the long side wall and the short groove wall of the receiving groove 7511.

[0173] In the present embodiment, the semiconductor heater 710 is arranged in the receiving groove 7511, and the side of the semiconductor heater 710 abuts against each second limiting portion 752 to form a thermal insulation gap between the side of the semiconductor heater 710 and the groove wall of the receiving groove 7511. In this way, on the one hand, compared with the solution of directly abutting and limiting the groove wall of the receiving groove 7511 and the side of the semiconductor heater 710, the present embodiment can reduce the heat transfer between the limiting seat 750 and the semiconductor heater 710. On the other hand, the static air in the thermal insulation gap has good thermal insulation performance, which can achieve thermal isolation between the cold and hot ends of the semiconductor heater 710.

[0174] It should be noted that the aforementioned heat insulating material can be a well-known heat insulating material.

[0175] When the second main body 751 has a receiving groove 7511, in some embodiments, refer to Fig.15The second substrate 731 of the heat conducting mechanism 730 can also be arranged in the accommodating groove 7511, and the second limiting portion 752 is also in contact with the side of the second substrate 731, so as to achieve the horizontal limitation of the second substrate 731. Combined with the clamping of the clamping mechanism 740, the heat conducting mechanism 730 can be completely positioned.

[0176] When the heating assembly 700 further includes a stopper 750, in some embodiments, Fig.15 and Fig.16 The heat conducting mechanism 730 includes a second substrate 731 and a heat conducting component 732 connected to the second substrate 731, a first substrate 741 is connected to the heat sink 720, and a plurality of pressing components 742 are connected to the same side of the first substrate 741 and are all in contact with the heat conducting mechanism 730 to press the heat conducting mechanism 730 against the second side 712 of the semiconductor heater 710. The second substrate 731 and the heat conducting component 732 of the second substrate 731 of this embodiment can be understood with reference to the aforementioned embodiments.

[0177] In order to ensure the heat transfer efficiency between the semiconductor heater 710 and the heat conducting mechanism 730 without crushing the semiconductor heater 710, the pressing force of the heat conducting mechanism 730 on the semiconductor heater 710 needs to be within a certain range, neither too large nor too small. In some embodiments, a set torque can be applied to the first threaded fastener 743 by a tool such as a torque wrench, so as to ensure that the pressing force of the heat conducting mechanism 730 on the semiconductor heater 710 is within a suitable range. In other embodiments, refer to Figure 7 Along the direction in which the clamping component 742 abuts against the heat conducting mechanism 730, for example, the downward direction in the figure, the first substrate 741 abuts against the limiting seat 750, and the limiting seat 750 limits the clamping force applied to the heat conducting component 732 by the clamping mechanism 740. There is no need to lock the first threaded fastener 743 with a torque wrench, and the operation is more convenient.

[0178] Based on the aforementioned heating assembly, in some embodiments, referring to Figures 14 to 17 The heat-conducting mechanism 730 includes a second substrate 731 and a heat-conducting component 732 connected to the second substrate 731. The second substrate 731 is attached to the second side 712 of the semiconductor heater 710, and the pressing mechanism 740 presses the second substrate 731 to the second side 712. For example, the second substrate 731 is pressed to the second side 712 by the aforementioned pressing component 742.

[0179] The end of the heat conducting component 732 away from the second substrate 731 has a receiving hole 733. Fig.14 The receiving hole 733 is a tapered hole, which is convenient for centering the sample container. When the sample container is inserted into the receiving hole 733, the heat conducting component 732 surrounds the inserted part of the sample container and heats it, and the heating efficiency is high.

[0180] In some embodiments, the heat conduction mechanism 730 includes a plurality of heat conduction components 732, and the plurality of heat conduction components 732 are arranged on the second substrate 731 in a linear arrangement, a matrix arrangement, etc. Fig.13 As shown in FIG. , a plurality of heat-conducting components 732 are arranged in a straight line, and corresponding avoidance grooves are provided on the first substrate 741 .

[0181] The second embodiment of the present invention also proposes a sample analyzer. The sample analyzer of this embodiment can be an all-in-one machine integrating sample pre-processing, sample extraction, sample amplification and sample detection, or a PCR detection device that only includes sample amplification and sample detection functions.

[0182] The sample analyzer mainly includes an amplification module 10, a detection module and a fourth driving module, wherein the amplification module 10 is used to amplify the nucleic acid sample extracted from the biological sample through the polymerase chain reaction to significantly increase the trace amount of nucleic acid sample in a shorter time, and the detection module is used to detect the amplified sample.

[0183] Specifically, refer to Figure 1 The amplification module 10 includes a base 100, a heating component and a pressure cover component 300, wherein the base 100 is used as the main bearing structure, and the heating component and the pressure cover component 300 are directly or indirectly connected to the base 100. Figure 3 In the illustrated embodiment, the base 100 is shown as a plate-like structure extending along the height direction (or referred to as the vertical direction and the up-down direction).

[0184] The heating assembly (not shown) is fixedly connected to the base 100 by means of a threaded fastener or other structure, wherein a heating chamber is provided therein for accommodating the multi-tube, and the heating assembly also includes a heating device capable of generating heat, such as an electric heating device, to heat the sample in the sample container. The gland assembly 300 includes a gland 310, which can move between an eighth position and a ninth position relative to the base 100. When the gland 310 is in the eighth position, the gland 310 can press the sample container tightly between the heating assembly and the gland 310. It should be noted that, in some embodiments, the eighth position in this embodiment can be understood with reference to the first position of the first embodiment, and the ninth position can be understood with reference to the third position of the first embodiment. In other embodiments, the eighth position or the ninth position can have other meanings. For example, the eighth position in this embodiment can be understood with reference to the first position of the first embodiment, and the ninth position can be understood with reference to the second position of the first embodiment, that is, the pressure cover 310 can press the sample container after rotating, or the eighth position in this embodiment can be understood with reference to the second position of the first embodiment, and the ninth position can be understood with reference to the third position of the first embodiment, that is, the pressure cover 310 can press the sample container after moving downward.

[0185] The pressure cover 310 includes a first main body, a plurality of pressure blocks 320 and a plurality of third elastic members 330. The plurality of pressure blocks 320 are connected to the same side of the first main body, specifically a side facing the sample container, such as the lower side. In the illustrated embodiment, the lower end of the pressure block 320 extends from the first main body so that the pressure block 320 can first contact the sample container when pressed. The pressure block 320 can be a cylindrical structure to adapt to the shape of the sample container.

[0186] The third elastic member 330 is connected between the pressing block 320 and the first main body. The third elastic member 330 can be selected as a compression spring. Specifically, one end of the third elastic member 330 abuts against the pressing block 320, and the other end abuts against the first main body. After the pressing block 320 abuts against the sample container, as the gland 310 moves, the pressing block 320 can move relative to the first main body, while compressing the third elastic member 330. When the pressing block 320 is separated from the sample container as the gland 310 is reset, the third elastic member 330 drives the pressing block 320 to reset to the initial state. The gland assembly of this embodiment is suitable for multi-tubes. Since each pressing block 320 is correspondingly provided with a third elastic member 330, it can abut against the corresponding sample container and independently move relative to the first main body. Therefore, even if the heights of the tubes of the multi-tube are inconsistent, the pressing block 320 can also ensure uniform pressing force of each tube through the adaptive adjustment of the third elastic member 330.

[0187] It should be noted that, according to the different movement modes of the pressure cover 310, the fourth driving module of this embodiment can have different schemes. For example, when the pressure cover 310 adopts the movement mode of rotating from the first position to the second position and then moving to the third position in the first embodiment, the fourth driving module can include the various types of first driving modules and second driving modules mentioned in the first embodiment. When the pressure cover 310 adopts the movement mode of rotating from the first position to the second position for pressing, the fourth driving module can be a rotation driving module, for example, including a rotation motor, or a linear driving module, for example, the linear movement is converted into the movement of the pressure cover 310 through the combination of the first sliding seat 420 and the connecting rod 410 in the first embodiment. When the pressure cover 310 adopts the movement mode of moving from the second position to the third position for pressing, the fourth driving module can be a linear driving module.

[0188] In some embodiments, the fourth module is different from the existing driving module of the sample analyzer for driving the transfer device 200 to transfer the sample container, and the fourth module can keep the pressure cover 310 in the ninth position for pressing. In some embodiments, the fourth module can also be used to reset the pressure cover 310. In other embodiments, the reset component of the first embodiment can also be provided, and the reset component can be used to reset the pressure cover 310.

[0189] In some embodiments, the fourth module may be an existing driving module of the sample analyzer for driving the transfer device 200 to transfer the sample container. Based on this, the present embodiment may also be provided with the self-locking component of the first embodiment, and the pressure cover 310 may be maintained in the ninth position for compression by the self-locking component. In some embodiments, when the self-locking component is provided, the reset component of the first embodiment may also be provided, and the reset component may be used to reset the pressure cover 310.

[0190] As a specific installation method of the pressing block 320, the first main body includes a mounting seat 311 and a mounting plate 312. The mounting seat 311 is provided with a through mounting hole. The mounting plate 312 is fixedly connected to the mounting seat 311 by a threaded fastener, thereby closing the upper end opening of the mounting hole. The pressing block 320 is installed in the mounting hole, and the lower end extends out of the mounting hole. The pressing block 320 is abutted against the mounting seat 311 through a flange for limiting. One end of the third elastic member 330 abuts against the pressing block 320, and the other end abuts against the mounting plate 312.

[0191] When the pressure cover assembly 300 is provided with a pressure block 320 capable of elastic movement, in some embodiments, when the pressure block 320 is in the initial state, the third elastic member 330 is configured to have a set preload force. For example, for the compression spring, the third elastic member 330 has a certain amount of compression. On the one hand, it can press the pressure block 320 in the initial state to prevent the pressure block 320 from shaking relative to the pressure cover 310. On the other hand, since the third elastic member 330 has a certain preload force, the third elastic member 330 only needs to continue to deform slightly to meet the clamping force requirement. That is, it can shorten the moving distance of the pressure block 320 relative to the pressure cover 310 and reduce the thickness of the pressure cover assembly 300.

[0192] When the pressure cover 310 is provided with a pressure block 320 capable of elastic movement, in some embodiments, the preload force of the third elastic member 330 can also be adjusted. Specifically, the pressure cover 310 further includes an adjustment component, the adjustment component is connected to the first main body, the third elastic member 330 is connected between the first main body and the adjustment component, and the adjustment component is used to move relative to the first main body to adjust the preload force of the third elastic member 330. Fig. 9 Taking the example shown, the adjustment component can be understood with reference to the mounting plate 312. When the adjustment component moves upward relative to the pressure cover 310, the compression amount of the third elastic component 330 becomes smaller, and the preload force becomes smaller. Conversely, when the adjustment component moves downward relative to the pressure cover 310, the compression amount of the third elastic component 330 becomes larger, and the preload force becomes larger, thereby being able to adjust the corresponding preload force according to sample containers of different heights.

[0193] The third embodiment of the present invention also proposes a sample analyzer. The sample analyzer of this embodiment can be an all-in-one machine integrating sample pre-processing, sample extraction, sample amplification and sample detection, or a PCR detection device that only includes sample amplification and sample detection functions.

[0194] The sample analyzer mainly includes an amplification module 10, a detection module and a fifth driving module, wherein the amplification module 10 is used to amplify the nucleic acid sample extracted from the biological sample through the polymerase chain reaction, so as to significantly increase the trace amount of nucleic acid sample in a shorter time, and the detection module is used to detect the amplified sample.

[0195] Specifically, refer to Figure 1 The amplification module 10 includes a base 100, a heating component and a pressure cover component 300, wherein the base 100 is used as the main bearing structure, and the heating component and the pressure cover component 300 are directly or indirectly connected to the base 100. Figure 3 In the illustrated embodiment, the base 100 is shown as a plate-like structure extending along the height direction (or referred to as the vertical direction and the up-down direction).

[0196] The heating assembly (not shown) is fixedly connected to the base 100 by means of a threaded fastener or other structure, wherein a heating chamber is provided therein for accommodating the multi-tube, and the heating assembly also includes a heating device capable of generating heat, such as an electric heating device, to heat the sample in the sample container. The gland assembly 300 is connected to the base 100 by means of a transmission assembly 400, specifically located on the upper side of the heating assembly, and the gland assembly 300 can press the sample container into the heating assembly or release the compression of the sample container by corresponding movement.

[0197] The pressure cover assembly 300 has a pressure cover 310, and the pressure cover 310 has a pressing surface, and the pressing surface is used to press the sample container. The fifth driving module is used to drive the pressure cover 310 to move downward from the tenth position to the eleventh position in the vertical direction, so as to press the sample container between the heating component and the pressure cover 310. That is, the difference between this embodiment and the first embodiment includes: in this embodiment, the pressure cover 310 does not need to rotate, but is directly pressed by moving in the vertical direction.

[0198] Specifically, in this embodiment, the pressure cover 310 is in the tenth position in the initial state, that is, a relatively high position, and the distance between the pressure cover 310 and the heating component is large, which is suitable for the sample container to enter or move out of the heating component. When the pressure cover 310 needs to press the sample container, the pressure cover 310 can be driven to rotate from the tenth position to the eleventh position first, at which time the position of the pressure cover 310 is relatively low and can press the sample container.

[0199] It should be noted that in other embodiments, the fifth module is different from the existing driving module of the sample analyzer for driving the transfer device 200 to transfer the sample container, and the fifth module can keep the pressure cover 310 at the eleventh or nineteenth position for pressing. In some embodiments, the fifth module can also be used to reset the pressure cover 310. In other embodiments, the reset component of the first embodiment can also be provided, and the reset component can be used to reset the pressure cover 310.

[0200] In some embodiments, the fifth driving module may be an existing driving module of the sample analyzer for driving the transfer device 200 to transfer the sample container, such as the first driving module of the first embodiment. Based on this, the present embodiment may also be provided with a self-locking component of the first embodiment, and the gland 310 may be maintained in the ninth position for compression by the self-locking component. In some embodiments, when a self-locking component is provided, a reset component of the first embodiment may also be provided, and the reset component may be used to reset the gland 310.

[0201] In some embodiments, when the pressure cap 310 is in the tenth position and the eleventh position, the pressing surface of the pressure cap 310 is perpendicular to the axis of the sample container. Usually, the sample container is placed vertically in the heating assembly. Therefore, when the pressure cap 310 is in the third position, the pressing surface is parallel to the horizontal direction, that is, parallel to the upper end surface of the sample container. In this way, all parts of the upper end of the sample container can contact the pressure cap 310 at the same time. The pressure cap 310 is applied to the sample container and faces vertically downward, so that the sample container can be evenly pressed. It can also prevent the sample container from being skewed due to local force, and improve the problem of uneven pressing force of the pressure cap 310.

[0202] The embodiments of the utility model are described in detail above in conjunction with the accompanying drawings, but the utility model is not limited to the above embodiments. Various changes can be made within the knowledge of ordinary technicians in the relevant technical field without departing from the purpose of the utility model. In addition, the embodiments of the utility model and the features in the embodiments can be combined with each other without conflict.

Claims

1. A sample analyzer, characterized in that: include: The amplification module comprises a base, a heating component and a pressure cover component, wherein the heating component is connected to the base and is used to place a sample container and heat the nucleic acid sample contained in the sample container, and the pressure cover component comprises a pressure cover having a pressing surface for pressing the sample container; A first driving module, used for driving the pressing cover to rotate relative to the base between a first position and a second position; A second driving module, used for driving the pressing cover to move downward from the second position to a third position along a vertical direction relative to the base, so as to press the sample container tightly between the pressing surface of the pressing cover and the heating component; A detection module, used for detecting the amplified nucleic acid sample; When the pressure cover is in the first position, the angle of the crimping surface relative to the horizontal plane is a first angle, and when the pressure cover is in the second position, the angle of the crimping surface relative to the horizontal plane is a second angle, and the first angle is greater than the second angle.

2. The sample analyzer according to claim 1, characterized in that: The amplification module further includes a transmission assembly, the transmission assembly includes a connecting rod, a first sliding seat and a second sliding seat, the gland is rotatably connected to the second sliding seat, and the connecting rod is rotatably connected to the gland and the first sliding seat respectively; Wherein, the first driving module drives the first sliding seat to move downward in a vertical direction relative to the base, so as to drive the pressure cover to rotate from the first position to the second position through the connecting rod; The second driving module is used to drive the first sliding seat and the second sliding seat to move downward along the vertical direction, so as to drive the pressing cover to move downward along the vertical direction from the second position to the third position.

3. The sample analyzer according to claim 2, characterized in that: The first driving module and the second driving module are the same module, the first sliding seat has a first abutting portion, and the second sliding seat has a second abutting portion. When the pressure cover is located at the second position, the first abutting portion abuts against the second abutting portion in a vertical direction. When the first driving module drives the first sliding seat to move downward in the vertical direction, the first sliding seat drives the second sliding seat to move downward in the vertical direction, so that the pressure cover moves from the second position to the third position.

4. The sample analyzer according to claim 2, characterized in that: The amplification module also includes a locking component, and the first sliding seat has an abutment surface. The sample analyzer also includes a third driving module, and the third driving module is used to drive the locking component to move between a fourth position and a fifth position relative to the base. When the locking component is located at the fourth position, the locking component abuts against the abutment surface of the first sliding seat to limit the upward movement of the first sliding seat in the vertical direction. When the locking component is located at the fifth position, the locking component disengages from the abutment surface.

5. The sample analyzer according to claim 4, characterized in that: The amplification module also includes a reset component, which includes a first elastic member and a second elastic member, the first elastic member is connected between the first sliding seat and the base, and the second elastic member is connected between the second sliding seat and the base. When the pressure cover is located at the third position, the first elastic member and the second elastic member both have a deformation amount. When the locking component is separated from the abutment surface, the first elastic member drives the first sliding seat to move upward by its own elastic force, and the second elastic member drives the second sliding seat to move upward by its own elastic force.

6. The sample analyzer according to claim 4, characterized in that: The amplification module also includes a reset component, which includes a second elastic member and a fifth elastic member. The second elastic member is connected between the second sliding seat and the base, and the fifth elastic member is connected between the pressure cover and the second sliding seat. When the pressure cover is located at the third position, the second elastic member and the fifth elastic member both have a deformation amount. When the locking component is disengaged from the abutment surface, the second elastic member drives the second sliding seat to move upward by its own elastic force, and the fifth elastic member drives the pressure cover to rotate in the opposite direction of the rotation direction from the first position to the second position by its own elastic force.

7. The sample analyzer according to claim 4, characterized in that: The amplification module also includes a fourth elastic member, which is connected between the locking member and the base. When the locking member is in the fifth position, the fourth elastic member has a deformation amount. When the pressure cover moves to the third position, the fourth elastic member drives the locking member to move from the fifth position to the fourth position through its own elastic force.

8. The sample analyzer according to claim 4, characterized in that: The locking member is rotatably connected to the base, and has a fifth abutting portion for abutting against the first sliding seat, the fifth abutting portion can be rotated to a first side of the rotation axis of the locking member, and rotated to a second side opposite to the first side, when the fifth abutting portion is located at the first side, the locking member is in the fourth position, and when the fifth abutting portion is located at the second side, the locking member is in the fifth position; The first sliding seat has a first limiting portion. When the fifth abutting portion rotates to the fourth position, the fifth abutting portion abuts against the first sliding seat to keep the pressure cover in the third position, and the locking component abuts against the first limiting portion to limit the rotation of the locking component in the direction from the fifth position to the fourth position.

9. The sample analyzer according to claim 8, characterized in that: The amplification module further includes a transfer device for transferring the sample container, the first driving module, the second driving module and the third driving module are the same module, and the first driving module is further configured to drive the transfer device to move in a vertical direction and in a horizontal direction between a sixth position and a seventh position; Wherein, when the transfer device is in the sixth position and the pressure cover is in the first position, the first driving module drives the transfer device to move downward in the vertical direction to abut against the first sliding seat, and after abutting against the first sliding seat, the first sliding seat is driven by the transfer device to move downward in the vertical direction, so that the pressure cover rotates from the first position to the second position; when the pressure cover is in the second position, the first driving module drives the first sliding seat and the second sliding seat to move downward in the vertical direction through the transfer device, so that the pressure cover moves from the second position to the third position; Furthermore, when the transfer device is in the seventh position and the locking part is in the fourth position, the first driving module drives the transfer device to move downward in the vertical direction to abut against the locking part, and drives the transfer device to move downward in the vertical direction after abutting against the locking part to drive the fifth abutment part to rotate from the first side to the second side.

10. The sample analyzer according to claim 8, characterized in that: The amplification module also includes a transfer device for transferring the sample container, and the third driving module is also configured to drive the transfer device to move in a vertical direction, wherein when the locking part is in the fourth position and the transfer device abuts against the locking part, the third driving module drives the transfer device to move downward in the vertical direction to drive the fifth abutment portion to rotate from the first side to the second side.

11. The sample analyzer according to claim 2, characterized in that: The amplification module also includes a transfer device for transferring sample containers, the first driving module and the second driving module are the same module, and the first driving module is also configured to drive the transfer device to move in a vertical direction, wherein, when the pressure cover is in the first position and the transfer device abuts against the first sliding seat, the first driving module drives the first sliding seat to move downward in the vertical direction through the transfer device, so that the pressure cover rotates from the first position to the second position; when the pressure cover is in the second position, the first driving module drives the first sliding seat and the second sliding seat to move downward in the vertical direction through the transfer device, so that the pressure cover moves from the second position to the third position.

12. The sample analyzer according to claim 2, characterized in that: The amplification module also includes a reset component, the first driving module and the second driving module are the same module, the first driving module includes a first power device and a power output part, the first power device can drive the power output part to move in the vertical direction, wherein, when the pressure cover is in the first position and the power output part abuts against the first sliding seat, the power output part is driven by the first power device to drive the first sliding seat to move downward in the vertical direction, so that the pressure cover rotates from the first position to the second position, when the pressure cover rotates to the second position, the power output part is driven by the first power device to drive the first sliding seat and the second sliding seat to move downward in the vertical direction, so that the pressure cover moves to the third position, and, after the pressure cover moves to the third position, the power output part is stationary and remains in abutment with the first sliding seat, so that the pressure cover remains in the third position; The reset assembly includes a first elastic member and a second elastic member, the first elastic member is connected between the first sliding seat and the base, and the second elastic member is connected between the second sliding seat and the base. When the pressure cover is located at the third position, the first elastic member and the second elastic member both have a deformation amount. When the power output part is driven by the first power device to move upward in the vertical direction, the first elastic member drives the first sliding seat to move upward by its own elastic force, and the second elastic member drives the second sliding seat to move upward by its own elastic force.

13. The sample analyzer according to claim 2, characterized in that: The amplification module further includes a reset component, the first driving module and the second driving module are the same module, the first driving module includes a first power device and a power output part, the power output part is connected to the first sliding seat, wherein when the pressure cover is in the first position, the power output part can be driven by the first power device to drive the first sliding seat to move in the vertical direction, so that the pressure cover rotates from the first position to the second position, when the pressure cover rotates to the second position, the power output part is driven by the first power device to drive the first sliding seat and the second sliding seat to move downward in the vertical direction, so that the pressure cover moves to the third position, and after the pressure cover moves to the third position, the power output part is stationary, so that the pressure cover remains in the third position; The reset assembly includes a second elastic member, which is connected between the second sliding seat and the base. When the pressure cover is located at the third position, the second elastic member has a deformation amount. When the power output part is driven by the first power device to drive the first sliding seat to move upward in the vertical direction, the second elastic member drives the second sliding seat to move upward through its own elastic force.

14. The sample analyzer according to claim 1, characterized in that: The pressure cover includes a first main body, a pressure block and a third elastic member. The pressure block is connected to one side of the first main body, and the pressure surface is provided at one end of the pressure block away from the first main body. The third elastic member is connected between the pressure block and the first main body. When the pressure cover is in the third position, the pressure block can abut against the sample container and compress the third elastic member.

15. The sample analyzer according to claim 14, characterized in that: When the pressing block is in the initial state, the third elastic member is configured to have a set preload force, and the pressing cover also includes an adjusting component, which is connected to the first main body, and the third elastic member is connected between the first main body and the adjusting component, and the adjusting component is used to move relative to the first main body to adjust the preload force of the third elastic member.

16. The sample analyzer according to claim 14, characterized in that: The pressing cover includes a plurality of pressing blocks and a plurality of third elastic members, and the plurality of pressing blocks are connected in parallel to the same side of the first main body.

17. The sample analyzer according to claim 1, characterized in that: The pressing cover is configured such that, when in the second position, the pressing surface is perpendicular to the axis of the sample container.

18. The sample analyzer according to claim 1, characterized in that: The heating assembly includes a semiconductor heater, a heat sink, a heat conducting mechanism and a pressing mechanism. The heat sink is attached to a first side of the semiconductor heater, the heat conducting mechanism is attached to a second side of the semiconductor heater, the first side and the second side are arranged opposite to each other, the heat conducting mechanism has a receiving hole for receiving a sample container, and the pressing mechanism is used to press the heat conducting mechanism between the semiconductor heater and the pressing mechanism.

19. The sample analyzer according to claim 18, characterized in that: The clamping mechanism includes a first substrate and a plurality of clamping components, wherein the first substrate is connected to the heat sink, and the plurality of clamping components are connected to the same side of the first substrate and are all abutted against the heat conducting mechanism to press the heat conducting mechanism between the semiconductor heater and the clamping mechanism, wherein at least the clamping component is made of a heat insulating material.

20. The sample analyzer according to claim 19, characterized in that: The clamping mechanism further includes a fastener, and the first substrate is connected to the heat sink via the fastener; Wherein, the clamping mechanism further includes a heat insulating pad, and the heat insulating pad is arranged between the head of the fastener and the first substrate; And / or, the fastener is made of a heat insulating material.

21. The sample analyzer according to claim 18, characterized in that: The heating component also includes a limit seat made of a heat-insulating material, the limit seat includes a second main body and a plurality of second limit portions, the second main body has a receiving groove, the second limit portion is connected to the second main body and at least partially extends into the receiving groove, the semiconductor heater is arranged in the receiving groove, and the side surface of the semiconductor heater abuts against each of the second limit portions to form a heat-insulating gap between the side surface of the semiconductor heater and the groove wall of the receiving groove.

22. The sample analyzer according to claim 21, characterized in that: The clamping mechanism includes a first substrate and a plurality of clamping components, wherein the first substrate is connected to the heat sink, and the plurality of clamping components are connected to the same side of the first substrate and abut against the heat conducting mechanism to clamp the heat conducting mechanism between the semiconductor heater and the clamping mechanism, wherein the first substrate abuts against the limiting seat along the direction in which the clamping component abuts against the heat conducting mechanism.

23. The sample analyzer according to claim 18, characterized in that: The heat-conducting mechanism includes a second substrate and a heat-conducting component connected to the second substrate. The second substrate is attached to the second side of the semiconductor heater, and the clamping mechanism presses the second substrate between the semiconductor heater and the clamping mechanism. The heat-conducting component has the accommodating hole at one end away from the second substrate.

24. A sample analyzer, characterized in that: include: An amplification module, comprising a base, a heating component and a pressure cover component, wherein the heating component is connected to the base and is used to place a sample container and heat the nucleic acid sample contained in the sample container, the pressure cover component comprises a pressure cover that can move between an eighth position and a ninth position relative to the base, the pressure cover comprises a first main body, a plurality of pressure blocks and a plurality of third elastic members, the plurality of pressure blocks are connected in parallel to the same side of the first main body, and the third elastic member is connected between the first main body corresponding to the pressure blocks; a fourth driving module, used for driving the pressing cover to move between an eighth position and a ninth position relative to the base; A detection module, used for detecting the amplified nucleic acid sample; When the fourth driving module drives the pressing cover to move to the ninth position, each pressing block abuts against the corresponding sample container and independently moves relative to the first main body to press each sample container tightly between the heating component and the pressing cover; When the pressing cover moves from the ninth position to the eighth position to separate the pressing block from the sample container, the third elastic member drives the pressing block to return to an initial state.

25. The sample analyzer according to claim 24, characterized in that: When the pressing block is in the initial state, the third elastic member is configured to have a set preload force, and the pressing cover also includes an adjusting component, which is connected to the first main body, and the third elastic member is connected between the first main body and the adjusting component, and the adjusting component is used to move relative to the first main body to adjust the preload force of the third elastic member.

26. A sample analyzer, characterized in that: include: The amplification module comprises a base, a heating component and a pressure cover component, wherein the heating component is connected to the base and is used to place a sample container and heat the nucleic acid sample contained in the sample container, and the pressure cover component comprises a pressure cover having a pressing surface for pressing the sample container; a fifth driving module, used for driving the pressing cover to move downward from the tenth position to the eleventh position along the vertical direction relative to the base, so as to press the sample container between the pressing surface of the pressing cover and the heating component; The detection module is used to detect the amplified nucleic acid sample.

27. The sample analyzer according to claim 26, characterized in that: The pressing cover is configured such that: when in the tenth position and the eleventh position, the pressing surface is perpendicular to the axis of the sample container.

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