A production device for glycolide

Abstract

The utility model discloses a production device of glycolide, comprising a reactor, a heating interlayer is arranged outside the reactor, a stirring device is arranged inside the reactor, a solid material adding port and a polyethylene glycol 400 feeding pipeline are arranged at the top of the reactor, the polyethylene glycol 400 feeding pipeline of the reactor is connected to a polyethylene glycol 400 metering tank, the polyethylene glycol 400 metering tank feeding pipeline is connected to a polyethylene glycol 400 storage tank, a U-shaped tube is arranged at the steam outlet at the top of the reactor, two interfaces of the U-shaped tube are respectively connected to the steam outlet and the inlet of a collecting tank, a condensing port is also arranged at the top of the collecting tank, a condensing pipe is inserted on the condensing port, a pipe layer of the condensing pipe is connected to a condensed water inlet pipe and a water outlet pipe, an upper port of the condensing pipe is connected to a vacuum pipe, a vacuum valve is arranged on the vacuum pipe, the collecting tank is placed in a condensing tank, and a condensing medium is arranged in the condensing tank. The preparation steps are few, the reaction purity is high, and the efficiency is high.

Description

Technical Field

[0001] The utility model relates to the technical field of extraction systems, in particular to a production device for glycolide. Background Art

[0002] Poly(lactic-co-glycolic acid) (PLGA) is a biodegradable functional polymer organic compound, which is composed of two monomers, lactic acid and glycolic acid, and is non-toxic, has good capsule and film forming properties, and is widely used in pharmaceutical, medical engineering materials and modern industrial fields. It is prepared by copolymerization of lactide and glycolide, so high-purity glycolide is the key to the preparation of poly(lactic-co-glycolic acid) copolymer.

[0003] The existing synthesis method of glycolide mainly involves manual feeding between various processing equipment, which is prone to errors, high labor intensity and low work efficiency. Therefore, there is an urgent need for a production device for glycolide with fewer preparation steps, high purity and high efficiency. Utility Model Content

[0004] The utility model aims to solve the technical problems existing in the prior art, and particularly innovatively proposes a glycolide production device with fewer preparation steps, high reaction purity and high efficiency.

[0005] In order to achieve the above-mentioned purpose of the utility model, the utility model provides a production device of glycolide, including a reactor, a heating interlayer is arranged outside the reactor, a steam inlet pipe and a steam outlet pipe are arranged on the heating interlayer, a stirring device is arranged inside the reactor, a solid material addition port and a polyethylene glycol 400 feeding pipeline are arranged at the top of the reactor, the polyethylene glycol 400 feeding pipeline of the reactor is connected to the polyethylene glycol 400 metering tank, the polyethylene glycol 400 metering tank feeding pipeline is connected to the polyethylene glycol 400 storage tank, a U-shaped tube is arranged at the steam outlet at the top of the reactor, two interfaces of the U-shaped tube are respectively connected to the steam outlet and the inlet of the collecting tank, a condensing port is also arranged at the top of the collecting tank, a condensing pipe is inserted on the condensing port, the pipe layer of the condensing pipe is connected to the condensing water inlet pipe and the outlet pipe, the upper port of the condensing pipe is connected to the vacuum pipe, a vacuum valve is arranged on the vacuum pipe, the collecting tank is placed in a condensing tank, and a condensing medium is arranged in the condensing tank.

[0006] In the above scheme: a suction pipe is connected to the solid material feeding port of the reactor through a flange, and the suction pipe is connected to the antimony trioxide tank and the glycolic acid tank respectively. Antimony trioxide and glycolic acid can be sucked and added through the suction pipe, reducing labor costs.

[0007] In the above scheme: the condensation medium is ice cubes, and the material is simple and easy to obtain.

[0008] In the above scheme: the outer wall of the U-shaped tube is wrapped with a heat-insulating material to prevent water vapor from condensing in the U-shaped tube and then flowing back into the reactor.

[0009] In the above scheme: the thermal insulation material is fireproof cotton, which has low cost and good thermal insulation effect.

[0010] In the above scheme: the condensate inlet pipe and the outlet pipe are both provided with condensate valves, and the steam inlet pipe and the steam outlet pipe are provided with steam valves, so as to facilitate the regulation of the inflow and outflow of condensate and steam.

[0011] In the above scheme: the reactor is provided with an observation window, through which the material in the reactor can be observed.

[0012] According to the proportion of ingredients, add glycolic acid and antimony trioxide solid into the reactor, and then add polyethylene glycol 400 through the polyethylene glycol 400 metering tank. Pass heating steam into the heating interlayer, and add condensing medium into the condensing tank at the same time, so that the condensing medium submerges the collection tank. Slowly open the vacuum valve, heat the reaction, and gradually control the vacuum ≦-0.090Mpa; open the valves on the condensate inlet and outlet pipes, and control the appropriate flow rate. The water vapor generated during the reaction enters the collection tank through the U-shaped tube and is condensed and collected. When the product distillation changes from a solution to a white solid, it indicates that no water is distilled out, and the vacuum valve and condensate valve are closed in turn. Pour out the water in the collection tank. Then install the collection tank, open the vacuum valve again, and control the vacuum ≦-0.090Mpa.

[0013] Open the valve of condensed water and control the appropriate flow rate; open the steam valve, heat the temperature inside the reactor to a higher temperature for cracking and cyclization, and distill the product at the same time until there is basically no distillate in the product, stop stirring to obtain crude glycolide.

[0014] In summary, due to the adoption of the above technical scheme, the beneficial effects of the utility model are: only reaction, dehydration, distillation, and then condensing the distilled product through a condensing tank are required, with fewer operating steps and saving industrial equipment costs. The set reactor can mix glycolic acid, polyethylene glycol 400 and antimony trioxide to synthesize glycolide, with a high degree of automation, low labor cost and high efficiency. The set collecting tank is used to collect the distilled glycolide product, and a condensing tube is set on the collecting tank, so that the steam in the collecting tank will be condensed through the condensing tube and then refluxed into the collecting tank, thereby increasing the yield as much as possible. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0016] Figure 1 It is a system schematic diagram of the utility model. DETAILED DESCRIPTION

[0017] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0018] like Figure 1 As shown, a production device for glycolide includes a reactor 1, a heating interlayer 3 is arranged outside the reactor 1, a steam inlet pipe and a steam outlet pipe are arranged on the heating interlayer 3, and the reactor 1 is heated by steam. Steam valves are arranged on the steam inlet pipe and the steam outlet pipe to facilitate the adjustment of the inlet and outlet of steam. A stirring device 2 is arranged in the reactor 1, and a solid material addition port and a polyethylene glycol 400 feeding pipeline are arranged at the top of the reactor 1. The polyethylene glycol 400 feeding pipeline of the reactor 1 is connected to the polyethylene glycol 400 metering tank 4, and the feeding pipeline of the polyethylene glycol 400 metering tank 4 is connected to the polyethylene glycol 400 storage tank 5.

[0019] In order to reduce labor costs and avoid manual addition of materials, a suction pipe is connected to the solid material inlet of the reactor 1 through a flange, and the suction pipe is connected to the antimony trioxide tank 7 and the glycolic acid tank 6 respectively, so that antimony trioxide and glycolic acid can be sucked and added through the suction pipe.

[0020] An observation window is provided on the side wall of the reactor 1, through which the material in the reactor 1 can be observed.

[0021] The top steam outlet of the reactor 1 is provided with a U-shaped tube 9, and the outer wall of the U-shaped tube 9 is wrapped with a heat-insulating material 8 to prevent the steam from condensing in the U-shaped tube 9 and then flowing back into the reactor 1. The heat-insulating material 8 of this embodiment is fireproof cotton, which has low cost and good heat-insulating effect.

[0022] The two interfaces of the U-shaped tube 9 are respectively connected to the steam outlet and the inlet of the collecting tank 10, and the top of the collecting tank 10 is also provided with a condensation port. A condensation pipe 11 is plugged into the condensation port, and the pipe layer 14 of the condensation pipe 11 is connected to the condensation water inlet pipe and the outlet pipe. Condensation water valves are provided on the condensation water inlet pipe and the outlet pipe. The upper end of the condensation pipe 11 is connected to a vacuum pipe, and a vacuum valve is provided on the vacuum pipe. The collecting tank 10 is placed in a condensation tank 12, and ice cubes are provided in the condensation tank 12 as a condensation medium 13, and the materials are simple and easy to obtain.

[0023] During production, glycolic acid and antimony trioxide solid are added to the reactor 1 according to the proportion of ingredients, and then polyethylene glycol 400 is added through the polyethylene glycol 400 metering tank. Heating steam is introduced into the heating interlayer 3, and condensing medium 13 is added to the condensing tank 12 at the same time, so that the condensing medium 13 submerges the collecting tank 10. Slowly open the vacuum valve, heat the reaction, and gradually control the vacuum ≦-0.090Mpa; open the valves on the condensate inlet and outlet pipes, and control the appropriate flow rate. The water vapor generated during the reaction enters the collecting tank 10 through the U-shaped tube 9 and is condensed and collected. When the product distillation changes from a solution to a white solid, it indicates that no water is distilled out, and the vacuum valve and the condensate valve are closed in turn. Pour out the water in the collecting tank 10. Then install the collecting tank 10, open the vacuum valve again, and control the vacuum ≦-0.090Mpa.

[0024] Open the valve of condensed water and control the appropriate flow rate; open the steam valve, heat the temperature inside the reactor 1 to a higher temperature for cracking and cyclization, and distill the product at the same time until there is basically no distillate in the product, stop stirring to obtain crude glycolide.

Claims

1. A production device for glycolide, characterized in that: The invention comprises a reactor (1), wherein a heating interlayer (3) is arranged outside the reactor (1), a steam inlet pipe and a steam outlet pipe are arranged on the heating interlayer (3), a stirring device (2) is arranged inside the reactor (1), a solid material addition port and a polyethylene glycol 400 feeding pipeline are arranged at the top of the reactor (1), the polyethylene glycol 400 feeding pipeline of the reactor (1) is connected to a polyethylene glycol 400 metering tank (4), the feeding pipeline of the polyethylene glycol 400 metering tank (4) is connected to a polyethylene glycol 400 storage tank (5), and the top of the reactor (1) is connected to a polyethylene glycol 400 storage tank (5). A U-shaped tube (9) is provided at the steam outlet, and two interfaces of the U-shaped tube (9) are respectively connected to the steam outlet and the inlet of the collecting tank (10), and a condensation port is also provided at the top of the collecting tank (10), and a condensation pipe (11) is inserted into the condensation port, and a tube layer (14) of the condensation pipe (11) is connected to a condensate inlet pipe and an outlet pipe, and an upper end of the condensation pipe (11) is connected to a vacuum pipe, and a vacuum valve is provided on the vacuum pipe, and the collecting tank (10) is placed in a condensation tank (12), and a condensation medium (13) is provided in the condensation tank (12).

2. The production device of glycolide according to claim 1, characterized in that: A suction pipe is connected to the solid material feeding port of the reactor (1) via a flange, and the suction pipe is connected to the antimony trioxide tank (7) and the glycolic acid tank (6) respectively.

3. The production device of glycolide according to claim 1, characterized in that: The condensation medium (13) is ice.

4. The production device of glycolide according to claim 1, characterized in that: The outer wall of the U-shaped tube (9) is wrapped with a heat-insulating material (8).

5. The production device of glycolide according to claim 4, characterized in that: The thermal insulation material (8) is fireproof cotton.

6. The production device of glycolide according to claim 1, characterized in that: The condensate inlet pipe and the outlet pipe are both provided with condensate valves, and the steam inlet pipe and the steam outlet pipe are provided with steam valves.

7. The production device of glycolide according to claim 1, characterized in that: The reaction kettle (1) is provided with an observation window.

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