Ultrasonic fundus dosing device

Abstract

The utility model discloses an ultrasonic fundus dosing device which comprises an outer shell, and one end of the outer shell is provided with a containing cavity extending inwards in the axial direction. Liquid medicine is stored in the medicine storage tube, and the medicine storage tube is placed in the containing cavity. The input end of the medicine guide needle is inserted and connected into the medicine storage tube, and the medicine guide needle is used for guiding the liquid medicine from the medicine storage tube to the output end of the medicine guide needle through the medicine guide needle. The tail end of the ultrasonic cap is connected with one end of the outer shell, the ultrasonic cap comprises a vibration unit, the vibration unit is arranged at the top end of the ultrasonic cap, the output end of the medicine guide needle penetrates through the tail end of the ultrasonic cap and abuts against the vibration unit, and under high-frequency vibration of the vibration unit, liquid medicine is pushed out of the medicine guide needle. As long as the front end of the ultrasonic cap is tightly attached to a dosing position, liquid medicine can be pushed into an affected part under the pushing of ultrasonic waves, and the ultrasonic dosing device has the advantages of being convenient to use, higher in accuracy, adjustable in flow speed and the like.

Description

Technical Field

[0001] The utility model belongs to the field of ophthalmic medical instruments, and in particular relates to an ultrasonic fundus drug delivery device. Background Art

[0002] Age-related macular degeneration, diabetic retinopathy and other fundus diseases are important causes of irreversible blindness. At present, intravitreal injection of anti-vascular endothelial growth factor, hormones and other drugs has become the main way to treat fundus diseases. However, intravitreal injection is an invasive operation. Frequent injection not only has the risk of eye complications, but also brings a heavy burden to the medical system. Therefore, it is urgent to develop effective and safe intraocular drug delivery methods. Recent studies have found that ultrasound can increase the permeability of cells and tissues under certain conditions, thereby promoting drug delivery, which provides a new idea for intraocular drug delivery. At the same time, because the sclera is close to the fundus lesions and has a large surface area, the transscleral drug delivery route has advantages in clinical application. Whether pulsed ultrasound can promote the entry of drugs into the eye through the sclera and its mechanism is still unclear. Therefore, this application conducts research from three levels: in vitro, simulation, and in vivo. First, at the in vitro level, the effect of pulsed ultrasound-mediated transscleral drug delivery is explored, and suitable pulsed ultrasound drug delivery modes and mechanisms are explored; then, the acoustic field distribution and temperature change characteristics of ocular tissue under the action of pulsed ultrasound are studied through simulation; finally, based on the in vitro and simulation studies, the feasibility and pharmacokinetic characteristics of suitable pulsed ultrasound-mediated transscleral drug delivery to the eyes of living New Zealand white rabbits are explored, with the aim of developing a new non-invasive intraocular drug delivery device. Utility Model Content

[0003] The technical purpose of the utility model is to provide an ultrasonic fundus drug delivery device to solve the technical problem of the difficulty of drug injection in the prior art.

[0004] To solve the above problems, the technical solution of the utility model is:

[0005] An ultrasonic fundus drug delivery device, comprising:

[0006] An outer shell, one end of which is provided with a receiving cavity extending axially and inwardly;

[0007] A medicine storage tube, in which medicine liquid is stored and placed in the accommodating cavity;

[0008] A drug guiding needle, the input end of which is inserted into the drug storage tube and is used to guide the drug solution from the drug storage tube to the output end of the drug guiding needle through the drug guiding needle;

[0009] The ultrasonic cap has its tail end connected to one end of the outer shell, and includes a vibration unit disposed at the top of the ultrasonic cap. The output end of the drug guide needle passes through the tail end of the ultrasonic cap and abuts against the vibration unit. Under the high-frequency vibration of the vibration unit, the drug solution is pushed out of the drug guide needle.

[0010] Further preferably, the outer shell is also provided with at least one foolproof quick-connect hole and two electrodes;

[0011] The fool-proof quick-connect hole and the electrode are arranged at one end of the outer shell having a accommodating cavity, and are located around the opening of the accommodating cavity. The fool-proof quick-connect hole is used to connect the ultrasonic cap to achieve a positioning connection, and the electrode is electrically connected to the vibration unit to energize the vibration unit.

[0012] Further preferably, a main control unit is further provided in the outer shell, and the main control unit is electrically connected to the electrode and is used to output an electrical signal to the electrode to control the vibration unit.

[0013] The bottom of the medicine storage tube is provided with a liquid stopper extending axially and inwardly, and the medicine storage tube is quickly connected to the accommodating cavity so as to place the medicine storage tube in the accommodating cavity.

[0014] Further preferably, stainless steel beads are provided in the medicine storage tube to prevent the medicine liquid from overflowing due to excessive flow rate.

[0015] Specifically, the drug guiding needle includes a drug guiding rod, a protective sleeve, a spring, a limiting sleeve and a drug guiding shell;

[0016] The drug guiding rod penetrates the protective cover, one end of the drug guiding rod is inserted into and connected to the drug storage tube, and the other end of the drug guiding rod abuts against the vibration unit to guide the drug solution;

[0017] The protective sleeve is fixed in the limiting sleeve to protect the drug guiding rod;

[0018] The limiting sleeve is connected to the wide-mouth end of the medicine guiding shell and is used to limit the position of the medicine guiding rod and the protective sleeve;

[0019] The drug guiding shell is provided with a narrow end relative to the wide end, and the narrow end and the drug guiding rod inside it are inserted into and connected to the drug storage tube;

[0020] The spring sleeve is arranged on the protective sleeve and is located in the space between the protective sleeve and the medicine guiding shell. One end of the spring is against the protective sleeve, and the other end of the spring is connected to the inside of the medicine guiding shell to support the medicine guiding rod against the vibration unit.

[0021] Wherein, the ultrasonic cap comprises a connecting base and a cap cover;

[0022] A through hole is opened along the axial direction of the connecting base, and the drug guide needle penetrates the through hole. A joint and a metal pad are provided on the peripheral side of the through hole and at one end close to the outer shell;

[0023] The connector matches the foolproof quick-connect hole and is used to connect the ultrasonic cap to the outer shell;

[0024] The metal pad matches the electrode and is used to realize a circuit formed by the electrode, the metal pad and the vibration unit; the cap is snap-connected to the end of the connecting base away from the outer shell, the vibration unit is arranged in the space between the cap and the connecting base, and the vibration unit is electrically connected to the metal pad, and a microhole is provided in the top center of the cap, which is used to push the drug solution out of the device under the push of the vibration unit.

[0025] Wherein, the vibration unit is an ultrasonic ceramic sheet and a metal connector connected to the ultrasonic ceramic sheet;

[0026] The ultrasonic ceramic sheet is closely attached to the top of the cap, and the metal connector extends toward the connection base and is electrically connected to the corresponding metal pad.

[0027] Due to the adoption of the above technical solution, the utility model has the following advantages and positive effects compared with the prior art:

[0028] The utility model adopts an ultrasonic ceramic sheet to perform a high-frequency vibration of 1M to 2.4MHz, so that the drug solution is introduced into the micropore end of the center of the ceramic sheet through the drug guide rod, and the high-frequency vibration of the ultrasonic ceramic sheet will push out the drug solution at the center micropore. It only needs to put the front end of the ultrasonic cap close to the drug administration site, and the drug solution can be pushed into the affected area under the promotion of ultrasound, which makes the drug use convenient, high-precision, and adjustable flow rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] By reading the detailed description of the preferred embodiment below, various other advantages and benefits will become clear to those skilled in the art. The accompanying drawings are only for the purpose of illustrating the preferred embodiment and are not to be considered as limiting the present invention.

[0030] Figure 1 This is an overall disassembled diagram of an ultrasonic fundus drug delivery device of the utility model;

[0031] Figure 2 This is an overall sectional view of an ultrasonic fundus drug delivery device of the utility model;

[0032] Figure 3 It is an exploded three-dimensional diagram of an ultrasonic fundus drug delivery device of the utility model;

[0033] Figure 4 It is an enlarged schematic diagram of the ultrasonic cap of the utility model;

[0034] Figure 5 A three-dimensional schematic diagram of the ultrasonic cap of the utility model

[0035] Figure 6 It is an enlarged schematic diagram of the drug guiding needle of the utility model;

[0036] Figure 7 It is a three-dimensional schematic diagram of the drug guiding needle of the utility model;

[0037] Figure 8 It is an enlarged schematic diagram of the medicine storage tube of the utility model;

[0038] Fig. 9 It is an enlarged schematic diagram of the outer shell of the utility model.

[0039] Description of Reference Numerals

[0040] 1: Ultrasonic cap; 101: Cap; 102: Connecting base; 103: Vibrating unit; 2: Drug guide needle; 201: Drug guide rod; 202: Protective cover; 203: Spring; 204: Limiting cover; 205: Drug guide shell; 3: Drug storage tube; 301: Liquid stopper; 302: Stainless steel bead; 4: Outer shell; 401: Accommodating chamber; 402: Main control unit. DETAILED DESCRIPTION

[0041] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the specific implementation methods of the utility model will be described below with reference to the accompanying drawings. Obviously, the accompanying drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings and other implementation methods can be obtained based on these drawings without creative work.

[0042] In order to simplify the drawings, only the parts related to the utility model are schematically shown in each figure, and they do not represent the actual structure of the product. In addition, in order to simplify the drawings and facilitate understanding, in some figures, only one of the parts with the same structure or function is schematically drawn or marked. In this article, "one" not only means "only one", but also means "more than one".

[0043] The advantages and features of the present invention will be more clearly understood from the following description and claims.

[0044] Example

[0045] See also Figures 1 to 9 This embodiment provides an ultrasonic fundus drug delivery device, which mainly includes four main components, namely, an outer shell 4, a drug storage tube 3, a drug guide needle 2 and an ultrasonic cap 1.

[0046] See also Figures 1 to 3 and Fig. 9 The outer shell 4 is now described: First, the outer shell 4 can be made of Figure 3As shown, it can be split into two sub-shells, upper and lower, in half, and the specific shape of the shell is not limited. A receiving chamber 401 extending inward along its own axial direction is provided at the left end of the outer shell 4, and the receiving chamber 401 is used to place the drug storage tube 3. Further, at least one foolproof quick-connect hole and two electrodes (two foolproof quick-connect holes and two electrodes in the figure) are provided at the left end of the outer shell 4. The foolproof quick-connect hole is used to cooperate with the ultrasonic cap 1 to achieve positioning connection, and the electrode can be electrically connected to the vibration unit 103 in the ultrasonic cap 1 for energizing the vibration unit 103. It can be found that there is also a space on the right side of the receiving chamber 401, in which the main control unit 402 of this embodiment is arranged, and the main control unit 402 is electrically connected to the electrode for outputting an electrical signal to the electrode to control the vibration unit 103. Of course, corresponding buttons can also be set on the outer shell 4 to input instructions to the main control unit 402, or the control host connected to the main control unit 402 signal can issue instructions.

[0047] Next, see Figures 1 to 3 and Figure 8 , the medicine storage tube 3 stores liquid medicine and is placed in the accommodating chamber 401. Specifically, a liquid stopper 301 extending axially and inward is provided at the bottom of the medicine storage tube 3 to prevent liquid leakage. One end of the liquid stopper 301 provided on the medicine storage tube 3 is inserted into the accommodating chamber 401 and is quickly connected to the accommodating chamber 401, so that the medicine storage tube 3 is placed in the accommodating chamber 401. Preferably, a stainless steel bead 302 is also provided in the medicine storage tube 3 to prevent the liquid medicine from overflowing due to excessive flow rate.

[0048] See also Figures 1 to 3 and Figure 6 as well as Figure 7 , the drug guiding needle 2 is now explained. The overall input end of the drug guiding needle 2 is inserted and connected to the drug storage tube 3, and is used to guide the drug solution from the drug storage tube 3 to the output end of the drug guiding needle 2 through the drug guiding needle 2. Specifically, the drug guiding needle 2 includes a drug guiding rod 201, a protective sleeve 202, a spring 203, a limiting sleeve 204 and a drug guiding shell 205. The drug guiding rod 201 is the core component of the component and runs through the entire drug guiding needle 2. One end of the drug guiding rod 201 is inserted into the drug storage tube 3, and the other end of the drug guiding rod 201 is against the vibration unit 103, which is used to guide the drug solution. The protective sleeve 202 is sleeved on the drug guiding rod 201, so that the drug guiding rod 201 is wrapped therein, so as to protect the drug guiding rod 201. The limiting sleeve 204 is also sleeved on the protective sleeve 202, that is, the limiting sleeve 204 limits the protective sleeve 202 in the lateral direction. According to Figure 6 or Figure 7, it can be known that the left opening of the medicine guiding housing 205 is larger, which is named as the wide-mouth end, and the left opening of the medicine guiding housing 205 is smaller, which is named as the narrow-mouth end. The limiting sleeve 204 is connected with the wide-mouth end by interference fit, so that the position of the limiting sleeve 204 is relatively fixed therein. The medicine guiding rod 201 with the protective cover 202 extends into the narrow-mouth end, so that it can be inserted into the medicine storage tube 3 together with the narrow-mouth end. The spring 203 is sleeved on the protective cover 202, and is located in the space between the protective cover 202 and the medicine guiding housing 205. One end of the spring 203 resists the raised ring extending outward from the protective cover 202, and the other end of the spring 203 is connected to the inside of the medicine guiding housing 205, so as to use the medicine guiding housing 205 as a support point, and an elastic force is applied outward to the medicine guiding rod 201, so that the medicine guiding rod 201 can withstand the vibration unit 103.

[0049] See also Figures 1 to 5 The ultrasonic cap 1 of this embodiment is now described. The tail end of the ultrasonic cap 1 is connected to one end of the outer shell 4. The ultrasonic cap 1 includes a vibration unit 103. The vibration unit 103 is arranged at the top of the ultrasonic cap 1. The output end of the drug guide needle 2 passes through the tail end of the ultrasonic cap 1 and abuts against the vibration unit 103. Under the high-frequency vibration of the vibration unit 103, the drug solution is pushed out of the drug guide needle 2.

[0050] Specifically, the ultrasonic cap 1 includes a connecting base 102 and a cap 101. A through hole is provided along the axial direction of the connecting base 102, and the drug guide needle 2 penetrates the through hole. A joint and a metal pad are provided on the peripheral side of the through hole and at one end for connecting the outer shell 4. The joint adopts a foolproof quick joint, which can match the foolproof quick joint hole to realize the connection between the ultrasonic cap 1 and the outer shell 4. The metal pad matches the electrode to realize that the electrode, the metal pad and the vibration unit 103 constitute a complete circuit. Of course, it can also be set in reverse, that is, the electrode is set at the connecting base 102, and the metal pad is set at the corresponding position of the outer shell 4. The cap 101 is snap-connected to the end of the connecting base 102 that is not connected to the outer shell 4, and a certain space is left between the cap 101 and the connecting base 102, and the vibration unit 103 is set in the space. A microhole is provided at the top center of the cap 101, and the vibration unit 103 is electrically connected to the metal pad, so that the liquid medicine can be pushed out of the device under the push of the vibration unit 103. Specifically, the vibration unit 103 is an ultrasonic ceramic sheet and a metal connector connected to the ultrasonic ceramic sheet. The ultrasonic ceramic sheet is tightly attached to the top of the cap 101. The metal connector extends to the connecting base 102 and is electrically connected to the corresponding metal pad. The main control unit 402 controls the high-frequency vibration of the ultrasonic ceramic sheet to push out the medicine.

[0051] The implementation of this embodiment is now described: first, the drug storage tube 3 is placed in the accommodating cavity 401 of the outer shell 4, and then the drug guide needle 2 is forcefully inserted into the drug storage tube 3. At this time, the front end of the drug guide needle 2 will be pushed into the medicine cup, and the liquid medicine in the medicine cup can be guided out through the drug guide rod 201. At this time, take out the ultrasonic cap 1 and directly connect the ultrasonic cap 1 with the outer shell 4 in the direction of the foolproof joint. Finally, start the switch on the outer shell 4. At this time, the ultrasonic ceramic sheet in the ultrasonic cap 1 will perform a high-frequency vibration of 1M to 2.4MHz, and the liquid medicine will be introduced into the microporous end of the center of the ceramic sheet via the drug guide rod 201. The high-frequency vibration of the ultrasonic ceramic sheet will push the liquid medicine at the central micropore. So far, this embodiment has guided the liquid medicine out. As long as the front end of the ultrasonic cap 1 is close to the drug administration site, the liquid medicine will be pushed into the affected area under the promotion of ultrasound.

[0052] The above is a detailed description of the embodiments of the present invention in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and their equivalents, they still fall within the protection scope of the present invention.

Claims

1. An ultrasonic fundus drug delivery device, characterized in that: include: An outer shell, one end of which is provided with a receiving cavity extending axially and inwardly; A medicine storage tube, wherein the medicine storage tube stores liquid medicine and is placed in the accommodating cavity; A drug guiding needle, the input end of which is inserted into the drug storage tube and is used to guide the drug solution from the drug storage tube to the output end of the drug guiding needle through the drug guiding needle; An ultrasonic cap, wherein the tail end of the ultrasonic cap is connected to one end of the outer shell, the ultrasonic cap comprises a vibration unit, and the vibration unit is arranged at the top end of the ultrasonic cap. The output end of the drug guide needle passes through the tail end of the ultrasonic cap and abuts against the vibration unit. Under the high-frequency vibration of the vibration unit, the drug solution is pushed out of the drug guide needle.

2. The ultrasonic fundus drug delivery device according to claim 1, characterized in that: The outer shell is also provided with at least one foolproof quick-connect hole and two electrodes; The fool-proof quick-connect hole and the electrode are arranged at one end of the outer shell where the accommodating cavity is provided, and are located around the opening of the accommodating cavity. The fool-proof quick-connect hole is used to connect the ultrasonic cap to achieve a positioning connection. The electrode is electrically connected to the vibration unit to energize the vibration unit.

3. The ultrasonic fundus drug delivery device according to claim 2, characterized in that: A main control unit is also provided in the outer shell. The main control unit is electrically connected to the electrode and is used to output an electrical signal to the electrode to control the vibration unit.

4. The ultrasonic fundus drug delivery device according to claim 1, characterized in that: A liquid stopper extending axially and inwardly is provided at the bottom of the medicine storage tube, and the medicine storage tube is quickly connected to the accommodating cavity so as to place the medicine storage tube in the accommodating cavity.

5. The ultrasonic fundus drug delivery device according to claim 4, characterized in that: Stainless steel beads are also arranged in the medicine storage tube to prevent the medicine liquid from overflowing due to excessive flow rate.

6. The ultrasonic fundus drug delivery device according to claim 1, characterized in that: The drug guiding needle comprises a drug guiding rod, a protective sleeve, a spring, a limiting sleeve and a drug guiding shell; The drug guiding rod penetrates the protective cover, one end of the drug guiding rod is inserted into and connected to the drug storage tube, and the other end of the drug guiding rod abuts against the vibration unit to guide the drug solution; The protective sleeve is fixed in the limiting sleeve and is used to protect the drug guiding rod; The limiting sleeve is connected to the wide-mouth end of the medicine guiding housing and is used to limit the position of the medicine guiding rod and the protective sleeve; The drug guiding shell is provided with a narrow end relative to the wide end, and the narrow end and the drug guiding rod inside it are inserted into and connected to the drug storage tube; The spring sleeve is arranged on the protective sleeve and is located in the space between the protective sleeve and the medicine guiding shell. One end of the spring is against the protective sleeve, and the other end of the spring is connected to the inside of the medicine guiding shell to support the medicine guiding rod against the vibration unit.

7. The ultrasonic fundus drug delivery device according to claim 2, characterized in that: The ultrasonic cap comprises a connecting base and a cap cover; A through hole is opened along the axial direction of the connecting base, the drug guiding needle penetrates the through hole, and a joint and a metal pad are provided on the peripheral side of the through hole and at one end close to the outer shell; The connector matches the foolproof quick-connect hole and is used to connect the ultrasonic cap to the outer shell; The metal pad matches the electrode to form a loop with the electrode, the metal pad and the vibration unit; The cap is buckled and connected to one end of the connecting base away from the outer shell. The vibration unit is arranged in the space between the cap and the connecting base, and the vibration unit is electrically connected to the metal pad. A microhole is provided in the top center of the cap for pushing the medicine liquid out of the device under the push of the vibration unit.

8. The ultrasonic fundus drug delivery device according to claim 7, characterized in that: The vibration unit is an ultrasonic ceramic sheet and a metal connector connected to the ultrasonic ceramic sheet; The ultrasonic ceramic sheet is closely attached to the top of the cap, and the metal connector extends toward the connection base and is electrically connected to the corresponding metal pad.

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