Auxiliary fixing device for intrathecal injection of large and small laboratory mice

Abstract

The utility model relates to the technical field of medical equipment, in particular to an auxiliary fixing device for intrathecal injection of large and small laboratory mice, which comprises an outer shell and a fixing mechanism, the outer shell is a hollow box body with an openable top cover and is made of transparent materials, and the fixing mechanism is arranged in the outer shell and is fixed on the outer shell. One end of a spiral piston in the fixing mechanism abuts against the corresponding clamping plate, the other end of the spiral piston penetrates through the four walls of the outer shell and extends to the outer side, the relative distance between the clamping plates can be adjusted by rotating a handle, then the size of the space defined by the four clamping plates is adjusted, and the movement operation of the laboratory mouse is limited. The clamping plate is adjusted to move slowly through the spiral piston to adapt to rat and mouse types and prevent rat and mouse stress reaction caused by too fast movement of the clamping plate, and the laboratory mouse can be slowly fixed and controlled in a waking state. The laboratory mouse intrathecal injection device overcomes the defects of an existing laboratory mouse intrathecal injection device, and researchers can conduct intrathecal injection when a laboratory mouse is in a waking state.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, in particular to an auxiliary fixing device for intrathecal injection of large and small experimental mice. Background Art

[0002] Intrathecal injection is the injection of drugs directly into the subarachnoid space through a pre-placed intrathecal catheter, which allows the drugs to diffuse in the cerebrospinal fluid without passing through the blood-brain barrier and directly act on the spinal cord and brain. This method of drug administration is widely used in the study of central nervous system diseases and other fields. It can ensure the effective concentration of drugs that are difficult to pass through the blood-brain barrier and avoid adverse reactions caused by large doses of intravenous drugs.

[0003] However, during the injection process, due to the low degree of cooperation of mice and rats, intrathecal injection cannot be performed when they are awake. Therefore, the operation is currently performed under anesthesia, and multiple anesthesia may not only affect the physiological and vital status of mice and rats, but also may have a certain impact on the research results. Utility Model Content

[0004] The utility model aims to provide an auxiliary fixing device for intrathecal injection of large and small experimental mice, and aims to provide a fixing device suitable for large and small mice of different body sizes, so that researchers can perform intrathecal injection when the experimental mice are awake.

[0005] To achieve the above-mentioned purpose, the utility model provides an auxiliary fixation device for intrathecal injection of large and small experimental mice, comprising an outer shell and a fixing mechanism, wherein the fixing mechanism is arranged in the outer shell, and the outer shell is a hollow box with an openable top cover, which is made of transparent material. The fixing mechanism comprises a head and tail fixing clamp, a left and right fixing clamp and four spiral pistons, wherein the head and tail fixing clamp and the left and right fixing clamp are respectively formed by two independent clamping plates arranged opposite to each other, and the four clamping plates are opposite to each other in pairs and can complete the encirclement action, and one end of the four spiral pistons is respectively abutted on the corresponding clamping plate, and the other end passes through the four walls of the outer shell and extends to the outside.

[0006] Wherein, the spiral piston comprises a threaded rod and a rotating handle, wherein the rotating handle is arranged on one end passing through the outer shell, and a thread matching the threaded rod is provided at a through-hole position of the outer shell.

[0007] Wherein, the head and tail fixing clamps are arranged inside the left and right fixing clamps, and the width of the clamping plates of the left and right fixing clamps is greater than the width of the clamping plates of the head and tail fixing clamps.

[0008] Wherein, semicircular arch openings are arranged under the two clamping plates of the head and tail fixing clamps.

[0009] Wherein, an injection operation port is opened in the middle of the top cover of the outer shell.

[0010] The utility model provides an auxiliary fixing device for intrathecal injection of large and small experimental mice, including an outer shell and a fixing mechanism. The outer shell is a hollow box with an openable top cover, made of transparent material, and the fixing mechanism is arranged in the outer shell. One end of the spiral piston in the fixing mechanism is against the corresponding clamping plate, and the other end passes through the four walls of the outer shell and extends to the outside. The relative distance between the clamping plates can be adjusted by turning the handle, and then the size of the space surrounded by the four clamping plates can be adjusted to achieve the operation of limiting the movement of the experimental mice. The slow movement of the clamping plates by adjusting the spiral piston can adapt to the large and small mice and prevent the clamping plates from moving too fast to cause stress reactions in the large and small mice. The experimental mice can be slowly fixed and controlled in a sober state. The utility model solves the shortcomings of existing intrathecal injection devices for experimental mice, allowing researchers to perform intrathecal injections when the experimental mice are awake. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0012] Figure 1 The utility model is a structural schematic diagram of an auxiliary fixation device for intrathecal injection of large and small experimental mice.

[0013] Figure 2 The utility model is a schematic diagram of a main view angle of an auxiliary fixation device for intrathecal injection of large and small experimental mice.

[0014] Figure 3 The utility model is a schematic diagram of a side view of an auxiliary fixation device for intrathecal injection of large and small experimental mice.

[0015] Figure 4 The utility model is a schematic diagram of a top view of an auxiliary fixation device for intrathecal injection of large and small experimental mice.

[0016] 1-outer shell, 2-fixing mechanism, 21-head and tail fixing clamps, 22-left and right fixing clamps, 23-spiral piston, 30-threaded rod, 31-rotating handle, 40-semicircular arch opening, 41-injection operation port. DETAILED DESCRIPTION

[0017] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and should not be construed as limiting the present invention.

[0018] See also Figures 1 to 4 The utility model proposes an auxiliary fixation device for intrathecal injection of large and small experimental mice, comprising an outer shell 1 and a fixing mechanism 2, wherein the fixing mechanism 2 is arranged in the outer shell 1, and the outer shell 1 is a hollow box with an openable top cover, which is made of transparent material, and the fixing mechanism 2 comprises a head and tail fixing clamp 2, a left and right fixing clamp 22 and four spiral pistons 23, wherein the head and tail fixing clamp 2 and the left and right fixing clamp 22 are respectively formed by two independent clamping plates arranged opposite to each other, and the four clamping plates are opposite to each other in pairs and can complete the encirclement action, and one end of the four spiral pistons 23 is respectively abutted on the corresponding clamping plate, and the other end passes through the four walls of the outer shell 1 and extends to the outside.

[0019] The spiral piston 23 includes a threaded rod 30 and a rotating handle 31 . The rotating handle 31 is arranged on one end passing through the outer shell 1 . A thread matching the threaded rod 30 is provided at a through hole of the outer shell 1 .

[0020] The head and tail fixing clamps 2 are arranged inside the left and right fixing clamps 22 , and the width of the clamping plates of the left and right fixing clamps 22 is greater than the width of the clamping plates of the head and tail fixing clamps 2 .

[0021] A semicircular arch opening 40 is provided below the two clamping plates of the head and tail fixing clamp 2 .

[0022] An injection operation port 41 is provided in the middle of the top cover of the outer shell 1 .

[0023] In this embodiment, the experimental mouse that needs to be injected intrathecally is placed in the auxiliary fixation device for intrathecal injection of experimental mice of different sizes, the top cover is closed, and the spiral pistons 23 of the head and tail fixing clamps 2 and the left and right fixing clamps 22 are slowly rotated to limit the movement of the limbs of the experimental mouse, forcing its head and tail to move toward the semicircular arch openings 40 of the head and tail fixing clamps 2 respectively. After the head and tail of the experimental mouse extend out from the semicircular arch and fit in the corresponding position, the piston is adjusted to be stably rotated for fixation, and the experimenter puts his hand in through the injection operation port 41 on the top for intrathecal injection.

[0024] Specifically, the utility model has the following beneficial effects:

[0025] 1. The spiral piston adjusts the splint to move slowly, which can limit the movement of the head, tail and limbs of mice and rats and prevent the splint from moving too fast and causing stress to mice and rats. Ordinary mouse cages are much larger than mice and rats, and cannot effectively limit the movement of mice and rats. During intrathecal injection, mice and rats are easily injured or the indwelling catheter is pulled out. The utility model improves these problems by changing and adjusting the position of the splint to limit the movement of mice and rats.

[0026] 2. Due to the low degree of cooperation of large and small experimental mice, they usually need to be anesthetized before intrathecal injection. The use of this device can reduce the number of deaths caused by short-term repeated anesthesia affecting the physiological functions of large and small mice. Intrathecal injection can be performed without waiting for the anesthetic to take effect, which greatly shortens the operation time.

[0027] 3. The overall material is more environmentally friendly and durable. The outer shell is made of transparent material, which not only allows the observation of the reaction of mice and rats during drug administration, but also highlights the concept of environmental protection.

[0028] The above disclosure is only a preferred embodiment of the present invention, and certainly cannot be used to limit the scope of rights of the present invention. Ordinary technicians in this field can understand that all or part of the processes of the above embodiment and equivalent changes made according to the claims of the present invention still fall within the scope covered by the utility model.

Claims

1. An auxiliary fixation device for intrathecal injection of large and small experimental mice, comprising an outer shell and a fixing mechanism, wherein the fixing mechanism is arranged in the outer shell, and is characterized in that: The outer shell is a hollow box with an openable top cover, made of transparent material, the fixing mechanism includes head and tail fixing clamps, left and right fixing clamps and four spiral pistons, the head and tail fixing clamps and the left and right fixing clamps are respectively formed by two independent clamping plates arranged opposite to each other, the four clamping plates are opposite to each other in pairs and can complete the encircling action, one end of the four spiral pistons is respectively abutted on the corresponding clamping plate, and the other end passes through the four walls of the outer shell and extends to the outside; The spiral piston comprises a threaded rod and a rotating handle, wherein the rotating handle is arranged on one end passing through the outer shell, and a thread matching the threaded rod is provided at a through hole of the outer shell; The head and tail fixing clips are arranged inside the left and right fixing clips, and the width of the clamping plates of the left and right fixing clips is greater than the width of the clamping plates of the head and tail fixing clips.

2. The intrathecal injection auxiliary fixation device for large and small experimental mice as claimed in claim 1, characterized in that: Semicircular arched openings are arranged below the two clamping plates of the head and tail fixing clamps.

3. The intrathecal injection auxiliary fixation device for large and small experimental mice as claimed in claim 1, characterized in that: An injection operation port is provided in the middle of the top cover of the outer shell.

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