Biodegradable fixing and supporting system implanted with radioactive particles

Abstract

The utility model belongs to the field of medical instruments, and particularly relates to a biodegradable fixing and supporting system for implanting radioactive particles, which comprises a guide plate and a hollow source placing tube, the source placing pipes are filled with a plurality of radioactive particles to form a bead string-shaped radioactive line source, and the source placing pipes are inserted into the plurality of guide holes and are inserted into tumor tissues in a matrix arrangement manner. According to the fixing and supporting system, various movements of implanted particles in a focus are effectively reduced, reasonable space distribution among the linear radioactive sources is kept, and overlapping and omission of the linear radioactive sources are eliminated and reduced.

Description

Technical Field

[0001] The utility model belongs to the field of medical devices, and particularly relates to a biodegradable fixation and support system for implanting radioactive seeds. Background Art

[0002] Malignant tumors are the second major diseases endangering human health after cardiovascular diseases. In order to treat malignant tumors, the clinical application of anti-tumor technology of radioactive implanted seeds emerged in the 1970s of the last century, and its clinical indications have gradually extended to dozens of tumors such as lung cancer, liver cancer, tongue cancer, sarcoma, and intracranial nucleoplasm tumors.

[0003] At present, the advantage of implantable radioactive seed therapy is that there is a very high radiation dose in the tumor, but only a very low radiation dose in the adjacent normal tissues. In this way, both the goal of radical treatment of tumor lesions can be achieved, and the normal tissues can be well protected. It has a good dose ratio difference and has significant advantages compared with external radiotherapy technology. However, due to the attenuation principle of the physical properties of implantable radiation sources, the point source or line source attenuates outward in an inverse square law. Especially for point sources or line sources with smaller geometric volumes, the attenuation gradient of the radiation is more severe. When the irradiation exceeds the effective range of a point source or line source, it is necessary to calculate and plan the effective irradiation range to reduce or eliminate the radiation damage range caused by low-dose leakage and high-dose hot spots, and achieve a relatively uniform state of radiation dose distribution.

[0004] The applicant has summarized and found in the long-term clinical treatment process that due to the following reasons, it is almost impossible to achieve a relatively uniform distribution of radiation dose for a radioactive seed as a point source in the prior art and clinical operations:

[0005] 1. Due to the heterogeneous nature of tumor tissues, the density and texture of tumor tissues are not uniform, resulting in uneven tension everywhere in the tissues;

[0006] 2. Due to poor blood supply in the central part of the tumor, central necrosis often occurs, presenting a liquefied or semi-liquefied state, and the texture density is very different from that of the peripheral tissues of the tumor;

[0007] 3. When implanting seeds, it will cause local edema and inflammatory reactions in the tumor tissues, and the seeds will be displaced after the edema subsides;

[0008] 4. After implanting the seeds, due to the centripetal non-uniform contraction and collapse of the tumor during regression, the seeds will also be displaced;

[0009] 5. Due to the squeezing of various movements and activities of various organs and tissues of the human body, the seeds will also be displaced;

[0010] 6. Due to the lack of mutual support and connection among the punctiform particles, it is impossible to form a relatively standard and ideal linear arrangement and multi-linear parallel arrangement to compose a three-dimensional effective radiation range volume.

[0011] 7. Due to the operation technical level error of the doctor in implanting the particles, it will also cause uneven distribution of the implanted particles.

[0012] Due to the above-mentioned multiple reasons, it is difficult to achieve an ideal uniform distribution dose of the implanted particles in the tumor bed area. Inevitably, there will be excessive irradiation of the internal part of the tumor body or normal tissues, causing damage to normal tissues; and local low-dose missed irradiation of the tumor body, resulting in poor local curative effect and local tumor residue and recurrence. Due to the above results, the radiotherapy efficacy of the implanted particles is poor, the treatment fails, and various complications occur. Therefore, it has seriously affected the further development of radiotherapy with implanted particles. At present, it is urgent to overcome the above-mentioned clinical bottlenecks and difficulties technically and in clinical practice, and it is necessary to further improve the clinical use of implanted radioactive particles to improve the radiotherapy efficacy. Summary of the Invention

[0013] In order to solve the problems existing in the prior art, the purpose of the present utility model is to provide a biodegradable fixed support system for implanting radioactive particles. This fixed support system effectively reduces various movements of the implanted particles in the lesion, and maintains a reasonable spatial distribution among the linear radiation sources, eliminating and reducing the overlap and omission of the linear radiation sources.

[0014] In order to achieve the above-mentioned utility model purpose, the present utility model provides the following technical solutions:

[0015] A biodegradable fixed support system for implanting radioactive particles, the fixed support system includes a guide plate and a hollow source placement tube. Among them, a number of guide holes are provided on the guide plate, and a number of radioactive particles are filled in the source placement tube to form a bead-shaped radioactive line source. The source placement tube is inserted into a number of the guide holes and is inserted into the tumor tissue in a matrix arrangement.

[0016] Preferably, a number of radioactive particles and intermediate blocks are sequentially filled in the source placement tube to form a bead-shaped radioactive line source.

[0017] Preferably, the guide plate includes at least two types of guide plates, namely a first guide plate and a second guide plate.

[0018] Preferably, the first guide plate is provided with first guide holes arranged in a matrix and second guide holes located between the first guide holes; the second guide plate is only provided with the first guide holes arranged in a matrix.

[0019] Preferably, a first radioactive source with a first radiation range is disposed in the first guiding hole on the first guiding plate, and a second radioactive source with a second radiation range is disposed in the second guiding hole on the first guiding plate. The distance between two adjacent first guiding holes on the first guiding plate is the diameter of the first radiation range; wherein, the second radiation range is smaller than the first radiation range.

[0020] Preferably, a third radioactive source with a third radiation range is disposed in the first guiding hole on the second guiding plate, and the distance between two first guiding holes in the diagonal direction on the second guiding plate is the diameter of the third radiation range.

[0021] Preferably, the source placement tube at least includes a first installation section and a second installation section with different sizes, and the first installation section and the second installation section are alternately arranged in sequence. The first installation section is used for installing first implantable particles, and the second installation section is used for installing second implantable particles.

[0022] Preferably, the intermediate stopper is installed in the first installation section or the second installation section where no implantable particles are installed.

[0023] Preferably, a plurality of outwardly protruding fixing structures are axially arranged along the outer periphery of the source placement tube, and the fixing structures are used to limit the axial movement of the source placement tube in the tumor tissue; wherein, the fixing structures are barbs structures axially inclined.

[0024] Preferably, when viewed along the axis of the source placement tube, the fixing structures are located in the middle of the first installation section and the second installation section.

[0025] Compared with the prior art, a biodegradable fixed support system for implanting radioactive particles provided by the present utility model has the following beneficial technical effects:

[0026] 1. By implanting radioactive particles into the source placement tube to form a bead-shaped radioactive source, the present utility model reduces the movement of the particles in the lesion. Meanwhile, a guiding plate is provided, and a plurality of different guiding holes are opened on the guiding plate to facilitate the accurate insertion of the source placement tube into a predetermined position of the tumor tissue. By using the guiding holes pre-opened on the guiding plate, it can be ensured that the radioactive sources inserted into the tumor tissue are arranged in a matrix, making the radiation dose distribution in the tumor tissue relatively uniform.

[0027] 2. The utility model sets different types of guide plates. For one type of guide plate, source tubes with a larger radiation range are arranged at the four corners of the matrix. The distance between two adjacent guide holes at the four corners of the matrix is the diameter of the radiation range of the source tube, and a source tube with a smaller radiation range is arranged in the central area, so that the radiation ranges basically do not overlap and there is basically no omission. This type of guide plate is suitable for patients who need a smaller radiation dose. For the other type of guide plate, only source tubes with a larger radiation range are arranged at the four corners of the matrix, and the distance between two guide holes at the diagonal corners of the matrix is the diameter of the radiation range of the source tube, so that there is no omission in the radiation range and the overlapping radiation range is as small as possible. This type of guide plate is suitable for patients who need a larger radiation dose.

[0028] 3. The utility model can quickly and conveniently prepare radioactive sources with different radiation ranges according to actual needs, and at the same time, it is used in conjunction with different types of guide plates to form a more uniform radiation range according to the actual treatment needs, avoiding the overlap or omission of the radiation range of the radioactive source.

[0029] 4. The utility model axially arranges a number of outwardly protruding barbs on the outer periphery of the source tube. When the source tube is inserted into the tumor tissue, the barb structure can penetrate into the tumor tissue, thereby restricting the axial movement of the source tube in the tumor tissue and ensuring that the radioactive source is in the accurate position in the tumor tissue. At the same time, by arranging the barb structure in the middle of the first installation section and the second installation section, when the implanted particles are located in the installation section, it will effectively support the barb structure, ensuring that the barb structure can stably penetrate into the tumor tissue and further preventing the source tube from axially moving. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 is a schematic diagram of the fixed support system of the utility model;

[0031] Figure 2 is a schematic diagram of the structure of the guide plate;

[0032] Figure 3 is a schematic diagram of the first embodiment of the fixed support system;

[0033] Figure 4 is a schematic diagram of the second embodiment of the fixed support system;

[0034] Figure 5 is a schematic diagram of the source tube.

[0035] Among them, the meanings of the reference symbols in the figure are as follows:

[0036] 1. Guide plate; 2. Source tube; 3. Guide hole; 4. Skin tissue; 5. Tumor tissue;

[0037] 11. First guide plate; 12. Second guide plate;

[0038] 21. First radiation range; 22. Second radiation range; 23. Third radiation range; 24. Fixing structure; 25. First installation section; 26. First implanted particle; 27. Second installation section; 28. Second implanted particle;

[0039] 31. First guide hole; 32. Second guide hole. Detailed implementation manners

[0040] To make the objectives, technical solutions and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some but not all of the embodiments of the present utility model.

[0041] Therefore, the following detailed description of the embodiments of the present utility model is not intended to limit the scope of the present utility model claimed, but merely represents some embodiments of the present utility model. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts fall within the scope of protection of the present utility model.

[0042] It should be noted that, without conflict, the embodiments in the present utility model and the features and technical solutions in the embodiments may be combined with each other.

[0043] It should be noted that similar reference numerals and letters denote similar items in the following drawings. Therefore, once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings.

[0044] In the description of the present utility model, it should be noted that the orientation or positional relationship indicated by terms such as "upper", "lower", etc. is based on the orientation or positional relationship shown in the drawings, or the orientation or positional relationship in which the product of the present utility model is usually placed during use, or the orientation or positional relationship commonly understood by those skilled in the art. Such terms are only for the convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be construed as a limitation of the present utility model. In addition, terms such as "first", "second", etc. are only used for descriptive distinction and cannot be understood as indicating or implying relative importance.

[0045] See the attached Figure 1 - attached Figure 5As shown in the figure, the present utility model provides a biodegradable fixed support system for implanting radioactive seeds. The fixed support system includes a guiding plate 1 and a hollow source placement tube 2. A plurality of guiding holes 3 are provided on the guiding plate 1. A plurality of radioactive seeds are filled in the source placement tube 2 to form a bead-shaped radioactive line source. The source placement tube 2 is inserted into a plurality of guiding holes 3, passes through the skin tissue 4, and is inserted into the tumor tissue 5 in a matrix arrangement. Preferably, a plurality of radioactive seeds and intermediate stoppers are sequentially filled in the source placement tube 2 to form a bead-shaped radioactive line source.

[0046] According to the technical solution provided by the present utility model, by implanting radioactive seeds into the source placement tube to form a bead-shaped radioactive line source, the movement of the seeds in the lesion is reduced. At the same time, a guiding plate is provided, and a plurality of different guiding holes are provided on the guiding plate to facilitate the accurate insertion of the source placement tube into a predetermined position of the tumor tissue. By using the guiding holes pre-opened on the guiding plate, it can be ensured that the radioactive line sources inserted into the tumor tissue are arranged in a matrix, so that the radiation dose distribution in the tumor tissue is relatively uniform.

[0047] In the above embodiment, the source placement tubes are inserted into the tumor tissue in a matrix arrangement at equal intervals. Among them, the projection of the radiation range of the source placement tube on the plane is a cylinder centered on the source placement tube. If the inserted radioactive line sources are arranged improperly, there will be a large overlap or omission in the radiation range of the radioactive line sources.

[0048] Preferably, the guiding plate 1 includes at least two types of guiding plates, namely a first guiding plate 11 and a second guiding plate 12.

[0049] Preferably, the first guiding plate 11 is provided with first guiding holes 31 arranged in a matrix and second guiding holes 32 located between the first guiding holes 31. A first radioactive line source with a first radiation range 21 is provided in the first guiding holes 31, and a second radioactive line source with a second radiation range 22 is provided in the second guiding holes 32. The distance between two adjacent first guiding holes 31 on the first guiding plate 11 is the diameter of the first radiation range 21. Among them, the second radiation range 22 is smaller than the first radiation range 21.

[0050] In the above embodiment, source placement tubes with a larger radiation range are arranged at the four corners of the matrix, and the distance between two adjacent guiding holes at the four corners of the matrix is the diameter of the radiation range of the source placement tube. A source placement tube with a smaller radiation range is arranged in the central area, as shown in the attached Figure 3 figure, so that the radiation ranges basically do not overlap and there is basically no omission. This type of guiding plate is suitable for patients who require a smaller radiation dose.

[0051] Preferably, only first guiding holes 31 arranged in a matrix are provided on the second guiding plate 12, and a third radioactive ray source having a third radiation range 23 is provided in the first guiding holes 31. The distance between two first guiding holes 31 in the diagonal direction on the second guiding plate 12 is the diameter of the third radiation range 23.

[0052] In the above embodiment, by only arranging the source tubes with a larger radiation range at the four corners of the matrix, and the distance between two guiding holes in the diagonal of the matrix is the diameter of the radiation range of the source tube, as shown in the appendix Figure 4 shown, so that there is no omission in the radiation range, and the overlapping radiation range is as small as possible. This type of guiding plate is suitable for patients who need a larger radiation dose.

[0053] Of course, on the basis of not departing from the concept of the present invention, various types of guiding plates can be set to meet the needs of different treatment purposes.

[0054] Preferably, in order to obtain radioactive ray sources with different radiation ranges, the source tube 2 at least includes a first installation section 25 and a second installation section 27 with different sizes. The first installation section 25 and the second installation section 27 are arranged alternately in sequence. The first installation section 25 is used to install the first implanted particles 26, and the second installation section 27 is used to install the second implanted particles 28. An intermediate block can be installed in the first installation section 25 or the second installation section 27 where no implanted particles are installed, so as to limit the movement of the first implanted particles 26 or the second implanted particles 28 along the axial direction of the source tube 2.

[0055] For example, when all the first implanted particles 26 are installed in the first installation section 25 and all the intermediate blocks are installed in the second installation section 27, the source tube 2 forms a radioactive ray source with a larger radiation range; and when all the second implanted particles 28 are installed in the second installation section 27 and all the intermediate blocks are installed in the first installation section 25, the source tube 2 forms a radioactive ray source with a smaller radiation range. Of course, on the basis of not departing from the concept of the present invention, multiple installation sections can be provided in the source tube to meet the needs of preparing radioactive ray sources with different radiation ranges.

[0056] According to the above embodiment, the present invention can quickly and conveniently prepare radioactive ray sources with different radiation ranges according to actual needs, and at the same time be used in combination with different types of guiding plates to form a more uniform radiation range according to the actual treatment needs, avoiding the overlap or omission of the radiation range of the radioactive ray source.

[0057] Preferably, a plurality of outwardly protruding fixing structures 24 are axially provided on the outer periphery of the source placement tube 2. After the source placement tube 2 is inserted into the tumor tissue 5, the fixing structures 24 are used to limit the axial movement of the source placement tube 2 in the tumor tissue 5, wherein the fixing structures 24 are barbed structures that are axially inclined. When viewed along the axis of the source placement tube 2, the fixing structures 24 are located in the middle of the first installation section 25 and the second installation section 27.

[0058] In the utility model, a plurality of barbed structures protruding outward are axially arranged on the outer periphery of the source placement tube. When the source placement tube is inserted into the tumor tissue, the barbed structures can penetrate into the tumor tissue, thereby restricting the axial movement of the source placement tube in the tumor tissue and ensuring that the radioactive source is in an accurate position in the tumor tissue. At the same time, by arranging the barbed structures in the middle of the first installation section and the second installation section, when the implanted particles are located in the installation section, an effective support is formed for the barbed structures, ensuring that the barbed structures can stably penetrate into the tumor tissue and further preventing the source placement tube from axially moving.

[0059] The above embodiments are only used to illustrate the utility model and do not limit the technical solutions described in the utility model. Although the present specification has described the utility model in detail with reference to the above respective embodiments, the utility model is not limited to the above specific implementation manners. Therefore, any modification or equivalent replacement to the utility model; and all technical solutions and their improvements that do not depart from the spirit and scope of the utility model are covered by the scope of the claims of the utility model.

Claims

1. A biodegradable fixation and support system for implanting radioactive seeds, characterized in that: The fixed support system includes a guide plate and a hollow source placement tube. A number of guide holes are formed in the guide plate. The source placement tube is filled with a number of radioactive particles to form a bead-string-shaped radioactive source line, and the source placement tube is inserted into a number of the guide holes and inserted into the tumor tissue in a matrix arrangement.

2. The fixed support system according to claim 1, wherein: A bead-string-shaped radioactive source line is formed after a number of radioactive particles and intermediate stoppers are sequentially filled in the source placement tube.

3. The fixed support system according to claim 2, wherein: The guide plate includes at least two types of guide plates, namely a first guide plate and a second guide plate.

4. The fixed support system according to claim 3, wherein: The first guide plate is provided with first guide holes arranged in a matrix and second guide holes located between the first guide holes; the second guide plate is only provided with the first guide holes arranged in a matrix.

5. The fixed support system according to claim 4, characterized in that: A first radioactive source line with a first radiation range is arranged in the first guide holes on the first guide plate, and a second radioactive source line with a second radiation range is arranged in the second guide holes on the first guide plate. The distance between two adjacent first guide holes on the first guide plate is the diameter of the first radiation range; wherein, the second radiation range is smaller than the first radiation range.

6. The fixed support system according to claim 5, wherein: A third radioactive source line with a third radiation range is arranged in the first guide holes on the second guide plate, and the distance between two first guide holes in the diagonal direction on the second guide plate is the diameter of the third radiation range.

7. The fixed support system according to claim 6, wherein: The source placement tube at least includes a first installation section and a second installation section with different sizes. The first installation section and the second installation section are alternately arranged in sequence. The first installation section is used to install first implant particles, and the second installation section is used to install second implant particles.

8. The fixed support system according to claim 7, characterized in that: The intermediate stopper is installed in the first installation section or the second installation section where no implant particles are installed.

9. The fixed support system according to claim 8, characterized in that: A number of outwardly protruding fixing structures are axially arranged along the outer periphery of the source placement tube. The fixing structures are used to limit the axial movement of the source placement tube in the tumor tissue; wherein, the fixing structures are barbed structures inclined axially.

10. The fixed support system according to claim 9, characterized in that: Viewed along the axis of the source placement tube, the fixing structures are located in the middle of the first installation section and the second installation section.

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