Separation and purification device for nervous system medicine
By designing a separation and purification device with a rotating disk and a distribution pipe, the pollution and low efficiency problems of existing centrifugal equipment are solved, and continuous centrifugation and efficient separation of pharmaceutical materials are achieved.
Patent Information
- Application Number
- CN202422455784.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-11
- Publication Date
- 2025-09-05
- Estimated Expiration
- 2034-10-11
AI Technical Summary
Existing centrifugal equipment has contamination risks and problems with sustained centrifugation in drug production, especially the unreasonable design of large-capacity centrifuge rotors, which leads to material obstruction and low efficiency.
A separation and purification device including a rotating disk and a distribution pipe was designed. The rotating disk has a gradually decreasing cross-sectional profile and a partition structure. Combined with an electronically controlled valve and a discharge hole, it can achieve separation of density materials and continuous centrifugal operation.
It realizes the continuous centrifugal treatment of pharmaceutical materials, improves the centrifugal efficiency and efficiency, avoids the risk of contamination, and does not affect the radial flow of materials.
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Figure CN223300171U_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the technical field of centrifugal purification, in particular to a device for separating and purifying nervous system drugs. Background Art
[0002] In the production and preparation process of drugs, such as nervous system drugs such as clomipramine hydrochloride tablets, amitriptyline hydrochloride tablets, and compound diazepam tablets, centrifugal equipment is usually used to centrifuge the drug solution to purify the target substance.
[0003] For example, the patent subject, "Large-Capacity Centrifuge Rotor and Continuous-Flow Centrifuge," has the application number "CN201310159948.7." In this solution, the material is fed into the rotor through an inlet pipe. During the rotation process, the material at the edge is discharged through an outlet pipe. Since the upper end of the rotor is open, it is prone to contamination. At the same time, the device is only equipped with two pipes and no second outlet pipe, which cannot achieve continuous centrifugation. Finally, the outlet pipe and inlet pipe are only fixed to the upper cover and do not move with the rotor, causing obstruction to the material during centrifugation. Summary of the Invention
[0004] To address the aforementioned issues, the present invention discloses a device for separating and purifying drugs for the nervous system. The device comprises a housing, within which a rotating disk is rotatably mounted. The cross-sectional profile of the rotating disk decreases in vertical dimension from the center toward the sides. Several radially arranged baffles are fixedly attached to the rotating disk at equal angles. The rotating disk is thick in the center and thin at the edges. The radial baffles do not affect the radial movement of the material, but rather promote its rotation with the rotating disk, allowing the material to quickly acquire rotational kinetic energy and promoting the centrifugal effect.
[0005] The rotating disk is equipped with a distribution pipe inside. This distribution pipe is composed of several transverse tubes, one end of which extends radially from the rotating disk. The sidewalls of these transverse tubes are vertically provided with discharge holes. Several electrically controlled valves are fixedly connected at equal angles to the edge of the rotating disk. A collection cladding is installed on the outside of the rotating disk. Material is fed into the rotating disk through the distribution pipe. As the rotating disk rotates, it undergoes centrifugal treatment. High-density material reaches the edge of the rotating disk. Opening the electrically controlled valves causes the material to be ejected from the rotating disk and enter the collection cladding, separating materials of different densities.
[0006] Preferably, the upper and lower sides of the middle of the rotating disk are fixedly connected with a rotating shaft, and the middle of the rotating shaft is provided with a channel. The rotating shaft is also a component supporting the rotating disk, and the material with low density is sent out from the rotating shaft above.
[0007] Preferably, a driving motor is fixedly connected to the interior of the housing, and a motor shaft of the driving motor is fixedly connected to a rotating shaft below the rotating disk. When the driving motor is started, the rotating disk is rotated via the motor shaft.
[0008] Preferably, a rotating ring is rotatably connected to the rotating shaft below the rotating disk, and a feed pipe is fixedly connected to the side wall of the rotating ring. The other end of the feed pipe extends from the housing and is connected only to the distribution pipe. Material is fed into the distribution pipe through the feed pipe and is simultaneously discharged from the material hole in the horizontal pipe. The purpose of providing the rotating ring is to ensure that the rotating shaft does not affect the material transportation during the rotation process.
[0009] Preferably, a first discharge pipe is fixedly connected to the bottom of the collecting cladding, and the other end of the first discharge pipe extends from the shell, that is, the material falling into the collecting cladding is discharged through the first discharge pipe.
[0010] Preferably, the rotating shaft above the rotating disk is rotatably coupled to a second discharge pipe, through which the material with a lower density is discharged.
[0011] Preferably, foot pads are fixedly connected to the four corners of the lower end of the shell to improve the stability of the device during use.
[0012] The beneficial effects of the present invention are as follows:
[0013] 1. A rotating disc is provided, and the material is fed into the internal preset distribution pipe from the bottom of the rotating disc, while the material with higher density is sent out from the electric control valve on the edge, and the material with lower density is sent out from the upper end of the rotating disc, which can realize the continuous centrifugal operation of the material.
[0014] 2. During the centrifugal treatment of materials, the discharge position is reasonably arranged. Specifically, the material with higher density is thrown from the edge to the collection shell, and the material with lower density is sent out from the upper end of the rotating disk without affecting the rotation of the rotating disk. This feeding and discharging method is more ingenious.
[0015] 3. A distribution pipe and a partition are provided inside the rotating disk. The distribution pipe delivers the material to the middle between the center and the edge, while the partition pushes the material to rotate with the rotating disk without affecting the radial flow of the material, thereby improving the effect and efficiency of the centrifugation. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] Figure 1 It is a three-dimensional schematic diagram of the present invention;
[0017] Figure 2 It is an explosion diagram of the present invention;
[0018] Figure 3 It is a cross-sectional schematic diagram of the present invention;
[0019] Figure 4 It is a three-dimensional schematic diagram of the material distribution pipe of the present invention.
[0020] List of reference numerals:
[0021] 1. Shell; 2. Feed pipe; 3. First discharge pipe; 4. Second discharge pipe; 5. Drive motor; 6. Rotating ring; 7. Distributing pipe; 8. Electric control valve; 9. Rotating disk; 10. Rotating shaft; 11. Collection cladding; 12. Foot pad; 13. Partition;
[0022] 71. Horizontal pipe; 72. Discharge hole. DETAILED DESCRIPTION
[0023] The present invention will be further described below with reference to the accompanying drawings and specific embodiments. It should be understood that the following specific embodiments are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. It should be noted that the terms "front," "rear," "left," "right," "up," and "down" used in the following description refer to directions in the accompanying drawings, and the terms "inward" and "outward" refer to directions toward or away from the geometric center of a particular component, respectively.
[0024] like Figures 1 to 4 As shown, a device for separating and purifying nervous system drugs includes a shell 1. The shell 1 is a flat rectangular structure as a whole, and the four vertical corners are rounded to improve the overall aesthetics of the device. A rotating disk 9 is provided inside the shell 1, that is, the rotating disk 9 is a rotating part, which is the main component of the centrifuge. The cross-sectional profile of the rotating disk 9 gradually decreases from the middle to the two sides, that is, the middle part of the rotating disk 9 is thicker and the edges are thinner. The interior of the rotating disk 9 is fixedly connected to a number of radially arranged partitions 13 at equal angles. The setting of the partition 13 will not affect the radial flow of the material, but during the rotation of the rotating disk 9, the material therein can be pushed to rotate with the rotating disk 9, which is conducive to centrifugal treatment.
[0025] The inside of the rotating disk 9 is provided with a distribution pipe 7, which feeds the material into the inside of the rotating disk 9. The distribution pipe 7 is composed of a plurality of transverse pipes 71. As shown in the figure, the number of transverse pipes 71 is preferably 6, and one end of the transverse pipe 71 extends radially toward the rotating disk 9. The position of the end thereof is preferably half of the radius of the rotating disk 9, that is, the material is fed out at the midpoint between the center and the edge of the rotating disk 9, ensuring that during centrifugal treatment, the material with high density flows directly to the edge and the material with low density flows toward the center of the circle. The side wall of the transverse pipe 71 is provided with a vertical The discharge hole 72, that is, the material is sent out in the vertical direction, to avoid the centrifugal effect of the material after being sent out radially, so that the material is thrown to the edge of the rotating disk 9. A number of electric control valves 8 are fixedly connected at equal angles to the edge side walls of the rotating disk 9. The through holes control the opening and closing of the electric control valves 8, and the material with higher density enriched at the edge of the rotating disk 9 can be sent out of the rotating disk 9. At the same time, a slip ring is provided on the control circuit of the electric control valve 8, and a collecting cladding 11 is provided on the outside of the rotating disk 9. The collecting cladding 11 is used to collect the material thrown out of the rotating disk 9, and also provides a layer of protection.
[0026] The upper and lower sides of the middle of the rotating disk 9 are fixedly connected with a rotating shaft 10, which is a structure supporting the rotating disk 9. A channel is provided in the middle of the rotating shaft 10, and the channel is used for the entry and exit of materials.
[0027] The interior of the housing 1 is fixedly connected to a drive motor 5, and the motor shaft of the drive motor 5 is fixedly connected to the rotating shaft 10 below the rotating disk 9. When the drive motor 5 is started, the rotating disk 9 is rotated through the motor shaft to centrifuge the material inside.
[0028] A rotating ring 6 is rotatably connected to the rotating shaft 10 below the rotating disk 9, that is, the rotating shaft 10 and the rotating ring 6 rotate relative to each other, and a feed pipe 2 is fixedly connected to the side wall of the rotating ring 6, and the material is continuously fed into the rotating disk 6 through the feed pipe 2, and the setting of the rotating ring 6 ensures the continuous feeding of the material. The other end of the feed pipe 2 extends from the shell 1, and the feed pipe 2 is only connected to the distribution pipe 7, that is, the material entering the rotating disk 6 can only be fed out from the distribution pipe 7.
[0029] The bottom of the collecting cladding 11 is fixedly connected to a first discharge pipe 3 , and the other end of the first discharge pipe 3 extends from the shell 1 , that is, the material in the collecting cladding 11 is discharged from the first discharge pipe 3 .
[0030] The rotating shaft 10 above the rotating disk 9 rotates in conjunction with the second discharge pipe 4. Materials with lower density will be enriched at the center of the circle, and will eventually be sent out from the second discharge pipe 4. The distribution pipe 7 is also provided to prevent the material from being sent out directly through the second discharge pipe 4 after being sent out at the circular position, and thus unable to undergo effective centrifugal treatment.
[0031] The four corners of the lower end of the housing 1 are fixedly connected with foot pads 12 for supporting and improving the stability of the device operation.
[0032] The technical means disclosed in the solution of the present invention are not limited to the technical means disclosed in the above-mentioned embodiment, but also include technical solutions composed of any combination of the above technical features.
Claims
1. A device for separating and purifying nervous system drugs, characterized in that: The invention comprises a housing (1), wherein a rotating disk (9) is rotatably provided inside the housing (1), wherein the cross-sectional profile of the rotating disk (9) gradually decreases in vertical dimension from the middle to both sides, and a plurality of radially arranged partitions (13) at equal angles are fixedly connected to the interior of the rotating disk (9); A distribution pipe (7) is provided inside the rotating disk (9), and the distribution pipe (7) is composed of a plurality of transverse pipes (71), and one end of the transverse pipe (71) extends radially toward the rotating disk (9), and a discharge hole (72) is provided on the side wall of the transverse pipe (71) in the vertical direction. A plurality of electrically controlled valves (8) are fixedly connected to the edge side wall of the rotating disk (9) at equal angles, and a collecting cladding (11) is provided on the outer side of the rotating disk (9).
2. The device for separating and purifying a nervous system drug according to claim 1, wherein: A rotating shaft (10) is fixedly connected to both the upper and lower sides of the middle of the rotating disk (9), and a channel is provided in the middle of the rotating shaft (10).
3. The device for separating and purifying a nervous system drug according to claim 2, characterized in that: A drive motor (5) is fixedly connected to the interior of the housing (1), and a motor shaft of the drive motor (5) is fixedly connected to a rotating shaft (10) below the rotating disk (9).
4. The device for separating and purifying a nervous system drug according to claim 1, wherein: A rotating ring (6) is rotatably connected to the rotating shaft (10) below the rotating disk (9), and a feed pipe (2) is fixedly connected to the side wall of the rotating ring (6). The other end of the feed pipe (2) extends from the shell (1), and the feed pipe (2) is only connected to the distribution pipe (7).
5. The device for separating and purifying a nervous system drug according to claim 1, characterized in that: A first discharge pipe (3) is fixedly connected to the bottom of the collecting cladding (11), and the other end of the first discharge pipe (3) extends from the shell (1).
6. The device for separating and purifying a nervous system drug according to claim 1, characterized in that: The rotating shaft (10) above the rotating disk (9) is rotatably coupled with a second discharge pipe (4).
7. The device for separating and purifying a nervous system drug according to claim 1, characterized in that: Foot pads (12) are fixedly connected to the four corners of the lower end of the shell (1).
Citation Information
Patent Citations
High-capacity centrifugal machine rotor and continuous flow centrifugal machine
CN103252293A