Dissolving kettle for refining dorzolamide hydrochloride
By designing a dissolving vessel for refining docoxam hydrochloride, and utilizing structures such as multi-layer heating tubes and liquid distributors, the problem of uneven heating of crude docoxam hydrochloride was solved, thereby improving dissolution efficiency and impurity removal, and enhancing product purity.
Patent Information
- Application Number
- CN202422966490.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-30
- Publication Date
- 2025-11-18
- Estimated Expiration
- 2034-11-30
AI Technical Summary
The existing docoxam hydrochloride production equipment is poorly designed, resulting in uneven heating of crude docoxam hydrochloride, low dissolution efficiency, and impurity removal.
A dissolving vessel for refining dzodamine hydrochloride was designed, including a vessel body, a feed inlet, a water inlet pipe, a discharge outlet, an external heating component, and an internal auxiliary heating component. The interior is equipped with first and second rotating shafts, on which a distributor, a stirring component, and a dispersing component are mounted. Uniform heating and stirring are achieved through multi-layer heating tubes and a liquid distributor, thereby improving the dissolution efficiency.
This method achieves uniform heating of crude dzodamine hydrochloride, improves dissolution efficiency, facilitates impurity removal, and enhances product purity.
Smart Images
Figure CN223555831U_ABST
Abstract
Description
TECHNICAL FIELD
[0001] The utility model relates to hydrochloric dazoxane production technical field especially relates to a kind of dissolving kettle for hydrochloric dazoxane refining. BACKGROUND
[0002] The Chinese name of hydrochloric dazoxane is (4S,6S)-4-ethylamino-5,6-dihydro-6-methyl-4H-thiophene [2,3b] pyran-2-sulfonamide-7,7-dioxide hydrochloride, which is a local eye carbonic anhydrase inhibitor, and can be widely used in the treatment of high eye pressure, glaucoma and other eye diseases. The existing production process obtains low-purity hydrochloric dazoxane product, which needs further refining and impurity removal. Currently, the crude hydrochloric dazoxane is first added to the kettle body, then water is added for stirring and dissolving, impurities are removed by filtration, and the collected filtrate is crystallized and dried to obtain high-purity hydrochloric dazoxane. However, the equipment used for dissolving the crude hydrochloric dazoxane is not reasonably designed, which leads to uneven heating of the crude hydrochloric dazoxane, low dissolution efficiency and affects the effective removal of impurities. Therefore, it is necessary to develop a dissolving kettle for hydrochloric dazoxane refining in view of the above problems. SUMMARY
[0003] The technical problem to be solved by the utility model is to provide a dissolving kettle for hydrochloric dazoxane refining, which can uniformly heat the crude hydrochloric dazoxane, improve the dissolution efficiency and facilitate the removal of impurities.
[0004] To solve the above technical problems, the technical scheme of the utility model is as follows:
[0005] A dissolving kettle for hydrochloric dazoxane refining, comprising a kettle body, a feed inlet is arranged at the top of the kettle body, water inlets are arranged at the two sides of the middle part of the kettle body, a discharge outlet is arranged at the bottom of the kettle body, a heating component is arranged outside the kettle body, and an auxiliary heating component is arranged inside the kettle body; a first rotating shaft and a second rotating shaft are arranged inside the kettle body, one end of the first rotating shaft is connected to a motor, a first gear is arranged on the first rotating shaft, and a second gear meshing with the first gear is arranged on the second rotating shaft; a distributing device is arranged on the upper part of the first rotating shaft, a dispersing component is arranged on the second rotating shaft, and the dispersing component is located inside the distributing device; a first stirring component, a second stirring component and a third stirring component are arranged below the distributing device in sequence, and a liquid distributor communicating with the water inlets is arranged between the first stirring component and the second stirring component.
[0006] As an improved technical scheme, the heating component is a jacket arranged outside the kettle body; the auxiliary heating component comprises a plurality of heating pipes connected to each other.
[0007] As an improved technical scheme, the cloth distributor comprises a disc body fixedly connected with the first rotating shaft, the disc body is provided with a baffle on the periphery, and the bottom of the disc body is provided with a plurality of conical bodies with different heights and hollow structures, and a plurality of cloth distribution holes are arranged on the conical bodies.
[0008] As an improved technical scheme, the dispersion component comprises a ring body fixedly connected with the bottom of the second rotating shaft, and the bottom of the ring body is provided with a plurality of stirring teeth.
[0009] As an improved technical scheme, the first stirring component and the second stirring component are stirring rods symmetrically arranged on both sides of the first rotating shaft.
[0010] As an improved technical scheme, the third stirring component comprises a ring-shaped pipe body fixedly connected with the first rotating shaft, a plurality of L-shaped stirring plates fixedly connected with the first rotating shaft are arranged on the upper portion of the pipe body, and a plurality of stirring rods are arranged below the pipe body.
[0011] As an improved technical scheme, the liquid distributor comprises a hollow body, a plurality of liquid distribution pipes with different heights are arranged on the upper surface of the body, a plurality of hollow auxiliary liquid distribution components are arranged on the periphery of the body, and a plurality of liquid distribution holes are arranged on the liquid distribution pipes and the auxiliary liquid distribution components respectively.
[0012] After the above technical scheme is adopted, the beneficial effects of the present application are as follows:
[0013] The utility model discloses a dissolving kettle for refining doxanamine hydrochloride, which comprises a kettle body, a feeding port arranged at the top of the kettle body, water inlets arranged at the two sides of the middle of the kettle body, a discharging port arranged at the bottom of the kettle body, a heating component arranged outside the kettle body, an auxiliary heating component arranged inside the kettle body, a first rotating shaft and a second rotating shaft arranged inside the kettle body, a motor connected to one end of the first rotating shaft, a first gear arranged on the first rotating shaft, a second gear arranged on the second rotating shaft and engaged with the first gear, a distributor arranged at the upper part of the first rotating shaft, a dispersing component arranged on the second rotating shaft and located inside the distributor, a first stirring component, a second stirring component and a third stirring component arranged below the distributor in sequence, and a liquid distributor arranged between the first stirring component and the second stirring component and connected to the water inlets.
[0014] The heating component is a jacket arranged outside the kettle body, and the auxiliary heating component comprises a plurality of heating pipes connected to each other.
[0015] The distributor comprises a disc body fixedly connected to the first rotating shaft, a baffle arranged around the disc body, a plurality of conical bodies with different heights and hollow structures arranged at the bottom of the disc body, and a plurality of distribution holes arranged on the conical bodies.
[0016] The dispersing component comprises a ring body fixedly arranged at the bottom of the second rotating shaft, and a plurality of stirring teeth arranged at the bottom of the ring body.
[0017] The first stirring component and the second stirring component are stirring rods symmetrically arranged at the two sides of the first rotating shaft.
[0018] The third stirring component comprises a circular tube fixedly connected with the first rotating shaft, the upper part of the tube is provided with a plurality of L-shaped stirring plates fixedly connected with the first rotating shaft, and the lower part of the tube is provided with a plurality of stirring rods.
[0019] The liquid distributor comprises a hollow body, the center of the body is provided with a through hole, the upper surface of the body is provided with a plurality of liquid distribution pipes with different heights, the periphery of the body is provided with a plurality of auxiliary liquid distribution components with hollow structures, and a plurality of liquid distribution holes are arranged on the liquid distribution pipes and the auxiliary liquid distribution components respectively. BRIEF DESCRIPTION OF DRAWINGS
[0020] Figure 1 It is a structure schematic view of a dissolving kettle for refining doxorubicin hydrochloride.
[0021] Among them, 1 is a kettle body, 2 is a water inlet pipe, 3 is a heating component, 4 is an auxiliary heating component, 5 is a first rotating shaft, 50 is a first stirring component, 51 is a second stirring component, 52 is a third stirring component, 520 is a tube, 521 is an L-shaped stirring plate, 522 is a stirring rod, 6 is a second rotating shaft, 7 is a motor, 8 is a first gear, 9 is a second gear, 10 is a distributor, 100 is a disc body, 101 is a baffle, 102 is a conical body, 11 is a dispersion component, 110 is a circular ring body, 111 is a stirring tooth, 12 is a liquid distributor, 120 is a body, 121 is a liquid distribution pipe, and 122 is an auxiliary liquid distribution component. DETAILED DESCRIPTION
[0022] In order to make the purpose, technical scheme and advantages of the utility model more clearly, the following will be further described in detail by combining with the drawings and examples.
[0023] A dissolving kettle for refining doxorubicin hydrochloride, such as Figure 1As shown, including kettle body 1, kettle body 1 top is provided with feed inlet, kettle body both sides of the middle part is provided with water inlet pipe 2, kettle body bottom is provided with discharge port, kettle body 1 outside is provided with heating component 3 (set in kettle body outside the jacket), kettle body 1 inside is provided with auxiliary heating component 4 (multilayer intercommunication heating pipe, adjacent two layers of heating pipe are communicated through connecting pipe, and each layer of heating pipe is welded and connected with kettle inner wall through connecting plate); Kettle body 1 inside is provided with first rotating shaft 5 and second rotating shaft 6 (kettle top is provided with bearing, second rotating shaft upper end passes through bearing), one end of first rotating shaft 5 is connected with motor 7, first rotating shaft 5 is provided with first gear 8, second rotating shaft 6 is provided with second gear 9 engaged with first gear 8; The upper portion of the first rotating shaft 5 is provided with a distributor 10, and the second rotating shaft 6 is provided with a dispersion component 11 (including a circular ring body 110 fixed on the bottom of the second rotating shaft 6 through a connecting rod, a plurality of stirring teeth 111 are arranged on the bottom of the circular ring body 110; The circular ring body is welded and connected with the second rotating shaft through the connecting rod, and the circular ring body is welded and connected with the stirring teeth); And the dispersion component 11 is located in the interior of the distributor 10, the distributor 10 is sequentially provided with a first stirring component 50, a second stirring component 51 and a third stirring component 52 below, a liquid distributor 12 is arranged between the first stirring component 50 and the second stirring component 51 and communicated with the water inlet pipe 2. Wherein the distributor 10 includes a disc body 100 fixedly connected with the first rotating shaft (the disc body is welded and connected with the first rotating shaft), a baffle 101 is arranged on the periphery of the disc body 100, a plurality of conical bodies 102 with different heights and hollow structures are arranged on the bottom of the disc body 100, and a plurality of distribution holes are arranged on the conical bodies 102. Wherein the liquid distributor 12 includes a hollow body 120 (fixedly connected with the inner wall of the kettle through a connecting plate), a through hole is arranged in the center of the body 120, a plurality of liquid distribution pipes 121 with different heights are arranged on the upper surface of the body, a plurality of auxiliary liquid distribution components 122 with hollow structures are arranged on the periphery of the body 120, and a plurality of liquid distribution holes are arranged on the liquid distribution pipes 121 and the auxiliary liquid distribution components 122 respectively.
[0024] In actual production, the staff first starts the motor to run, the first rotating shaft drives the cloth distributor, the first stirring part, the second stirring part and the third stirring part to rotate, the second rotating shaft and the dispersing part rotate with the first rotating shaft, the crude doxium chloride hydrochloride falls on the disc of the cloth distributor after entering the kettle body from the feeding port, the circular ring body and the plurality of stirring teeth of the dispersing part stir and disperse the material on the disc, and with the rotation of the disc, the material enters the plurality of conical bodies, is uniformly dispersed into the kettle body through the cloth holes, the purified water enters the body of the liquid distributor along the water inlet pipe under the action of the delivery pump, and then enters the plurality of liquid distribution pipes and the auxiliary liquid distribution part, is uniformly dispersed through the liquid distribution holes, and is fully contacted and mixed with the crude doxium chloride hydrochloride, the temperature required for dissolving is provided by the heat medium (steam) in the external jacket and the internal auxiliary heating part (the condensed water after heat exchange is discharged from the liquid discharge port at the bottom of the jacket and the liquid discharge port of the bottom layer heating pipe in the kettle body), and the first, second and third stirring parts fully stir and mix the crude doxium chloride hydrochloride and the purified water, so that the crude doxium chloride hydrochloride is fully contacted with the purified water, the mixing efficiency and the dissolving efficiency are greatly improved when the crude doxium chloride hydrochloride is uniformly heated, and the impurities in the crude doxium chloride hydrochloride are removed.
[0025] The first stirring part 50 and the second stirring part 51 are stirring rods symmetrically arranged on both sides of the first rotating shaft.
[0026] The third stirring part 52 comprises a circular ring-shaped pipe body 520 fixedly connected with the first rotating shaft (the pipe body is connected with the first rotating shaft through a connecting rod), a plurality of L-shaped stirring plates 521 fixedly connected with the first rotating shaft 5 are arranged on the upper portion of the pipe body 520, and a plurality of stirring rods 522 are arranged below the pipe body 520.
[0027] The above only describes preferred embodiments of the present application and is not used to limit the present application, and any modification, equivalent replacement and improvement made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims
1. A dissolving vessel for the purification of doxorubicin hydrochloride, characterized in that, The utility model provides a kind of multi-layered stirring kettle, including cauldron body, the top of the cauldron body is equipped with feed inlet, the middle part of the cauldron body is equipped with water inlet pipe on both sides, the bottom of the cauldron body is equipped with discharge outlet, the outside of the cauldron body is equipped with heating component, the inside of the cauldron body is equipped with auxiliary heating component;The inside of the cauldron body is equipped with first rotating shaft and second rotating shaft, one end of the first rotating shaft is connected motor, the first rotating shaft is equipped with first gear, the second rotating shaft is equipped with second gear and is engaged with the first gear;The upper portion of the first rotating shaft is equipped with distributor, the second rotating shaft is equipped with dispersion component, and the dispersion component is located inside the distributor;The distributor is equipped with first stirring component, second stirring component and third stirring component in sequence below, liquid distributor is equipped with between the first stirring component and the second stirring component and is connected with the water inlet pipe.
2. The dissolving vessel for refining doxorubicin hydrochloride according to claim 1, characterized in that, The heating component is a jacket arranged outside the cauldron body.
3. The dissolving vessel for refining doxorubicin hydrochloride according to claim 1, characterized in that, The distributor includes a disc body fixedly connected with the first rotating shaft, a baffle is arranged on the periphery of the disc body, a plurality of conical bodies with different heights and hollow structures are arranged on the bottom of the disc body, and a plurality of distribution holes are arranged on the conical bodies.
4. The dissolving vessel for purifying doxazosin hydrochloride according to claim 1, wherein The dispersion component includes a circular ring body fixedly connected with the bottom of the second rotating shaft, and a plurality of stirring teeth are arranged on the bottom of the circular ring body.
5. The dissolving vessel for purifying doxazosin hydrochloride according to claim 1, wherein The first stirring component and the second stirring component are stirring rods symmetrically arranged on both sides of the first rotating shaft.
6. The dissolving vessel for refining doxorubicin hydrochloride according to claim 1, characterized by The third stirring component includes a circular ring-shaped tube body fixedly connected with the first rotating shaft, a plurality of L-shaped stirring plates fixedly connected with the first rotating shaft are arranged on the upper portion of the tube body, and a plurality of stirring rods are arranged below the tube body.
7. The dissolving vessel for refining doxorubicin hydrochloride according to claim 1, characterized by The liquid distributor includes a hollow body, a through hole is arranged in the center of the body, a plurality of liquid distribution pipes with different heights are arranged on the upper surface of the body, a plurality of auxiliary liquid distribution components with hollow structures are arranged on the periphery of the body, and a plurality of liquid distribution holes are respectively arranged on the liquid distribution pipes and the auxiliary liquid distribution components.