Head model for treating object by near-infrared light

Abstract

The utility model provides a head die for a near-infrared light treatment object, the head die is configured to be used for measuring light attenuation and transmission conditions in an accommodating space of near-infrared light treatment equipment, the absorption rate of the surface of the head die for near-infrared light is greater than a preset absorption rate, the structure meets a first group of structure parameters, and the first group of structure parameters comprises: the head circumference is 525-583 mm, and the head circumference is greater than the preset absorption rate. The length of the head ranges from 170 mm to 196 mm, and the width of the head ranges from 140 mm to 166 mm. On the basis of the corresponding condition of the head model and the real human body, as for the performance shown by the near-infrared light treatment equipment designed by using the head model, it can be considered that the near-infrared light treatment equipment can show the same performance on the real human body, and therefore the near-infrared light treatment equipment can be improved in a targeted mode. Therefore, the head die can be used for detecting and improving near-infrared light treatment equipment for performing near-infrared irradiation on the head.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, in particular to a head mold for near-infrared light treatment of a subject. BACKGROUND

[0002] Alzheimer's disease (AD) often occurs in the elderly population. Epidemiological investigations show that the prevalence of AD increases with age in people over 60 years old. In addition to drug combination therapy, in recent years, people have tried to treat AD using photobiomodulation (PBM) therapy. By irradiating the brain with a suitable dose of transcranial light (infrared or near-infrared light) in a certain wavelength range, nerve regulation can be achieved. The light energy in this wavelength range is mild and has good penetration. Many studies have shown that PBM therapy is effective in treating AD.

[0003] However, the existing various photobiomodulation devices (hereinafter referred to as near-infrared light treatment devices) have ambiguous, chaotic and very different definitions of irradiation parameters. In addition, the irradiation parameters defined in the body position do not have practicality for the irradiation control of the near-infrared light treatment device. For example, the light power density at a depth of several centimeters under the dura mater cannot be detected by invasive detection of the light power density at a depth of several centimeters under the dura mater in the brain each time the near-infrared light treatment device is operated.

[0004] In summary, the existing technologies have different and even contradictory statements about the dose required by the near-infrared light treatment device, which hinders the promotion and development of the near-infrared light treatment device and even the near-infrared light treatment method. CONTENT OF THE INVENTION

[0005] The present application provides a head mold for near-infrared light treatment of a subject. The head mold is configured to measure the light attenuation and transmission in the accommodation space of the near-infrared light treatment device. The absorption rate of the surface of the head mold to near-infrared light is greater than a preset absorption rate, and the structure satisfies a first set of structure parameters. The first set of structure parameters includes: a head circumference between 525-583 mm, a head length between 170-196 mm, and a head width of 140-166 mm.

[0006] Exemplarily, at least the electrode positions of the 10-20 international standard electrode system are marked on the head mold, or at least the electrode positions of the 10-10 international standard electrode system are marked.

[0007] Exemplarily, a groove is formed at each electrode position. The groove is configured to accommodate a probe of a light power meter and make the detection surface of the probe substantially flush with the surface of the head mold.

[0008] Exemplarily, an identifier corresponding to the electrode position is arranged in the groove.

[0009] Exemplarily, the groove edge is provided with an extending slot configured to at least partially accommodate a wire connected to the probe.

[0010] Exemplarily, the absorption rate of the head model surface to near-infrared light is adapted to the absorption rate of the head surface of the represented target population to near-infrared light.

[0011] Exemplarily, the head model surface is black, and a head length-width index composed of the head length and the head width is 81.0-85.4.

[0012] Exemplarily, the parameters of the head model further include: a morphological face length is between 104-130mm, a head sagittal arc is between 304-372mm, an inter-tragus arc is between 320-375mm, and a head height is between 206-253mm.

[0013] Exemplarily, the morphological face length is 109.3mm, the head sagittal arc is 355.6mm, the inter-tragus arc is 324.1mm, and the head height is 206mm.

[0014] Exemplarily, the head circumference is 536.7mm, the head length is 184mm, and the head width is 152mm.

[0015] Exemplarily, the head width and the head length of the head model are determined based on a mean value of a P50 parameter value of the head width and the head length of a female in an age range of 61-70 years old and a P50 parameter value of the head width and the head length of a male in an age range of 61-70 years old.

[0016] Exemplarily, the head model is further marked with one or more of the following external visible boundary lines: a total boundary line, the total boundary line passing through the glabella point of the head model along the brow bone, through the preauricular points on both sides, and converging backward around the inion and between the electrode positions O1, OZ and O2 of the 10-10 international standard electrode system; a first boundary line, the first boundary line sequentially passing between the electrode positions of the 10-10 international standard electrode system as follows: between F7 and FT7, between F5 and FC5, between FC3 and C3, between FC1 and C1, between FCZ and CZ, between FC2 and C2, between FC4 and C4, between F6 and FC6, and between F8 and FT8; a second boundary line, the second boundary line sequentially passing between the electrode positions of the 10-10 international standard electrode system as follows: between FC3 and C3, between FC1 and C1, between FCZ and CZ, between FC2 and C2, between FC4 and C4, between C6 and C4, between CP6 and CP4, between P6 and P4, between PO4 and P4, between PO4 and P2, between POZ and P2, between POZ and PZ, between POZ and P1, between PO3 and P1, between PO3 and P3, between P5 and P3, between CP5 and CP3, and between C5 and C3; a third boundary line, the third boundary line sequentially passing between the electrode positions of the 10-10 international standard electrode system as follows: between FT7 and F7, between FC5 and F5, between FC5 and FC3, between C5 and C3, between CP5 and CP3, between P5 and P3, between P5 and PO5, between P7 and PO7; a fourth boundary line, the fourth boundary line sequentially passing between the electrode positions of the 10-10 international standard electrode system as follows: between FT8 and F8, between FC6 and F6, between FC6 and FC4, between C6 and C4, between CP6 and CP4, between P6 and P4, between P6 and PO6, between P8 and PO8; a fifth boundary line, the fifth boundary line sequentially passing between the electrode positions of the 10-10 international standard electrode system as follows: between P7 and PO7, between P5 and PO5, between P3 and PO3, between P1 and POZ, between PZ and POZ, between P2 and POZ, between P4 and PO4, between P6 and PO6, between P8 and PO8.

[0017] Exemplarily, the boundary lines are configured to satisfy one or more of the following conditions: a first region enclosed by the first boundary line and the total boundary line corresponds to the upper anterior part of the subject’s head; a second region enclosed by the second boundary line corresponds to the parietal part of the subject’s head; a third region enclosed by the third boundary line and the total boundary line corresponds to the left lateral part of the subject’s head; a fourth region enclosed by the fourth boundary line and the total boundary line corresponds to the right lateral part of the subject’s head; a fifth region enclosed by the fifth boundary line and the total boundary line corresponds to the posterior part of the subject’s head.

[0018] Based on the correspondence between the head model and the real human body, the performance of the near-infrared light treatment device designed using the head model can be considered to be able to exhibit the same performance on the real human body, so that the near-infrared light treatment device can be improved accordingly. Therefore, the head model can be used to detect and improve the near-infrared light treatment device for near-infrared irradiation of the head.

[0019] A series of simplified concepts are introduced in the utility model content, which will be further described in detail in the specific embodiment part. The utility model content part does not mean to try to limit the key features and necessary technical features of the claimed technical solutions, and even less means to try to determine the protection scope of the claimed technical solutions.

[0020] The advantages and features of the present application will be described in detail below in combination with the drawings. BRIEF DESCRIPTION OF DRAWINGS

[0021] The following drawings of the present application are hereby incorporated into the present application as part of the present application for understanding the present application. The embodiments of the present application and their description shown in the drawings are used to explain the principles of the present application. In the drawings,

[0022] Figure 1 Fig. 1 is a schematic view showing a head model according to a first embodiment of the present application accommodated in a light treatment device;

[0023] Fig. 2(a) is a schematic view showing a head model according to a second embodiment of the present application accommodated in a light treatment device;

[0024] Fig. 2(b) is a schematic view showing a head model according to a third embodiment of the present application accommodated in a light treatment device;

[0025] Figures 3(a)-3(f) Fig. 3 shows a diagram showing characteristic parameters of a head model of a head of a subject or a subject population according to a fourth embodiment of the present application;

[0026] Fig. 4(a) shows a schematic view of electrode positions on the cranial anterior superior part of a head model as an example of a subject head based on the 10-10 international standard electrode system according to a fifth embodiment of the present application;

[0027] Fig. 4(b) shows a schematic view of electrode positions on the cranial anterior superior part of a head model as an example of a subject head based on the 10-10 international standard electrode system according to a sixth embodiment of the present application;

[0028] Fig. 4(c) shows a schematic view of electrode positions on the cranial anterior superior part of a head model as an example of a subject head based on the 10-10 international standard electrode system according to a seventh embodiment of the present application;

[0029] Fig. 5(a) shows a front view of a head model as an example of a subject's head on which electrode positions of the 10-10 international standard electrode system, a total boundary line of a reference head cap portion, and boundary lines among a cranial superior anterior portion, a cranial left portion, and a cranial right portion are shown, according to the eighth embodiment of the present application;

[0030] Fig. 5(b) shows a left side view of a head model as an example of a subject's head on which electrode positions of the 10-10 international standard electrode system, a total boundary line of a reference head cap portion, and boundary lines among a cranial superior anterior portion, a cranial left portion, a cranial superior portion, and a cranial posterior portion are shown, according to the eighth embodiment of the present application;

[0031] Fig. 5(c) shows a right side view of a head model as an example of a subject's head on which electrode positions of the 10-10 international standard electrode system, a total boundary line of a reference head cap portion, and boundary lines among a cranial superior anterior portion, a cranial right portion, a cranial superior portion, and a cranial posterior portion are shown, according to the eighth embodiment of the present application;

[0032] Fig. 5(d) shows a top view of a head model as an example of a subject's head on which electrode positions of the 10-10 international standard electrode system, a total boundary line of a reference head cap portion, and boundary lines among a cranial superior anterior portion, a cranial superior portion, a cranial left portion, a cranial right portion, and a cranial posterior portion are shown, according to the eighth embodiment of the present application;

[0033] Fig. 5(e) shows a rear view of a head model as an example of a subject's head on which electrode positions of the 10-10 international standard electrode system, a total boundary line of a reference head cap portion, and boundary lines among a cranial superior portion, a cranial left portion, a cranial right portion, and a cranial posterior portion are shown, according to the eighth embodiment of the present application;

[0034] Figure 6 Fig. 6 shows a division method of a cranial superior anterior portion, a cranial superior portion, a cranial left portion, and a cranial right portion, according to an embodiment of the present application. DETAILED DESCRIPTION

[0035] In the following description, a large number of details are provided in order to thoroughly understand the present application. However, it can be appreciated by those skilled in the art that the following description only shows the preferred embodiments of the present application in some embodiments, and the present application can be implemented without one or more such details. In addition, in order to avoid confusion with the present application, some technical features known in the art are not described in detail.

[0036] To at least partially solve the above technical problems, in the process of developing and manufacturing a near-infrared light treatment device, a head model of a subject population can be used to simulate the attenuation and transmission of near-infrared light. The present application provides a head model of a near-infrared light treatment subject. The near-infrared light treatment device can be used to simulate the attenuation and transmission of near-infrared light in the head model of the subject population, and the simulation result can be used to determine the optimal treatment parameters of the near-infrared light treatment device. Figure 1The head cap is configured to accommodate the LED lamp panel. The LED lamp panel is arranged in the shell of the head cap. The LED lamp panel is arranged at a predetermined distance from the head of the subject. There is a gap between the LED lamp panel and the head of the subject. The gap causes the light to attenuate. The near-infrared light treatment device can be configured as shown in FIG. 2(a). Several LED lamp panels are arranged in a light-emitting unit. The light-emitting unit is arranged close to the head of the subject. The near-infrared light treatment device can be configured as shown in FIG. 2(b). The LED lamp panel is arranged at a large distance from the head of the subject. In order to detect the light power density of the near-infrared light emitted by different near-infrared light treatment devices, or to detect the light power density of the near-infrared light emitted by the same near-infrared light treatment device in different modes, the head mold of the present application can be used to replace the head of the subject. The head mold of the present application is configured to measure the light attenuation and transmission in the accommodation space of the near-infrared light treatment device.

[0037] Exemplarily, the surface of the head mold can be configured to have an absorption rate of the near-infrared light greater than a preset absorption rate. The preset absorption rate can be set according to the absorption rate of the scalp of a real human body to the near-infrared light. According to tests, the reflectivity of the head of a human body to the near-infrared light is low. The surface of the head mold can be black to more accurately simulate the absorption of light by the head of a human body. The test procedure is as follows: for the same near-infrared light treatment device, the same operation is used to irradiate the same size head mold. The surface of the head mold is pasted with an aluminum foil. The actually measured surface light power density is 5-12 mW / cm 2 greater than the surface light power density measured by the black head mold. This can be due to the reflection of the near-infrared light between the surface of the head mold and the near-infrared light treatment device, causing the superposition of the near-infrared light reaching the detection device. In some embodiments, the measured light power density can be calibrated according to the absorption rate and reflectivity of the skin of the head of a real human body.

[0038] Exemplarily, the absorption rate of the surface of the head mold to the near-infrared light can also be adapted to the absorption rate of the head surface of the represented treatment subject population to the near-infrared light. This can be suitable for different skin color populations, such as Africans, Europeans, etc.

[0039] The size of the head mold, in particular, can be configured according to the size of the head of the treatment subject population. The head mold is representative of the size. The structure of the head mold satisfies a first set of structure parameters. The first set of structure parameters includes: the head circumference is between 525-583 mm, the head length is between 170-196 mm, and the head width is between 140-166 mm. The parameters are shown in Figures 3(a)-3(f) .

[0040] The present application is directed to a near-infrared light treatment device that accommodates a head in an accommodation space and applies near-infrared light for treatment. In the case of an embodiment in which the head of a subject is inserted into the accommodation space from below, the length, width, and circumference of the head of the subject need to be taken into consideration in priority. Otherwise, it can not be possible to wear the device, or it can be uncomfortable to wear. In the case of a head model, in the process of designing, it is necessary to ensure that, when a detection probe is disposed on the head model, the detection surface of the detection probe is in the same position as the surface of a real human head with respect to the near-infrared light treatment device.

[0041] Through clinical research and statistical analysis, it is found that the concentrated age range of AD patients is over 60 years old. For this age range of treatment subjects, representative head parameters are selected to greatly reduce the workload. Exemplarily, the head width and length of the head model are determined based on the average of the P50 parameter values of the head width and length of females in the age range of 61-70 years old and the P50 parameter values of the head width and length of males in the age range of 61-70 years old. In statistics, P50 usually refers to the 50th percentile, also known as the median.

[0042] Specifically, the parameter range of the head model falls within the intersection of the P1, P5, P10, P50, P90, P95, and P99 parameter values of females in this age range and the P1, P10, P50, P90, P95, and P99 parameter values of males in this age range, and thus is representative of both males and females in this age range. For example, the head circumference mentioned above is between 525-583 mm, the head length is between 170-196 mm, and the head width is between 140-166 mm, which fall within the intersection. Specifically, the structural parameters of the reference head model further include: an arbitrary value in the range of 104-130 mm for the morphological face length, an arbitrary value in the range of 304-372 mm for the head sagittal arc, an arbitrary value in the range of 320-375 mm for the inter-tragus arc, and an arbitrary value in the range of 206-253 mm for the head height. These parameters also fall within the intersection.

[0043] Exemplarily, the structural parameters of the reference head model specifically include: a morphological face length of 104-111.9 mm, a head sagittal arc of 348.8-362.4 mm, an inter-tragus arc of 320-329.6 mm, and a head height of 206-210.7 mm.

[0044] In some embodiments, the parameters of the head phantom can be refined as follows: the head width is 152 mm, the head length is 184 mm, the head circumference is 536.7 mm, the metopic length is 109.3 mm, the sagittal arc is 355.6 mm, the intertragion arc is 324.1 mm, and the head height is 206 mm. The refined parameters are determined based on the P50 parameter values of females in this age group and the P50 parameter values of males in this age group, wherein the head width and the head length are the average of the two corresponding P50 parameter values. The P50 parameter values of females in this age group are as follows: the head width is 149 mm, the head length is 180 mm, the head circumference is 548 mm, the metopic length is 111 mm, the sagittal arc is 335 mm, the intertragion arc is 342 mm, and the head height is 228 mm. The P50 parameter values of males in this age group are as follows: the head width is 155 mm, the head length is 188 mm, the head circumference is 565 mm, the metopic length is 121 mm, the sagittal arc is 343 mm, the intertragion arc is 351 mm, and the head height is 231 mm. Thus, for example, the head circumference of the head phantom can be 536.7 mm, the head length can be 184 mm, and the head width can be 152 mm. It can be seen that the parameters of the head phantom are in good agreement with the P50 parameters of females and males in this age group, and thus are more representative.

[0045] For example, the surface of the head phantom can be configured to be black. This makes the head phantom easier to manufacture and less expensive. The actual light power density difference can be obtained by compensating for the detection value. The head length and head width dimensions form a head length-width index of 81.0-85.4. Further, the cephalo-facial index of the parameters can be 82%, which also corresponds to the range of the head-facial index of the dominant head type in Chinese people (even East Asian populations) - round head type (Brachycephaly). Thus, the parameters of the head phantom have particularly good representativeness in Chinese and East Asian populations.

[0046] Thus, in the development and manufacture of near-infrared light treatment equipment, a representative head phantom can be prepared for the target object population, and the verification of parameters such as the irradiation space range and the irradiation power can be performed on the surface of the skull portion of the head phantom. Based on the correspondence between the head phantom and the real human body, the performance exhibited by the near-infrared light treatment equipment designed using the head phantom can be considered to exhibit the same performance on a real human body, so that the near-infrared light treatment equipment can be improved accordingly. Thus, the head phantom can be used to detect and improve the near-infrared light treatment equipment for near-infrared irradiation of the head.

[0047] Exemplarily, the head phantom is marked with at least the electrode positions of the externally visible 10-20 international standard electrode system, or at least the electrode positions of the externally visible 10-10 international standard electrode system. In this way, simulation or testing can be carried out according to the details of the local focused stimulation scheme or the multi-zone balanced stimulation scheme intended to be implemented, and the configuration of the light treatment device, especially the spatial arrangement of the lamp panels, can be adjusted according to the results of the simulation or testing, so as to facilitate the designed light treatment device to meet the required synergistic irradiation conditions under the intended implementation scheme. After the simulation or testing verification is completed, a prototype of the designed light treatment device can be manufactured, and the prototype can be used to irradiate the physical head phantom to perform actual verification. It can be understood that if the actual verification result on the physical head phantom is good, and since the size of the head phantom is well representative of the size of the individual head of the subject population, for example, the parameters of the head of the subject population are 80% to 120% of the parameters of the head phantom of the subject population, the subsequent light treatment test on the subject population has a higher degree of agreement. Such a manufacturing process can balance the manufacturing cost and the treatment effect.

[0048] Some existing optical power meter probes are calibrated and have high detection accuracy. However, the probes usually have a relatively thick size, for example, 3-10 mm, and the detection surface is located on the outer surface of the probe. If the inner side of the probe is directly attached to a head phantom that is proportional to the real human head, the detection surface may be too close to the light source of the near-infrared light treatment device and too far from the surface of the head phantom, so that the detected optical power density does not match the actual optical power density received by the head of the object. In the case of superposition of near-infrared light irradiated to the head, the measurement accuracy will be worse. Exemplarily, a groove can be provided at each electrode position, and the groove is configured to accommodate the probe of the optical power meter and make the detection surface of the probe substantially flush with the surface of the head phantom. In this way, the detection surface of the optical power meter and the surface of the head of the actual object are approximately in the same plane. In some embodiments, the depth of the optical power meter probe embedded can also be changed to detect the optical power density of the head surface of different head size objects or the optical power density at different depths of the brain.

[0049] Exemplarily, an identification corresponding to the electrode position can be provided in the groove. Due to the large number of point positions, the identification can avoid data confusion. In some embodiments, the identification can also be provided outside the groove, and the identification will not be blocked when the probe is embedded in the groove.

[0050] Exemplarily, an extended fine groove is provided at the edge of the groove, and the fine groove is configured to at least partially accommodate the wiring connected to the probe. The wires of part of the probe are led out from the side surface of the probe. When the probe is embedded in the groove, the fine groove can avoid the wires from hindering the probe from entering the groove. In another aspect, the fine groove can avoid the wires from being damaged when the probe is embedded in the groove. Of course, in the case where the fine groove extends to the bottom of the groove, part of the wires led out from the bottom of the probe can also be applicable to the head phantom.

[0051] Exemplarily, the head model can also be marked with boundary lines. The head model can be marked with one or more of a total boundary line, a first boundary line, a second boundary line, a third boundary line, a fourth boundary line, and a fifth boundary line, so as to facilitate determination of the parts corresponding to the brain regions.

[0052] The boundary lines are configured to satisfy one or more of the following conditions:

[0053] 1) a first region enclosed by the first boundary line and the total boundary line corresponds to a cranial anterior superior part of the head of the subject;

[0054] 2) a second region enclosed by the second boundary line corresponds to a cranial parietal part of the head of the subject;

[0055] 3) a third region enclosed by the third boundary line and the total boundary line corresponds to a cranial left part of the head of the subject;

[0056] 4) a fourth region enclosed by the fourth boundary line and the total boundary line corresponds to a cranial right part of the head of the subject;

[0057] 5) a fifth region enclosed by the fifth boundary line and the total boundary line corresponds to a cranial posterior part of the head of the subject.

[0058] Specifically, the cranial anterior superior part 500a is within a first region enclosed by the first boundary line 502b and the total boundary line 501. In some embodiments, the cranial anterior superior part 500a occupies more than 60%, or more than 70%, or more than 80% of the surface area of the first region. For example, the cranial anterior superior part 500a can be implemented in a patch manner (see FIG. 4(a)) or a connected domain manner (see FIG. 4(b)) with multiple openings, which can or can not correspond to the electrode positions, to achieve the desired percentage of the surface area of the first region. In some embodiments, the cranial anterior superior part 500a can also cover the first region (see FIG. 4(c)) to achieve a non-corner irradiation of the first region. This can also apply to other parts, such as the cranial parietal part 500b, the cranial left part 500c, and the cranial right part 500d, which are not described here.

[0059] In some embodiments, the cranial parietal part 500b is within a second region enclosed by the second boundary line 502c. The cranial parietal part 500b occupies more than 60%, or more than 70%, or more than 80% of the surface area of the second region.

[0060] In some embodiments, the left cranial portion 500c occupies more than 60%, or more than 70%, or more than 80% of the surface area of the third region, and the right cranial portion 500d occupies more than 60%, or more than 70%, or more than 80% of the surface area of the fourth region.

[0061] The general boundary line passes through the preauricular points on the brow ridge, and then converges at the occipital protuberance, and the electrode positions O1, OZ and O2 of the 10-10 international standard electrode system. As shown in Figures 5(a)-5(e) The general boundary line encompasses most of the important target points for near-infrared light treatment. The near-infrared light treatment device can irradiate within the range defined by the general boundary line to cover whole brain treatment. As mentioned above, the head mold can be provided with a groove for accommodating a probe. For clarity, the points are Figures 5(a)-5(e) The head mold shown in FIG. 5(a) does not show the groove, but shows a corresponding protrusion.

[0062] According to the 10-10 standard electrode system, the first boundary line 502b sequentially passes between the following electrode positions: between F7 and FT7, between F5 and FC5, between FC3 and C3, between FC1 and C1 (see FIG. 5(b)), between FCZ and CZ (see FIG. 5(d)), between FC2 and C2, between FC4 and C4, between F6 and FC6, and between F8 and FT8 (see FIG. 5(c)).

[0063] According to the 10-10 standard electrode system, the second boundary line 502c sequentially passes between the following electrode positions: between FC3 and C3, between FC1 and C1, between FCZ and CZ, between FC2 and C2, between FC4 and C4 (see FIG. 5(d)), between C6 and C4, between CP6 and CP4, between P6 and P4 (see FIG. 5(c)), between PO4 and P4, between PO4 and P2, between POZ and P2, between POZ and PZ, between POZ and P1, between PO3 and P1, between PO3 and P3 (see FIG. 5(e)), between P5 and P3, between CP5 and CP3, and between C5 and C3 (see FIG. 5(b)).

[0064] According to the 10-10 standard electrode system, the third boundary line 502d passes sequentially between the following electrode positions (see Fig. 5(b)): between FT7 and F7, between FC5 and F5, between FC5 and FC3, between C5 and C3, between CP5 and CP3, between P5 and P3, between P5 and PO5, and between P7 and PO7. The fourth boundary line 502e passes sequentially between the following electrode positions (see Fig. 5(c)): between FT8 and F8, between FC6 and F6, between FC6 and FC4, between C6 and C4, between CP6 and CP4, between P6 and P4, between P6 and PO6, and between P8 and PO8.

[0065] According to the 10-10 standard electrode system, the fifth boundary line 502a passes sequentially between the following electrode positions (see Figs. 5(b), 5(c), and 5(e)): between P7 and PO7, between P5 and PO5, between P3 and PO3, between PI and POZ, between PZ and POZ, between P2 and POZ, between P4 and PO4, between P6 and PO6, and between P8 and PO8.

[0066] In some embodiments, the cranial anterior superior portion 500a, the cranial parietal portion 500b, as well as the cranial left lateral portion 500c and the cranial right lateral portion 500d can be divided according to the sets of electrode positions they contain. For example, according to the 10-10 standard electrode system, see Figure 6 , each portion can contain the following electrode positions, respectively.

[0067] The cranial anterior superior portion 500a contains the electrode positions FP2, FPZ, FP1, AF3, AF4, AF7, AF8, AFZ, FZ, F1, F2, F3, F4, F5, F6, F7, F8, FC1, FC2, FC3, FC4, FCZ. The cranial parietal portion 500b contains the electrode positions CZ, C1, C2, C3, C4, CPZ, CP1, CP2, CP3, CP4, PZ, PI, P2, P3, P4. The cranial left lateral portion 500c contains the electrode positions FT7, FC5, T7, C5, TP7, CP5, P7, P5, and the cranial right lateral portion 500d contains the electrode positions FT8, FC6, T8, C6, TP8, CP6, P8, P6.

[0068] In some embodiments, the cranial posterior portion 500e can also be defined using the electrode positions it contains, for example, the cranial posterior portion 500e can contain the electrode positions PO7, PO5, PO3, POZ, PO4, PO6, PO8, O1, OZ, and O2.

[0069] In some embodiments, the cranial posterior portion 500e can also be defined using anatomical landmarks, for example, the cranial posterior portion 500e can contain at least the occipital region superior to the inion.

[0070] In some embodiments, each of the sections can contain sparser electrode positions, i.e. shrink the coverage. For example, according to the 10-10 standard montage, the fronto superior section 500a can contain electrode positions AFZ, FZ, F1, F2, FP1, FP2. The parietal section 500b contains electrode positions CZ, C1, C2, and CPZ. The left temporal section 500c contains electrode positions FT7, FC5, T7, C5, or TP7, CP5, P7, or P5, and the right temporal section 500d contains electrode positions FT8, FC6, T8, C6, or TP8, CP6, P8, P6. While shrinking the coverage of each section, by providing sufficient time-averaged irradiance power to each section, it is still possible to break through the spatial separation and spread to the nearby core network nodes and brain regions of the default mode network (DMN), the central executive network (ECN, also known as executive control network), the salience network (SN), the sensory-motor network (SMN), and the dorsal attention network (DAN) to perform AD suppression processing along the spread path of the functional connectivity regions, such as suppressing or eliminating the deposition of Aβ plaques, suppressing or eliminating the abnormal aggregation of Tau proteins, suppressing or improving the tangle of neuronal fibers, and thus effectively suppressing or cutting off the development process of neurodegenerative diseases caused by Aβ plaques and Tau proteins along the spread of the brain functional network.

[0071] In some embodiments, the fronto superior section 500a, the parietal section 500b, as well as the left temporal section 500c and the right temporal section 500d can be divided as needed based on the set of electrode positions contained therein. Please note that such division can be for the convenience of light therapy device light control, or for the specific structure of the light therapy device, especially the spatial arrangement of each unit in the array of near-infrared irradiation units. Thus, the set of electrode positions contained in each of the fronto superior section 500a, the parietal section 500b, as well as the left temporal section 500c and the right temporal section 500d can be flexibly divided as long as they can cover or be sufficiently adjacent to the core network nodes and brain regions of the default mode network (DMN), the central executive network (ECN, also known as executive control network), the salience network (SN), the sensory-motor network (SMN), and the dorsal attention network (DAN).

[0072] In the description of the present application, it should be understood that the orientation words such as "front", "back", "upper", "lower", "left", "right", "transverse", "vertical", "vertical", "horizontal" and "top", "bottom" and the like indicated orientation or position relationship is generally based on the orientation or position relationship shown in the drawings, only for the convenience of describing the present application and simplifying the description, without making the opposite statement, these orientation words do not indicate and imply that the device or device must have a particular orientation or be constructed and operated in a particular orientation, therefore, it cannot be understood as a limitation on the scope of protection of the present application; the orientation words "inner", "outer" refer to the inner and outer of the contour of each component itself.

[0073] For the convenience of description, the area relative terms such as "on", "above", "upper surface", "upper" and the like can be used herein to describe the area position relationship of one or more components or features shown in the figure with other components or features. It should be understood that the area relative terms not only include the orientation of the components described in the figure, but also include different orientations in use or operation. For example, if the components in the figure are inverted as a whole, the components "above" or "above" other components or features will include the components "below" or "below" other components or structures. Thus, the exemplary term "above" can include both "above" and "below". In addition, these components or features can also be positioned at other different angles (for example, rotated by 90 degrees or other angles), and all these cases are intended to be included herein.

[0074] It should be noted that the terms used herein are only for the purpose of describing specific embodiments, and are not intended to limit the exemplary embodiments according to the present application. As used herein, the singular form is intended to include the plural form unless the context clearly indicates otherwise, and furthermore, it should be understood that when the terms "comprise" and / or "include" are used in the specification, it means that the features, steps, operations, components, assemblies and / or combinations thereof are present.

[0075] The present application has been described by the above examples, but it should be understood that the above examples are only for the purpose of example and illustration, and are not intended to limit the present application to the scope of the described embodiments. In addition, those skilled in the art can understand that the present application is not limited to the above examples, and more variations and modifications can be made according to the teachings of the present application, which are within the scope of the present application. The scope of protection of the present application is defined by the appended claims and their equivalent scope.

Claims

1. A head model for near-infrared light therapy, characterized in that, The head mold is configured for measuring light attenuation and transmission in a space for accommodating a near-infrared light treatment device, the head mold surface has an absorption rate for near-infrared light greater than a preset absorption rate, and the structure satisfies a first set of structure parameters, the first set of structure parameters including: a head circumference between 525-583 mm, a head length between 170-196 mm, and a head width of 140-166 mm.

2. The headform of claim 1, wherein The head mold is marked with at least externally visible electrode positions of a 10-20 international standard electrode system, or at least externally visible electrode positions of a 10-10 international standard electrode system.

3. The headform of claim 2, wherein, A groove is formed at each electrode position, the groove being configured to accommodate a probe of a power meter and to make a detection surface of the probe substantially flush with a surface of the head mold.

4. The headform of claim 3, wherein, An identifier of the corresponding electrode position is provided in the groove.

5. The headform of claim 3, wherein, An extended slot is formed at an edge of the groove, the slot being configured to at least partially accommodate a wire connected to the probe.

6. The headform of any of claims 1-5, wherein, The absorption rate of the head mold surface for near-infrared light is adapted to the absorption rate of a head surface of a representative treatment subject population for near-infrared light.

7. A headform according to any one of claims 1 to 5 wherein, The head mold surface is black, and a head length-width index composed of the head length and the head width is 81.0-85.

4.

8. The headform of any of claims 1-5, wherein, The parameters of the head mold further include: a morphological face length between 104-130 mm, a head sagittal arc between 304-372 mm, an inter-tragus arc between 320-375 mm, and a head height between 206-253 mm.

9. The headform of claim 8, wherein, The morphological face length is 109.3 mm, the head sagittal arc is 355.6 mm, the inter-tragus arc is 324.1 mm, and the head height is 206 mm.

10. The headform of claim 8, wherein, The head circumference is 536.7 mm, the head length is 184 mm, and the head width is 152 mm.

11. The headform of any of claims 1-5, wherein, The head width and the head length of the head mold are each determined based on a mean of a P50 parameter value of the head width and the head length of a female in an age group of 61-70 years old and a P50 parameter value of the head width and the head length of a male in an age group of 61-70 years old.

12. The headform of any of claims 2-5, wherein, The head mold is further marked with one or more of the following externally visible boundary lines: a total boundary line that passes through the glabella point of the head mold along the supraorbital ridge, through the preauricular points on both sides, and then converges backward through the inion and between the electrode positions O1, OZ, and O2 of the 10-10 international standard electrode system; a first boundary line that sequentially passes between the following electrode positions of the 10-10 international standard electrode system: between F7 and FT7, between F5 and FC5, between FC3 and C3, between FC1 and C1, between FCZ and CZ, between FC2 and C2, between FC4 and C4, between F6 and FC6, and between F8 and FT8; and a second boundary line that sequentially passes between the following electrode positions of the 10-10 international standard electrode system: between F7 and FT7, between F5 and FC5, between FC3 and C3, between FC1 and C1, between FCZ and CZ, between FC2 and C2, between FC4 and C4, between F6 and FC6, and between F8 and FT8. a second boundary line sequentially passing between the following electrode positions of the 10-10 international standard electrode system: between FC3 and C3, between FC1 and C1, between FCZ and CZ, between FC2 and C2, between FC4 and C4, between C6 and C4, between CP6 and CP4, between P6 and P4, between PO4 and P4, between PO4 and P2, between POZ and P2, between POZ and PZ, between POZ and PI, between PO3 and PI, between PO3 and P3, between P5 and P3, between CP5 and CP3, and between C5 and C3; a third boundary line sequentially passing between the following electrode positions of the 10-10 international standard electrode system: between FT7 and F7, between FC5 and F5, between FC5 and FC3, between C5 and C3, between CP5 and CP3, between P5 and P3, passing between P5 and PO5, between P7 and PO7; a fourth boundary line sequentially passing between the following electrode positions of the 10-10 international standard electrode system: between FT8 and F8, between FC6 and F6, between FC6 and FC4, between C6 and C4, between CP6 and CP4, between P6 and P4, between P6 and PO6, between P8 and PO8; a fifth boundary line sequentially passing between the following electrode positions of the 10-10 international standard electrode system: between P7 and PO7, between P5 and PO5, between P3 and PO3, between PI and POZ, between PZ and POZ, between P2 and POZ, between P4 and PO4, between P6 and PO6, between P8 and PO8.

13. The headform of claim 12, wherein, The total boundary line, the first boundary line, the second boundary line, the third boundary line, the fourth boundary line, and the fifth boundary line are configured to satisfy one or more of the following conditions: a first region enclosed by the first boundary line and the total boundary line corresponds to a cranial anterior superior portion of a head of the subject; a second region enclosed by the second boundary line corresponds to a cranial top portion of the head of the subject; a third region enclosed by the third boundary line and the total boundary line corresponds to a cranial left portion of the head of the subject; a fourth region enclosed by the fourth boundary line and the total boundary line corresponds to a cranial right portion of the head of the subject; a fifth region enclosed by the fifth boundary line and the total boundary line corresponds to a cranial posterior portion of the head of the subject.

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